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All Journal JURNAL KIMIA SAINS DAN APLIKASI e-Journal Pustaka Kesehatan Jurnal Pengembangan Pendidikan STOMATOGNATIC- Jurnal Kedokteran Gigi Jurnal Kimia Terapan Indonesia Eksakta : Berkala Ilmiah Bidang MIPA Jurnal Ilmiah Farmasi Farmasyifa Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Al-Khidmah Jurnal Pengabdian Masyarakat Journal of Pharmacy Science and Technology Borneo Journal of Pharmacy Journal of Agropharmacy
Ayik Rosita Puspaningtyas1
Faculty Of Pharmacy, University Of Jember, Jember, East Java|University Of Jember|Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Social Sciences

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UJI AKTIVITAS ANTI TUBERKULOSIS H37RV EKSTRAK DAN FRAKSI TANAMAN MERBAU (Intsia bijuga) Ayik Rosita Puspaningtyas; Dian Agung Pangaribowo; Tasya Salsabila Multazam
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 1 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i1.1619

Abstract

Tuberculosis (TB) is recognized as one of the top ten potentially fatal diseases. TB is caused by the bacterium Mycobacterium tuberculosis, which attacks the lungs. Indonesia has a variety of plants that can potentially serve as a treatment, one of which is the merbau plant (Intsia bijuga). The purpose of this study was to determine the anti-tuberculosis activity of extracts and fractions of merbau stem bark against Mycobacterium tuberculosis H27Rv bacteria based on IC50 values. Merbau bark was extracted using maceration method using methanol solvent. Then fractionated using n-hexane, dichloromethane (DCM) and ethyl acetate solvents. Next was phytochemical screening test using KLT method. In vitro anti-tuberculosis activity test using resazurin colorimetric method with concentrations of 25, 100, 500, and 1000 µg/mL. The results of the in vitro anti-tuberculosis test showed that the n-hexane fraction had the smallest IC50 of the extracts and other fractions with a result of 2,920 µg/mL, which indicates that it has the best activity as an anti-tuberculosis agent. Screening results from the n-hexane fraction showed positive for alkaloid and flavonoid compounds.
Pelatihan Pemanfaatan Daun Beluntas (Pluchea indica) Sebagai Produk Kesehatan di Sidomekar Semboro Kabupaten Jember Puspaningtyas, Ayik Rosita; Sary, Indah Purnama
Al-Khidmah Jurnal Pengabdian Masyarakat Vol. 5 No. 2 (2025): MEI-AGUSTUS
Publisher : Institute for Research and Community Service (LPPM) of the Islamic University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56013/jak.v5i2.4464

Abstract

The many kinds of health benefits of beluntas (Pluchea indica) are already known, but are still limited for vegetables, even though its essential oil is very high. Essential oils, based on research, can be used as an antibacterial and an inhibitor of viruses. Therefore, we conducted counseling and training on the utilization of Beluntas leaf essential oil through isolation to be developed into health products in the Babatan Sidomekar community, Semboro, Jember. The Covid 19 virus pandemic in Indonesia has had an economic impact on small communities. One way to do this is to provide new knowledge and technology by producing products that can be used to increase income and preventive against COVID-19. Presentation products are more modern, have high selling value, and are more durable, which will be easily accepted by the market. The stages of implementing the activity were socialization in the Babatan Sidomekar community, Semboro, Jember, which was carried out well from August to November 2022, and the community was very enthusiastic about receiving counseling and training in making hand sanitizer and antiseptic soap products from the essential oil of beluntas leaf
Phyrochemical Screening and Potential Inhibition of Pacing Extract (Costus speciousus, J.Sm) Against Mycobacterium Tuberculosis H37Rv Puspaningtyas, Ayik Rosita; Rumaikewi, Carolin Enjelin; Sari, Indah Purnama
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 25 No. 03 (2024): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol25-iss03/451

Abstract

Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis (Mtb) and can attack various organs of the body. Transmission occurs through sputum splashes when coughing, sneezing or talking. TB treatment using antituberculosis drugs (OAT) can cause side effects that affect health. Therefore, alternative therapies from natural ingredients are needed. This study aims to explore secondary metabolites in extracts and plant fractions of Pacing (Costus speciousus, J.Sm) and determine their effectiveness against Mycobacterium tuberculosis H37Rv. The extraction method used is remaceration with methanol solvent. The concentrations of the samples tested varied with isoniazid positive controls. The results showed that Pacing plant extracts and fractions contained alkaloids, flavonoids, saponins, and tannins. Terpenoid compounds were not detected in the samples tested. The antituberculosis test showed that the n-hexane fraction had the best anti-TB activity, although the IC50 value of the extract and fraction was still lower than isoniazid as a positive control. However, Pacing extract and fraction still have potential as very strong anti-TB agents because their IC50 values ​​are below 50 ppm.
Skrining fitokimia dan potensi daya hambat ekstrak pacing (Costus speciousus, J.Sm) terhadap Mycobacterium tuberculosis H37Rv Puspaningtyas, Ayik Rosita
Journal of Agropharmacy Vol. 1 No. 3 (2024)
Publisher : Faculty of Pharmacy, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/joa.v1i3.1311

Abstract

Tuberculosis (TB) is an infectious disease caused by the bacteria Mycobacterium tuberculosis (Mtb) and can attack other body organs. Transmission occurs through splashes of phlegm when coughing, sneezing or talking. TB treatment using antituberculosis drugs (OAT) has side effects ranging from mild to severe side effects, namely hepatotoxicity. Therefore, alternative therapy from natural ingredients is needed because natural ingredients have few side effects when used appropriately. This research aims to determine the class of secondary metabolite compounds in the extract and fraction of the Pacing plant (Costus speciousus, J.Sm) and determine its effectiveness against Mycobacterium tuberculosis H37Rv. The extraction method used is remaceration with methanol solvent. The concentrations of the samples tested varied with the positive control of isoniazid. The research results showed that Pacing plant extracts and fractions contained alkaloids, flavonoids, saponins and tannins. Terpenoid compounds were not detected in the samples tested. The antituberculosis test showed that the n-hexane fraction had the best anti-TB activity, although the IC50 value of the extract and fraction was still lower than that of isoniazid as a positive control. However, Pacing extract and fraction still have potential as a very strong anti-TB agent because the IC50 value is below 50 ppm.
Structure Modification of Cinnamic Acid to (E)-1-(3,4-dihydroisoquinoline-2(1H)-yl)-3-phenylprop-2-en-1-one and Antioxidant Activity Test by DPPH Method Pangaribowo, Dian Agung; Fathunnisa, Fathunnisa; Nugraha, Ari Satia; Puspaningtyas, Ayik Rosita; Sary, Indah Purnama
Borneo Journal of Pharmacy Vol. 7 No. 3 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i3.6163

Abstract

Antioxidants can protect cells from free radical damage by stabilizing them. One of the compounds that has antioxidant activity is cinnamic acid. Cinnamic acid and its derivatives have several activities: antibacterial, anticancer, and antioxidant. However, the ability of cinnamic acid to capture free radicals is still relatively low. One of the efforts that can be made to increase the antioxidant activity of cinnamic acid is to modify its structure. Structure modification is an effort to improve the pharmacological activity of a compound through chemical synthesis reactions. The cinnamic acid structure can be modified by changing the carboxylic -OH group into an amine group through an N-atom acylation reaction. This study was conducted by reacting cinnamoyl chloride (1a), which is a cinnamic acid derivative with 1,2,3,4-tetrahydroisoquinoline (2b) which is a compound of isoquinoline group to produce (E)-1-(3,4-dihydroisoquinoline-2(1H)-yl)-3-phenylprop-2-en-1-one (3b) and then tested for antioxidant activity using DPPH method. The resulting product compound was yellow crystals with a yield of 81.56%. The antioxidant activity produced by the product is more significant than that of cinnamic acid compounds at the same concentration.
Co-Authors . Ifada Ari Satia Nugraha Bambang Kuswandi Brahmansyah Diar Rosiarto Dian Agung Pangaribowo Dian Agung Pangaribowo Diana Holidah Dyah Purwaningtyas Dyan Wigati Eka Mustika Wati Estu Wilujeng Fathunnisa, Fathunnisa Fifteen Aprila Fifteen Aprila Fajrin Hadiyatun Nuroniyah Hasana, Ani Riani Ika Oktavianawati Ika Oktavianawati Indah Purnama Sari Indah Purnama Sary Indah Purnama Sary, Indah Purnama Lindawati Setyaningrum Maasyitoh Sari Latifah Mohammad Rofik Usman Nia Kristiningrum Puspita Arum Wijayanti Rumaikewi, Carolin Enjelin Tasya Salsabila Multazam Triodora Hutahuruk Wahyu Novandari Herdiyanti Yuni Retnaningtyas