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All Journal E-Jurnal Medika Udayana JURNAL BIOMEDIK Berkala Ilmu Kesehatan Kulit dan Kelamin ISM (Intisari Sains Medis) : Jurnal Kedokteran Bali Dermatology and Venereology Journal Neurologico Spinale Medico Chirurgico IJAAM (Indonesian Journal of Anti-Aging Medicine) Journal of Global Pharma Technology Bali Dermatology Venereology and Aesthetic Journal
Anak Agung Gde Putra Wiraguna
Department Of Dermatology Faculty Of Medicine, Udayana University
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Journal : Journal of Global Pharma Technology

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Administration of Topical Passion Fruit Extract Cream (Passiflora edulis) inhibits the Increase of MMP-1 Levels and Decreases the Amount of Collagen in Wistar Rats (Rattus norvegicus) Exposed to UV-B Rays Anak Agung Gde Putra Wiraguna
Journal of Global Pharma Technology Volume 10 Issue 12.
Publisher : Journal of Global Pharma Technology

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Introduction: Aging skin is most prevalent due to exposure to sunlight, especially UV-B rays. UV-B rays which stimulate the formation of free radicals are highly reactive molecules with unpaired electrons that can cause elevated levels of MMP-1, causing a decrease in the amount of skin collagen. This study was an experimental animal study with a post-test only control group design.  Method: A total of 36 Wistar rat were divided into 2 groups, each consisting of 18 Wistar rat, the control group was smeared with placebo cream and the treatment intervention group was smeared with passion fruit seed extract cream 100%, all groups were exposed to UV-B with a total dose of 840 mJ / cm ² for 4 weeks, then an excision was carried out for the examination of dermis collagen amount and level of MMP-1.  Result: The results of the comparative analysis of the two groups using independent t-test showed that there were significant differences between the two groups, the mean level of MMP-1 and the mean amount of collagen with p <0.05. The mean level of MMP-1 and the mean amount of collagen treatment in intervention group were 2.32% and 70.32%, and control group showed the mean level of MMP-1 and the average amount of collagen at 2.99% and 63.63% respectively.  Conclusion: the administration of passion fruit seed extract cream inhibited the increase of level of MMP-1 and the decrease of total collagen level in Wistar rat skin was exposed to UV-B.Keywords: Passion fruit, MMP-1, collagen, Skin.
Topical Applications of Caulerpa spp. Extract Preventing Skin Aging through Improving Skin Moisture, Pigmentation and Decrease Laxity Anak Agung Gde Putra Wiraguna
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Background: Caulerpa spp. extract contains neoxanthin, free astaxanthin, antheraxanthin, canthaxanthin, astaxanthin monoester, fucoxanthin, astaxanthin diester, and beta carotene, vitamins A, C, and E, minerals, amino acids and polyphenols which are photocemoprotective as to protect skin from damage caused by exposure to UV-B rays. This study aims to determine the effectiveness of topical 0.2% Caulerpa spp. extract in preventing premature skin aging in research subjects assessed by the parameters of skin moisture, pigmentation, and laxity of the skin. Method: This study was purely experimental research, using the randomized double-blind pretest-posttest control group design. A total of 40 research subjects participated in this study and were divided into two groups, namely the treatment group of 20 subjects, who were given interventions in the form of topical 0.2% Caulerpa spp. extract gel on the face, and the control group of 20 subjects who were given intervention in the form of application topical base cream on the face. All groups performed a pretest with a simple A-one scanner to assess skin aging with moisture, pigmentation, and laxity parameters on the skin. The two study groups were then treated for one month and post-tested. The research data was then collected for statistical analysis of using independent t-test and paired sample t-test. Results: Differences in skin assessments were analysed before and after therapy. Differences in assessment before therapy obtained p<0.05 on laxity and pore variables. Differences in assessment after treatment were found to be p<0.05 also in laxity and pores. Test differences in skin assessment in the two groups with Mann-Whitney using the difference in values after and before therapy obtained p<0.05 in pigmentation, laxity, humidity, pores, sebum U zone, and sebum T zone. Conclusion: Topical administration of topical Caulerpa spp. gel on the face has a photo protective effect by reducing pigmentation and laxity and increasing skin moisture.Keywords: Caulerpa spp., Skin aging, Pigmentation, Laxity.
Co-Authors Angela Sandi Tagaroi Rahasia Anne Carolina Kencanawati Astried Haryanto Balqis Wasliati Batan, Putu Nila Wardhani Bunge Dianmentari Chynthia Friama Diana Niti Santoso Dwindi Saptania Erwin Sugito Fatri Idana Fiter, Joni Gde Ngurah Idraguna Pinatih Golda Bernadet Lemewu I Dewa Ayu Vanessa Vijayamurthy I Gusti Ayu Agung Dwi Karmila I Gusti Ayu Agung Elis Indira I Gusti Ayu Agung Praharsini I Gusti Made Aman I Ketut Agus Somia Ida Bagus Gede Jayadharma Ida Sri Iswari Junivan Lindra Komang Aditya Yudistira Komang Saputra Yadnya Luh Made Mas Rusyati Made Kusuma Dewi Maharani Made Wardhana Maharani, Made Kusuma Dewi Marrietta Sugiarti Sadeli Martina Windari Maya Cesarya Simangunsong Meiny Linda Setiawan Ni Luh Putu Ratih Vibriyanti Karna Ni Made Dwi Puspawati Ni Wayan Winarti Olivia Julita Pande Agung Mahariski Phery Candres Prima Saraswati Sanjiwani Sudarsa Priskila Ariana Putu Nila Wardhani Batan Rahel Lisana Debora Hutagalung Somia Sri Subramaniam Stefani Nurhadi Vanessa Vijayamurthy Vijayamurthy, I Dewa Ayu Vanessa Wimpie I Pangkahila Yuziana Yuziana