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All Journal Jurnal Ilmu Kimia Universitas Brawijaya The Journal of Pure and Applied Chemistry Research SEMIRATA 2015 JKPK (Jurnal Kimia dan Pendidikan Kimia) Tri Dharma Mandiri: Diseminasi dan Hilirisasi Riset Kepada Masyarakat (Jurnal Pengabdian Kepada Masyarakat) Makara Journal of Science
Sasangka Prasetyawan
Chemistry Department, Brawijaya University
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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Journal : The Journal of Pure and Applied Chemistry Research

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The Effect of KIO3 and KI Salt Towards Iodium Levels (I2) in Urine, Malondialdehyde (MDA) and The Histology of Thyroid Gland of Goitrogenic Rat Heli, Risman; Mahdi, Chanif; Prasetyawan, Sasangka
The Journal of Pure and Applied Chemistry Research Vol. 3 No. 3 (2014)
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (544.921 KB) | DOI: 10.21776/ub.jpacr.%y.03.03.181

Abstract

Goitrogenic substances can inhibit of iodine taking by the thyroid gland. Thus iodine concentration in thyroid gland will be low, and this phenomena is indicated by inflammation in the thyroid gland. Moreover, it can cause releaseing of an excessive amount of free radicals. This radicals, in the body, causes oxidative stress and also increase the levels of malondialdehyde (MDA). This is also as an indicator for lipid peroxidation and the decreasing of urinary iodine excretion levels (EIU). The treatment with KIO3and KI salt was intended to study the level of supplementation of iodine (I2) toward level of MDA in serum and histological description of rat’s thyroid gland. The MDA levels was determined through TBA test (Thio Barbituric Acid), meanwhile the histological pattern of  rat thyroid gland was determined by Hematoxylen-Eosin staining (HE). The results indicated both of KIO3 and KI salt significantly (p<0.01) reduced MDA level in the serum. Treatment with KIO3 salt gave 33.62% while KI salt slightly higher (37,02%). In addition, both of treaments displayed an recovering effect in thyroid gland.
Co-Authors A.A. Ketut Agung Cahyawan W Ani Mulyasuryani Anna Roosdiana Annisa, Choirin Ardian Retno Sari Ardyan Sukma Sulistyaningtyas Aulanni'am, Aulanni'am Chanif Mahdi Iftakhul Mufarrikha intan permata sari Megawati Sistin Agustita Mufida, Fadillah Prayoga, Indrajid Risman Heli Safitri, Anna Sari, Intan Permata Satriana Satriana Selvi Marcellia Suhaili, Ahmad Tantowidjojo, Vanessa Rachmani Wardani, Kartika Kusuma Wijaya, Anik Sri Yustika, Agnes Ratna