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Analisis Ketahanan Hidup Pasien Kanker Paru di RSUD Dr. Saiful Anwar Pratiwi, Suryanti Dwi; Setyawan, Ungky Agus; Falyani, Silvy Amalia; Permatasari, Adinda Pramitra; Santosa, Andrew; Febriawati, Juwita; Prasetyo, Kevin Wahyudy; Yokanan
Jurnal Klinik dan Riset Kesehatan Vol 3 No 3 (2024): Edisi Juni
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.03.3.2

Pendahuluan: Kanker paru insidennya sebesar 14% dari semua kanker, dan merupakan penyebab utama kematian akibat keganasan di seluruh dunia. Berbagai studi menunjukkan perbedaan terkait angka ketahanan hidup, serta berbagai faktor yang signifikan terkait dengan angka ketahanan hidup tersebut pada pasien kanker paru. Tujuan: Penelitian ini bertujuan untuk mengetahui profil dan angka tahan hidup (ATH) pasien kanker paru yang mendapatkan kemoterapi di RSUD dr. Saiful Anwar pada tahun 2018-2020. Metode: Studi kohort retrospektif dengan menggunakan data rekam medik pasien terdiagnosis kanker paru pada tahun 2018 – 2020 yang mendapatkan kemoterapi. Analisis data dilakukan menggunakan uji log rank Mantel Cox, serta ketahanan hidup pasien berupa progression free survival (PFS) dan overall survival (OS) ditampilkan dengan kurva Kaplan Meier. Hasil: Pasien kanker paru terbanyak berjenis kelamin laki-laki (73,2%). Adenokarsinoma merupakan jenis sel kanker paru terbanyak (59,8%) dengan mutasi EGFR wild type 20,6%. Karboplatin–Paklitaksel merupakan jenis kemoterapi yang paling sering digunakan (54,6%). Analisis ATH menunjukkan terdapat hubungan signifikan antara usia dengan PFS dan OS (p < 0,05). Kesimpulan: Berbagai faktor seperti jenis kelamin, jenis sel kanker, mutasi EGFR, dan jenis kemoterapi diketahui tidak berkaitan signifikan dengan ATH pasien kanker paru. Hubungan signifikan antara usia dengan ATH menunjukkan potensi faktor usia sebagai prediktor ketahanan hidup pasien kanker paru.

Potential of Volatile Organic Compound (VOC) and Serum Interleukin-17 for Evaluation of Lung Cancer Therapy Based on Response Evaluation Criteria in Solid Tumors (RECIST) Permatasari, Adinda Pramitra; Setyawan, Ungky Agus; Rakhma, Sastia; Djajalaksana, Susanthy; Wardoyo, Arinto Yudi Ponco
Indonesian Journal of Cancer Vol 18, No 4 (2024): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i4.1127

Background: Lung cancer is the second leading cause of death in the world due to delays in diagnosis. Non-invasive Volatile Organic Compound (VOC) method to diagnose and monitor the progressivity of lung cancer. Interleukin-17 (IL-17) has an important role in the progression and treatment of lung cancer. Objective evaluation of chemotherapy using Response Evaluation Criteria in Solid Tumors (RECIST 1.1). This study aims to determine the relationship between VOC, IL-17, and lung cancer chemotherapy response based on RECIST at Saiful Anwar General Hospital, East Java.Methods: In a prospective cohort study, 47 lung cancer patients received first-line chemotherapy pre and post-three series of chemotherapy. Exhaled breath was collected with Tedlar Bags and then analyzed with µβreath for VOC. IL-17 in blood serum is determined by an enzyme-linked immunosorbent assay (ELISA). The data were analyzed using the Wilcoxon, Mann-Whitney, and Spearman tests.Results: There were significant in VOC Components (p 0.05) Formaldehyde (CH2O), Toluene (C7H8), Acetone (C3H6O), Hexane (C6H14), Methane (CH4), RECIST non-target lesions, and new lesions pre and post-three series of chemotherapy but not found in IL-17. Acetone (C3H6O) pre and Methane (CH4), IL-17 post-three series of chemotherapy based on RECIST Overall Response (OR) found significant. The analysis showed a positive correlation between Formaldehyde (CH2O) pre and Methane (CH4), IL-17 post-three series of chemotherapy based on RECIST OR, but a negative correlation between Acetone (C3H6O) pre-chemotherapy. Conclusions: There was a significant decrease in formaldehyde, toluene, hexane, methane and an increase in acetone in lung cancer patients pre and post-three series of chemotherapy. There was a significant relationship between formaldehyde, acetone pre-chemotherapy, and methane, IL-17 post-three series of chemotherapy based on the RECIST overall response

Analisis Ketahanan Hidup Pasien Kanker Paru di RSUD Dr. Saiful Anwar Pratiwi, Suryanti Dwi; Setyawan, Ungky Agus; Falyani, Silvy Amalia; Permatasari, Adinda Pramitra; Santosa, Andrew; Febriawati, Juwita; Prasetyo, Kevin Wahyudy; Yokanan
Jurnal Klinik dan Riset Kesehatan Vol 3 No 3 (2024): Edisi Juni
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.03.3.2

Background: Comprising 14% of all cancer, lung cancer is the main cause of cancer-related mortality worldwide. Previous studies showed various findings regarding the survival rate of lung cancer, and factors significantly correlated with survival rate in lung cancer patients. Aim: This research aims to identify the profile and survival rate of lung cancer patients receiving chemotherapy in Saiful Anwar General Hospital from 2018 to 2020. Methods: This cohort retrospective study used medical records of patients diagnosed with lung cancer who underwent chemotherapy from 2018 to 2020. Data analysis was done using the Mantel Cox log rank test. Survival data shown as progression free survival (PFS) and overall survival (OS) were shown using Kaplan-Meier curves. Results: Subjects were largely male (73,2%). Adenocarcinoma is the most often type of lung cancer found (59,8%) with wild type EGFR mutation being the most prevalent (20,6%). Carboplatin – Paclitaxel is the most widely used chemotherapy regimen (54,6%). Survival analysis showed a significant correlation between age, OS, and PFS (p < 0,05) Conclusion: Various factors such as gender, cancer cell type, EGFR mutation, and chemotherapy regimen were not found to be related to survival rate in lung cancer patients. A significant correlation between age and survival rate showed potential in utilizing age as a predictor of survival rate in lung cancer patients.

The Case Report : Challenges in the Management of Pneumothorax for COVID-19 Patient Permatasari, Adinda Pramitra; Rakhma, Sastia; Putra, Ngakan Putu Parsama
Malang Respiratory Journal Vol. 5 No. 1 (2023): Volume 5 No 1, March 2023
Publisher : Universitaas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mrj.2023.005.01.1

INTRODUCTION : Pneumothorax has been reported in minority of COVID-19 cases. Spontaneus Pneumothorax is an uncommon complication of COVID-19. The incidence and risk factors are still unknown. Here we will review where there are challenges with case of Pneumothorax in COVID-19 patients. CASE ILLUSTRATION : We report one case at Dr. Saiful Anwar hospital, a 42 years old man was diagnosed with Spontaneous Pneumothorax and tested positive for COVID-19 via nasopharyngeal swab. Management in this case requires consideration from emergency treatment, risk of virus transmission and the aerolization of the procedure. Invasive procedure such as insertion chest tube and pharmacologic therapy be the treatment in this case. After 2 weeks of treatment, there was improvement on clinical and radiological imaging. DISCUSSION : Various strategies to reduce the risk of exposure to COVID-19 infection on Spontaneus Pneumothorax. This literature discusses about the risk factor that lead to Pneumothorax with COVID-19 and the management of Pneumothorax cases in COVID-19 patients. CONCLUSION: Spontaneous Pneumothorax is a rare complication of COVID-19. Management in this case requires consideration from emergency treatment, risk of virus transmission and the aerolization of the procedure. Key words : Pneumothorax; COVID-19; Chest Tube

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