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Kehamilan pada Usia Remaja Sebagai Faktor Risiko Terjadinya Ketuban Pecah Dini Prasetyo, Kevin Wahyudy; Angelia, Affi; Primadewi, Novi
Nexus Kedokteran Klinik Vol 2, No 3 (2013): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.046 KB)

Background: Premature Rupture of Membranes (PROM) is a complication that happens in 10% of pregnancy and it increases the risk of fetal death. Teenagers who get pregnant have risk for having PROM. This condition is related to nutrition factor that changes the immunity of mother. The goal of this research is to acknowledge teenage pregnancy as risk factor of PROM. Methods: This research is a case control based study. The sample used by researcher is term pregnant women with and without PROM complication with a total sample of 30 people. The data is collected from medical record and questionnaire. The data, afterwards, analyzed with multiple logistic regression analysis. Result: There is a statistically significant relationship between teenage pregnancy and PROM. Pregnant teenagers have risk to get PROM 11,808 times bigger than those of adult (p = 0,021; OR = 11,808). Conclusion: Based on the result, it can be concluded that teenage pregnancy has risk to get PROM 11,808 times bigger than those of adult. Keyword: teenage pregnancy, Premature Rupture of MembranesÂ

Kehamilan pada Usia Remaja Sebagai Faktor Risiko Terjadinya Ketuban Pecah Dini Kevin Wahyudy Prasetyo; Affi Angelia; Novi Primadewi
Nexus Kedokteran Klinik Vol 2, No 3 (2013): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.046 KB)

Background: Premature Rupture of Membranes (PROM) is a complication that happens in 10% of pregnancy and it increases the risk of fetal death. Teenagers who get pregnant have risk for having PROM. This condition is related to nutrition factor that changes the immunity of mother. The goal of this research is to acknowledge teenage pregnancy as risk factor of PROM. Methods: This research is a case control based study. The sample used by researcher is term pregnant women with and without PROM complication with a total sample of 30 people. The data is collected from medical record and questionnaire. The data, afterwards, analyzed with multiple logistic regression analysis. Result: There is a statistically significant relationship between teenage pregnancy and PROM. Pregnant teenagers have risk to get PROM 11,808 times bigger than those of adult (p = 0,021; OR = 11,808). Conclusion: Based on the result, it can be concluded that teenage pregnancy has risk to get PROM 11,808 times bigger than those of adult. Keyword: teenage pregnancy, Premature Rupture of Membranes

Analisis Ketahanan Hidup Pasien Kanker Paru di RSUD Dr. Saiful Anwar Pratiwi, Suryanti Dwi; Setyawan, Ungky Agus; Falyani, Silvy Amalia; Permatasari, Adinda Pramitra; Santosa, Andrew; Febriawati, Juwita; Prasetyo, Kevin Wahyudy; Yokanan
Jurnal Klinik dan Riset Kesehatan Vol 3 No 3 (2024): Edisi Juni
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.03.3.2

Pendahuluan: Kanker paru insidennya sebesar 14% dari semua kanker, dan merupakan penyebab utama kematian akibat keganasan di seluruh dunia. Berbagai studi menunjukkan perbedaan terkait angka ketahanan hidup, serta berbagai faktor yang signifikan terkait dengan angka ketahanan hidup tersebut pada pasien kanker paru. Tujuan: Penelitian ini bertujuan untuk mengetahui profil dan angka tahan hidup (ATH) pasien kanker paru yang mendapatkan kemoterapi di RSUD dr. Saiful Anwar pada tahun 2018-2020. Metode: Studi kohort retrospektif dengan menggunakan data rekam medik pasien terdiagnosis kanker paru pada tahun 2018 – 2020 yang mendapatkan kemoterapi. Analisis data dilakukan menggunakan uji log rank Mantel Cox, serta ketahanan hidup pasien berupa progression free survival (PFS) dan overall survival (OS) ditampilkan dengan kurva Kaplan Meier. Hasil: Pasien kanker paru terbanyak berjenis kelamin laki-laki (73,2%). Adenokarsinoma merupakan jenis sel kanker paru terbanyak (59,8%) dengan mutasi EGFR wild type 20,6%. Karboplatin–Paklitaksel merupakan jenis kemoterapi yang paling sering digunakan (54,6%). Analisis ATH menunjukkan terdapat hubungan signifikan antara usia dengan PFS dan OS (p < 0,05). Kesimpulan: Berbagai faktor seperti jenis kelamin, jenis sel kanker, mutasi EGFR, dan jenis kemoterapi diketahui tidak berkaitan signifikan dengan ATH pasien kanker paru. Hubungan signifikan antara usia dengan ATH menunjukkan potensi faktor usia sebagai prediktor ketahanan hidup pasien kanker paru.

Volatile Organic Compounds (VOC) and Serum Leukotriene B4 between COPD Patients and COPD with Lung Cancer Patients Djajalaksana, Susanthy; Listyoko, Aditya Sri; Prasetyo, Kevin Wahyudy; Wardoyo, Arinto Yudi Ponco
Jurnal Respirasi Vol. 10 No. 3 (2024): September 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.3.2024.222-227

Introduction: Chronic obstructive pulmonary disease (COPD) is estimated to become the third leading cause of death worldwide in 2030. COPD can affect the lungs and cause chronic systemic inflammation. Leukotriene B4 (LTB4) is involved in COPD and lung cancer pathogenesis. There has been the development of non-invasive methods for detecting lung disease in the last few decades, such as the examination of volatile organic compounds (VOC). This study aimed to analyze the serum LTB4 and the difference of VOCs in exhaled breath of stable COPD patients and COPD with lung cancer patients. Methods: This case-control study recruited 20 stable COPD patients and 20 patients with COPD and lung cancer. An exhaled breath sample was collected in Tedlar bags and analyzed using an arrayed sensor breath analyzer to check the concentration of VOCs. Meanwhile, a venous blood sample was collected to examine the level of LTB4 using an ELISA kit. Independent t-test and Mann-Whitney test were used to analyze the data. Results: The carbon dioxide (CO2), nitrogen dioxide (NO2), carbon monoxide (CO), benzene (C6H6), and propane (C3H8) levels were significantly different (p <0.05) in COPD-only patients compared to COPD with lung cancer patients. Serum LTB4 increased in both groups. Conclusion: CO2, CO, and C3H8 levels increased, but the NO2 level decreased in COPD patients with lung cancer compared to COPD-only patients. Serum LTB4 increased in COPD with lung cancer patients.

Analisis Ketahanan Hidup Pasien Kanker Paru di RSUD Dr. Saiful Anwar Pratiwi, Suryanti Dwi; Setyawan, Ungky Agus; Falyani, Silvy Amalia; Permatasari, Adinda Pramitra; Santosa, Andrew; Febriawati, Juwita; Prasetyo, Kevin Wahyudy; Yokanan
Jurnal Klinik dan Riset Kesehatan Vol 3 No 3 (2024): Edisi Juni
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.03.3.2

Background: Comprising 14% of all cancer, lung cancer is the main cause of cancer-related mortality worldwide. Previous studies showed various findings regarding the survival rate of lung cancer, and factors significantly correlated with survival rate in lung cancer patients. Aim: This research aims to identify the profile and survival rate of lung cancer patients receiving chemotherapy in Saiful Anwar General Hospital from 2018 to 2020. Methods: This cohort retrospective study used medical records of patients diagnosed with lung cancer who underwent chemotherapy from 2018 to 2020. Data analysis was done using the Mantel Cox log rank test. Survival data shown as progression free survival (PFS) and overall survival (OS) were shown using Kaplan-Meier curves. Results: Subjects were largely male (73,2%). Adenocarcinoma is the most often type of lung cancer found (59,8%) with wild type EGFR mutation being the most prevalent (20,6%). Carboplatin – Paclitaxel is the most widely used chemotherapy regimen (54,6%). Survival analysis showed a significant correlation between age, OS, and PFS (p < 0,05) Conclusion: Various factors such as gender, cancer cell type, EGFR mutation, and chemotherapy regimen were not found to be related to survival rate in lung cancer patients. A significant correlation between age and survival rate showed potential in utilizing age as a predictor of survival rate in lung cancer patients.

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