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All Journal Dentika Dental Journal Majalah Kedokteran Gigi Indonesia Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Dental Journal (Majalah Kedokteran Gigi) Denta: Jurnal Kedokteran Gigi
Yosaphat Bayu Rosanto
Departemen Bedah Mulut Dan Maksilofasial, Fakultas Kedokteran Gigi, Universitas Gadjah Mada, Yogyakarta
Decision Sciences, Operations Research & Management Dentistry

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EFEK PEMBERIAN GEL GETAH BATANG TANAMAN PISANG SECARA TOPIKAL TERHADAP KEPADATAN SERABUT KOLAGEN PADA PROSES PENYEMBUHAN LUKA PASCA EKSTRAKSI GIGI MARMUT: EFFECT OF TOPICAL APPLICATION OF BANANA STEM SAP GEL ON THE DENSITY OF COLLAGEN FIBER IN THE WOUND HEALING PROCESS AFTER TOOTH EXTRACTION IN THE GUINEA PIG , Yosaphat Bayu Rosanto; Juni Handajani; Heni Susilowati
Dentika: Dental Journal Vol. 17 No. 1 (2012): Dentika Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (286.838 KB) | DOI: 10.32734/dentika.v17i1.1849

Abstract

Getah batang pisang mengandung saponin, flavonoid, vitamin C, dan tanin yang berperan dalam proses penyembuhanluka. Penelitian ini bertujuan untuk mengetahui efek gel getah aplikasi topikal gel getah batang pisang raja terhadapkepadatan serabut kolagen pada proses penyembuhan luka pasca pencabutan pada soket gigi marmut (Cavia cobaya).Lima puluh empat marmut dibagi menjadi 3 kelompok, masing-masing terdiri atas 18 marmut. Pencabutan gigi marmutdilakukan pada gigi insisivus sentralis kiri rahang bawah. Kelompok kontrol positif diperlakukan dengan iod gliserin dankelompok kontrol negatif dengan CMC-Na. Subjek pada kelompok perlakuan diberi gel getah batang pisang 80% secaratopikal. Setelah perlakuan, pada 3 marmut dari masing-masing kelompok dilakukan dekapitasi pada 1, 3, 5, 7, 14,dan 24 hari pasca pencabutan gigi. Rahang bawah marmut dipotong lalu dibuat preparat histologis untuk pengecatanMallory. Kepadatan serabut kolagen diamati dengan mikroskop cahaya, kemudian data dianalisis dengan Uji KruskallWallis dan Mann-Whitney. Hasil penelitian menunjukkan ada perbedaan bermakna serabut kolagen (p < 0,05) antarakelompok perlakuan dan kontrol. Peningkatan serabut kolagen menunjukkan perbedaan yang signifikan pada 3, 5, 7, dan14 hari pasca pencabutan gigi antara kelompok perlakuan dengan kontrol negatif dan positif. Kesimpulannya, aplikasitopikal gel getah pisang 80% dapat mempercepat pembentukan serabut kolagen pada proses penyembuhan luka soketgigi marmut pasca pencabutan gigi marmut.
Pengaruh konsentrasi cobalt chromium pada uji hemolisis sebagai implan gigi Yosaphat Bayu Rosanto; W. Widjijono; Teguh Triyono
Majalah Kedokteran Gigi Indonesia Vol 2, No 3 (2016): December
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (259.708 KB) | DOI: 10.22146/majkedgiind.10737

Abstract

The effect of concentration of cobalt chromium in hemolysis test for dental implant. Dental implants are used to replace tooth/teeth loss and its function. Cobalt chromium has ideal characteristics to be made as dental implants material. It is required that the material to be implanted must be biocompatible with cells and tissues. One of biocompatibility characteristics is hemocompatibility. Hemocompatibility of materials can be observed with hemolysis test. Thus the purpose of this research is to know whether cobalt chromium as dental implants material affect the hemolysis of rabbit blood or not. This research was done with rabbit blood (Oryctolagus cuniculus) and devided into 3 groups (treatment, positive and negative control). The tested material was cobalt chromium Remanium® GM 800, a product from Dentaurum. The contact between blood and material was done with ASTM-F075 hemolysis test. Cobalt chromium was not hemolytic at 2,5%, 5%, and 10% of concentration, slightly hemolytic at 20% of concentration, and hemolytic at 40% and 80% of concentration. The conclusion of this research was variety of concentration of cobalt chromium affected hemolysis percentage signi cantly.ABSTRAKImplan gigi digunakan untuk mengganti gigi yang hilang untuk dan dapat mengembalikan fungsi gigi. Cobalt chromium memiliki sifat-sifat yang memenuhi persyaratan sebagai material implan. Material yang diimplankan dalam tubuh harus memiliki sifat biokompatibilitas. Salah satu sifat biokompatibilitas yang harus dimiliki material yang diimplankan dalam tubuh adalah sifat hemokompatibilitas. Sifat hemokompatibilitas dapat diketahui dengan uji hemolisis. Penelitian ini bertujuan untuk mengetahui ada/tidaknya pengaruh logam cobalt chromium sebagai material implan gigi terhadap hemolisis pada darah kelinci. Penelitian ini dilakukan menggunakan sampel darah yang didapat dari kelinci (Oryctolagus cuniculus) yang dibagi menjadi 3 kelompok, yaitu perlakuan, kontrol positif dan negatif. Bahan penelitian yang diuji adalah cobalt chromium Remanium GM 800 produksi Dentaurum. Kontak darah dengan bahan uji dilakukan menggunakan uji hemolisis ASTM-F075. Hasil penelitian menunjukkan material logam cobalt chromium tidak menimbulkan hemolisis pada konsentrasi 2,5%, 5%, dan 10%, menimbulkan hemolisis ringan pada konsentrasi 20%, dan hemolisis pada konsentrasi 40% dan 80%. Kesimpulan dari penelitian ini adalah perbedaan konsentrasi logam cobalt chromium berpengaruh secara signikan terhadap persentase hemolisis.
Sialostent for Warthon’s Duct Repair in Submandibular Sialolithiasis in Pediatric Patient Yosaphat Bayu Rosanto; Maria Goreti Widiastuti; Poerwati Soetji Rahajoe
Denta Journal Kedokteran Gigi Vol 13 No 2 (2019): Agustus
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Sialolithiasis is disease found in the salivary glands which is marked by obstruction of salivary secretion by salivary gland stone. Submandibular gland is the highest predilection for sialolithiasis with 80% occurrence rate. The gland stones in Wharton's duct cause ductal stenosis and inflammation that causing pain. The main purpose of surgery on sialolithiasis is not only to take salivary gland stones, but the most important thing is to maintain the warthon duct as an outlet for the submandibular salivary glands. Objective: This paper explains case of sialolithiasis related to the management of Warthon’s duct repair surgery with sialostent in pediatric. Case: A 5 years-old female patient came to our hospital with a complaint of swealing in the floor of the mouth for 2 weeks that sometimes disturbing when eating. Clinical examination revealed a mobile 5 mm swealing and inflamation in the floor of the mouth in the sublingual caruncle. Ultrasoundgraphy examination results showed a picture of a very hyperechoic circle measuring 3 mm. Patient was planned for surgical removal of gland stone and Warthon’s duct repair with sialostent under general anesthesia. Case management: The suture technique for sialostent fixation is an important key to the success of this surgery, especially in children, because children often feel uncomfortable and want to remove this sialostent that appears intraorally. Result of this successful surgery is the Warthon’s duct can be maintained without relapse. Good soft tissue healing and normal salivary gland function. There was no complications in this surgical result. Sialolithectomy in combination with sialostent is a promising method for repairing the Wharthon duct. Conclusion: This method is able to correct the unfavorable curvature of the Warthon duct, prevent stenosis, and avoid sublingual caruncle closure due to inflammatory and healing processes.
Rehabilitation of Toothless Conditions with Dental Implants to Improve the Nutritional Status and General Health of the Terban Village Community Rosanto, Yosaphat Bayu; Listyarifah, Dyah; Budi Nagari, Hanni Handayani
Jurnal Pengabdian kepada Masyarakat (Indonesian Journal of Community Engagement) Vol 10, No 1 (2024): March
Publisher : Direktorat Pengabdian kepada Masyarakat Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jpkm.90557

Abstract

Terban Village is a village that has a significant number of residents who suffer from toothless conditions. This condition directly affects the village population’s nutritional status and general health. This community service aimed to rehabilitate the condition of toothlessness with dental implants to improve the nutritional status and general health of the people of Terban Village. The methods used in this community service were counseling, general health, mental and dental examinations, health utility levels, radiological examinations, and dental implant treatment for the residents. The output of this community service was a counseling session that involved 70 Terban Village residents. The DMFT index of Terban Village residents was 7.47 and was still above the WHO baseline. Five respondents were selected to undergo rehabilitation procedures with dental implants. Rehabilitation of edentulous conditions with dental implants will have a positive impact on improving the nutritional status and general health of the people of Terban Village. In addition, the general health of the population has also experienced improvements, such as reducing the number of cases of nutrition-related diseases and improving the overall quality of life.
Caspase-3/-9 as tongue cancer cell apoptosis target induced by ibuprofen Supriatno; Rosanto, Yosaphat Bayu; Karina, Vincensia Maria
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 4 (2025): December
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i4.p355-360

Abstract

Background: Tongue carcinoma is different from oral cancer in other areas because it has a high amount of cell growth, localized migration, and a higher rate of spreading to cervical lymphatic nodes. Therapeutic alternatives, particularly concerning recurrent malignancies, are notably constrained. Nevertheless, it is imperative to explore novel methodologies for refractory neoplasms, one of which may involve the application of ibuprofen. Purpose: The goal of this study was to look at how well caspase-3 and -9 break down proteins as possible targets for apoptosis in tongue cancer cells that were caused by ibuprofen. Methods: A controlled laboratory experiment employing a post-test-only design was executed. We used a colorimetric test for caspase-3 and -9 to check for the induction of apoptosis. The suppression of cellular invasion was verified through the Boyden chamber assay. Western blot analysis was utilized to identify the presence of caspase-3 and -9 proteins. The administered doses of ibuprofen were calibrated at 0, 5, 10, 25, 50, and 100 µg/mL. Data were subjected to analysis using two-way ANOVA followed by post-hoc Least Significant Different (LSD), with a significance threshold set at 95%. Results: It was established that ibuprofen at dosages ranging from 25 to 100 µg/mL significantly facilitated apoptosis in cells through an augmentation of the proteolytic activity of caspase-3 and -9. Notably, caspase-9 exhibited a superior proteolytic activity (1.85-fold) compared to caspase-3 (1.30-fold) (P = 0.038) at the 100 µg/mL concentration. The upregulation of caspase-3 and -9 proteins was observed in cells treated with ibuprofen. Ultimately, ibuprofen demonstrated an ability to inhibit the invasion of tongue carcinoma cells across various dosages. Conclusion: Ibuprofen has been shown to induce the proteolytic activities of caspase-3 and -9 in tongue carcinoma cells. However, the proteolytic activity of caspase-9 surpassed that of caspase-3, suggesting that targeting this protein may constitute a promising novel therapeutic strategy for this cancer variant.
Co-Authors Budi Nagari, Hanni Handayani Dyah Listyarifah Heni Susilowati Heni Susilowati Juni Handajani Poerwati Soetji Rahajoe Poerwati Soetji Rahajoe, Poerwati Soetji Supriatno Vincensia Maria Karina W. Widjijono Widiastuti, Maria Goreti Yoga Yuniadi