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All Journal Jurnal Kedokteran Brawijaya The Indonesian Biomedical Journal Jurnal SOLMA Journal of Islamic Medicine Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai
Ermin Rachmawati
Departemen Fisiologi Fakultas Kedokteran Universitas Lampung Bandar Lampung
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Other

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FRUCTOSE ALTERS THE EXPRESSION OF TYPE B LEPTIN RECEPTOR IN HYPHOTALAMUS AND INTESTINUM OF Rattus Novergicus Rachmawati, Ermin; Kristanti, Risma Aprinda; Susanti, Nurlaili
Journal of Islamic Medicine Vol 2, No 2 (2018): Journal of Islamic Medicine
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (486.841 KB) | DOI: 10.18860/jim.v2i2.5776

Abstract

Background: Several epidemiological data’s reported significant correlation between fructose consumption and diabetes mellitus type 2 by inducing insulin resistance. Leptin resistance induced by fructose was proposed as one novel mechanism that induce insulin resistance but the exact mechanism remains unclear.  We hypothesize that fructose diminish the type b leptin receptors in hypothalamus and intestine.Aim: This study was aimed to elucidate fructose effect on the expression of leptin receptor type b in hypothalamus and intestine of Rattus novergicus.Method: twenty eight rats were used and divided into 4 groups: Group 1 was control, group 2 was given fructose 10%, group 3 was given fructose 30% and group 4 was given fructose 55% for 2 months. At the end of treatment, the animal were sacrificed and then the hypothalamus and intestine were collected. The expression of type b leptin receptor were measured by immunohistochemistry technique with primary antibody from Bioss antibodies type Leptin receptor polyclonal antibody bs-0109R using Staining kit Skytec Laboratories and DAB chromogen. A positive expression can be seen as a brown colour in cell cytoplasm and counted in 100 cell. The expression then analysed using SPSS 18 with anova one way tes (p0,05) followed by post hoc test after the data showed normality and homogeneity using Saphiro wilk and Levene test (p0,05).Result: There was significant differences in type b leptin receptors found in hypothalamus between each group (p0.05). The significant differences also could be seen in the expression between control and group fructose 30 and 50% in intestinal cell (p0.05).Conclusion: the consumption of Fructose 55% for 2 months attenuates the expression of type b leptin receptors in hypothalamus and intestine of Rat novergicus. 
Efek Ekstrak Etanolik Daun Sirsak pada Proliferasi dan Apoptosis Sel HeLa yang Dimediasi oleh p53 Rachmawati, Ermin; Karyono, Setyawati; Suyuti, Hidayat
Jurnal Kedokteran Brawijaya Vol 27, No 1 (2012)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (620.589 KB) | DOI: 10.21776/ub.jkb.2012.027.01.5

Abstract

Kanker  serviks  merupakan  penyebab  utama  kedua  kematian  kanker  pada wanita  di seluruh  dunia, menyebabkan  240.000 kematian  setiap  tahunnya.  Ekstrak  daun  Annona  muricata  berpotensi  baik  sebagai  obat  anti  kanker .  T ujuan  dari  penelitian ini  adalah  untuk  mengetahui  pengaruh  ekstrak  etanol  daun  sirsak  (Annona  muricata)  dalam  menghambat  dan menginduksi  aktivasi apoptosis yang dimediasi oleh stabilisasi p53 pada pertumbuhan kanker serviks.  Sebuah percobaan in vitro dilakukan dengan menggunakan kultur sel HeLa. Penghambatan proliferasi diukur dengan MTT assay. Apoptosis dideteksi  dengan  menggunakan  flowcytometry  Annexin  V  Biotin  Kit  Apoptosis  Detection.  Konfirmasi  dan  perhitungan ekspresi  p53  ditentukan  oleh  imunocytochemistry.  Ekstrak  etanol  dari  daun  Annona muricata  secara  efektif  menghambat proliferasi sel HeLa dengan dosis tertentu pada paparan 48 jam. Nilai  IC50 ekstrak etanol daun Annona muricata adalah 111,75  ug/ml.  200  mg/ml  ekstrak  menginduksi  apoptosis  sel  HeLa  tergantung  dari  lama  pemaparan.  Ekstrak  ini  juga meningkatkan  ekspresi  p53  sel  HeLa  tergantung  dosis  pemberian  (25,  50,  100,  200  μg/ml)  dan  lama  pemberian  (24  dan  48 jam).  Dapat  disimpulkan  bahwa  ekstrak  etanol  daun  sirsak  menghambat  pertumbuhan  sel  HeLa  dan  menginduksi apoptosis.  Mekanisme  ekstrak  daun  sirsak  menghambat  proliferasi  dan  apoptosis  inducing  berhubungan  dengan stabilisasi  dan  aktivasi  p53.Kata  Kunci:  Daun  Annona  muricata,  apoptosis,  ekstrak  etanol,  proliferasi,  ekspresi  p53
Interprofessional Education for Optimizing the Fostering Candidate Pilgrimage Program in Waiting Period to Achieve Istitha’ah Rachmawati, Ermin; Riskiyah, Riskiyah; Dharma Dewi, Tanaya Jati; Wijaya, Dhani; Syarifuddin, Sadli; Aisa, Amalia Nur; indrawan, Doby
Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Vol 14, No 1 (2025): March
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jpki.96864

Abstract

Background: The Faculty of Medicine and Health Sciences of the State Islamic University (FKIK UIN) Malang needs to build recognition in realizing its superior curriculum, namely hajj health through hajj pilgrimage interprofessional education (HIPE) course. On the other hand, there is an opportunity from the Batu City Government and Ministry of Religion to collaborate in fostering the waitingperiod of Prospective Hajj Pilgrims (CJH) to achieve istitha'ah.Objective: This study aimed to compile and evaluate the learning instructional design of the Hajj Pilgrimage Interprofessional Education (HIPE) program as a manifestation of the superior curriculum of FKIK UIN Malang which is part of the prospective hajj pilgrimage waiting period program of the Batu city government.Research Method: This research was conducted from June to December 2023. The participants of the study included the executive board of faculty incluring dean and vice dean, head of medical bachelor and bachelor of pharmacy educational program, head of the ministry of religion, the hajj and umrah organization division, head program director of the health service district and from 5 primary health center, along with hajj pilgrimage candidate of Batu city in 2023. The data used was primary data from the program satisfaction survey questionnaire and secondary data in the form of formal documents.Results: The learning instructional design has been approved by the faculty leader, head of medical and pharmacy bachelor program, head of ministry of religion, and head of Batu city health office in Focus Group Discussion meeting with the topic of Hajj Health Superior Curriculum marked by the issuance of the MoU, the organizational structure of the faculty unit called Unit of Medical and Health Profession Education (UMHPE), and the Dean's Decree for the unit in charge. The organizational structure involved all parties including the ministry of religion of Batu city, the health officer and hajj program director in 5 primary health centers in the Batu city, and the Faculty with its study program. Longitudinal courses in 2 bachelor program was arranged with a spiral curriculum entitled HIPE 1, 2, 3. HIPE 3 as the final course applied the Project Based Learning (PJBL) approach providing intervention program to achieve istitha'ah which is implemented through hajj pilgrimage candidate serial home visits. The quality cycle has been applied in the entire series of learning programs. The results of the satisfaction survey from hajj pilgrimage candidate and external stakeholders showed a positive response to the HIPE program and the objectives of HIPE itself.Conclusion: The HIPE learning prototype as a superior curriculum of FKIK UIN Malang to foster hajj pilgrimage candidate during the waiting period in Batu City already facilitated a mutual collaboration between FKIK UIN Malang, the Health Office and the Ministry of Religion of Batu City.
The Effect of Sleep Duration on Systolic Pressure And Nitric Oxide Concentration in Hypertensive Patients Riskiyah, Riskiyah; Rachmawati, Ermin; Kholis, Mukhamad Nur
Journal of Islamic Medicine Vol 6, No 2 (2022): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2022
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v6i2.14069

Abstract

Background: Poor blood pressure control of hypertensive patients is caused partially by bad lifestyle management, which increases the risk of a cardiovascular event by stimulating the defective endothelial function. Objective: This study aimed to investigate the effect of night sleep duration on systolic blood pressure and Nitric Oxide concentration in hypertensive patients. Methods: 60 hypertensive patients age 40 years based on the medical record participated in this study. The sleep duration and sleep quality were performed using the PSQI questionnaire. The 40 participants thus selected randomly for the NO concentration assay using NO Salivary Elisa Kit ab65238. Results: 53 participants experienced night sleep duration ≤ 6 hours, and 44 (73.7%) participants had poor sleep quality. Night sleep duration was associated significantly with hypertensive patients' systolic blood pressure (p = 0,000 0.05; Odds ratio=0.008). Conclusion: The longer duration of sleep at night among hypertension patients, the lower systolic pressure were found. There was no correlation between night sleep duration on NO concentration (p 0.05). These findings provide evidence that night sleep duration is associated strongly with the increased systolic blood pressure but not directly caused by the alteration of endothelial function.Keywords: sleep duration. systolic blood pressure, hypertension, endothelial function, Nitric Oxide 
Association Between Stress Level, Sleep Quality, Physical Activity With Cardiorespiratory Fitness In Medical Students: A Cross Sectional Study Rachmawati, Ermin; Milliana, Alvi; Filzah, Sefira Maulida; Kresnanda, Adhitya Wishnu
Journal of Islamic Medicine Vol 7, No 1 (2023): JOURNAL OF ISLAMIC MEDICINE EDISI MARET 2023
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v7i1.20429

Abstract

Introduction Modern life style and high burden of academic tasks contribute to the upsurge of stress, poor sleep quality, lack of sufficient physical activity in medical student society nowadays. The unhealthy life style act as one cardiovascular risk factor which can be predicted using Cardiorespiratory Fitness (CRF) examination. Objectives to identify the association between stress, sleep quality, physical activity with CRF level among medical students. Design The cross-sectional data was collected between September until November 2021. A total of 38 male and 73 female students of Faculty of Medicine and Health Sciences UIN Maulana Malik Ibrahim Malang were participated in this study. Stress level was assessed with DASS-21, sleep quality with PSQI, physical activity with GPAQ questionnaire.  The level of CRF was measured using the Harvard Step Test. Statistical analysis for bivariate correlation ordinal scale was tested using Spearman Rank. Results 83 participants (74,8%) had low CRF. Meanwhile, 76 participants (68,5%) experienced no stress. In addition, 75 participants (67,6%) had poor sleep quality. A total number of 79 participants (71%) had low physical activity. There was no significant correlation between stress level, sleep quality, physical activity with CRF ( p=0,962; 0,772; 0,114, respectively). The participants who had low physical activity and low CRF was found in 56 participants (50,45%). Conclusions There was no association between stress level, sleep quality, physical activity with CRF among medical students. Keywords: Cardiorespiratory fitness; Stress; Sleep quality; Physical activity.
Vegetables Spices Fermentation Extract Inhibit NAFLD Development by Attenuation of Steatosis through Suppression of C/EBPα and TNFα mRNA Expression Rachmawati, Ermin; Machdaniar, Maulidya; Kinasih, Larasati Sekar; Sargowo, Djanggan; Syarifuddin, Brillian Putra; Putri, Fayza Cinta Rahmadina; Ismail, Mahrus
The Indonesian Biomedical Journal Vol 16, No 2 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i2.2934

Abstract

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD), characterized by inflammation and steatosis, is one of the metabolic problems that trigger serious complications. Statin is usually used for NAFLD therapy, however, statin intolerance and resistance reduce the effectiveness of NAFLD treatment. Therefore, this study was conducted to develop the phytopharmaca against NAFLD by elucidating the anti-inflammatory and steatosis suppression of vegetable spices fermentation extract (VSFE) in rabbits induced with high-fat diet (HFD).METHODS: Twenty New Zealand White rabbits were determined into 4 groups; which were groups receiving standard diet (SD), HFD, HFD and 100 mg/kgBW VSFE, as well as HFD and 200 mg/kgBW VSFE. mRNA expressions of tumor necrosis factor alpha (TNFα) and CCAAT/enhancer-binding protein alpha (C/EBPα) were evaluated. The TNFα concentration was quantified after protein and RNA isolation. Inflammation and steatosis were observed in liver hematoxylin-eosin-stained preparate using microscope.RESULTS: Macrophage cells and hepatic steatosis showed significant decrease in a drug dependent manner. An effective dose of 200 mg/kgBW decreased C/EBPα and TNFα expression to 0.45±0.32 and 0.72±0.29 (p=0.013 and p=0.002, compared to the HFD group), respectively. TNFα inflammatory cytokine concentrations also responded to the administration of 100 mg/kgBW and 200 mg/kgBW doses, with the value of 31.72±10.40 mg/dL and 48.35±7.15 mg/dL (p=0.009 and p=0.002, compared to the HFD group), respectively.CONCLUSION: VSFE might prevent NAFLD by inhibit steatosis and inflammation through suppression of C/EBPα expression and TNFα expression.KEYWORDS: C/EBPα, TNFα, fermentation, steatosis, NAFLD
Expression of Plasma miRNA-133a is Significantly Lower in Acute Coronary Syndrome (ACS) than in Healthy/Non-ACS Subjects Rachmawati, Ermin; Sargowo, Djanggan; Saputra, Indra Wahyu; Riskiyah, Riskiyah; Handirosiyanto, Ikhwan; Hakim, Arief Rachman; Ismail, Mahrus; Tarsadi, Tarsadi; Maulana, Syafiq; Ahdi, Iwal Reza; Puspitasari, Alvina; Wardhani, Syanindita Puspa
The Indonesian Biomedical Journal Vol 16, No 5 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i5.3243

Abstract

BACKGROUND: The current biomarker diagnostic modality for acute coronary syndrome (ACS), cardiac troponin, has several limitations. Emerging studies showed that micro-RNA (miR)-133a was released from infarcted heart to circulation, yet the diagnostic value of miR-133a in ACS demonstrated a conflicting result. Therefore, this study was conducted to investigate the potency of plasma miR-133a as a biomarker candidate of ACS.METHODS: This was a case-controlled study, involving ACS and control subjects. The sociodemographic and clinical characteristics were assessed through medical records. A final of 39 ACS and 31 control subjects (consist of healthy and non-ACS subjects) passed the selection procedure by demonstrating a high purity of RNA. miR-133a from ACS and control subjects were detected by quantitative polymerase chain reaction (qPCR). Expression of miR-133a was evaluated for sensitivity and specificity as an ACS biomarker diagnostic using the receiver operating characteristic (ROC) curve.RESULTS: Plasma miR-133a expression was stably found in ACS subjects. The plasma miR-133a level was lower in ACS than in control subjects. miR-133a effectively distinguished ACS subjects from healthy subjects (AUC=0.911) and exhibited high diagnostic performance, with a sensitivity of 87.1% and specificity of 100% at a cut-off value of 44.035. In an extended model including both control subjects (healthy and non-ACS with comorbid conditions), miR-133a maintained diagnostic significance (AUC=0.874), showing sensitivity of 76.9% and specificity of 100% at a cut-off value of 11.69.CONCLUSION: Plasma miR-133a is significantly lower and effectively distinguishes ACS patients from both healthy individuals and non-ACS individuals with comorbid, with a cut-off value of 11.69. Therefore, plasma miR-133a is suggested to be a good candidate for diagnostic biomarkers of ACS.KEYWORDS: circulating miRNA, miRNA-133a, acute coronary syndrome, diagnostic biomarker
Deteksi dini Gangguan Gizi (Malnutrisi) pada Kelompok Berisiko Anggraini, Dian Isti; Soleha, Tri Umiana; Rachmawati, Ermin; Ramadhian, M. Ricky
JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Vol. 1 No. 1 (2015): JURNAL PENGABDIAN MASYARAKAT RUWA JURAI
Publisher : FK Unila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jpmrj.v1i1.1144

Abstract

Indonesia saat ini mengalami permasalahan beban ganda dalam menghadapi masalah gizi, ketika permasalahan gizi kurang belum teratasi, muncul permasalahan baru yaitu permasalahan gizi lebih. Beban ganda masalah gizi ini banyak terjadi pada kelompok penduduk berisiko seperti bayi dan balita, wanita usia subur, wanita hami dan menyusui serta kaum lanjut usia (lansia). Tujuan dari kegiatan ini adalah untuk melakukan deteksi dini gangguan gizi pada kelompok berisiko. Khalayak sasaran kegiatan pengabdian kepada masyarakat ini adalah masyarakatdi kampung Totokaton kecamatan Punggur kabupaten Lampung Tengah. Metode yang digunakan dalam kegiatan ini yaitu penilaian status gizi kelompok sasaran dan edukasi status gizi melalui pembagian leaflet.Penilaian status gizi kelompok bayi, anak di bawah dua tahun (baduta), pra lansia dan lansia dengan metode antropometrik. Pengabdian kepada masyarakat ini dilaksanakan Tanggal 11 Oktober 2014, Pukul 08.30 sampai dengan selesai. Tempat kegiatan pengabdian ini adalah pos kesehatan desa di kampung Totokaton kecamatan Punggur kabupaten Lampung Tengah. Hasil kegiatan didapatkan bahwa malnutrisi pada kelompok pralansia terdapat 22 orang (75,86%) yaitu 6 orang (20,68%) berstatus gizi kurang, 8 orang (27,58%) berstatus gizi lebih dan 8 orang (27,58%) berstatus gizi obes. Pada kelompok lansia terdapat 9 orang (64,28%) yang mengalami malnutrisi yaitu 6 orang (42,85%) berstatus gizi kurang, 2 orang (14,28%) berstatus gizi lebih dan 1 orang (7,14%)berstatus gizi obes. Pada kelompok bayi dan baduta terdapat 1 orang (5,88%) yang mengalami malnutrisi yaitu berstatus gizi lebih. Kesimpulan: malnutrisi tinggi pada kelompok dewasa dan lansia sehingga intervensidisarankan difokuskan pada kelompok tersebut untuk meningkatkan derajat kesehatan dan kualitas hidup manusia.Kata Kunci: gangguan gizi, malnutrisi
Pemeriksaan Kesehatan dan Peningkatan Pengetahuan tentang Menjaga Kesehatan serta Gizi saat Ibadah Haji dan Umroh Riskiyah, Riskiyah; Rachmawati, Ermin; Sekar Kinasih, Larasati; Sanyya Azamy, Shirly; Taqiyyudin, Althof; Maulina, Alodia
Jurnal SOLMA Vol. 14 No. 3 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/solma.v14i3.20519

Abstract

Background: Jemaah haji serta umrah rentan menderita gangguan kesehatan, terutama lansia dengan penyakit kronis seperti hipertensi, diabetes mellitus, dan hiperurisemia. Kegiatan pengabdian ini bertujuan untuk melakukan pemeriksaan kesehatan dan meningkatkan pengetahuan jemaah melalui penyuluhan tentang menjaga kesehatan dan gizi saat ibadah haji dan umrah. Metode: Kegiatan dilakukan kepada 54 peserta Majelis Taklim Assalam di Kota Malang melalui pemeriksaan kesehatan, penyuluhan berbasis ceramah, serta evaluasi pretest dan posttest dengan Wilcoxon rank test. Hasil: Mayoritas peserta adalah lansia (57,4%) dengan pendidikan S1 (55,6%). Hasil pemeriksaan menunjukkan 35,2% peserta mengalami hipertensi tingkat 1, 5,6% kadar gula darah >200 mg/dL, dan 42,6% mengalami hiperurisemia. Uji Wilcoxon rank test memperlihatkan peningkatan pengetahuan secara signifikan (p<0,05) sesudah penyuluhan. Kesimpulan: Pemeriksaan dan penyuluhan kesehatan efektif sebagai upaya promotif dan preventif untuk mendukung kesehatan jemaah saat menjalankan ibadah haji dan umrah.
Co-Authors Ahdi, Iwal Reza Aisa, Amalia Nur Alvi Milliana Anggraini, Dian Isti Arief Rachman Hakim Dhani Wijaya, Dhani Dharma Dewi, Tanaya Jati Djanggan Sargowo Doby Indrawan Filzah, Sefira Maulida Handirosiyanto, Ikhwan Hidayat Suyuti Ismail, Mahrus Kholis, Mukhamad Nur Kresnanda, Adhitya Wishnu Larasati Sekar Kinasih Machdaniar, Maulidya Maulana, Syafiq Maulina, Alodia Muhammad Ricky Ramadhian Nurlaili Susanti Puspitasari, Alvina Putri, Fayza Cinta Rahmadina riskiyah, Riskiyah - Risma Aprinda Kristanti Sadli Syarifuddin Sanyya Azamy, Shirly Saputra, Indra Wahyu Sekar Kinasih, Larasati Setyawati Karyono Syarifuddin, Brillian Putra Taqiyyudin, Althof Tarsadi, Tarsadi Tri Umiana Soleha Wardhani, Syanindita Puspa