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All Journal Jurnal Kedokteran Brawijaya Universa Medicina Jurnal Respirasi (JR) Malang Respiratory Journal Jurnal Klinik dan Riset Kesehatan Journal of Community Health and Preventive Medicine (JOCHAPM)
Pratiwi, Suryanti Dwi
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Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Relationship of TTF-1 and EGFR on Lung Adenocarcinoma at Dr. Saiful Anwar General Hospital Malang lumban gaol, andy; Pratiwi, Suryanti Dwi; Putra, Ngakan Putu; Norahmawati, Eviana; Rasyid, Harun Al
Jurnal Kedokteran Brawijaya Vol 31, No 1 (2020)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2020.031.01.9

Abstract

There is a correlation between mutation of Epidermal Growth Factor Receptor (EGFR) and lung adenocarcinoma. Unfortunately, examination for EGFR mutation is difficult because surgery must be conducted to obtain the best specimen. Thyroid Transcription Factor-1 (TTF-1) is a marker for lung adenocarcinoma. This observational study took place at Dr. Saiful Anwar Hospital from stored biological materials from 2013-2018. Samples were lung adenocarcinoma patients that undergo EGFR examination. Data then analyzed using Fischer's Exact Test to determine the relationship between EGFR and TTF-1. Specificity/sensitivity value is 0.75/0.90, p: 0.617, odds ratio 0.333 (0.032-3.515). However, Receiver Operating Characteristic (ROC) curve of TTF- 1 show AUC 0.614 (95CI, 0.35- 0.878). TTF-1 examination has a moderate strength in determining EGFR mutation on lung adenocarcinoma patients at Dr. Saiful Anwar Hospital.         
Bone metastases tend to increase in non-small cell lung cancer with epidermal growth factor receptor mutation Maleachi, Reginald; Erawati, Dini Rachma; Pratiwi, Suryanti Dwi; Andarini, Sri
Universa Medicina Vol. 41 No. 1 (2022)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2022.v41.4-10

Abstract

BackgroundIncreased understanding in molecular pathology of advanced non-small cell lung cancer (NSCLC) over the past decades has led to personalized treatment approaches being advocated. Epidermal growth factor receptor (EGFR) mutation that often occurs in NSCLC can be identified using immunohistochemical examinations. Moreover, clarifying the relationship between computed tomography (CT) and EGFR mutation of NSCLC might inform therapeutic decision-making. The purpose of this study was to determine the relationship between metastatic sites on primary chest CT-scan and EGFR mutation in NSCLC lung cancer patients. MethodsAn cross-sectional design using secondary data was conducted, involving 76 NSCLC patients. EGFR mutations were determined by immunohistochemical examination and metastatic sites by chest CT-scan with contrast. The collected metastatic sites comprised hilar and mediastinal lymphadenopathy, pulmonary nodules, and bone, liver, spleen and suprarenal metastases. A Chi square test was used to analyze the data. ResultsThis study revealed that the highest NSCLC stage was IVb, found in 39 samples (51.3%), while 34 (44.7%) subjects had EGFR mutation. There was no statistically significant difference between metastatic site and positive EGFR mutation, although positive bone metastases (54.8%) tend to have more numerous positive EGFR mutations compared to negative bone metastases (37.7%) (p=0.142). ConclusionsPatients with positive bone metastases tend to have higher positive EGFR mutation compared to negative bone metastases in NSCLC lung cancer patients. Prospective studies evaluating patients with EGFR mutation for bone metastases should be considered. This can provide information on therapeutic decision-making to obtain good clinical outcomes.
Analisis Ketahanan Hidup Pasien Kanker Paru di RSUD Dr. Saiful Anwar Pratiwi, Suryanti Dwi; Setyawan, Ungky Agus; Falyani, Silvy Amalia; Permatasari, Adinda Pramitra; Santosa, Andrew; Febriawati, Juwita; Prasetyo, Kevin Wahyudy; Yokanan
Jurnal Klinik dan Riset Kesehatan Vol 3 No 3 (2024): Edisi Juni
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.03.3.2

Abstract

Pendahuluan: Kanker paru insidennya sebesar 14% dari semua kanker, dan merupakan penyebab utama kematian akibat keganasan di seluruh dunia. Berbagai studi menunjukkan perbedaan terkait angka ketahanan hidup, serta berbagai faktor yang signifikan terkait dengan angka ketahanan hidup tersebut pada pasien kanker paru. Tujuan: Penelitian ini bertujuan untuk mengetahui profil dan angka tahan hidup (ATH) pasien kanker paru yang mendapatkan kemoterapi di RSUD dr. Saiful Anwar pada tahun 2018-2020. Metode: Studi kohort retrospektif dengan menggunakan data rekam medik pasien terdiagnosis kanker paru pada tahun 2018 – 2020 yang mendapatkan kemoterapi. Analisis data dilakukan menggunakan uji log rank Mantel Cox, serta ketahanan hidup pasien berupa progression free survival (PFS) dan overall survival (OS) ditampilkan dengan kurva Kaplan Meier. Hasil: Pasien kanker paru terbanyak berjenis kelamin laki-laki (73,2%). Adenokarsinoma merupakan jenis sel kanker paru terbanyak (59,8%) dengan mutasi EGFR wild type 20,6%. Karboplatin–Paklitaksel merupakan jenis kemoterapi yang paling sering digunakan (54,6%). Analisis ATH menunjukkan terdapat hubungan signifikan antara usia dengan PFS dan OS (p < 0,05). Kesimpulan: Berbagai faktor seperti jenis kelamin, jenis sel kanker, mutasi EGFR, dan jenis kemoterapi diketahui tidak berkaitan signifikan dengan ATH pasien kanker paru. Hubungan signifikan antara usia dengan ATH menunjukkan potensi faktor usia sebagai prediktor ketahanan hidup pasien kanker paru.
The Difficulty To Distinguishing Between Embryonal Cell Carcinoma In The Anterior Mediastinal And Lung Adenocarcinoma Fahmi, Kristia; Pratiwi, Suryanti Dwi; Setyawan, Ungky Agus
Malang Respiratory Journal Vol. 7 No. 1 (2025): March 2025 Edition
Publisher : Universitaas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mrj.2025.007.01.04

Abstract

Background: Frequently encountered malignant anterior mediastinal tumors include thymoma, lymphoma and germ-cell tumors. Non-seminomatous germ-cell tumors histologically classified as embryonal-cell carcinoma, choriocarcinoma, yolk sac tumor, teratoma1. Embryonal-cell carcinoma is an exceedingly rare case (8%) of primary mediastinal germ-cell tumors, with poor prognosis. Case Presentation: An 18-year-old-male presented with severe dyspnea, echocardiography revealed pericardial effusion, leading to emergency pericardiocentesis and pigtail catheter insertion, draining a total of 1900 cc serohemorrhagic fluid. Thoracic CT scan+contrast unveiled a big mass (10.6 x 17 x 14.4 cm) in the anterior-middle-left posterior mediastinal, causing compression left main bronchus, encasing the left pulmonary artery and aortic arch. Two challenging Trans-Thoracic Needle Aspiration (TTNA) attempts led to difficulty in distinguishing between Embryonal-cell Carcinoma and Adenocarcinoma. A multidisciplinary discussion leaned toward an Embryonal-cell Carcinoma diagnosis. Due to the patient's worsening state and impracticality of open biopsy, chemotherapy was initiated. The patient improved clinically, achieving stable disease based on RECIST criteria until the third chemotherapy cycle but experienced a decline in their condition after the fourth cycle. Discussion: Embryonal-cell carcinoma of the mediastinal is a rare condition4 with poor prognosis, with the three-year survival rate 47.4% and five-year survival rate 23%5. Achieving precise diagnosis by TTNA is challenging. Open biopsy and histopathological biomarkers play a pivotal role in identifying the cell type and determining appropriate therapy6. The patient initially exhibited favorable response to chemotherapy, which later decline after the fourth cycle. Conclusion: Precise diagnosis of embryonal-cell carcinoma provides certainty in treatment and improve survival rates. Keywords: Embryonal, Adenocarcinoma, Diagnosis
Prognosis of Tyrosine Kinase Inhibitor Therapy for Non-Small Cell Lung Cancer Santoso, Agus Andreas; Pratiwi, Suryanti Dwi; Sugiri, Yani Jane; Al Rasyid, Harun; Listyoko, Aditya Sri
Jurnal Respirasi Vol. 11 No. 2 (2025): May 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.2.2025.140-146

Abstract

Introduction: Non-small cell lung cancer (NSCLC) was the primary cause of death in lung cancer. Tyrosine kinase inhibitors (TKIs) were one of the management options for NSCLC. Meanwhile, serum carcinoembryonic antigen (CEA) plays a crucial role in the diagnosis and prognosis of NSCLC patients. This study aimed to determine the effectiveness of epidermal growth factor receptor (EGFR)-TKI based on progression-free survival (PFS) and overall survival (OS) in NSCLC patients with common EGFR mutations. Methods: This retrospective cohort study used a total sampling method. The serum CEA level was measured before the initial treatment. Tyrosine kinase inhibitors therapy was monitored with PFS and OS. Statistical analysis for comparing prognosis in NSCLC among TKI groups used Kruskal-Wallis, analysis of variance (ANOVA), Mann-Whitney, and Spearman’s rho tests. A significant analysis referred to a p-value of <0.05. Results: The participants were 189 patients, consisting of 106 on gefitinib, 43 on erlotinib, and 40 on afatinib. The average PFS values in the gefitinib, erlotinib, and afatinib groups were 9.9±5.25, 8.77±4.53, and 12.83±7.02 months, respectively (p=0.016). Furthermore, there were no significant OS among the gefitinib (14.91±7.61 months), erlotinib (14.54±7.64 months), and afatinib group (15.51±8.13 months, p=0.867). There was a significant correlation between CEA levels and PFS (r=0.146; p=0.046) and between CEA levels and OS (r=0.223; p=0.004). Conclusion: Although afatinib may prolong PFS compared with gefitinib and erlotinib, it did not significantly impact OS. Increased serum CEA levels before treatment significantly improved PFS and OS. However, elevated CEA levels are usually associated with a poor prognosis in NSCLC.
INFLUENCE OF INDIVIDUAL, ENVIRONMENT, AND MOTIVATION FACTORS OF ATTENDING PHYSICIANS (DPJPs) ON PATIENT ROUND TIMELINESS AT DR. SAIFUL ANWAR REGIONAL HOSPITAL EAST JAVA PROVINCE ON THE PUNCTUALITY OF VISITES AT DR. SAIFUL ANWAR HOSPITAL, EAST JAVA PROVINCE Pratiwi, Suryanti Dwi; Holipah, Holipah; Rahmah, Shofi Nur
Journal of Community Health and Preventive Medicine Vol. 5 No. Issue Supplement 1 (2025): JOCHAPM Vol. 5, Issue Supplement 1, March 2025
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

The timeliness of patient rounds by Attending Physicians (DPJPs) in hospitals significantly impacts various aspects of healthcare delivery, such as patient waiting times, treatment efficiency, and discharge processes. At Dr. Saiful Anwar Hospital, the level of compliance with punctual patient round standards remains below the national benchmark, which is recorded at 68.83%. This study aimed to analyze the influence of individual, environment, and motivation factors on the timeliness of rounds conducted by DPJPs at Dr. Saiful Anwar Regional Hospital, East Java Province. A quantitative, cross-sectional research design was used by involving 240 respondents selected through consecutive sampling. Data were collected using a questionnaire and analyzed using multiple linear regression. The results indicated that individual factors (gender, age, length of employment, and employment status), environment factors (access routes and medical facilities), and motivational factors (income, hospital policies, time pressure, and co-worker support) had no significant effect on patient round timeliness. This study found that timeliness was more influenced by adherence to professional ethics and a commitment to patient care, indicating that DPJPs continue to prioritize service quality despite operational challenges. In conclusion, external conditions and personal characteristics do not appear to be the primary determinants of timely rounds. To enhance service efficiency, hospitals are encouraged to optimize internal systems, such as scheduling, interprofessional coordination, and operational policy evaluation, to better support the timely execution of DPJP responsibilities.
Risk Analysis of Obstructive Sleep Apnea and Mental Disorders with Self-Reporting Questionnaire (SRQ-20) in Hospitalized COVID-19 Patients Falyani, Silvy Amalia; Pratiwi, Suryanti Dwi; Sugiri, Yani Jane Rosihaningsih; Djajalaksana, Susanthy; Listyoko, Aditya Sri
Malang Respiratory Journal Vol. 7 No. 2 (2025): Volume 7 No 2, September 2025 Edition
Publisher : Universitaas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mrj.2025.007.02.07

Abstract

Introduction: Obstructive Sleep Apnea (OSA) is closely related to diseases such as hypertension, diabetes, cardiovascular disease, and obesity. Evaluation of sleep disorders and mental health in COVID-19 patients who are hospitalized has not been widely studied. The purpose of this study was to analyze the risk of OSA with STOP-Bang and mental disorders with the Self-Reporting Questionnaire (SRQ-20) in hospitalized COVID-19 patients at RSUD dr. Saiful Anwar Malang. Case: Thirty five respondents with confirmed mild and moderate COVID-19 criteria randomly selected and agreed to give informed consent were given the STOP-Bang and SRQ-20 questionnaires, then the score was associated with the oxygenation ratio through blood gas levels. The research was conducted by cross sectional and statistical test using Chi Square and Mann Whitney test with p<0.05. Thirty five respondents were divided into two groups, 17 people (48%) with mild criteria and 18 people (52%) with severe criteria. The severity of COVID-19 had low effect on the risk of OSA (p=0.581) and mental disorders (p=0.191). The risk of mental disorders through SRQ-20 scoring had low effect on the severity of COVID-19 (p=0.229) and on the oxygenation ratio (p=0.068). Conclusion: The severity of COVID-19 and oxygenation ratio had low effect to the risk of OSA and mental disorders through the STOP-Bang and SRQ-20 scores in hospitalized COVID-19 patients at dr. Saiful Anwar Malang.
Co-Authors Djajalaksana, Susanthy Erawati, Dini Rachma Eviana Norahmawati Fahmi, Kristia Falyani, Silvy Amalia Febriawati, Juwita Harun Al Rasyid Harun Al Rasyid Holipah, Holipah Kevin Wahyudy Prasetyo Listyoko, Aditya Sri lumban gaol, andy Maleachi, Reginald Permatasari, Adinda Pramitra Putra, Ngakan Putu rahmah, shofi nur Santosa, Andrew Santoso, Agus Andreas Setyawan, Ungky Agus Sri Andarini Sugiri, Yani Jane Sugiri, Yani Jane Rosihaningsih Yokanan