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SRI ISDADIYANTO
Departemen Biologi Fakultas Sains Dan Matematika Universitas Diponegoro
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Liver Histopathology of Rats Induced by High-Fat Feed After Giving Neem Leaf Ethanol Extract Sri Isdadiyanto; Anggih Retno Pratiwi; Siti Muflichatun Mardiati
Biosaintifika: Journal of Biology & Biology Education Vol 14, No 2 (2022): August 2022
Publisher : Department of Biology, Faculty of Mathematics and Sciences, Semarang State University . Ro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v14i2.34383

Abstract

Foods that contain high levels of fat can cause hyperlipidemia, which is one of the triggering factors for non-alcoholic fatty liver disease. Neem leaves contain flavonoids, alkaloids and tannins which have the ability to act as hepatoprotectors. This study aimed to determine the Liver Histopathology of Rats Induced by High-Fat Feed After Giving Neem Leaf Ethanol Extract. Twenty-four the male white rats (Rattus norvegicus L.) were divided into 6 treatment groups, namely: normal control (P0); negative control (P1: given high-fat diet); P2 treatment (P1+ 8 mg/200gBW simvastatin); and P1+ the dose of neem leaf ethanolic extract of  75; 100; and 125 mg/200gBW (P3; P4; and P5). Fixation process with 10% Neutral Formalin Buffer (NFB) solution. Liver histopathological preparations were made by paraffin method and Hematoxylin-Eosin staining, histopathological observations with a 400x magnification microscope. Liver histopathology was analyzed descriptively, homogeneous and normally distributed data of liver weight and hepatocyte diameter were analyzed statistically using ANOVA followed by Duncan's test with a significance level of 5% using SPSS 16.0 software. The results showed that the administration of ethanolic extract of neem leaves could improve the liver histology structure. From this study it was concluded that the ethanolic extract of neem leaves can be used as an alternative hepatoprotector.
Co-Authors Agung Janika Sitasiwi Agung Janika Sitasiwi Agung Putra Nugraha Anggih Retno Pratiwi Anisa Nurul Hasana Ayu Dwi Lestari Azmi Syafanah Nur Hasna Citra Riandika Didik Setiyo Widodo Eka Fitriani Eka Wahyu Cahya Ningrum Elsa Billah Septiva Fani Fahriyansyah Fauziah Mustika Putri Fitra Nilla Sari Ginanjar Argo Pambudi Ika Oktavia Nurmila Kasiyati Kasiati khabibi Khabibi Luthfiana Ulil Albab Luthfiana Ulil Albab Mohammad Farhan Aditya Muhammad Anwar Djaelani Muhammad Farizan Adani Nunuk Shofiati Ratih Nur Fitriani Rd Yudhi Tresnadi Kusumah Retno Ariadi Lusiana Silvana Tana Siti Muflichatun Mardati Siti Muflichatun Mardiati Siti Muflichatun Mardiati Siti Nur Jannah Sunarno Sunarno Tazkia Annisa Tyas Rini Saraswati Winda Arini