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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Syntax Literate: Jurnal Ilmiah Indonesia JSFK (Jurnal Sains Farmasi & Klinis) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmiah Farmasi Farmasyifa Borneo Journal Of Pharmascientech Jurnal Pengabdian Masyarakat Indonesia Jurnal Hasi Penelitian Dan Pengkajian Ilmiah Eksakta - JPPIE Jurnal Pengabdian Masyarakat Dharma Andalas Jurnal Sains dan Kesehatan
Rosiana Rizal
1Program Studi FarmasiUniversitas Dharma Andalas
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FORMULASI CANGKANG KAPSUL DARI PEKTIN KULIT BUAH NANGKA (Artocarpus heterophyllus Lam) DAN UJI WAKTU HANCUR KAPSUL Rosiana Rizal; Salman Salman; Eka Wulandari
Jurnal Ilmiah Farmasi Farmasyifa Vol 6, No 2 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiff.v6i2.11933

Abstract

Capsule is capsule preparations which consisting of a drug in a soft capsule and hard capsule sell. Capsule is the preparations that most people used to discover the unpleasant taste of the drug. Most of capsule sell are made of gelatin, but it can also made with starch or other ingredients. The other ingredients which can substitute gelatin is pectin. Pectin is an ingredient belong to the class of carbohydrates. This study aim to find others alternative that can be used as new ingredients of capsule sell, which is jack fruit peels. Dissolved 20 mg jack fruit peels in 1000 ml of distilled water and, added 5% of citric acid. Then extracted on a hot plate with a stirring speed 600 rpm, temperature of 85ͦC, for 120 minutes. The yield obtained was 0.319%. The best formulations results were 2 (0.7 gram pectin, 5.00 gram carrageenan, 100ml disttiled water). The result of the evaluation of capsule sell standards with a body diameter of 6,2 mm, 6,3 mm, of a lid diameter, a body length of 15,2 mm, a lid length of 07.8 mm, and those that are unqualified with 0.09 gram of capsule weights. The organleptic results are light brown color, texture a little loud and there is no fragrance. The capsule sell disintegration should meet the requirements set by the Indonesian Pharmacopoeia V edition, is 13 minutes 47 seconds.Keywords: jackfruit skin (Artocarpus heterophyllus Lam), pectin, capsule shell
Uji Efektifitas Ekstrak Etanol Daun Arbei (Rubus rosifolius Sm.) Terhadap Penurunan Kadar Glukosa Darah pada Mencit Diabetes Helmice Afriyeni; Rosiana Rizal; Armenia Armenia; Mike Esfika; Dwisari Dillasamola
JSFK (Jurnal Sains Farmasi & Klinis) Vol 10 No 2 (2023): J Sains Farm Klin 10(2), Agustus 2023
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.10.2.248-255.2023

Abstract

Daun arbei (Rubus rosifolius Sm.) mengandung senyawa metabolit aktif seperti pomolic acid, tormentic acid, quercetin dan euscaphic acid yang berpotensi sebagai antihiperglikemia. Penelitian ini dilakukan untuk mengetahui pengaruh ekstrak etanol daun arbei (Rubus rosifolius Sm.) dan lama pemberian terhadap penurunan kadar glukosa darah mencit diabetes. Sebanyak 25 ekor mencit diinduksi dengan aloksan dosis 150 mg/kg secara intraperitonial. Pemeriksaan glukosa darah dilakukan dengan metode enzimatis menggunakan glukometer. Mencit dengan kadar glukosa darah sewaktu >200 mg/dL dibagi menjadi 5 kelompok yaitu kontrol positif (Na.CMC 0,5%), pembanding (glimepirid) dan kelompok ekstrak uji dosis 100, 200 dan 400 mg/kg. Perlakuan diberikan selama 15 hari dan pengukuran kadar glukosa darah dilakukan pada hari ke 5, 10 dan 15. Data hasil penelitian dianalisis menggunakan Anova Dua Arah dan dilanjutkan dengan uji Duncan post hoc pada tingkat kepercayaan 95%. Pemberian ekstrak uji berpengaruh signifikan (p<0.05) terhadap penurunan kadar glukosa darah mencit. Semua kelompok dosis ekstrak uji memberikan efek penurunan glukosa darah yang tidak berbeda signifikan (p>0.05) dengan kelompok yang diberi glimepiride. Efek penurunan kadar glukosa darah semakin besar seiring bertambah lama waktu pemberian ekstrak uji (p<0,05), nilai penurunan terbesar ditunjukkan pada hari ke 15. Hasil penelitian mengindikasikan ekstrak etanol daun arbei efektif menurunkan kadar glukosa darah dan nilai penurunannya sebanding dengan glimepirid.
Pengaruh Pemberian Ekstrak Etanol Daun Sisik Naga (Pyrrosia Piloselloides L.) terhadap Penurunan Kadar Kolesterol Total Mencit Hiperkolesterolemia: Effect of Dragon Scales Leaf Ethanol Extract (Pyrrosia Piloselloides L.) on Reducing Total Cholesterol Levels in Hypercholesterolemic Mice Helmice Afriyeni; Nesya Indah Putri; Rosiana Rizal
Jurnal Sains dan Kesehatan Vol. 5 No. 4 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i4.1582

Abstract

Hypercholesterolemia is one of the risk factor for cardiovascular disease such as stroke, atherosclerosis and coronary heart disease. The purpose of this study was to determine the effect of ethanol extract of dragon scales leaves (Pyrrosia piloselloides L.) on reducing total cholesterol (TC) of test animals. The instrument to test was 25 male white mice were induced hypercholesterolemia by eating a high fat diet (MDLT) in around 14 days. The animals were declared as hypercholesterolemia if the total of cholesterol level (TC) more than 230 mg/dl. Then the Animals divided into five groups namely positive control, comparison (simvastatin), and the group given the test extract doses of 25, 50, 100 mg/kgBB. The treatment was given for 15 days, and TC level were checked on days 0, 5, 10 and 15. The data were analyzed by Two Way of ANOVA and continued with Duncan's test. The results showed that the dose of the tested extract and the duration of administration had a significant effect (p
Co-Authors Afriyani Armenia, Armenia Dwisari Dillasamola Eka Wulandari Helmice Afriyeni Islahuddin Islahuddin Kamal, Sefrianita Laras Alhabil Lusia Eka Putri M. Rifqi Efendi Mei Nissar Yulas Tari Mei Nissar Yulas Tari Mesa Sukmadani Rusdi Mike Esfika Muslim Suardi Nesya Indah Putri Nofrizal Nurunnisa Aprilya Yulfi Rustini Rustini Salman - Sara Surya Sara Surya Sara Surya Sefrianita Kamal Widia Rahma Putri Yulihasri