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Analisis Kandungan Logam Berat Timbal (Pb) dalam Kerang (Anadara sp) yang Beredar di Kota Semarang Susanti, Maria Mita; Kristiani, Monica
IJMS - Indonesian Journal on Medical Science Vol 3, No 1 (2016): IJMS - 2016
Publisher : IJMS - Indonesian Journal on Medical Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (131.838 KB)

Abstract: Water pollution by waste could cause environmental pollution of land, air and water. Waste that goes into the waters in the form of waste material inorganic coming from the rest of the production printing industry, chemical plants, textile, pharmaceutical, electronics and potentially damaging to the environment because they contain hazardous materials and toxic (B3) under which there are heavy metals, such as lead (Pb), cadmium (Cd), mercury (Hg), chromium (Cr), nickel (Ni), cobalt (Co), manganese (Mn), copper (Cu) and tin (Sn). Lead will be sediment in bottom waters, and will contaminate shrimp, crab,and bolod clams. Blood clams consumed by many people, but in fact a lot of people who do not understand how to properly blood clams processing, allowing the entry of lead in the body.This research usedÂ exploratory method and the number of sample was 20 shells that circulate in the city, taken by random sampling. The data obtained were processed descriptivelyThe result showed that the levels of lead in mussel skewers that circulate in the city of Semarang is still below the set threshold value of 1.5 ppm is the minimum content value was 0.39 ppm and the maximum level of 0.81 ppm.Keywords: Spectrophotometry, Atomic Absorption, , Lead , blood clams, Anadara spÂ Abstrak: Pencemaran air oleh limbah dapat menyebabkan pencemaran lingkungan baik tanah, udara maupun air. Limbah yang masuk ke dalam perairan berupa bahan buangan anorganik berasal dari sisa produksi industri percetakan, pabrik kimia, tekstil, farmasi, dan elektronika berpotensi merusak lingkungan karena mengandung bahan berbahaya dan beracun (B3) yang diantaranya terdapat logam berat, seperti Timbal (Pb), Kadmium (Cd), Raksa (Hg), Krom (Cr),Nikel (Ni), Kobalt (Co), Mangan (Mn), tembaga (Cu) dan timah (Sn). Logam berat seperti Pb yang ada pada perairan akan turun dan mengendap pada dasar perairan kemudian membentuk sedimen, dan akan menyebabkan organisme yang mencari makan didasar perairan seperti udang, ranjungan dan kerang akan memiliki peluang yang besar untuk terpapar logam berat. Kerang banyak dikonsumsi oleh masyarakat, namun pada kenyataanya banyak masyarakat yang belum memahami bagaimana cara pengolahan kerang secara benar , sehingga memungkinkan masuknya logam berat Pb dalam tubuh. Tujuan peneletian ini adalah untuk menganalisa kadar Pb dalam kerang dengan menggunakan jenis penelitian eksplorasi dan jumlah sampel 20 kerang yang beredar di Kota Semarang, diambil secara random sampling. Data yang diperoleh diolah secara deskriptif. Hasil penelitian menunjukkan bahwa Kadar logam berat Pb dalam sate kerang yang beredar di Kota Semarang masih dibawah nilai ambang batas yang ditetapkan yaitu 1,5 ppm yaitu dengan nilai kadar minimal adalah 0,39 ppm dan kadar maksimalÂ sebesar 0,81 ppm.Kata kunci: Spektrofotometri, Serapan Atom, Timbal, Kerang, Anadara sp

Sosialisasi DAGUSIBU (Dapatkan, Gunakan, Simpan, Buang) obat dengan benar pada guru dan karyawan SMA Theresiana I Semarang Anasthasia Pujiastuti; Monica Kristiani
Indonesian Journal of Community Services Vol 1, No 1 (2019): May 2019
Publisher : Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/ijocs.1.1.62-72

AbstrakBerbagai masalah kesehatan, khususnya terkait obat masih ditemui di masyarakat. Berbagai permasalahan terkait obat dapat dikarenakan masyarakat kurang paham tentang penggunaan dan penanganan obat dengan benar. Salah satu cara pengelolaan obat yang baik dan benar adalah dengan menerapkan program DAGUSIBU (DApatkan, GUnakan, SImpan, BUang). Berdasarkan informasi yang diperoleh, guru dan karyawan SMA Theresiana I Semarang belum pernah mendapatkan informasi tentang DAGUSIBU sehingga perlu dilakukan sosialisasi tentang DAGUSIBU. Adanya kegiatan ini diharapkan para guru dan karyawan SMA Theresiana I Semarang dapat membagikan informasi tentang penggunaan dan penanganan obat yang benar kepada anggota keluarganya serta siswa siswi SMA Theresiana I Semarang. Metode yang digunakan dalam kegiatan ini adalah pengenalan masalah, pelaksanaan sosialisasi DAGUSIBU dengan cara penyuluhan, diskusi interaktif, dan pambagian buku saku DAGUSIBU. Kegiatan sosialisasi tentang DAGUSIBU berjalan dengan lancar. Tingkat kehadiran peserta sebanyak 89,3%. Para peserta yang hadir sangat antusias dalam mendengarkan penjelasan dan aktif bertanya terkait penggunaan obat dan penanganannya. Hal ini dapat menunjang terwujudnya program pemerintah dalam peningkatan pelayanan kesehatan bagi masyarakat. Sosialisasi ini meningkatkan pemahaman peserta tentang pengelolaan obat dengan benar, diharapkan peserta dapat menerapkan pengetahuan yang telah diperoleh dalam lingkungan keluarga dan masyarakat. Kata Kunci: DAGUSIBU; obat; sosialisasi. AbstractSome parts of our society are having problems with handling drugs properly. One of the causes is not all people understand how to heal their sickness with many kinds of drugs. Various drugs-society related problems can be caused by people's lack of understanding about the use and handling of drugs correctly. One way to inform society how to manage drugs properly is to implement the DAGUSIBU (DApatkan, GUnakan, SImpan, BUang). Based on the information obtained, the teachers and employees of SMA Theresiana I Semarang have never received information about DAGUSIBU. That’s why it is necessary to socialize DAGUSIBU in their community. The purpose of this activity is to make them understand and share information about the correct way to receive, apply, install and waste the medicines among their family members and students. The method used in this dissemination is ellucidation by socializing problems of handling drugs improperly as introduction and then the implementation of DAGUSIBU by means of counseling, interactive discussions, and the distribution of DAGUSIBU pocket books. The dissemination about DAGUSIBU went smoothly. The attendance rate was 89.3%. The participants were very enthusiastic in listening to the explanation and actively asked about drugs-society related problems. This can support the realization of government programs in improving health services for the community. This socialization increases participants' understanding of drug management correctly, it is expected that participants can apply the knowledge gained in the family and community environment. Keywords: DAGUSIBU; drug; socialization.

Formulasi Dan Uji Aktifitas Nanoemulsi Minyak Atsiri Daun Kemangi (Ocimum basilicum L.) Terhadap Salmonella typhi Monica Kristiani; Septiana Laksmi Ramayani; Klara Yunita; Meilina Saputri
Jurnal Farmasi Indonesia Vol 16 No 1 (2019): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Essential oil of basil (Ocimum basilicum L.) leaves with a concentration of 2.5% can be estimated to have a diameter of inhibition zone with an average value of 8.67 ± 0.58 mm. Essential oils have volatile characteristics, and are easily oxidized so that they can affect their activities as antibacterial. To increase stability, essential oils of basil leaves need to be packaged in a special delivery system. Nanoemulsion is made by spontaneous emulsification method. Nanoemulsion was further tested for physical characteristics including droplet size, polydispersity index, zeta potential and nanoemulsion morphology using a Transmission Electron Microscope (TEM). The preparation was then tested for its activity against Salmonella thypi. The method used is the Kirby-Bauer disk diffusion method. From the test of physical characteristics obtained the average particle size of 10.6 nm, polydispersity index 0.03 and zeta potential -36.4. The results of the observation using TEM form the particles produced are spherical. Antibacterial test results were shown by the formation of inhibition zones of basil leaf essential oil (9.3 mm), positive control (6.6 mm), negative control (7.5 mm), nanoemulsion of basil leaf essential oil (8.3 mm), Virgin Coconut Oil (7 mm). Based on the results of statistical analysis it was found that there were no significant differences in treatment between groups.

Formulasi dan Uji Stabilitas Mekanik Hand and Body Lotion Sari Buah Tomat (Licopersicon esculentum Mill.) sebagai Antioksidan Anasthasia Pujiastuti; Monica Kristiani
Jurnal Farmasi Indonesia Vol 16 No 1 (2019): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Antioxidants are contained in various types of fruits and vegetables. One of them is tomato (Lycopersicumesculentum Mill). Tomato has lycopene, flavonoids and vitamin C as antioxidants. Tomato can be made into fruit juice using the pressing method. Tomato extracts can be made in pharmaceuticals in the form of hand and body lotion (H&B lotion). The aim of this study is to recognize the physical characteristics and stability of mechanical H&B fruit extracts and to know the antioxidant activity.The free variable in this study is the concentration of fruit juice as active as 20%, 35%, and 50%. The binding variable from this study is the physical characteristics of the tomato juice extract, which is bioleptic, pH, viscosity, emulsion type, mechanical stability lotion and activity of antioxidant. The data obtained from the research results are compared with those in the literature whose relevance to statistical analysis between 95% trusts.The results of the research for physical characteristic show that concentrated fruit extract were not affected by the physical equipment of H&B lotion. The results for stability of mechanical H&Blotion fruit extracts test show that all the formulations had the phase separation. The test also shows that H&Blotion of Tomato had an activity of oxidation with IC50 value in formula I 5.697 μg/mL, formula II 6,530 μg/mL, and formula III 5,106 μg/mL.

HARD CANDY SARI BUAH TOMAT (Licopersicon Esculentum Mill.) SEBAGAI ANTIOKSIDAN ALAMI Anasthasia Pujiastuti; Monica Kristiani
JURNAL ILMU KESEHATAN BHAKTI SETYA MEDIKA Vol. 2 (2017): Jurnal Bhakti Setya Medika
Publisher : Politeknik Kesehatan Bhakti Setya Indonesia

Buah tomat memiliki kandungan likopen, flavonoid dan vitamin C yang dapat bermanfaat sebagai antioksidan. Buah tomat dapat dibuat menjadi serbuk sari buah tomat dengan menggunakan metode spray drying dengan suhu inlet 110Â°C. Sari buah tomat diperoleh dengan cara dibuat juice tanpa penambahan air, kemudian dibuat menjadi serbuk dengan menambahkan 0,5% tween 80 dan maltodekstrin 15 %. Serbuk sari buah tomat dapat dibuat sediaan hard candy yang praktis dalam pemakaian. Komponen bahan tambahan hard candy terdiri dari sukrosa, sirup glukosa, air dan flavor. Pembuatan hard candy sari buah tomat dengan metode molding mixture dengan perbandingan konsentrasi sukrosa dan sirup glukosa yang digunakan adalah formula I (75% : 25%), formula II (50% : 50%), dan formula III (25% : 75%). Variabel terikat dari penelitian ini adalah karakteristik fisik hard candy sari buah tomat. Pada penelitian ini juga dilakukan uji aktivitas antioksidan hard candy sari buah tomat. Data dianalisis secara statistik menggunakan metode Anova dengan taraf kepercayaan 95%. Hasil penelitian hard candy berwarna jingga, berasa manis khas tomat, tekstur padat dan keras dengan keseragaman bobot Â± 2,87 gram. Kombinasi kadar sukrosa dan sirup glukosa sebagai pemanis berpengaruh terhadap karakteristik fisik hard candy sari buah tomat meliputi kekerasan dan waktu larut dengan nilai signifikansi 0,000 < 0,05. Hasil uji kruskal wallis hard candy sari buah tomat pada konsentrasi 300 ppm, 400 ppm, 500 ppm, 800 ppm, 900 ppm dan 1000 ppm memiliki aktivitas antioksidan yang berbeda tidak bermakna, hal ini ditunjukkan dengan nilai signifikansi > 0,05.

Analisis Kandungan Logam Berat Timbal (Pb) dalam Kerang (Anadara sp) yang Beredar di Kota Semarang Maria Mita Susanti; Monica Kristiani
Indonesian Journal on Medical Science Vol 3 No 1 (2016): IJMS - 2016
Publisher : Unit Penelitian dan Pengabdian Masyarakat Politeknik Kesehatan Bhakti Mulial

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (131.838 KB)

Abstract: Water pollution by waste could cause environmental pollution of land, air and water. Waste that goes into the waters in the form of waste material inorganic coming from the rest of the production printing industry, chemical plants, textile, pharmaceutical, electronics and potentially damaging to the environment because they contain hazardous materials and toxic (B3) under which there are heavy metals, such as lead (Pb), cadmium (Cd), mercury (Hg), chromium (Cr), nickel (Ni), cobalt (Co), manganese (Mn), copper (Cu) and tin (Sn). Lead will be sediment in bottom waters, and will contaminate shrimp, crab,and bolod clams. Blood clams consumed by many people, but in fact a lot of people who do not understand how to properly blood clams processing, allowing the entry of lead in the body.This research usedÂ exploratory method and the number of sample was 20 shells that circulate in the city, taken by random sampling. The data obtained were processed descriptivelyThe result showed that the levels of lead in mussel skewers that circulate in the city of Semarang is still below the set threshold value of 1.5 ppm is the minimum content value was 0.39 ppm and the maximum level of 0.81 ppm.Keywords: Spectrophotometry, Atomic Absorption, , Lead , blood clams, Anadara spÂ Abstrak: Pencemaran air oleh limbah dapat menyebabkan pencemaran lingkungan baik tanah, udara maupun air. Limbah yang masuk ke dalam perairan berupa bahan buangan anorganik berasal dari sisa produksi industri percetakan, pabrik kimia, tekstil, farmasi, dan elektronika berpotensi merusak lingkungan karena mengandung bahan berbahaya dan beracun (B3) yang diantaranya terdapat logam berat, seperti Timbal (Pb), Kadmium (Cd), Raksa (Hg), Krom (Cr),Nikel (Ni), Kobalt (Co), Mangan (Mn), tembaga (Cu) dan timah (Sn). Logam berat seperti Pb yang ada pada perairan akan turun dan mengendap pada dasar perairan kemudian membentuk sedimen, dan akan menyebabkan organisme yang mencari makan didasar perairan seperti udang, ranjungan dan kerang akan memiliki peluang yang besar untuk terpapar logam berat. Kerang banyak dikonsumsi oleh masyarakat, namun pada kenyataanya banyak masyarakat yang belum memahami bagaimana cara pengolahan kerang secara benar , sehingga memungkinkan masuknya logam berat Pb dalam tubuh. Tujuan peneletian ini adalah untuk menganalisa kadar Pb dalam kerang dengan menggunakan jenis penelitian eksplorasi dan jumlah sampel 20 kerang yang beredar di Kota Semarang, diambil secara random sampling. Data yang diperoleh diolah secara deskriptif. Hasil penelitian menunjukkan bahwa Kadar logam berat Pb dalam sate kerang yang beredar di Kota Semarang masih dibawah nilai ambang batas yang ditetapkan yaitu 1,5 ppm yaitu dengan nilai kadar minimal adalah 0,39 ppm dan kadar maksimalÂ sebesar 0,81 ppm.Kata kunci: Spektrofotometri, Serapan Atom, Timbal, Kerang, Anadara sp

PENGARUH PERBANDINGAN TWEEN 80 DAN SPAN 80 SEBAGAI EMULGATOR TERHADAP KRIM BODY SCRUB EKSTRAK DAUN KELOR (Moringa oleifera Lamk.) Monica Kristiani; Anasthasia Pujiastuti; Rakhmi Hidayati
Cendekia Journal of Pharmacy Vol 6, No 2 (2022): Cendekia Journal of Pharmacy
Publisher : STIKES Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/cjp.v6i2.212

Dampak yang paling terlihat akibat paparan radikal bebas pada kulit adalah penuaan dini seperti adanya kerutan dan flek hitam. Salah satu upaya melindungi kulit dari pengaruh radikal bebas adalah dengan penggunaan kosmetika antioksidan. Salah satu tanaman yang berkhasiat sebagai antioksidan adalah daun kelor (Moringa oleifera Lamk.), yang selanjutnya dibuat dalam bentuk sediaan krim body scrub. Krim body scrub dibuat dengan menggunakan bahan tambahan tween – span 80 sebagai emulgator dengan perbandingan 1:1, 2:1, 1:2. Penelitian ini bertujuan untuk mengetahui pengaruh variasi konsentrasi emulgator terhadap karakteristik fisik krim body scrub ekstrak daun kelor..Pembuatan krim body scrub daun kelor (Moringa oleifera Lamk.) menggunakan metode pencampuran. Karakteristik fisik krim body scrub yang diujikan meliputi organoleptis, homogenitas, pH, daya lekat, daya sebar, tipe krim. Data hasil pengujian di analisis menggunakan pendekatan teoritis dan statistik mengunakan uji parametrik Oneway ANOVA.Hasil pengujian organoleptis, formula I, II dan III krim body scrub ekstrak daun kelor menunjukkan hasil yang sama yaitu bentuk setengah padat, memiliki bau khas ekstrak daun kelor, warna hijau, terasa kasar saat diaplikasikan pada kulit dan menunjukkan homogenitas yang baik. Nilai pH semua formula sama yaitu 6. Rata-rata diameter penyebaran yang dihasilkan pada semua formula berada pada rentang nilai 4,9 – 5,03 cm. Daya lekat semua formula lebih dari 1 detik. Hasil analisis statistik pada semua hasil pengujian menyatakan bahwa perbandingan jumlah emulgator tween-span 80 tidak berpengaruh pada hasil mutu fisik sediaan. Tipe krim body scrub yaitu minyak dalam air (M/A).

Penentuan Nilai Sun Protecting Factor dan Uji Stabilitas Krim Ekstrak Daun Waru Laut (Hibiscus tiliaceus L.): Determination of Sun Protecting Factor Value and Cream Stability Test Waru Laut Leaf Extract (Hibiscus tiliaceus L.) Monica Kristiani; Arsita; Meida Maharani
Indonesian Journal of Pharmacy and Natural Product Vol. 6 No. 01 (2023): Indonesian Journal of Pharmacy and Natural Product
Publisher : Universitas Ngudi Waluyo

Exposure to UV light can trigger the formation of free radicals. Free radicals can be inhibited by antioxidant compounds. Sea hibiscus leaf extract contains flavonoids which functions as an antioxidant. Antioxidant compounds can be made into sunscreen cream, because they can stick to the surface of the skin for a long time and are easier to clean with water. Sunscreen cream also has an effectiveness level based on the measurement of the Sun Protecting Factor (SPF) value. The SPF value indicates the ability of the sunscreen to provide skin protection in the sun without the skin experiencing erythema. This study aims to evaluate the physical stability of cream preparations of sea waru leaf extract. The research method is explorative experimental research. The research design used is the One Case Study Design. The cream was made using one formula with three replications, then tested for physical characteristics, stability tests, and determined the SPF value. The test results of sea hibiscus leaf extract cream showed that the cream met the physical characteristics requirements, having an SPF value for cream base of 1.87 (minimum protection) while for sun waru leaf extract cream was 6.37 (extra protection). In the stability test, the cream preparations of sea hibiscus leaf extract had good physical stability during storage, this was indicated by the mixing of the oil phase and the water phase in the cream preparations of sea hibiscus leaf extract with light stirring. Â ABSTRAK Paparan sinar UV dapat memicu terbentuknya radikal bebas. Radikal bebas dapatÂ dihambatÂ olehÂ senyawa antioksidan.Â EkstrakÂ daunÂ waruÂ laut mengandung senyawa flavonoid yang berfungsi sebagaiÂ antioksidan. Senyawa antioksidan dapat dibuat menjadi sediaan krim tabir surya, karena mampu melekat pada permukaan kulit dalam waktu yang cukup lama dan lebih mudah dibersihkan dengan air.Â Krim tabir surya juga memilikiÂ Â tingkat efektifitas berdasarkan pengukuran nilai Sun Protecting Factor (SPF). Penelitian ini bertujuan untuk mengevaluasi stabilitas fisik sediaan krim ekstrak daun waru laut. Metode penelitian ini adalah penelitian eksperimental eksploratif.Â Rancangan penelitian yang digunakan yaitu One Case Study Design.Â Krim dibuat menggunakan satu formula dengan tiga kali replikasi, selanjutnya dilakukan uji karakteristik fisik, uji stabilitas dan penentuan nilai SPF. Hasil pengujian krim ekstrak daun waru laut menunjukkan krim memenuhi syarat karakteristik fisik, memiliki nilai SPF untuk basis krim sebesar 1,87 (proteksi minimal), sedangkan untuk krim tabir surya ekstrak daun waru laut sebesar 6,37 (proteksi ekstra). Pada uji stabilitas sediaan krim ekstrak daun waru laut memiliki stabilitas fisik yang baik selama penyimpanan, hal ini ditunjukkan dengan tercampurnya kembali fase minyak dan fase air pada sediaan krim ekstrak daun waru laut dengan pengadukan ringan.Â

PENGARUH VARIASI KONSENTRASI CROSCARMELLOSE SODIUM SEBAGAI SUPERDISINTEGRANT TERHADAP KARAKTERISTIK FISIK FAST DISSOLVING TABLET (FDT) GLIBENKLAMID Sendy Fitriani; Monica Kristiani
Journal Clinical Pharmacy and Pharmaceutical Science Vol. 1 No. 1 (2022): April: Journal of Clinical Pharmacy and Pharmaceutical Science
Publisher : Prodi D3 Farmasi Politeknik Katolik Mangunwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61740/jcp2s.v1i1.4

Glibenclamide is a second generation DM drug sulfonylurea group with the properties of lowering blood sugar levels. Most glibenklamid preparations are available in conventional tablet form and can be developed into pharmaceutical preparations that are more practical and accelerate the therapeutic effect of Fast Dissolving Tablet (FDT). The physical characteristics of the FDT are faster wetting and disintegration times compared to conventional tablets. Superdisintegrant is an important component in FDT preparations because it affects the time of wettability and disintegration time of FDT. The purpose of this study was to determine the effect of variations in the concentration of croscarmellose sodium as a superdisintegrant on the physical characteristics of FDT glibenclamide preparations of croscarmellose sodium concentration which gave the best characteristics.The type of research used is experimental research. Used study design a completely randomized pattern design in line with one factor. The manufacture of glibenclamide FDT uses the direct press method. The croscarmellose sodium concentration used is 3%, 4%, and 5%. The testing of FDT physical characteristics includes organoleptic, uniformity of weight, dimensions, hardness, friability, wettability time and FDT disintegration time.The results of statistical analysis showed that variations in the concentration of croscarmellose sodium as a superdisintegrant had an effect on the physical characteristics of FDT glibenclamide which included hardness, wettability and disintegration time, but had no effect on organoleptic, uniform weight, dimensions, and fragility. Based on the results of the characteristics and statistics, the formula III is the formula that provides the best physical characteristics.

Uji Karakteristik Fisik Dan Uji Iritasi Krim Ekstrak Daun Waru Laut (Hibiscus tiliaceus L.) Kristiani, Monica; Filadelfian, Shallom
Indonesian Journal on Medical Science Vol 11 No 1 (2024): IJMS 2024
Publisher : Unit Penelitian dan Pengabdian Masyarakat Politeknik Kesehatan Bhakti Mulial

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55181/ijms.v11i1.476

Sea hibiscus leaves (Hibiscus tiliaceus L.) are useful as antioxidants because they contain flavonoids that can ward off free radicals. The flavonoids produced in sea waru leaves are 50%, namely 1.43 mg/mL. Antioxidant compounds can be made into cosmetic preparations, for example, cream, because they have a moisturizing effect on the skin. Physical characterization of the preparation is important to determine the quality of the preparation. Cream preparations need to be tested for irritation to see skin reactions such as erythema and edema, to ensure the safety of a preparation before being used on human skin. This research aims to determine the results of the characterization and skin irritation effects of raw materials or final products from sea waru leaf extract cream preparations. This research is an exploratory experimental method. The research stages include extracting sea waru leaves using the remaceration method with 96% ethanol solvent. The results of sea waru leaf extract were tested qualitatively for flavonoid compounds. The cream is then evaluated for its physical characteristics including organoleptic, homogeneity, pH test, viscosity, spreadability, stickiness, washability, protective power and type of cream. The research results showed that the physical characteristics met the requirements and the cream irritation test showed that it did not irritate in the form of erythema and edema on the skin.

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