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All Journal Majalah Kedokteran Bandung Althea Medical Journal Pharmaceutical Sciences and Research (PSR) International Conference on Islamic Studies Tartib: Jurnal of Educational Management
Ahmad Ramdan
Departemen Orthopaedi & Traumatologi Fakultas Kedokteran Universitas Padjadjaran-Rumah Sakit Dr. Hasan Sadikin, Bandung
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Keberhasilan Fusi Tulang Belakang pada Spondilitis Tuberkulosis Rahim, Agus Rahadian; Tiksnadi, Bambang; Hidayat, Nucki N.; Ramdan, Ahmad
Majalah Kedokteran Bandung Vol 43, No 3
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Fusi tulang belakang pada spondilitis tuberkulosis bertujuan untuk menghilangkan sumber infeksi, koreksi deformitas, dan mengatasi komplikasi neurologis. Data tingkat keberhasilan fusi ini masih belum tersedia. Kendala lain adalah harga instrumentasi bermerek untuk operasi fusi tulang belakang sangat mahal. Penelitian studi kohort retrospektif ini untuk evaluasi keberhasilan fusi tulang belakang pada spondilitis tuberkulosis di Rumah Sakit Dr. Hasan Sadikin, Bandung tahun 2005–2009. Didapatkan 115 kasus spondilitis tuberkulosis yang dioperasi terdiri atas 34 (29,3%) kasus anterior decompresion spinal fusion (ADSF) dan 81 (70,7%) kasus dengan menggunakan instrumentasi posterior. Dari 81 kasus tersebut, terdapat 3, 27, 26, dan 19 orang berturut-turut mengalami fusi tulang belakang setelah 4, 3, 2, dan 1 tahun pascaoperasi. Hanya 6 kasus yang belum mengalami fusi. Tingkat keberhasilan fusi tulang belakang pada kasus spondilitis tuberkulosis terbukti tinggi, 93%. Selain itu, instrumentasi lokal dapat digunakan sebagai alternatif instrumentasi yang bersifat cost effective untuk tindakan operasi fusi tulang belakang pada kasus spondilitis tuberkulosis dengan p=0,63. Sebagai kesimpulan, kasus spondilitis tuberkulosis yang memerlukan tindakan operasi fusi tulang belakang dapat ditangani dengan baik di RS Dr. Hasan Sadikin, dengan tingkat keberhasilan tinggi dan cost effective. [MKB. 2011;43(3):134–9].Kata kunci: Fusi tulang belakang, spondilitis tuberkulosisSuccessful Rate of Spinal Fusion in Spondylitis TuberculosisSpinal fusion for spondylitis tuberculosis is performed to diminish infection source, correct deformity and overcome neurologic complication. Data of spinal fusion rate has not been available yet. The other problem is that branded instrumentation price is very expensive. The aim of this retrospective cohort study was to evaluate successful rate of spinal fusion in spondylitis tuberculosis performed in Dr. Hasan Sadikin General Hospital, Bandung year 2005–2009. There were 115 cases of spondylitis tuberculosis which treated by operations, 34 cases (29.3%) with anterior decompresion spinal fusion (ADSF) and 81 cases (70.7%) using posterior instrumentation. From those 81 cases, 3, 27, 26, and 19 patients after surgery 4, 3, 2, dan 1 year had spinal fusion, consecutively. Only 6 cases who had not fused yet. The successful rate of spinal fusion in spondylitis tuberculosis, Bandung was proved to be high, 93%, and local instrument product could be used as a costly effective and good alternative treatment in operative management of spondylitis tuberculosis with p=0.63. As a conclusion, spondylitis tuberculosis cases which need spinal fusion can be well treated in Dr. Hasan Sadikin Hospital with high successful rate and cost effective. [MKB. 2011;43(3):134–9].Key words: Spinal fusion, spondylitis tuberculosis DOI:  http://dx.doi.org/10.15395/mkb.v43n3.59
Effect of Iron Supplementation in Anti-Tuberculosis Drug Treatment on Interferon-γ Level in Tuberculosis Spondylitis Patients Perdana, M. F. Nanda; Rasyid, Hermawan Nagar; Ramdan, Ahmad; Ismiarto, Yoyos Dias
Majalah Kedokteran Bandung Vol 52, No 3 (2020)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v52n3.1712

Abstract

Tuberculosis (TB) is still one of the major health problems in the community. Micronutrients, including iron, are crucial in the body's defense mechanism. Iron modulates the activation of IFN-γ, which in turn will activate the macrophages. This study explores the effect of iron supplementation given with anti-tuberculosis drug therapy on the IFN-γ level in tuberculosis spondylitis patients. This was a single-blind randomized control trial study at Dr. Hasan Sadikin General Hospital Bandung, from December 2018 to March 2019, using the consecutive sampling approach. Thirty-four respondents with category 1 TB spondylitis and an sTfR level of> 21.7 pg /µL were recruited and randomized into control and experimental groups. The control group (n=17) was treated with 2 RHZE for 2 months while the experimental group (n=17) received 2 RHZE and iron tablet for 2 months. An increase in the IFN-γ level of the experimental group was observed from an average of 21.7 pg/ml before therapy to an average of 72.39 pg/mL after therapy. Meanwhile, the IFN-γ level in the control group increases from an average of 22.5 pg/mL to an average of 35.35 pg/mL. This difference was statistically significant based on the analysis using the independent t-test (p-value <0.05). Therefore, the administration of anti-tuberculosis drugs with the addition of iron can increase the body's immune response, which is indicated by the increasing level of IFN-γ.Pengaruh Penambahan Zat Besi Pada Pengobatan Obat Anti Tuberkulosis Terhadap Kadar Interferon-γ Pada Pasien Spondilitis Tuberkulosis Tuberkulosis (TB) masih merupakan salah satu masalah kesehatan yang cukup besar di masyarakat. Gangguan imunitas tubuh penderita berperan dalam proses terjadinya infeksi tuberculosis. Mikronutrient yang penting dalam pertahanan tubuh salah satunya adalah zat besi. Pada penelitian ini akan dipelajari mengenai pengaruh penambahan zat besi pada terapi OAT terhadap kadar IFN-γ pada pasien spondilitis tuberkulosis. Penelitian ini merupakan penelitian dengan metode single blind randomized control trial di Rumah Sakit Dr. Hasan Sadikin Bandung pada Desember 2018 hingga Maret 2019, dengan metode pengambilan sampel consecutive sampling. Dilakukan randomisasi pada 34 responden. Responden yaitu: penderita spondilitis TB kategori 1 dengan kadar sTfR >21,7 pg/µL. Kelompok kontrol 17 responden diterapi 2 RHZE. Kelompok eksperimen 17 responden diterapi 2 RHZE dengan tablet besi selama 2 bulan. Pada penelitian ini didapatkan peningkatan kadar IFN-γ rata-rata kelompok eksperimen (pemberian obat anti tuberkulosis dengan penambahan zat besi) dari 21,7 pg/mL sebelum dilakukan pemberian terapi menjadi rata-rata 72,39 pg/mL setelah dilakukan pemberian terapi diuji dengan uji t sampel independen (nilai p<0,05), secara statistik berbeda signifikan dengan kelompok kontrol (pemberian obat anti tuberkulosis), yaitu dari 22,5 pg/mL sebelum dilakukan pemberian terapi menjadi rata-rata 35,35 pg/mL setelah dilakukan pemberian terapi.  Simpulan, pemberian obat anti tuberkulosis dengan penambahan zat besi dapat meningkatkan respon imun tubuh, yang ditandai dengan meningkatnya kadar IFN-γ.
The Effectivity of Losartan Tablet for Decreasing Fibrotic Tissue Formation in Gastrocnemius Muscle Injury Grade I of Rabbits Priono, Boby Harul; Rasyid, Hermawan; Ismiarto, Yoyos; Ramdan, Ahmad
Pharmaceutical Sciences and Research Vol. 6, No. 1
Publisher : UI Scholars Hub

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Abstract

Muscle injuries among athletes require a complete recovery to be able to function optimally as before. However, in spite of implementing the management with PRICE (Protection, Rest, Immobilization, Compression and Elevation), during the recovery processes, fibrotic tissue will be formed, which is an unwanted non-functional muscle. Losartan is a blood pressure-lowering drug which has the inhibitory effect of inhibitory effect of TGF-? cytokines (fibrotic tissue regulators). TGF-? is the key to fibrotic formation and differentiation. Losartan has an effect on decreasing the TGF-? production and it may affect the fibrotic tissue. This research is conducted by an experimental comparative method on the rabbit as study objects. Based on Federer formula sampling, twenty samples totally occurred. The random sampling method is adopted for comparing fibrotic tissue in two different groups (control group and losartan group). Losartan is administered orally. There were significant differences in the proportion of fibrotic tissue between the sample groups. The losartan group showed that the level of fibrotic intensity, distribution, and H-score was decreased compared to the control group. Moreover, the result of Mann Whitney statistic test, for determining the H-score for both groups, showed that p is less than 0.05 (p<0.05), which implies that this research is statistically significant. This research proves that giving Losartan tablets brings a significant impact in reducing the formation of muscle fibrosis in muscle injury grade 1 in gastrocnemius rabbits.
Correlation between Gibbus and Neurological Status in Patients with Tuberculous Spondylitis and its impact after Operative Intervention Egypti, Lubna; Rahim, Agus Hadian; Ganiem, Ahmad Rizal; Ramdan, Ahmad; Dian, Sofiati
Althea Medical Journal Vol 11, No 1 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n1.2991

Abstract

Background: Tuberculous (TB) spondylitis is a chronic infectious disease associated with Mycobacterium tuberculosis that affects the spine. This disease is a challenging disease to treat due to its serious complications and high morbidity rate. Neurological deficits and spinal deformities that can occur along with gibbus are some of the most common complications. Early diagnosis and treatment are essential to cure this disease, with the administration of anti-TB drugs and operative intervention. This study aimed to analyze the correlation between gibbus and neurological status as well as the impact of operative intervention on the degree of gibbus and neurological status.Methods: This was an observational-analytic study with a cross-sectional design on 32 medical records of TB spondylitis patients who underwent operative intervention from January 2018 to December 2021 at Dr. Hasan Sadikin General Hospital. Gibbus determined by x-ray analysis and neurological status determined by the American Spinal Injury Association (ASIA) impairment scale (AIS) were examined before and after the intervention. The sample was chosen based on consecutive sampling. All data collected was tested using Spearman's correlative analysis, paired t-test, and Wilcoxon sign-rank test with a p-value <0.05 considered statistically significant.Results: There was a significant correlation between gibbus and neurological status-AIS (r=-0.708; p<0.05); and a significant positive impact of operative intervention on the degree of gibbus (p<0.05) and neurological status-AIS (p<0.05).Conclusion: There is a correlation between gibbus and neurological status-AIS. In addition, operative intervention also has a significant positive impact on the degree of gibbus and AIS, resulting in good clinical and radiological outcomes.
Effectiveness of Short-Term Use Denosumab and Risedronate Using β-Crosslaps and Histopathology as a Parameter in Osteoporotic Rat Model Siwendro, Afrisya Bimo; Ramdan, Ahmad; Ismiarto, Yoyos Dias; Yantisetiasti, Anglita; fachri, Dliyauddin
Majalah Kedokteran Bandung Vol 56, No 3 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3016

Abstract

Osteoporosis is a condition of decreased bone mass density. Pharmacological management uses drugs that decrease bone resorption or increase bone formation. The most commonly used drugs are bisphosphonates. Risedronate is one of these bisphosphonates. It inhibits osteoclasts, resulting in osteoclast apoptosis. Denosumab is a human monoclonal antibody that inhibits receptor activator kappa-B ligand, inhibiting osteoclast activation. Both drugs are widely used. Research on the efficacy of these two mechanisms has yet to obtain conclusive results. β-cross-laps is a parameter that can be used to evaluate the effectiveness of therapy through monitoring the bone resorption process. This experimental study used female rats >9 weeks old and was conducted at the Pharmacology and Therapeutic Laboratory, Universitas Padjadjaran Bandung, Indonesia, from  June to September 2021. This study utilized a simple random sampling to allocate 24 experimental animals into three groups: control, risedronate, and denosumab. β-Crosslaps expression values before ovariectomy, post ovariectomy before receiving medication, and post ovariectomy and receiving medication was recorded and statistically analyzed using the SPSS version 24.0. The analysis of 24 samples revealed a statistically significant decrease in the median value of β-Crosslaps after ovariectomy in the denosumab group (p=0.036) when compared to the control group, whereas the decrease in the risedronate group was not significant (p=0.687). Administration of denosumab in rat models is more effective in reducing bone resorption compared to risedronate.
Penerapan Konsep 7P sebagai Strategi Pemasaran Perguruan Tinggi untuk Meningkatkan Jumlah Mahasiswa di STAI Darussalam Kunir Kusumadewi, Riema Afriani; Ramdan, Ahmad
International Conference on Islamic Studies Vol. 3 No. 2 (2022): December
Publisher : Sekolah Tinggi Agama Islam Darul Ulum Banyuanyar Pamekasan

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Abstract

Entering the society era 5.0, competition in various institutions, especially educational institutions, is increasing. The need for education is increasing, especially in higher education, also the increasing population of Indonesia, causing the emergence of many new private universities one of which is STAI Darussalam Kunir. As a new private university, STAI Darussalam Kunir needs to formulate a marketing strategy to increase the number of students by applying the 7 P concept. This study aims to find out marketing strategies, conducted by STAI Darussalam Kunir to increase the number of students. The subjects of this study are the Head of STAI Darussalam Kunir, the admission committee for new students, and the Heads of Study Programs, while the object is the marketing strategy of STAI Darussalam Kunir. The research method used descriptive qualitative methods. The results showed that the marketing strategy carried out by STAI Darussalam Kunir is to apply the concept of the 7 P as follows : Product (Various Service Products offered by STAI Darussalam Kunir ), Price (The price of services offered by STAI Darussalam is relatively cheaper than other campuses), Place (The strategic location of STAI Darussalam Kunir is close to residential housing), Promotion (Using Traditional Promotion), People (having lecturers and employees who have academic qualifications), Phisycal Evidence (having Infrastructure that supports learning activities) and Process (The process of services offered is to accommodate the process of teaching and learning activities and that can meet the needs of students). The application of the 7P concept as a university marketing strategy to increase the number of students at STAI Darussalam Kunir needs to be maximized, especially in terms of promotion
Manajemen Rekrutmen Tenaga Pendidik Di Sekolah Albiruni Irfan, Ali; Ramdan, Ahmad; Nurhakim, Aam
Tartib: Jurnal of Educational Management Vol. 1 No. 1 (2022): Tartib: Jurnal of Educational Management
Publisher : Sekolah Tinggi Agama Islam Darussalam Kunir

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62824/jhedvt51

Abstract

Tujuan riset ini untuk mengetahui proses rekrutmen dan seleksi, orientasi dan penempatan, pelatihan dan pengembangan, serta penilaian performa pendidik di Sekolah Al Biruni Tegal. Penelitian ini didasarkan pada pemikiran, jika pengelolaan tenaga pendidik di sebuah lembaga pendidikan tersebut baik, maka akan berdampak pada kualitas pendidikan yang efektif dan efisien. Pengumpulan data dilakukan dengan cara wawancara, observasi/ pengamatan, dan studi dokumen. Jenis yang digunakan adalah data kualitatif, bersumber dari unsur manajeman pendidikan, kepala sekolah, dan tenaga pendidik. Metode penelitian yaitu analisis deskriftif berupa kata-kata dan perilaku yang dapat diamati. Hasil penelitian ini menunjukkan bahwa proses rekrutmen tenaga pendidik dilakukan setelah melakukan analisa kebutuhan tenaga pendidik. Adapun standard yang ditetapkan oleh manajemen yang paling utama dalam proses rekrutmen adalah calon tenaga pendidik harus memiliki sikap, kecerdasan, dan keterampilan hidup (lifeskill) yang memadai. Ketiga kompetensi ini akan terus diasah dalam program pelatihan guru.
Co-Authors Agus Hadian Rahim Ahmad Rizal Ganiem, Ahmad Rizal ALI IRFAN, ALI Anglita Yantisetiasti Bambang Tiksnadi Egypti, Lubna fachri, Dliyauddin Hermawan Nagar Rasyid, Hermawan Nagar Ismiarto, Yoyos Kusumadewi, Riema Afriani Nucki N. Hidayat Nurhakim, Aam Perdana, M. F. Nanda Priono, Boby Harul Rasyid, Hermawan Siwendro, Afrisya Bimo Sofiati Dian Yoyos Dias Ismiarto