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Journal : Majority

Diagnosis and Management of Bacterial Vaginosis in Pregnant Women Rizky Aprilia Wikayanti; Bagus Pratama; Rodiani
MAJORITY Vol 11 No 1 (2022): MAJORITY
Publisher : Majority

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Abstract

Bacterial vaginosis is a disease that is a public health problem, especially in women, both non-pregnant and pregnant women. Bacterial vaginosis is caused by an excess and overgrowth of anaerobic bacteria such as Gardnerella vaginalis, Ureaplasma urealyticum, Mycoplasma hominis, Mobiluncus sp., Prevotella sp., and other anaerobic bacteria. Bacterial vaginosis is characterized by the presence of an itchy greyish white discharge with a fishy odor, an increase in the pH of the vaginal fluid and is found clue cells on Whiff's test using KOH10%. Management of bacterial vaginosis is in the form of antibiotics with the drug of choice being metronidazole 500 mg orally twice a day for 7 days. In pregnant women, bacterial vaginosis has been reported to increase the incidence of abortion, premature rupture of membranes, preterm labour, low birth weight, and intrauterine infection. Therefore, early diagnosis and appropriate management of bacterial vaginosis can reduce maternal and infant morbidity and mortality.
Phantom Limb Pain on Post-Surgical Amputation Osteosarcoma Children Patient Bagus Pratama; Jason Mikail Amper; Gatra Hadimuti Wibowo; Rogatianus Bagus Pratignyo
MAJORITY Vol 11 No 1 (2022): MAJORITY
Publisher : Majority

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Abstract

Osteosarcoma is a musculoskeletal malignancy that often occurs in pediatric patients requiring multidisciplinary management. Management in the form of amputation surgery (limb-salvage surgery) with a combination of chemotherapy or radiotherapy. Post-amputation complications that are often experienced by patient is postsurgical pain. Persistent Postsurgical Pain (PPSP) in pediatric patients is influenced by risk factors such as age, gender, preoperative preparation (pain intensity, anxiety, pain efficacy), intraoperative measures (site of surgery, potential for nerve damage, administration of analgesia regimens, technique of anesthesia), and postoperative management. The incidence of PPSP in osteosarcoma postamputation patients is related to Phantom Limb Syndrome with varying incidence and duration. This syndrome is a phenomenon that often occurs after post-amputation procedures in the form of sensation (Phantom Limb Sensation) or pain (Phantom Limb Pain) due to loss of part of the body. Phantom Limb Pain (PLP) is an effect and complication that occurs after amputation surgery in pediatric osteosarcoma patients. The PLP pathomechanism is related to the interaction of the Central Nervous System (Cortical Remapping Theory and Proprioceptive Theory) and the Peripheral Nervous System (Dorsal Root Ganglia and nocireceptor stimulation). Management of PLP consists of neuropathic pain medications such as antidepressants, opioids, anticonvulsants, N-methyl-D-aspartate (NMDA) receptor antagonists and other anesthetic agents.