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Hubungan Jumlah Viral Load dengan Kejadian TBC pada Pasien HIV/AIDS yang Mendapatkan Terapi ARV Andri Baedowi; Zulfian; Hetti Rusmini; Toni Prasetia
ARTERI : Jurnal Ilmu Kesehatan Vol 1 No 3 (2020): Mei
Publisher : Puslitbang Sinergis Asa Professional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/arteri.v1i3.76

Abstract

Viral Load (VL) is a direct indicator of the total amount of cells produced by the virus in a person infected with HIV. TB becomes a challenge for controlling Acquired Immunodeficiency Syndrome (AIDS) because it is the most opportunistic infection in people living with HIV / AIDS (PLWHA). TB can increase HIV progression and the risk of death for people living with HIV. Immunosuppression can increase the likelihood that dormant TB germs reactivate. The pathogenesis of TB infection in HIV patients is directly related to the decline in the immune system, specifically CD4 T lymphocytes. HIV infection will cause a decrease in CD4 T lymphocytes thereby reducing the immunological response to Mycobacterium tuberculosis. This will result in reactivation from the latent period of TB to an active infection. This study conducted to discover the relationship between the amount of viral load and the tuberculosis case in HIV / AIDS patients that undertake ARV therapy at RSUD Dr. H. Abdul Moeloek Lampung Province in 2019. Observational analytic approach with cross sectional design was used in this present study. The data taken is secondary data from the medical record of HIV / AIDS patients in Dr. H. Abdul Moeloek Lampung Province in 2019. The sampling technique used was a purposive sampling method and it was obtained a total sample of 196 people. The data was analyzed through Chi Square test. There was a significant relationship between the amount of viral load in HIV / AIDS patients and the tuberculosis case (p-value = 0.004). From the analysis above, it was obtained OR value = 2.52 which represents that patients who have a viral load ≥ 10,000 have a risk of 2.52 times to encounter TB. A high amount of Viral Load can cause immunosuppression in the host and increase the virulence of TB microbes.
Pengaruh Madu Ceiba Pentandra Terhadap Kadar LDL Tikus Rattus Norvegicus Yang Diberi Diet Tinggi Lemak Hetti Rusmini; Devita Febriani Putri; Hidayat Hidayat; Dhani Risandy
Jurnal Ilmiah Kesehatan Sandi Husada Vol 9 No 1 (2020): Jurnal Ilmiah Kesehatan Sandi Husada
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Akademi Keperawatan Sandi Karsa (Merger) Politeknik Sandi Karsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35816/jiskh.v11i1.331

Abstract

Background: Hypercholesterolemia is a condition of the body that has increased cholesterol levels above the normal threshold (<200 mg/dL). Hypercholesterolemia can occur because of lifestyle that not healthy, ranging from diet is not balanced to the lack of sporting activity. Hypercholesterolemia is the main risk factor for atherosclerosis which is the increase in Low Density Lipoprotein (LDL). Methodology: The type of research used is purely experimental using a pre and post test design with group design. The population used in this study were 25 male Wistar strain rats which were divided into 5 groups. Sampling using the method of total sampling. Data were analyzed by Paired T-test and Anova. Research Results: In this study, from the 5 sample groups obtained the results of the analysis Paired T-Test, obtained a significant increase (p <0.05) of LDL levels after giving a high-fat diet in the negative group (p = 0.025), treatment group 2 (p = 0.001), and treatment group 3 (p= 0.001). In the treatment after the administration of honey, there was a significant decrease (p <0.05) of LDL levels in 2 groups, namely in the treatment group 2 (p = 0.026), and the treatment group 3 (p = 0.092). With Anova analysis, a significant difference was found in the treatment after the administration of a high-fat diet and after the provision of honey honey with the same p value, namely p = 0.001 (P <0.05). Conclusion: There are differences that influence the administration of honey honey on LDL levels in wistar strain rats given a high-fat diet.
Identifikasi Escherichia coli Penyebab Waterborne Disease pada Air Mimun Kemasan dan Air Mimunm Isi Ulang Gusti Rizka Khairunnida; Hetti Rusmini; Esteria Maharyuni; Efrida Warganegara
Jurnal Ilmiah Kesehatan Sandi Husada Vol 9 No 2 (2020): Jurnal Ilmiah Kesehatan Sandi Husada
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Akademi Keperawatan Sandi Karsa (Merger) Politeknik Sandi Karsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35816/jiskh.v12i2.370

Abstract

Abstract. Background : Refilled water drinking store and packaged water drinking often can be found in cities with a high demand of water by the community, whether it’s drinking water or for daily basis. Contaminated water if being consumed, will cause a disease. Purpose : To know contamination of Escherichia coli bacteria cause of waterborne disease on refilled drinking water and packaged drinking water in Kelurahan Kemiling Raya by filtering method and isolate and identified on differential selective media. Method : Descriptive research design with experimental qualitative approach. Sample of refilled drinking water sample and packaged water drinking are filtered with a membrane filter and incubated on differential selective media Chromogenic Coliform Agar to know whether there is a contamination of Escherichia coli cause of waterborne disease. Result : There are Escherichia coli bacteria cause waterborne disease colonies in refilled drinking water on sample X, Y, and Z with each having 2,4 x 102 cfu/100ml, 6,8 x 102 cfu/100ml and sample Z having categorized by TBUD because of too much colonies, but on sample W there isn’t any. On packaged drinking water sample A and B both have the same number of colonies Escherichia coli which 2,0 x 100 cfu/250ml. Conclusion : The number of Escherichia coli bacteria on refilled drinking water is greater than packaged drinking water. There isn’t any Escherichia coli bacteria cause of waterborne disease in refilled drinking water whom uses reserved osmosis technology.