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All Journal eJournal Kedokteran Indonesia The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia
Dono Antono
Divisi Kardiologi, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Hubungan Frailty dengan Kesintasan Satu Tahun pada Pasien Lanjut Usia dengan Tumor Padat Ganas Stadium Lanjut Satrio, Trian; Rizka, Aulia; Prasetyawaty, Findy; Widhani, Alvina; Dwimartutie, Noto; Anggoro, RM Suryo; Yulianti, Mira; Antono, Dono
Jurnal Penyakit Dalam Indonesia
Publisher : UI Scholars Hub

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Abstract

Introduction. Frailty is characterized by a multisystem physiological decline that increases the risk of morbidity and mortality, especially in patients with advanced-stage solid malignancies. The association between frailty and one-year survival in older adults with solid malignancies in Indonesia has not yet been established. This study aimed to assess the association between frailty status and one-year survival in elderly patients with advanced-stage solid tumors. Methods. This was a retrospective cohort study conducted at Dr. Cipto Mangunkusumo National General Hospital, Jakarta utilizing patient data from a previous study conducted between November 2020 and 2021. Subjects were cancer patients aged >60 years with advanced-stage solid tumors. Frailty was assessed using the FRAIL scale, and one-year survival was determined through medical records and direct follow-up confirmation. Data analysis included bivariate tests, Kaplan-Meier survival analysis, log-rank test, and multivariate Cox regression. Results. A total of 106 elderly patients with advanced solid tumors were analyzed, with a frailty prevalence of 41.5%. A total of 44.3% of patients died within one year. Multivariate analysis showed that frailty was a significant independent predictor of survival. Frail patients had a 2.131 times higher risk of death. Other factors such as nutritional status, polypharmacy, and comorbidities were not significant. Conclusion. Frailty was identified as a significant independent predictor of reduced one-year survival in elderly patients with advanced-stage cancer.
Co-Authors Adityo Susilo, Adityo Afifah Is Afistianto, Muhammad Fikri Aida Lydia Alvina Widhani, Alvina Andri Sanityoso Sulaiman Anggoro, RM Suryo Antono, Akbarbudhi Arif Mansjoer Asir, Taufik Rizkian Aulia Rizka, Aulia Azri Nurizal, Azri Bernard Agus Sakti Dhaki Bernard Agus Sakti Dhaki, Bernard Agus Sakti Birry Karim Chudahman Manan Chudahman Manan Cleopas Martin Rumende Dharmeizar Dharmeizar Dharmeizar Dharmeizar E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Eka Ginanjar Em Yunir Em Yunir, Em Erni Juwita Nelwan, Erni Juwita Esthika Dewiasty Esthika Dewiasty, Esthika Fahmi Razi Darkuthni Findy Prasetyawaty, Findy Gerie Amarendra Gerie Amarendra Hakim, Manfaluthy Harry Isbagio Harry Isbagio Ika P Wijaya, Ika P Ika Prasetya Wijaya Ikhwan Rinaldi Imam Subekti Krishna Adi Wibisana Krishna Adi Wibisana, Krishna Adi Kuntjoro Harimurti Lukman H Makmun Lukman H Makmun Lukman H. Makmun Lusiani Lusiani Marcellus Simadibrata Maruhum B.H. Marbun Mira Yulianti, Mira Muhadi Muhadi Muhadi Muhadi, Muhadi Muhammad Artisto Adi Yussac Muhammad Artisto Adi Yussac Murdani Abdullah Murdani Abdullah Murdani Abdullah Noto Dwimartutie Pringgodigdo Nugroho, Pringgodigdo Rudi Putranto Sally Aman Nasution Satrio, Trian Siti Setiati Subekti, Imam Sulistianingsih, Dyah Purnamasari Taufik Rizkian Asir Vera D. Joewono Wismandari Wisnu