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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN The Indonesian Biomedical Journal Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Perinatology
William Alexander Setiawan
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health

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Various birth techniques: home birth, water birth, lotus birth, hypno birth, and birth position Winata, I Gde Sastra; Harrista, Daniel Victor; Setiawan, William Alexander
Indonesian Journal of Perinatology Vol. 5 No. 1 (2024): Available online: 1 June 2024
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v5i1.52

Abstract

Background: The birth process varies greatly; health workers should be able to provide education about each technique and help patients plan their labor process. Each delivery technique is assessed from the mother's side and the baby's side, not only for patient satisfaction but also for patient safety. This article will provide a review of various birth technique known which are home birth, water birth, lotus birth, hypno birth, and including various birth position. Methods: This article is a systematic review of qualitative and quantitative studies from studies published in PubMed, Cochrane, the British Medical Journal, BioMed Central, and Elsevier, published in 2015 to 2023. The study sample included healthy maternal nulliparous or multiparous women with a low risk of complications. The focus of the research is on childbirth using home birth techniques, water birth, lotus birth, hypno birth, and birth positions. This article includes research conducted in hospitals, maternity homes, and patients' homes. Results: There are 6 studies included in this review. Each of which provide the perspectives and experiences of patients and healthworkers regarding various birth technique used. Conclusions: Each birthing technique has its own advantages and disadvantages. Each birthing technique also has its own recommendation criteria so that a birthing technique cannot be used for every birthing patient. The birthing technique and birthing position must be adjusted to the patient's condition and the medical facilities available at that time.
Prognostic significance of tumor angiogenesis markers in advanced cervical cancer undergoing chemotherapy Mahendra, I Nyoman Bayu; Winata, I Gde Sastra; Setiawan, William Alexander; Putra, Ida Bagus Agung Widnyana; Darmayasa, Putu Bagus
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 15, No 2 (2024): December 2024
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v15i2.28943

Abstract

Cervical cancer is the second leading cause of cancer-related deaths among women worldwide. Despite advancements in screening programs and vaccination efforts, a significant proportion of patients present with advanced-stage disease, characterized by severe manifestations and a poor prognosis. Clinical evidence highlights substantial variability in the sensitivity of chemotherapy regimens among cervical cancer patients, often resulting in suboptimal therapeutic outcomes and increased risk of complications. This underscores the need for reliable molecular markers to predict prognosis and optimize therapy. Angiogenesis plays a pivotal role in the development and progression of solid tumors, including cervical cancer. Key tumor angiogenesis markers, such as vascular endothelial growth factor (VEGF) and its receptor (VEGFR), are critical in driving tumor progression in advanced cervical cancer. Studies have demonstrated significant correlations between VEGF levels and important prognostic parameters, including tumor size, metastasis, and chemotherapy response. Consequently, tumor angiogenesis markers like VEGF and VEGFR hold potential as valuable predictive tools to guide the management of advanced cervical cancer, particularly in patients undergoing chemotherapy.
Hypomethylation of the Soluble Fms-like Tyrosine Kinase 1 (sFlt-1) Gene Promoter Region and Elevated sFlt-1 Placental Expression as Risk Factors for Preeclampsia Kusuma, Anak Agung Ngurah Jaya; Darmayasa, I Made; Putra, I Gede Mega; Suardika, Anom; Pangkahila, Evert Solomon; Duarsa, Vidya Saraswati Putri; William, William
The Indonesian Biomedical Journal Vol 17, No 4 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i4.3744

Abstract

BACKGROUND: Preeclampsia significantly contributes to maternal and fetal morbidity and mortality worldwide, marked by an imbalance of angiogenic factors, particularly increased soluble Fms-like tyrosine kinase-1 (sFlt-1), leading to endothelial dysfunction. Epigenetic regulation, including DNA methylation of the sFlt-1 promoter, has been suggested to influence sFlt-1 expression, but the data in Indonesian population are limited. This study was perfmed to determine whether hypomethylation of the sFlt-1 promoter and elevated placental sFlt-1 expression are associated with increased risk of preeclampsia.METHODS: A case-control study was conducted involving 30 women with preeclampsia and 30 normotensive pregnant women. Subjects were selected based on eligibility criteria that included singleton pregnancy and gestational age of ≥37 weeks. DNA methylation of the sFlt-1 promoter was assessed using methylation-specific polymerase chain reaction (PCR), and sFlt-1 expression was measured by enzyme-linked immunosorbent assay (ELISA). Statistical analyses, including Mann-Whitney U, Chi-square tests, Receiver-operating characteristic (ROC) curve analysis, and multivariate logistic regression, were performed to evaluate the relationship between methylation levels, gene expression, and preeclampsia risk.RESULTS: The preeclampsia group had significantly lower methylation levels of sFlt-1 promoter and higher placental sFlt-1 expression (both p<0.001). Hypomethylation of sFlt-1 promoter (adjusted odd ratio (AOR): 21.18; 95% CI: 2.49–179.72; p=0.005), high sFlt-1 expression (AOR: 12.55; 95% CI: 1.95–80.83; p=0.008), and obesity (AOR: 11.15; 95% CI: 2.01–61.78; p=0.006) were identified as independent risk factors for preeclampsia.CONCLUSION: Hypomethylation of sFlt-1 promoter and elevated placental sFlt-1 expression are significant independent risk factors for preeclampsia. These findings suggest that hypomethylation of sFlt-1 promoter and elevated placental sFlt-1 expression may serve as potential epigenetic biomarkers for early detection and targeted intervention in preeclampsia.KEYWORDS: preeclampsia, sFlt-1, gene expression, hypomethylation, placenta, risk factor
Co-Authors A.A. Gde Marvy Khrisna Pranamartha Anom Suardika Anthony Stephen Halim Darmayasa, Putu Bagus DPG Jananuraga Maharddhika Duarsa, Vidya Saraswati Putri Ernest TB Sianturi Evert Solomon Pangkahila Fenyta Christyani Harrista, Daniel Victor I Gde Sastra Winata I Gede Mega Putra I Ketut Suwiyoga I Made Darmayasa I Nyoman Bayu Mahendra Kusuma, Anak Agung Ngurah Jaya Marvy Khrisna Pranamartha, Anak Agung Gde Ni Luh Wita Astari Widhusadi Ni Luh Wita Astari Widhusadi Nyoman Bayu Mahendra Putra, Ida Bagus Agung Widnyana Putu Bagus Darmayasa Ryan Saktika Mulyana Sastra Wianta, I Gde Tjokorda Gde Agung Suwardewa