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All Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Leonita Anniwati
Universitas Airlangga
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Serum Receptor Activator of Nuclear Factor-κβ Ligand and Osteoprotegerin Levels and Ratio in Correlation with Bone Mineral Density Fauqa Arinil Aulia; Sri Lestari Utami; Leonita Anniwati; Sony Wibisono Mudjanarko; Ferdy Royland Marpaung
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 27 No. 1 (2020)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v27i1.1627

Abstract

Osteoporosis is a disorder represented by manifestations of low bone mass, decreased bone tissue, and disrupted bone microarchitecture. The diagnosis of osteoporosis so far has been based on fracture manifestations after minimal trauma or by detecting low Bone Mineral Density (BMD). Measurement of Receptor Activator of Nuclear Factor-κβ Ligand (RANKL) and Osteoprotegerin (OPG) levels has opened the discourse of a more specific assessment of osteoblast and osteoclast regulation. The RANKL/OPG ratio can represent resorption and bone formation more significantly when correlated with BMD features. This study aimed to analyze the correlation between serum RANKL and OPG levels and ratio with BMD. A total of 58 post-menopausal females from 13 elderly in Integrated Community Health Care Surabaya and Sidoarjo were enrolled. Data were collected by recording age, onset of menarche, onset of menopause, and Body Mass Index (BMI). Serum RANKL and OPG levels were evaluated using sandwich ELISA from Elabscience®. The RANKL/OPG ratio was obtained from the ratio between measured RANKL and OPG levels in serum. The proximal femur and lumbar spine BMDs were measured using Hologic® Discoveryâ„¢ QDRâ„¢ Dual-Energy X-ray Absorptiometry (DEXA). Pearson's correlation test in this study showed no significant correlation between BMD and RANKL levels (lumbar: p=0.203; hip: p=0.283). The insignificant result was also shown in the correlation between BMD and OPG levels (lumbar: p=0.412; hip: p=0.617). A significant result between lumbar BMD and RANKL/OPG ratio was only found in the osteopenia subjects (p=0.001). The RANKL/OPG ratio had a significant correlation only with osteopenia-BMD in post-menopausal females. Therefore, it could be used as supporting data in osteoporosis screening.
MDRD, CKD-Epi and Creatinine Clearance with 24-Hour Urine Collection Results in Patients with Chronic Kidney Disease Siti Nurul Hapsari; Leonita Anniwati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 27 No. 1 (2020)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v27i1.1628

Abstract

Kidney disease is a global public health problem, affecting over 750 million people worldwide. Glomerular Filtration Rate (GFR), which is calculated by measuring the creatinine clearance with 24-hour urine collection (CC) can be inaccurate due to improper urine collection, causing the need for an easier and accurate method of calculation. This study was an observational analytical cross-sectional research using consecutive retrospective sampling. Samples were data of patients with Chronic Kidney Disease (CKD) who underwent CC test at the Clinical Pathology Laboratory of the Dr. Soetomo Hospital Surabaya during September-October 2018. Data were compared with the results of Cockcroft-Gault (CG), MDRD, and CKD-Epi formula, and were analyzed using the one-sample Kolmogorov-Smirnov test, paired T-test, and Wilcoxon Signed Rank test. Correlation of CC results with CG, MDRD, and CKD-Epi results was tested with Spearman's rho and Bland Altman test. The difference test of CC with CG, MDRD, and CKD-Epi showed results of (p=0.000), (p=0.194), and (p=0.468), respectively. There were significant differences between CC compared to CG, but not MDRD and CKD-Epi. There was a moderate correlation between CG, MDRD, CKD-Epi, and CC with r=0.529; 0.448, and 0.463, respectively. The most compatible formula was CKD-Epi. The measurement of GFR with CC correlated with CG, MDRD, and CKD-Epi; therefore, they could be used as an alternative method to calculate GFR. Further experiments using an exogenous marker should be performed to determine a suitable eGFR formula according to the degree of damage to the kidney. 
Co-Authors Aminuddin Aminuddin Aryati Aryati Cicilia Indriaty Fauqa Arinil Aulia Ferdy Royland Marpaung Isnin Anang Marhana Lukitasari, Lina Muhammad Saiful Rahman Nadya Husni Pande Putu Ayu Patria Dewi Putranto, J.Nugroho Eko SATRIYAS ILYAS Siti Nurul Hapsari Sony Wibisono Sri Lestari Utami Suprabawati, Desak Gede Agung Veronika Juanita Maskito