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All Journal The Indonesian Biomedical Journal The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia
Gerie Amarendra
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Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

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Self Expanding Metallic Stent Placement as a Palliative Therapy for an Advanced Gastric Cancer Patient Rabbinu Rangga Pribadi; Gerie Amarendra; Marcellus Simadibrata; Ari Fahrial Syam
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 14, NUMBER 1, April 2013
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (413.091 KB) | DOI: 10.24871/141201354-58

Abstract

Patients with gastric cancer which infiltrates distal esophagus often complain of dysphagia. Stenting is currently the therapy of choice for malignant dysphagia. Self expanding metallic stent (SEMS) placement has become the standard stenting therapy.We reported a case of 63 year old male patient with an advanced gastric adenocarcinoma which infiltrated distal esophagus who complained of dysphagia. The diagnosis was made based on esophago gastro duodenoscopy (EGD), histopathology study and contrast enhanced abdominal computed tomography (CT) scan. Patient underwent esophageal stenting successfully. This case report demonstrates SEMS placement as an effectivepalliation therapy in patient with an advanced gastric cancer which infiltrated distal esophagus.Keywords: gastric cancer, self expanding metallic stents, malignant dysphagia
Peran Tindakan Revaskularisasi terhadap Kesintasan Pasien Non ST Elevation Myocardial Infarction (NSTEMI) Amarendra, Gerie; Makmun, Lukman H.; Antono, Dono; Dewiasty, Esthika
Jurnal Penyakit Dalam Indonesia Vol. 1, No. 1
Publisher : UI Scholars Hub

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Abstract

Pendahuluan. Pengaruh revaskularisasi terhadap kesintasan pasien non ST elevation myocardial infarction (NSTEMI) masih belum jelas. Waktu revaskularisasi yang optimal pada pasien NSTEMI belum ditemukan. Penelitian ini bertujuan mengetahui pengaruh revaskularisasi terhadap kesintasan pasien NSTEMI, juga mengetahui pengaruh waktu revaskularisasi terhadap kesintasan pasien NSTEMI. Metode. Penelitian dengan disain kohort retrospektif diakukan terhadap 300 pasien non ST elevation myocardial infarction yang dirawat di RSUPNCM pada kurun waktu Desember 2006-Maret 2011. Data klinis, laboratorium, elektrokardiografi (EKG), ekokardiografi, dan angiografi koroner dikumpulkan. Pasien yang telah terhitung enam bulan setelah onset kemudian dihubungi melalui telepon untuk melihat status mortalitasnya. Perbedaan kesintasan revaskularisasi ditampilkan dalam kurva Kaplan Meier dan perbedaan kesintasan diantara dua kelompok diuji dengan Log-rank test dengan batas kemaknaan Hasil. Terdapat perbedaan kesintasan yang bermakna pada uji log rank (p Simpulan. Kesintasan enam bulan pasien NSTEMI yang menjalani terapi medikamentosa dan revaskularisasi lebih baik dibandingkan dengan terapi medikamentosa saja. Tidak terdapat perbedaan kesintasan enam bulan pasien NSTEMI berdasarkan waktu revaskularisasi.
APOA2–265 T>C Polymorphism as A Genetic Marker Associated with Lipid Profiles and Cardiovascular Risk in A Healthy Indonesian Population Hartanti, Monica Dwi; Hizbulloh, Ilham; Satibi, Janice Puteri; Virgo, Ricardo Lie; Anastasya, Karina Shasri; Adli, Mizanul; Amarendra, Gerie; Junnata, Agung
The Indonesian Biomedical Journal Vol 17, No 3 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i3.3472

Abstract

BACKGROUND: Apolipoprotein A (APOA)2–265 T>C polymorphism significantly affects lipid metabolism and body composition, as well as plays a key role in cardiovascular diseases (CVD) and metabolic syndrome. In this study, association between the APOA2 polymorphism, lipid profiles, body composition, and cardiovascular disease (CVD) risk in a healthy Indonesian population was investigated. Although similar studies have been conducted in other populations, this study addresses the urgent need to understand genetic factors influencing lipid profiles in Southeast and East Asia, where hypercholesterolemia rate keep rising, particularly in Indonesia.METHODS: A cross-sectional study involving 84 healthy participants was performed. Genotyping for the APOA2–265 T>C polymorphism was conducted using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Plasma levels of APOA2 and APOB100 were measured with enzyme-linked immunosorbent assay (ELISA), and APOB100/APOA2 ratio was calculated to assess CVD risk. Lipid profiles were evaluated with enzymatic methods, and body fat percentage was measured using calipers.RESULTS: CT/CC genotypes showed significantly lower plasma APOA2 levels compared to the TT genotype (p=0.0215). APOB100/APOA2 ratio was significantly higher in CT/CC genotypes (p=0.0020) and remained significant after Bonferroni correction. No significant differences were found in lipid profiles and body fat percentages between genotypes after correction, although trends suggested higher cholesterol and low-density lipoprotein (LDL) levels in TT genotypes and higher median body fat percentages in CC/CT genotypes.CONCLUSION: APOA2–265 T>C polymorphism is linked to changes in lipid profiles and body composition, potentially raising CVD risk in CT/CC genotypes. However, limited sample size and modest effect sizes suggest that the practical use of APOA2 genotyping for risk assessment might require further investigation.KEYWORDS: APOA2 polymorphism, APOB100, hypercholesterolemia, cardiovascular disease, lipid profile, body fat percentage
Co-Authors Adeputri Tanesha Idhayu Adli, Mizanul Anastasya, Karina Shasri Ari Fahrial Syam Dono Antono Esthika Dewiasty, Esthika Hizbulloh, Ilham Junnata, Agung Lukman H Makmun Lukman H. Makmun Marcellus Simadibrata Marcellus Simadibrata Monica Dwi Hartanti, Monica Dwi Rabbinu Rangga Pribadi Satibi, Janice Puteri Virgo, Ricardo Lie