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All Journal Medika Kartika : Jurnal Kedokteran dan Kesehatan Muhammadiyah Medical Journal Jurnal MedScientiae Jurnal Kedokteran Meditek
Donna Mesina Rosadini Pasaribu
Universitas Kristen Krida Wacana
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Journal : jurnal medscientiae

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Isolasi Bakteri Methicillin Resistant Staphylococcus aureus pada Gagang Pintu Gedung Kampus X di Jakarta Pasaribu, Donna Mesina Rosadini; Kelvin, Kelvin; Timotius, Kris Herawan
Jurnal MedScientiae Vol. 3 No. 1 (2024): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i1.3062

Abstract

Bacteria are one of the component parts in every ecosystem. Staphylococcus aureus (S. aureus) is a normal surface flora of the human body, as a temporary contaminant on inanimate objects such as clothing, cutlery and doorknobs, but also a oportunistic even pathogen on the host. The mutated strain of S. aureus has a cross-resistant strain against all antibiotics of the Beta Lactam, Methicillin, Oxacillin and Flucloxacillin groups, called Methicillin Resistant Staphylococcus aureus (MRSA). This research is needed because MRSA is a strain of bacteria that can be everywhere, especially in public facilities, such as doorknobs, which can be a place of transmission (transfer) of bacteria from one host to another. The samples in this study were taken by swabbing from the door handle in building X, Jakarta. A total of 62 samples were then cultured on Mannitol Salt Agar (MSA) media, the growing isolate was tested by Gram staining, catalase test, and mannitol. Isolate suspected of Staphylococcus aureus, ascertained whether MRSA strain using 30 μg antibiotic C efoxitin (fox) disc. The results of this study showed that 58 (87%) isolates were Staphylococcus aureus and sensitive to C efoxitin antibiotics, 8 (13%) isolates, mnitol test negative, sensitive to Ceroxitin antibiotics. The study concluded that the bacterial isolate found was Staphylococcus aureus sensitive methicillin (MSSA), no MRSA was found.
Uji Efektivitas Ekstrak Kulit Manggis terhadap Pertumbuhan Jamur Malassezia furfur Susanto, Inneke Kusumawati; Pasaribu, Donna Mesina Rosadini; Laurensia Charlina Nova Sambut
Jurnal MedScientiae Vol. 4 No. 3 (2025): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae.v4i3.3607

Abstract

Background Mangosteen is one of the medicinal plants that has long been known in Southeast Asia, with its skin having various of properties, including antibacterial, antifungal, anti-inflammatory, and antioxidant. Mangosteen skin in traditional medicine is used to cure various diseases. One of the fungi that can cause skin disease in human is Malassezia furfur, which is a lipophilic fungus and part of the normal skin microflora. Objective: This study aims to determine and prove whether mangosteen skin extract has antifungal activity against Malassezia furfur. Method: This study used an experimental method to test the antifungal activity of mangosteen skin extract. Testing was carried out using the Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC), and diffusion methods to measure the inhibitory power against Malassezia furfur at various extract concentrations. Results: The results showed that mangosteen skin extract has antifungal activity against Malassezia furfur. The extract concentration that gave the greatest inhibitory power was 100%, while the lowest concentration that showed inhibitory power was 20%. Conclusion: Mangosteen peel extract has been proven to have antifungal activity against Malassezia furfur, with a concentration of 100% providing the greatest inhibitory effect, while a concentration of 20% still shows an inhibitory effect, but weaker.
Pola Kepekaan Antibiotik Fosfomycin terhadap Bakteri Patogen Penyebab Infeksi Saluran Kemih Pasien Dewasa di Rumah Sakit X pada Periode Tahun 2023 Ebat, Aelred Parleso; Gunardi, Wani Devita; Pasaribu, Donna Mesina Rosadini
Jurnal MedScientiae Vol. 4 No. 3 (2025): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae.v4i3.3618

Abstract

Urinary Tract Infection (UTI) is an infection of the urinary tract structure which is generally caused by Escherichia coli with a prevalence of 5-15% with an estimated 180 thousand cases per year in Indonesia, making it the most common disease today. This is further exacerbated by increasing resistance to conventional antibiotics such as amoxicillin, cephalosporins, and fluoroquinolones which makes the selection of UTI therapy increasingly difficult. This study aims to determine the sensitivity of fosfomycin antibiotics to pathogens that cause UTI in adult patients at Hospital X in the period 2023. This study used an observational method, with a retrospective descriptive approach by collecting and analyzing secondary data from the microbiology laboratory of Hospital X. The sampling technique used total sampling with a sample size of 51. Using univariate analysis, it was found that women and the elderly group had a fairly high risk of UTI, with E. coli being the most common etiology (51.8%). Fosfomycin was shown to have a high level of sensitivity (96.55%) to E. coli. Therefore, it can be concluded that fosfomycin has a high level of sensitivity to pathogens that cause UTI infections in adult patients at Hospital X in 2023. This study will be more accurate if the number of samples can be increased again.
Penggunaan Gambaran Penggunaan Antibiotik pada Pasien Sepsis Dewasa di RSUD X Jakarta: Antibiotik pada Pasien Sepsis Pasaribu, Donna Mesina Rosadini; William, William; Siceria, Putri Denova
Jurnal MedScientiae Vol. 5 No. 1 (2026): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae.v5i1.3753

Abstract

Sepsis is a collection of symptoms that occur as a result of an overreaction of the human immune response caused by microbes. Sepsis can progress to septic shock and if it persists accompanied by decreased immunity can cause death. Antibiotic therapy should be given as soon as the diagnosis, starting with empiric antibiotics which are then adjusted according to clinical response or culture results. This study aims to describe the use of antibiotics in RSUD X Jakarta, in adult sepsis cases. The research method is descriptive observational with consecutive sampling in accordance with the inclusion and exclusion criteria. Data collection was obtained through medical records of patients diagnosed with sepsis. The results showed that the most patients sepsis were aged less than 60 years, there were 51%, men 53%, the length of stay was less than 10 days, 62% and 55% patients had no comorbidities. The focus of infection was mostly in the lungs 38%, patients who sampled the most monotherapy antibiotics were Ceftriaxone 51.1%, the most combination use was Levofloxacin and Meropenem 21.1%, and the longest duration of antibiotic use less than 7 days with Ceftriaxone 43 (53.75%). There were 64 people (64%) of these sepsis patients died. The study concluded that the focus of infection in sepsis patients was mostly in the lungs, men aged less than 60 years, without any comorbid disease, length of stay less than 10 days. The choice of antibiotic monotherapy for septic patients, given Ceftriaxone, for combination therapy given Levofloxacin and Meropenem antibiotics.
Co-Authors Ade Dharmawan Ebat, Aelred Parleso Erma Mexcorry Sumbayak Haq, Satria Addienul Henny Tannady Tan Inneke Kusumawati Susanto Kelvin Kelvin Kris Herawan Timotius Laurensia Charlina Nova Sambut Septiana, Yorisye Siceria, Putri Denova Simanjuntak, Lasma Susi F. Suhandi, Priska Yoverani Wani Devita Gunardi Wijaya, Pande I Gede Indra William William