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All Journal HAYATI Journal of Biosciences Journal of Medicine and Health Journal of Medicine and Health
Edwin Setiabudi
Universitas Kristen Maranatha
Agriculture, Biological Sciences & Forestry Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Descriptive of Coronary Vessel Lesions Number in DM and non-DM Patients Based on CAG Edwin Setiabudi; Dimas P Baskara
Journal of Medicine and Health Vol. 4 No. 1 (2022)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v4i1.3033

Abstract

Diabetes Mellitus (DM) is a chronic hyperglycemia condition caused by inadequate insulin secretion or due to failure of insulin response, which is a risk factor for coronary heart disease (Coronary Artery Disease, CAD). CAD is caused by plaque buildup on the walls of the arteries that supply blood to the heart (called coronary arteries) and other parts of the body. The aim of this study was to compare the severity of coronary lesions in DM and non-DM patients who were equipped with CAD. Descriptive research design using 229 experimental subjects, the subjects involved were based on predetermined inclusion and exclusion criteria. The results showed that the DM group experienced more Triple Vessel Disease (TVD) (47.83% vs. 35.92%) than the non-DM group, however, the number of Single Vessel Disease (SVD) was smaller (17.38% vs. 26.70%). The conclusion from this study is that DM patients have a higher coronary lesion severity than non-DM patients as evidenced by the number of triple vessel disease (TVD) on examination by coronary angiographic. Keywords: coronary artery disease, coronary angiographic, diabetes mellitus, non-diabetes mellitus, triple vessel disease
Potential of Clitoria ternatea L. Extract Towards Insulin Receptor Expression and Marker of Inflammation in Diabetes Mellitus Rats Model Rusmana, Djaja; Tiono, Hartini; Widowati, Wahyu; Lucianus, Johan; Darsono, Lusiana; Onggowidjaja, Philips; Tjokropranoto, Rita; Vera, Vera; Setiabudi, Edwin; Obeng, Selonan; Kusuma, Hanna Sari Widya; Novianto, Agung
HAYATI Journal of Biosciences Vol. 31 No. 4 (2024): July 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.4.803-810

Abstract

Metabolic abnormalities caused by the accumulation of human, environmental, genetic and lifestyle variables can be found in diabetes mellitus (DM). An increase in blood glucose carried on by a reduction in insulin production can also result in DM. Insulin resistance often occurs as a result of obesity and a lack of physical activity and aging. Telang flower extract (Clitoria ternatea L.) is reported to have several qualities such as being able to treat DM, chronic bronchitis, goiter, mucosal disorders and leprosy. This study’s objective was to elucidate anti-dibetic effect of C. ternatea extract (CTE) in rats with diabetic complications related to dyslipidemia. Rats suffering from diabetes will be examined after being given oral doses of Simvastatin 0.9 mg/kg BW, Glibenclamide 0.45 mg/kg BW, and 200, 400, and 800 mg/kg BW CTE, model induced by streptozotocin. The expression of the insulin gene (INS-1) was investigated by qRTPCR, Tumor Necrosis Factor-α (TNF-α), and Interleukin-1β (IL-1β) pancreatic DM rats model using the Immunohistochemistry (IHC) test. Both descriptive and quantitative data were acquired for the data. After utilizing ANOVA to evaluate quantitative data, the Tukey post hoc test was used to analyze the data, the expression of TNF-α and IL-1β was found to decrease while INS-1 expression increased in response to CTE. This effect was attributed to the modulation of TNF-α, IL-1β, and INS-1 expression. These findings suggest that CTE possesses antidiabetic properties.
Descriptive of Coronary Vessel Lesions Number in DM and non-DM Patients Based on CAG Edwin Setiabudi; Dimas P Baskara
Journal of Medicine and Health Vol 4 No 1 (2022)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v4i1.3033

Abstract

Diabetes Mellitus (DM) is a chronic hyperglycemia condition caused by inadequate insulin secretion or due to failure of insulin response, which is a risk factor for coronary heart disease (Coronary Artery Disease, CAD). CAD is caused by plaque buildup on the walls of the arteries that supply blood to the heart (called coronary arteries) and other parts of the body. The aim of this study was to compare the severity of coronary lesions in DM and non-DM patients who were equipped with CAD. Descriptive research design using 229 experimental subjects, the subjects involved were based on predetermined inclusion and exclusion criteria. The results showed that the DM group experienced more Triple Vessel Disease (TVD) (47.83% vs. 35.92%) than the non-DM group, however, the number of Single Vessel Disease (SVD) was smaller (17.38% vs. 26.70%). The conclusion from this study is that DM patients have a higher coronary lesion severity than non-DM patients as evidenced by the number of triple vessel disease (TVD) on examination by coronary angiographic. Keywords: coronary artery disease, coronary angiographic, diabetes mellitus, non-diabetes mellitus, triple vessel disease
Co-Authors Agung Novianto, Agung Dimas P Baskara Djaja Rusmana Hanna Sari Widya Kusuma, Hanna Sari Widya Hartini Tiono Johan Lucianus Lusiana Darsono Obeng, Selonan Philips Onggowidjaja Rita Tjokropranoto vera vera, vera WAHYU WIDOWATI