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All Journal Jurnal Farmasi Indonesia Media Farmasi Indonesia JURNAL JAMU KUSUMA Nutriture Journal
Septiana Laksmi Ramayani
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Other

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Formulasi Dan Uji Aktifitas Nanoemulsi Minyak Atsiri Daun Kemangi (Ocimum basilicum L.) Terhadap Salmonella typhi Monica Kristiani; Septiana Laksmi Ramayani; Klara Yunita; Meilina Saputri
Jurnal Farmasi Indonesia Vol 16 No 1 (2019): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (927.746 KB) | DOI: 10.31001/jfi.v16i1.449

Abstract

Essential oil of basil (Ocimum basilicum L.) leaves with a concentration of 2.5% can be estimated to have a diameter of inhibition zone with an average value of 8.67 ± 0.58 mm. Essential oils have volatile characteristics, and are easily oxidized so that they can affect their activities as antibacterial. To increase stability, essential oils of basil leaves need to be packaged in a special delivery system. Nanoemulsion is made by spontaneous emulsification method. Nanoemulsion was further tested for physical characteristics including droplet size, polydispersity index, zeta potential and nanoemulsion morphology using a Transmission Electron Microscope (TEM). The preparation was then tested for its activity against Salmonella thypi. The method used is the Kirby-Bauer disk diffusion method. From the test of physical characteristics obtained the average particle size of 10.6 nm, polydispersity index 0.03 and zeta potential -36.4. The results of the observation using TEM form the particles produced are spherical. Antibacterial test results were shown by the formation of inhibition zones of basil leaf essential oil (9.3 mm), positive control (6.6 mm), negative control (7.5 mm), nanoemulsion of basil leaf essential oil (8.3 mm), Virgin Coconut Oil (7 mm). Based on the results of statistical analysis it was found that there were no significant differences in treatment between groups.
FORMULASI DAN UJI STABILITAS OBAT KUMUR EKSTRAK ETANOL 70% BIJI ALPUKAT (Persea americana Mill.) Nurika Rachmawati; Septiana Laksmi Ramayani; Riska Chandra Pradana
Jurnal Jamu Kusuma Vol. 2 No. 2 (2022): JURNAL JAMU KUSUMA
Publisher : Poltekkes Kemenkes Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (216.223 KB) | DOI: 10.37341/jurnaljamukusuma.v2i2.30

Abstract

Karies gigi terbentuk dari campuran komponen anorganik, rongga mulut sisa-sisa makanan serta bakteri yang melekat dipermukaan gigi. Penyebab utama terjadinya karies gigi ialah bakteri Streptococcus mutans. Ekstrak biji alpukat diketahui dapat menghambat jalannya pertumbuhan bakteri Streptococcus mutans. Salah satu cara untuk mengatasi terbentuknya karies gigi yaitu dengan menggunakan obat kumur. Penelitian ini bertujuan untuk mengetahui kestabilan dari sediaan obat kumur ekstrak biji alpukat. Sediaan obat kumur ekstrak biji alpukat dibuat dalam dua formula dengan menggunakan surfaktan yang berbeda yaitu PEG – 40 hydrogenated castor oil (F1) dan tween 80 (F2). Uji stabilitas yang dilakukan meliputi uji organoleptis, uji homogenitas, uji pH dan uji viskositas. Analisa hasil dilakukan dengan uji One Way Anova. Hasil penelitian menunjukkan bahwa sediaan obat kumur ekstrak biji alpukat pada formula 1 dan formula 2 menunjukkan hasil yang tidak stabil yaitu pada uji pH dan uji viskositas.
Uji Aktivitas Antibakteri Ekstrak Etil Asetat Daun Mangga (Mangifera indica L.) terhadap Staphylococcus aureus dan Staphylococcus epidermidis Muhammad Anugerah Alam Waris; Definingsih Yuliastuti; Septiana Laksmi Ramayani; Alfat Fadri
NUTRITURE JOURNAL Vol 1 No 3 (2022): Jurnal Nutriture
Publisher : Politeknik Kesehatan Kemenkes Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31290/nj.v1i3.3755

Abstract

Latar belakang: Infeksi bakteri saat ini, beberapa telah mengalami resistensi terhadap obat antibiotik yang menjadi tantangan besar dalam kesehatan masyarakat diseluruh dunia. Terjadinya evolusi resistensi mikroorganisme dapat menyebabkan beberapa obat antibiotik yang ada menjadi kurang efektif dalam pengobatan infeksi yang disebabkan oleh mikroorganisme. Salah satu yang mampu memberikan efek antibakteri yaitu daun mangga atau dengan nama latin M. indica L. yang berasal dari keluarga Anacardiaceae. Tujuan: Untuk mengetahui apakah ekstrak etil asetat daun Mangga memiliki aktivitas antibakteri terhadap S. aureus dan S. epidermidis Metode: Ekstrak daun Mangga (Mangifera indica L.) diperoleh dengan metode maserasi menggunakan cairan penyari Etil Asetat. Ekstrak yang diperoleh kemudian dilakukan pengujian antibakteri terhadap bakteri uji menggunakan metode difusi dengan variasi konsentrasi 2,5 persen, 5 persen, 10 persen (b per v), kontrol positif Ampicillin dan kontrol negatif DMSO 10 persen. Zona hambat yang terbentuk diukur setelah inkubasi selama 24 jam. Hasil: Terdapat zona hambat pada pengujian antibakteri ekstrak etil asetat daun Mangga (M. indica) terhadap S. aureus sebesar 7,6 mm, 8 mm, 8,7 mm dan 27,3 untuk kontrol positif. Untuk pengujian antibakteri ekstrak etil asetat daun Mangga (M. indica) terhadap S. epidermidis sebesar 7,8 mm, 8,4 mm, 8,6 mm dan 23,3 untuk kontrol positif Simpulan: Berdasarkan pengujian yang telah dilakukan, dapat disimpulkan bahwa ekstrak etil asetat daun Mangga (M. indica) memiliki senyawa antibakteri.
Antioxidant Test Of Granola Bar Functional Food With Cork Fish And Beetroot (Beta Vulgaris L) As Supplementary Food To Prevent Stunting Pradana, Riska; Septiana Laksmi Ramayani
Media Farmasi Indonesia Vol. 20 No. 1 (2025): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v20i1.307

Abstract

Stunting generally occurs in children who have not received nutritious food intake. Sources of nutrition are not only sourced from animal protein but can also be sourced from plants. Combining high-protein foods from animal and vegetable sources will reduce stunting rates in growing children. Snack bars are a beneficial food product that provides all the essential nutrients for the body. In addition, probar consumption in Indonesia is still relatively low, and some people don’t even know it exists. These snacks are high in usable energy and contain essential nutrients. This study aims to determine the free radical-catching activity of Granola Bar Functional Food with Cork Fish and Beetroot Fruit as Supplementary Food to Prevent Stunting. Free radical scavenging activity test was conducted using the DPPH (1,1- diphenyl- 2-picrylhydrazyl) method using quercetin as the comparative compound. Antioxidant activity analysis was performed using a spectrophotometer at a wavelength of 512 nm.
Co-Authors Alfat Fadri Definingsih Yuliastuti Eka Amalia Permatasari INDAH NOVITASARI Klara Yunita Maryana Maryana Meilina Saputri Monica Kristiani Muhammad Anugerah Alam Waris Nurika Rachmawati Pradana, Riska Riska Chandra Pradana