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All Journal Indonesian Journal of Cancer Chemoprevention Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Majalah Farmaseutik JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Ilmu Kefarmasian Indonesia Borneo Journal of Pharmacy
Sylvia Utami Tunjung Pratiwi
Faculty Of Pharmacy, Universitas Gadjah Mada. Yogyakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : INDONESIAN JOURNAL OF PHARMACY

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Efficacy of Thymol and Eugenol Against Polymicrobial Biofilm Hamzah, Hasyrul; Tunjung Pratiwi, Sylvia Utami; Hertiani, Triana
Indonesian Journal of Pharmacy Vol 29 No 4, 2018
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1354.744 KB) | DOI: 10.14499/indonesianjpharm29iss4pp214

Abstract

Biofilms associated with human infection have high levels of pathogenicity due to their resistance to antibiotics. The discovery of an active antibiofilm agent against polymicrobial biofilms is a necessary consequence for coping with biofilm-related infections. Thymol and Eugenol are essential oils that have potential as antibacterial and antifungal. This study aimed to determine the effectiveness of thymol and eugenol inhibits C. albicans, P. Aeruginosa, E. coli S. aureus and polymicrobial biofilm. Biofilm formation inhibition assay and biofilm degradation assay of thymol and eugenol were determined using microtiter broth method.The antibiofilm efficacy of thymol and eugenol towards polymicrobial biofilms were analyzed by calculating minimum biofilm inhibitor concentration (MBIC50) and minimum biofilm eradication concentration (MBEC50) values. The data were analyzed using Statistical Package for the Social Sciences (SPSS) with 95% confidence level. Thymol and eugenol showed inhibitory activity against the formation of mono and polymicrobial biofilms of the microbial tested.The result also demonstrated an evidence of activity of thymol and eugenol in breaking down mono and polymicrobial biofilm. Therefore, thymol and eugenol serves as a potential source for new antibiofilm drugs towards polymicrobial biofilm.
Effect of cengkeh leaves and kayu manis cortex essential oils blend as anti dental plaque Ardani, Marisya; Pratiwi, Sylvia Utami Tunjung; Hertiani, Triana
Indonesian Journal of Pharmacy Vol 21 No 3, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (300.487 KB) | DOI: 10.14499/indonesianjpharm0iss0pp191-201

Abstract

Dental  plaque  is  a  mouth  cavity  health  problem  related  to  microbial biofilm,  where  Streptococcus  mutans is  predominant.  Adding  of  essential  oils blend  in  mouthwash  has  been  reported  to  increase  the  dental  plaque  inhibitory activity.  The  essential  oils  of  clove  leaves  (Syzygium  aromaticum (L.)  Merr.  & Perry) and cinnamon cortex (Cinnamomum burmanniNees ex Bl.), are known as potential  antibacterial  and  antibiofilm  towards  S.  mutans.  This  research  aims were  to  reveal  the  influence  of  blending  the  clove  leaves  and  cinnamon  cortex essential  oils  in  antibacterial  and  anti  biofilm  activity  against  S.  mutans and  to find out the optimum composition. Antibacterial assay was performed in nutrient broth  media,  on  microplate  flat-bottom  polystyrene  96  wells.  Biofilm  formation inhibition  and  degradation  assays  were  done  in  BHI  +  2  %  sucrose  on microplate flexible U-bottom PVC 96 wells. Crystal violet1 % was used to stain the biofilm and Optical Density(OD) was measured at λ 595 nm. Simplex Lattice Design formula  was  used  to  calculate  the  blend  optimum  composition.  TLCbioautography and GC-MS assays were done to revealthe active substances. As conclusion,  it  was  proven  that  blending  the  clove  leaves  and  cinnamon  cortex essential  oils  increased  the  antibacterial  and  biofilm  degradation  potency,  but reduced  the  biofilm  formation  inhibitory effect against  S.  mutans. The  optimum composition  of  the  essential  oils  blend  was  27:73  (% v/v).  From  our  results  we suggest  that  the  clove  leaves  and  cinnamon  cortex  essential  oil  blend  used  in this study be developed as anti dental plaque.Key words : clove leaves, cinnamon cortex, essential oils blend, Streptococcus mutans
Co-Authors Adha, Tasya Hardina Aini Febriana Ardani, Marisya Bakhtiar, Muh. Irham Dian Mayasari Ema Damayanti FERRY RAHMA PUSPITA Fita Rahmawati Fransisca Priskaningtyas Wulandari Gunawan, Dede Reza Hamzah, Hasyrul Iramie Duma Kencana Irianto Joselin Ekaputri Khoirunnissa Hida MAULANA, RIZA Meiliana Meiliana Meta Juniatik Muhammad Subhan Ni'matul Munawaroh NURI IRIYANI Nurul Pangestuti Pratama, Virgiawan Yoga Rafika Sari Rina Kuswahyuning Ronny Martien Shinta Sari Dewi SINTAYU PUTRI WANDAN SARI Sudarsono Sudarsono Titik Nuryastuti Triana Hertiani Yosi Bayu Murti