Article Per Year (5 Year)
p-Index From 2021 - 2026
1.607
P-Index
This Author published in this journals
All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Journal Syifa Sciences and Clinical Research (JSSCR) Journal of Current Health Sciences Jurnal Ilmiah Sains Jurnal Novem Medika Farmasi
Musdalifah Musdalifah
Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Islam Makassar, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

Published : 9 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 9 Documents
Search

 1 
Formulasi Sediaan Salep Bisul dari Ekstrak Daun Bungur (Lagerstroemia speciosa L. Pers) Musdalifah Musdalifah; Muhammad Iqbal
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14140

Abstract

Staphylococcus aureus is a normal flora of the skin and mucous membranes in humans, it can cause human infection in the form of boils. One example of antimicrobials that can be obtained from nature is the flower plant because it contains active substances, namely saponins, flavonoids, and tannins. To increase the effectiveness and convenience of using bungur leaves, it is necessary to formulate it in a more practical form such as a preparation. This study aims to identify the active fraction of the leaf extract of bungur (Lagerstroemia speciosa L. Pers) in boils ointment against Staphylococcus aureus bacteria. The extraction method was used  the maceration method, which was followed by the preparation of a boil ointment formulation, then tested against the Staphylococcus aureus bacteria. The diameter of the resistance formed was measured and statistically analyzed using the Completely Randomized Design (CRD) method. The results showed that the average resistance diameter of 1% bungur leaf ointment was 11.5 mm, 5% was 12.7 mm, 10% was 15.8 mm, and positive control was 16.5 mm. It was concluded that the effective concentration of bungur leaf extract in the ointment preparation in inhibiting the growth of Staphylococcus aureus was 1%.
Formulasi dan Evaluasi Kestabilan Fisik Krim Ekstrak Biji Lada Hitam (Piper nigrum L.) Menggunakan Variasi Emulgator Andi Nur Zam Zam; Musdalifah Musdalifah
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14146

Abstract

Black papper seed extract has known for its antivitiligo potential. The  addition  of  black papper seed  extract was predicted can influence the physical  stability  of  the  cream.  Therefore, this research was aimed to test the physical stability of cream contained  black papper seed extract in varity of emulgator there is tween® 60-span® 60, tween® 80-span® 80, novemer®, dan viscolam®. Physical stability test using the cycling test method by storing the preparation at 4 ° ± 2 ° C for 24 hours and then storing it at 40°±2°C) for 24 hours. The storage time at these two different temperatures is considered as one cycle and carried out for 12 days. The stability parameters were organoleptic observations, homogeneity, dispersion, pH, viscosity and cycling test results. The results showed that there were differences in organoleptic values, pH, viscosity, homogeneity and dispersibility. The most stable cream was obtained, namely the cream formula using emulgator Tween® 60-span® 60, had a good organoleptic value, cream type m/a, pH 5.10, viscosity 46,800 cPs, spreadability 4.2 cm2, homogeneous cream . The results of this study indicate that black pepper seed extract cream can be formulated into a stable cream preparation.
PENGARUH KONSENTRASI EKSTRAK PROPOLIS DALAM SEDIAAN SALEP TERHADAP PENGHAMBATAN PERTUMBUHAN BAKTERI Staphylococcus aureus. Musdalifah .; M. Natsir Djide; Nur Ida
Majalah Farmasi dan Farmakologi Vol. 25 No. 2 (2021): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v25i2.10725

Abstract

Propolis adalah resin alami yang dikumpulkan oleh lebah madu dari tumbuhan dan digunakan secara luas dalam pengobatan tradisional. Sifat antibakteri dan antijamur dari ekstrak propolis telah diselidiki secara ekstensif, namun belum diketahui konsentrasi efektif propolis untuk diformulasikan sebagai salep antibakteri terhadap Staphylococcus aureus. Penelitian ini bertujuan untuk menentukan konsentrasi efektif ekstrak propolis dalam sediaan salep untuk menghambat pertumbuhan Staphylococcus aureus. Pengujian aktivitas antimikroba dilakukan dengan metode difusi menggunakan kertas cakram dengan masa inkubasi 24 jam. Diameter hambatan yang terbentuk diukur dan dianalisis secara statistik menggunakan metode Rancangan Acak Lengkap (RAL). Hasil penelitian menunjukkan diameter hambatan rata-rata salep propolis 1% sebesar 9,5 mm, 5% sebesar 9,7 mm, 10% sebesar 10,8 mm, dan kontrol positif sebesar 15,5 mm. Hasil analisis statistik nilai F hitung (36,6) > F tabel pada taraf 1% (7,591) dan 5% (4,006), sehingga menunjukkan ada pengaruh variasi konsentrasi ekstrak propolis pada sediaan salep terhadap luas diameter hambatan pada taraf 1% dan 5%. Disimpulkan bahwa konsentrasi yang efektif ekstrak propolis dalam sediaan salep dalam menghambat pertumbuhan Staphylococcus aureus adalah 1%.
Antipyretic Activity of Ethanol Extract from Beligo (Benincasa hispida (Thunb.) Cogn.) Fruit Flesh in Wistar Albino Rats (Rattus norvegicus) Nur Alim; Rusman Hasanuddin; Jasmiadi Jasmiadi; Musdalifah Musdalifah; A. Ihdinal Hagg; Nur Linda
Jurnal Ilmiah Sains Volume 23 Nomor 2, Oktober 2023
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jis.v23i2.48443

Abstract

The people of South Sulawesi employ beligo as a plant with fever-reducing properties. The utilized part is the flesh of its fruit. The beligo fruit contains fatty acids, flavonoids, phenolics, and steroids that hold promise as antipyretic agents. The study aimed to determine the antipyretic activity of ethanolic extract from beligo fruit flesh on male Wistar rats induced with peptone solution. The research method encompassed maceration extraction using 70% ethanol solvent and antipyretic activity testing using 15 male Wistar rats divided into five treatment groups. Group I served as the negative control and received SODIUM-CMC 1%, groups II, III, and IV received ethanolic extract of beligo fruit flesh at doses of 250 mg/kg BW, 500 mg/kg BW, and 750 mg/kg BW respectively, and group V, the positive control, received paracetamol tablets. Measurements of initial temperature, temperature after induction, and temperature after treatment were taken at 30-minute intervals for 180 minutes. Data were statistically analyzed using a Completely Randomized Design (CRD) and Duncan test. The research findings revealed a fever reduction percentage of 1,57% for group I, 4,03% for group II, 4,28% for group III, 4,45% for group IV, and 5,25% for group V. Data analysis indicated that ethanolic extract of beligo fruit flesh at doses of 250 mg/kg BW, 500 mg/kg BW, and 750 mg/kg BW exhibited significant antipyretic activity (p < 0.05). The ethanolic extract from beligo fruit flesh possesses antipyretic activity in induced Wistar rats, suggesting its potential use as a fever-reducing medication. Keywords: Antipyretic; Benincasa hispida (Thunb.) Cogn; fever
Toksisitas akut fraksi ekstrak etanol daun kawista (Limonia acidissima L.) dengan metode Brine Shirmp Lethality Test Fauziah, Sitti; Musdalifah, Musdalifah; Miratun, Miratun
Jurnal Novem Medika Farmasi Vol. 1 No. 2: volume 1 Issue 2
Publisher : Program Studi Farmasi, Universitas Islam Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59638/junomefar.v1i2.585

Abstract

Senyawa kimia yang terkandung pada tumbuhan kawista antara lain yaitu flavonoid, saponin dan glikosida. Penelitian tentang uji toksisitas akut fraksi ekstrak etanol daun kawista (Limonia acidissima L.) dengan metode Brine Shirp Lethalty Test telah dilakukan. Tujuan dari penelitian ini adalah untuk mengetahui toksisitas akut dari fraksi ekstrak etanol daun kawista (Limonia acidissima L.) terhadap larva Artemia salina Leach dengan menentukan nilai LC50 menggunakan metode Brine Shirp Lethalty Test. Simplisia daun kawista (Limonia acidissima L.) sebanyak 250 g diekstraksi secara maserasi dengan menggunakan pelarut etanol 96%. Ekstrak yang diperoleh, ditimbang sebanyak 20 g untuk dilakukan fraksinasi dengan menggunakan pelarut n-heksan, etil asetat dan etanol 96% diperoleh nilai LC50 yang berbeda tiap fraksi, dimana fraksi n-heksan memiliki nilai LC50 sebesar 21,086 μg/mL, ekstrak etil asetat memiliki nilai LC50 sebesar 19,9021 μg/mL, dan ekstrak etanol 96% memiliki nilai LC50 sebesar 11,776 μg/mL ketiganya dengan kategori toksik.
Aktivitas Antibakteri Ekstrak Etanol Daun Langsat (Lansium domesticum correa) Terhadap Staphylococcus aureus Dan Escherichia coli Pratama, Agus Sangka; jasmiadi, Jasmiadi; musdalifah; yusharumi
Jurnal Novem Medika Farmasi Vol. 1 No. 3: Volume 1 Issue 3
Publisher : Program Studi Farmasi, Universitas Islam Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59638/junomefar.v1i3.665

Abstract

Penelitian tentang uji aktivitas antibakteri ekstrak etanol daun Langsat (Lansium domesticum Correa) telah dilakukan. Tujuan penelitian ini adalah untuk mengetahui aktivitas antibakteri ekstrak etanol daun Langsat Lansium domesticum Correa) terhadap Bakteri Staphylococcus aureus dan Escherichia coli. Metode penelitian meliputi ekstraksi daun Langsat (Lansium domesticum Correa) secara maserasi menggunakan etanol 96%, pengujian aktivitas antibakteri terhadap bakteri Staphylococcus aureus dan Escherichia coli dengan metode difusi agar, dengan parameter zona hambatan yang terbentuk. Hasil penelitian menunjukkan konsentrasi 0,8%;1,6%;3,2; masing-masing memiliki diamenter hambatan sebesar 8,99 mm; 9,39 mm; 11,30 mm terhadap bakteri Staphylococcus aures dan 5,5%; 6%; 6,5% masing-masing memiliki diameter hambat sebesar 11,69 mm; 11,83 mm; 31,36 mm terhadap bakteri Escherichia coli. Daun Langsat (Lansium domesticum Correa) memiliki aktivitas antibakteri terhadap bakteri Staphylacoccus aureus dan Escherichia coli.
Aktivitas Antibakteri Ekstrak Etanol Klika Jambu Bol (Syzygium malaccense (L.) Merr. & Perry) terhadap Bakteri Shigella dysenteriae Jasmiadi, Jasmiadi; sangka pratama, agus; Musdalifah, Musdalifah; aprianti, ayu
Jurnal Novem Medika Farmasi Vol. 1 No. 3: Volume 1 Issue 3
Publisher : Program Studi Farmasi, Universitas Islam Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59638/junomefar.v1i3.540

Abstract

Penelitian tentang aktivitas antibakteri ekstrak etanol klika jambu bol telah dilakukan. Tujuan penelitian ini adalah untuk mengetahui apakah ekstrak etanol klika jambu bol memiliki daya hambat terhadap Bakteri Shigella dysenteriae. Metode penelitian meliputi ekstraksi secara maserasi menggunakan etanol 96% dan pengujian aktivitas antibakteri terhadap bakteri Shigella dysenteriae dengan metode difusi agar menggunakan kertas cakram. Konsentrasi ekstrak jambu bol yang digunakan, 6.25%,12.5%, 25%, dan masing-masing memiliki parameter zona hambat sebesar 7,96 mm; 8,93 mm; 10,38 mm. Hasil penelitian menunjukkan bahwa ekstrak jambu bol mempunyai aktivitas terhadap bakteri Shigella dysenteriae.
Activity Test of Extract Edible Bird’s Nest (Aerodramus fuciphagus) as a Natural Treatment to Lower LDL Levels Musdalifah; Zam, Andi Nur Zam; Astriani, Andi Dian
Jurnal Penelitian Pendidikan IPA Vol 11 No 8 (2025): August
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i8.12255

Abstract

This study aimed to evaluate the effect of edible bird’s nest (EBN) infusion (Aerodramus fuciphagus) on lowering low-density lipoprotein (LDL) levels in white rats (Rattus norvegicus) induced with hypercholesterolemia. Fifteen male Wistar rats were divided into five groups: negative control (distilled water), positive control (simvastatin 10 mg/kg BW), and three treatment groups receiving EBN infusion at doses of 10, 20, and 40 mg/200 g BW. LDL levels were measured before and after treatment using an enzymatic colorimetric method. The results showed that EBN infusion reduced LDL levels in all treatment groups, with the highest decrease at a dose of 40 mg/200 g BW (34.03%), followed by 20 mg (33.46%) and 10 mg (28.13%). Simvastatin, however, produced a greater LDL reduction (55.64%). In conclusion, EBN infusion can reduce LDL levels in hypercholesterolemic rats, particularly at doses of 20 mg/200 g BW, suggesting its potential as a natural lipid-lowering agent, although it is less effective than simvastatin.
Antibacterial Activity of the Traditional Drink Rorano Yuka Against Escherichia coli and Shigella dysenteriae Iqbal, Muhammad; Febrianty, Marisca; Musdalifah, Musdalifah; Hakim, Dian Safira B.
Journal of Current Health Sciences Vol. 5 No. 4: 2025
Publisher : Utan Kayu Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47679/jchs.2025136

Abstract

Antimicrobial resistance (AMR) remains a growing global challenge, particularly among enteric Gram-negative pathogens such as Escherichia coli and Shigella dysenteriae, which continue to cause high morbidity in low-resource settings. In response, ethnopharmacological approaches offer promising, locally grounded alternatives. This study investigated the antibacterial activity of the traditional North Maluku herbal drink Rorano Yuka—a polyherbal decoction of ginger, turmeric, clove, lemongrass, cinnamon, galangal, black pepper, nutmeg, and areca nut—and its infusion against E. coli and S. dysenteriae. Using an agar diffusion assay across graded concentrations (2.5–10% w/v), both preparations exhibited inhibitory effects, with process-dependent variations. The decoction (Yuka) showed a clear dose–response pattern and achieved the strongest inhibition, surpassing the positive control against S. dysenteriae at 10%, while the infusion displayed peak activity at intermediate concentration against E. coli. These findings indicate that heat treatment enhances extraction of polar, heat-stable phytochemicals with broad antibacterial potential, whereas milder infusion may preserve volatile constituents. The results support Rorano Yuka’s potential as a culturally accepted, plant-based antibacterial candidate and contribute to evidence-based validation of traditional remedies. Future work should include phytochemical characterization, MIC/MBC assays, and in vivo evaluations to guide dose standardization, safety assessment, and integration into community-level diarrheal disease management. Abstrak. Resistensi antimikroba (AMR) tetap menjadi tantangan global yang terus meningkat, terutama pada patogen enterik Gram-negatif seperti Escherichia coli dan Shigella dysenteriae yang masih menyebabkan angka kesakitan tinggi di wilayah dengan sumber daya terbatas. Sebagai respons terhadap permasalahan ini, pendekatan etnofarmakologi menawarkan alternatif yang menjanjikan dan berbasis kearifan lokal. Penelitian ini bertujuan untuk mengkaji aktivitas antibakteri dari minuman herbal tradisional Maluku Utara, Rorano Yuka—ramuan polih herbal hasil rebusan yang mengandung jahe, kunyit, cengkeh, serai, kayu manis, lengkuas, lada hitam, pala, dan pinang—serta hasil infusinya terhadap E. coli dan S. dysenteriae. Dengan menggunakan metode difusi agar pada berbagai konsentrasi (2,5–10% b/v), kedua sediaan menunjukkan efek penghambatan yang bervariasi tergantung pada proses persiapannya. Sediaan rebusan (Yuka) menunjukkan pola dosis–respon yang jelas dan menghasilkan daya hambat tertinggi, bahkan melampaui kontrol positif terhadap S. dysenteriae pada konsentrasi 10%, sementara sediaan infus mencapai aktivitas puncak pada konsentrasi menengah terhadap E. coli. Temuan ini menunjukkan bahwa proses pemanasan meningkatkan ekstraksi senyawa fitokimia polar dan stabil terhadap panas yang memiliki potensi antibakteri luas, sedangkan proses infus yang lebih ringan mampu mempertahankan komponen volatil. Hasil penelitian ini mendukung potensi Rorano Yuka sebagai kandidat antibakteri berbasis tanaman yang diterima secara budaya serta memberikan kontribusi terhadap validasi ilmiah obat tradisional. Penelitian lanjutan disarankan mencakup karakterisasi fitokimia, uji MIC/MBC, dan uji in vivo untuk menentukan standarisasi dosis, penilaian keamanan, serta integrasinya dalam pengelolaan penyakit diare berbasis masyarakat.
Co-Authors A. Ihdinal Hagg andi nur zam zam aprianti, ayu Astriani, Andi Dian Fauziah, Sitti Febrianty, Marisca Hakim, Dian Safira B. Hasanuddin, Rusman Jasmiadi Jasmiadi M. Natsir Djide Miratun, Miratun Muhammad Iqbal Nur Alim Nur Ida Nur Linda Pratama, Agus Sangka sangka pratama, agus yusharumi