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All Journal Jurnal Kesehatan Masyarakat JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE Jurnal Penelitian Farmasi dan Herbal International Journal Of Science, Technology & Management (IJSTM) FORTE JOURNAL Jurnal Pengabdian Masyarakat Putri Hijau
Gultom, Evi Depiana
Institusi Deli Tua Deli Husada, Deli Serdang, Indonesia
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RELAKSASI ILEUM YANG DIINDUKSI SEROTONIN Meilina, Rulia; Gultom, Evi Depiana; Dewi, Rahma
JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE Vol 7, No 1 (2021): APRIL 2021
Publisher : Universitas Ubudiyah Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33143/jhtm.v7i1.1421

Abstract

salah satu penyebab terjadi IBS karena terjadi ketidakseimbangan fungsi serotonin. Serotonin. Banyak ditemukan di saluran gastrointestinal.   Penelitian ini bertujuan untuk mengetahui efek relaksi  fraksi  daun  belimbing  wuluh  pada  otot  polos  ileum  yang  diinduksi  serotonin  pada reseptor   5HT3. Efek relaksasi Fraksi n-Heksan daun belimbing wuluh (FnHDBW), fraksi etil asetat daun belimbing wuluh (FEADBW) dan Fraksi sisa (FSDBW) dikontraksikan dengan se ri konsentrasi serotonin  (10-8  M sampai 3x10-4  M) dilakukan secara in vitro menggunakan organ ileum tikus yang diisolasi dalam larutan tirode. FEADBW memiliki nilai persen relaksasi dannilai  AUC  yang  paling  tinggi  dibandingakn  dengan  FnHDBW  dan  FSDBW  yaitu  sebesar80,01±1,57% dan 309,8278 ± 3,2527. Kesimpulan penelitian ini,  FnHDBW,  FEADBW danFSDBW memiliki efek reaksasi yang diinduksi oleh serotonis (5HT). Kata Kunci: serotonin, 5HT3, daun belimbing wuluh
UJI EFEKTIVITAS ANTIDIARE EKSTRAK ETANOL DAUN MENGKUDU (Morinda citrifolia L.) TERHADAP MENCIT JANTAN DENGAN METODE TRANSIT INTESTINAL Robiatun Rambe; Evi Depiana Gultom; Ovalina Sylvia Br. Ginting; Shela Diana
FORTE JOURNAL Vol 1 No 1 (2021): Edisi Januari 2021
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (229.431 KB) | DOI: 10.51771/fj.v1i1.34

Abstract

Mengkudu (Morinda citrifolia L.) merupakan tumbuhan dari famili Rubiceae, yang secara tradisional digunakan sebagai meningkatkan daya tahan tubuh, antiinflamasi, analgesik, antibakteri, antidiare, mencegah hipertensi, mengobati perut mual dan kembung, mengobati peradangan lambung dan usus. Kandungan metabolit sekunder triterpenoida/steroida, tanin, saponin, dan flavonoida yang dapat digunakan untuk mengobati diare. Tujuan penelitian ini untuk mengetahui karakterisasi, skrining fitokimia dan uji aktivitas antidiare ekstrak etanol daun situduh langit terhadap mencit jantan yang diinduksi dengan oleum ricini. Serbuk simplisia daun mengkudu dikarakterisasi dan diskrining fitokimia, kemudian diekstraksi dengan pelarut etanol 70% secara maserasi. Ekstrak yang diperoleh diuji efek antidiare terhadap mencit jantan yang diinduksi oleum ricini menggunakan metode transit intestinal yaitu dengan cara menghitung persen lintas yang dilewati tinta cina sebagai marker dan loperamid HCL dosis 0,52 mg/kg bb sebagai pembanding. Dosis ekstrak yang digunakan adalah 50, 100, dan 150 mg/kg bb. Hasil karakteristik serbuk simplisia diperoleh kadar air 10%, kadar sari larut air 6%, kadar sari larut etanol 16%, kadar abu total 9,5% dan kadar abu tidak larut asam 0,5%. Hasil skrining fitokimia diperoleh senyawa triterpenoida/steroida, tanin, saponin, flavonoida dan glikosida. Ekstrak etanol daun mengkudu dosis 50 dan 100 mg/kg bb memiliki efek antidiare sebanding dengan loperamid HCl dosis 0,52 mg/kg bb, sedangkan dosis 40 mg/kg bb memiliki efek antidiare yang lemah (P<0,05).
UJI AKTIVITAS ANTIDIARE EKSTRAK ETANOL DAUN CIPLUKAN (Physallis minima L.) TERHADAP MENICT JANTAN (Mus musculus) Evi Depiana Gultom; Robiatun Rambe; Ratih Paramitha; Ovalina Sylvia Br. Ginting
FORTE JOURNAL Vol 1 No 1 (2021): Edisi Januari 2021
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (333.857 KB) | DOI: 10.51771/fj.v1i1.37

Abstract

Daun ciplukan (Physallis minima L.) merupakan tanaman herbal yang mengandung flavonoid, saponin, alkaloid dan tanin. Senyawa tanin bersifat adstringent untuk mencegah disentri dan diare. Tujuan penelitian ini adalah untuk menguji efektivitas antidiare ekstrak etanol daun ciplukan pada mencit jantan(Mus musculus). Penelitian ini dilakukan secara in vivo dengan menggunakan hewan mencit. Pengujian aktivitas antidiare ekstrak etanol daun ciplukan (EEDC) diinduksi dengan minyak jarak 0,5 ml dan diamati parameter yang terdiri dari, onset, frekuensi diare, konsistensi dan berat feses, serta durasi diare setiap 30 menit selama 5 jam. Metode antimotilitas dilakukan untuk mengukur panjang usus yang dilintasi marker. Data dianalisis dengan menggunakan uji One-way ANOVA dan Post Hoc Tuckey. Uji efek antidiare EEDC pada mencit jantan menunjukkan bahwa dosis 50,100, 200 dan 400 mg/kg bb memiliki efek sebagai anti diare dengan menunjukkan perbedaan signifikan dengan kontrol negatif (p<0,05). Uji efek antidiare dengan metode induksi oleh minyak jarak menunjukkan bahwa EEDC dosis 200 mg/kg bb dan 400 mg/kg bb efektif sebagai antidiare dan tidak berbeda signifikan (p>0,05) dengan kontrol positif sedangkan metode antimotilitas EEDC dosis 400 mg/kg bb efektif sebagai antidiare karena tidak memiliki perbedaan siginifikan (p>0,05) dengan kontrol positif.
UJI EFEKTIVITAS GEL KOMBINASI EKSTRAK ETANOL DAUN BANGUN-BANGUN (Coleus amboinicus L.) DAN DAUN KELAPA SAWIT (Elaeis guieensis Jacq) SEBAGAI OBAT LUKA BAKAR TAHUN 2020 Evi Depiana Gultom
Jurnal Penelitian Farmasi & Herbal Vol 3 No 1 (2020): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v3i1.320

Abstract

Coleus amboinicus L leaves and Elaeis guieensis Jacq leaves contain various secondary metabolites such as saponins, tannins, alkaloids and flavonoids that function in wound healing. The purpose of this study was to determine the healing effect of burns using a gel preparation combination of ethanolic extract of Coleus amboinicus L. (EECAL) And ethanolic extract of Elaeis guineensis Jacq. (EEEGJ) In healing burns. Coleus amboinicus L leaves and Elaeis guieensis Jacq leaves contain are separated from the petiole and then dried in a drying cupboard so that it becomes a simplicia. Simplisia is extracted by maceration method then evaporated with a rotary evaporator and evaporated again on a water bath to produce a thick extract. EECAL and EEEGJ are then formulated into gel preparations with varying concentrations. Each rabbit was shaved on its back then cleaned with 70% alcohol. Furthermore, rabbits were anesthetized using 0.5 ml Lidocain HCL as much as 0.5 ml subcutaneously. Then mark the part that will be injured with a diameter of 2 cm, by lifting the rabbit skin using tweezers and then made a wound using a hot iron plate that has been sterilized beforehand with 70% alcohol. Wound diameter measurements showed that all treatment groups from day 1 to day 20 experienced changes in wound diameter. EECAL 15% and EEEGJ 10% have a more effective effect in healing of burn than in their single form.
UJI EFEK ANTIPIRETIK DAUN SENDUDUK (Melastoma malabathricum L.) PADA TIKUS PUTIH JANTAN (Rattus Norvegicus) Evi Depiana Gultom; Herti Ayu N Zebua; Robiatun Rambe
Jurnal Penelitian Farmasi & Herbal Vol 5 No 1 (2022): JURNAL PENELITIAN FARMASI & HERBAL
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v5i1.972

Abstract

The antipyretic effect of flavonoid in senduduk leaf (Melastoma malabathricum L.) is one of the traditional medicines that people used. The goal of this study is to determine the antipyretic effect of the extract of Senduduk leaf (Melastoma malabathricum L.) in male white mice and compare it to paracetamol. The design of this experimental study was a post-test only controlled group design. Twenty-five Wistar furrow mice, aged two months and weighing 200 grams, were utilized as animal models. The mice were divided into five groups, one of which was the negative control group (2 ml water), First dosage of Senduduk leaf extract (100 mg/200 g body weight mice), second dose of the extract (200 mg/200 g body weight mice), and third dose of the extract (300 mg/200 g body weight mice). Temperature measurements were taken before and after the DPT vaccination was administered to mice, and every 30 minutes post treatment until 150 minutes. The result after observing treatment at 30 minutes for dose I (37.930C), dose II (37.760C), and dose III (37.450C). The results at 150 minutes for dose I (37,470C), for dose II (37,150C), and for dose III (36.880C). The result of the research was to analyzed using the one way ANOVA test. The results of statistical observations using the one way ANOVA method showed the significant value was p < 0.05 (0.000). This indicates there are differences from each treatment in antipyretic testing. If continued with the Tukey test, a significant value of p> 0.05 (0.9480), the research concluded that there is no difference in terms of antipyretic testing at a dose of 300mg/KgBW compared to paracetamol. The research concluded is the EEDS at a dose of 300mg/KgBW has the best antipyretic properties compared to paracetamol.
Effectiveness of Ricinus communis as Natural Larvicide for Aedes aegypti Mosquito Larvae in Medan City Chahaya, Indra; Tumanggor, Winni R.E.; Gultom, Evi Depiana
Jurnal Kesehatan Masyarakat Vol 19, No 4 (2024)
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v19i4.47990

Abstract

Dengue Hemorrhagic Fever, a disease caused by Aedes aegypti, can be prevented by reducing larval density using natural larvicides. This research aimed to investigate the natural larvicide effectiveness in reducing the Aedes aegypti larvae density in Medan City in 2023. This quasi-experimental research conducted a pre-test and post-test on the Container Index (CI). The population in this study was 1,057 houses in Ladang Bambu Village, the sample being 150 houses. The treatments were control and Ricinus communis-seed powder at 40 mg, 80 mg, 100 mg, and 120 mg/l doses in ovitraps, placed next to the water reservoir. Consider specifying the unit of measurement for the container index. The container index was calculated before (day 0) and after treatment (day 7). Data were analyzed using paired T-test, one-way ANOVA, and LSD. The results were that the modified ovitrap with the seed of Ricinus communis was effective in reducing the Aedes aegypti mosquito larvae density. The analysis showed a significant difference in the mean CI between the control and the modified ovitrap, the most effective dose in reducing CI being 100 mg/l of water. The community can use the 100 mg/l seed of Ricinus communis in ovitraps as an eco-friendly vector control.
SOSIALISASI DAN EDUKASI BAHAYA PENGGUNAAN KOSMETIKA PEMUTIH KULIT DIKALANGAN REMAJA Gultom, Evi Depiana
Jurnal Pengabdian Masyarakat Putri Hijau Vol 4 No 4 (2024): Jurnal Pengabdian Masyarakat Putri Hijau (JPMPH)
Publisher : INSTITUT KESEHATAN DELI HUSADA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpmph.v4i4.2020

Abstract

Skin whitening products are one of the cosmetic products that contain active ingredients that can inhibit the formation of melanin or eliminate melanin that has already formed so gives the skin a whiter color. Limited knowledge about various cosmetic products bleach means that people do not know the negative impacts that can arise if they are not careful. Mercury, hydroquinone and retinoic acid are some of the active substances that are often misused by illegal cosmetic manufacturers. This activity was carried out with the aim of providing knowledge and skills to the community, especially students of Al Washliyah 3 Medan Private Vocational School. This activity is carried out using the counseling method and questions and answers about the material the dangers of using whitening cosmetics containing mercury and hydroquinone are continued with training to check cosmetic registration numbers at BPOM using an Android cellphone. From that activity carried out, it turns out that there are still many patients who do not know the dangers of using mercury, hydroquinone and retinoic acid in whitening cream and don't know how to check the registration number. cosmetics on the market. From this community service activity, it is hoped that students will know more about the dangers of mercury, hydroquinone and retinoic acid and can check directly on ordinary cosmetic products used everyday.
Diabetes UJI EFEKTIVITAS ANTIDIABETES KOMBINASI EKSTRAK ETANOL DAUN AFRIKA (Vernonia amygdalina) dan BUNGA ASOKA (Ixora paludosa) TERHADAP PENURUNAN KADAR GLUKOSA DARAH TIKUS YANG DIINDUKSI ALOKSAN Gultom, Evi Depiana
Jurnal Penelitian Farmasi Dan Herbal Vol 7 No 1 (2024): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v7i1.1981

Abstract

Diabeiteis meillitus is a diseiasei in which blood glucosei leiveils increiasei duei to damagei to pancreiatic ceill, meitabolic disordeirs and insulin reisistancei which can bei treiateid with traditional meidicineis deiriveid from plants. Onei eixamplei of a plant that can loweir blood glucosei leiveils is Afrika Leiaf and Asoka Floweir which contains flavonoids to loweir blood glucosei by increiasing ceill seinsitivity to insulin and stimulating insulin reileiasei in pancreiatic β ceills. To deiteirminei thei eiffeict of Afrika leaves and Asoka Floweir eixtract in loweiring blood glucosei leiveils compareid to glibeinclamidei. Expeirimeintal study using 25 rats induceid by alloxan and divideid into 5 groups. Group 1 (neigativei control) CMC Na 1%, group 2 (positivei control) glibeinclamidei dosei 0.45 mg/kg, group 3 Afrika leiaf and Asoka floweir eixtract dosei 100+50 mg/kgBB, group 4 Afrika leiaf and Asoka floweir eixtract dosei 200+100 mg/kgBB and group 5Afrika leiaf and Asoka floweir eixtract dosei 300+150 mg/kgBB. Extraction using maceiration meithod with 96% eithanol solveint. From thei reisults of thei study eiach treiatmeint group eixpeirieinceid a deicreiasei in blood glucosei leiveils. Of thei 5 treiatmeint groups, thei deicreiasei in blood glucosei leiveils that was comparablei to that of glibeinclamidei was thei Afrika Leiaf and Asoka Floweir eithanol eixtract group at a dosei of 300+150 mg/Kg BB.
Hiperlipidemia Uji Efektivitas Antihiperlipidemia Ekstrak Etanol Daun Kersen (Muntingia calabura L.) Pada Tikus Putih Jantan Yang Di Induksi Fruktosa Gultom, Evi Depiana
Jurnal Penelitian Farmasi Dan Herbal Vol 7 No 1 (2024): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v7i1.1985

Abstract

Hyperlipidemia is a condition of high lipid concentration which is characterized by increased concentrations of triglycerides, LDL (Low Density Lipoprotein), blood cholesterol that exceeds normal limits which is one of the risk factors for cardiovascular disease. Kersen leaf has contains secondary metabolites of flavonoids and saponins which are thought to reduce cholesterol levels in the blood. The aim of this study was to determine the antihyperlipidemic effectiveness of ethanol extract of kersen leaf (EEDK/EEKL) in fructose-induced male white rats. Testing the effectiveness of antihyperlipidemia was carried out using an experimental method using fructose-induced male rats as test animals. The test animals were divided into 5 groups, namely negative control (CMC Na 1%), positive control of simvastatin (0.9 mg/kgBB), EEDK dose of 350 mg/kgBB, EEDK dose of 400 mg/kgBB, EEDK dose of 500mg/kgBB. Cholesterol levels were measured using the point of care testing (POCT) method. The data obtained were analyzed statistically using the one way ANOVA test. The results of the analysis showed that there were significant differences between the negative control, positive control, EEDK 350 mg/kg, EEDK 400 mg/kg and EEDK 500 mg/kg (P<0.05). The decrease in cholesterol levels increased in line with the increase in the dose of cherry leaf ethanol extract. The most effective EEDK as antihyperlipidemia is the EEDK at a dose of 500 mg/kg BW. There was no significant difference between the positive control and the 500 mg/kg BW EEDK dose (P>0.05). Based on the results of the statistical analysis that has been carried out, it can be concluded that the ethanol extract of cherry leaves has an antihyperlipidemic effect on rats.
SOSIALISASI DAN EDUKASI DAGUSIBU PADA SISWA SMK AL RAZI SINAR HARAPAN MEDAN JOHOR Gultom, Evi Depiana
Jurnal Pengabdian Masyarakat Putri Hijau Vol 5 No 1 (2024): Jurnal Pengabdian Masyarakat Putri Hijau (JPMPH)
Publisher : INSTITUT KESEHATAN DELI HUSADA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpmph.v5i1.2144

Abstract

Background: Drug-related health problems in Indonesian society continue to increase over time. The majority of these problems arise because of the public's perspective which does not yet understand the proper and correct use and handling of medicines. The DAGUSIBU drug program is one of the right solutions to overcome this problem. Objective: This service aims to increase the knowledge of students at Al Razi Sinar Harapan Vocational School Medan Johor regarding how to obtain, use, store and dispose of medicines properly. Method: This activity is carried out using an educational method starting from how to use it to the correct disposal of medicines, then interactive discussions, demonstrations as well as eval_uation and monitoring through post tests and pre tests. Results: The socialization activities ran smoothly with participants who were cooperative and enthusiastic in participating in the program. On the other hand, based on the post-test results, it shows that participants better understand the concept of DAGUSIBU medication correctly, so they can minimize errors in drug use. Conclusion: With this socialization, students at Al Razi Sinar Harapan Vocational School Medan Johor can apply the knowledge they have gained to their environment and family.
Co-Authors Br Barus, Lidia Klorida Herti Ayu N Zebua Indra Chahaya Meilina, Rulia Ovalina Sylvia Br. Ginting Paramitha, Ratih Rahma Dewi Ratih Paramitha Robiatun Rambe Robiatun, Robiatun Rambe SEMBIRING, TIO RANTI SARI Shela Diana Sianipar, Masria Phetheresia Tumanggor, Winni R.E. Zulmai Rani