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All Journal Pharmacon Jurnal Ilmu Kefarmasian Indonesia
Syamsudin Abdillah
Universitas Pancasila
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Sifat Fisikokimia dan Aktivitas Antioksidan Crude Fukoidan Hasil Ekstraksi dari Sargassum cinereum Liliek Nurhidayati; Yashinta Fitriani; Syamsudin Abdillah; Esti Mumpuni; Mohamad Rafi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 1 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (951.109 KB) | DOI: 10.35814/jifi.v18i1.823

Abstract

Brown seaweed has been known as a fucoidan source that has various biological activities. Fucoidan could be obtained by various extraction methods. This study aims to extract, characterize and to evaluate the antioxidant activity of crude fucoidan extracted from Sargassum cinereum. Extraction was carried out by refluxing at 100oC for 4 and 5 hours and then precipitated with ethanol. The crude fucoidan was brown powder. The yield with 4 hours extraction time was 2.78% which did not differ significantly from the 5 hours extraction time. Phytochemical screening of crude extract showed that beside fucoidan there were flavonoids, saponins, steroids, triterpenoids, and tannins. The extraction with duration of 4 hours and 5 hours had sulfate content of 16.31% and 11.22%, total carbohydrate content were 22.94% and 22.85%, and in the FTIR spectrum showed OH absorption bands of carbohydrates, fucose, sulfates and uronic acid. Testing of antioxidant activity using the DPPH (1,1-diphenyl-2-picrylhyrazyl) free radical inhibition method produced IC50 values ​​of 721.9 µg/ml and 749.9 µg/ml respectively and it was concluded that crude fucoidan of Sargassum cinereum had weak antioxidant activity.
Aktivitas Anti Obesitas Ekstrak Daun Tin (Ficus carica Linn) pada Tikus yang diberi Diet Lemak Tinggi Errol Rakhmad Noordam; Swasono R. Tamat; Syamsudin Abdillah
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (423.482 KB) | DOI: 10.35814/jifi.v17i1.700

Abstract

Obesity is a health problem in the community because it can cause a risk of degenerative diseases such as type 2 diabetes mellitus, high blood pressure, heart disease, cancer, and atherosclerosis. Unhealthy lifestyles such as lack of physical activity by exercising, a diet high in carbohydrates and fats, can cause fat deposits in the body, especially in the abdomen. The use of chemical drugs such as Orlistat as a weight loss or to help reduce the risk of regaining lost weight, is less effective because it requires a long consumption time and the presence of side effects. Tin leaf content (Ficus carica Linn) is flavonoids, alkaloids, tannins and steroids, tin leaf extract has IC50 150mg/L antioxidant activity. This study was to determine the anti-obesity activity of tin leaf extract in male Sprague-Dawley rats given a high fat diet. 30 Sprague-Dawley rats were classified into 6 groups. The results obtained, in the group dose of 100 mg / kg obtained an average body weight of 381.8 grams, the test group 200 mg / kg obtained an average body weight of 414.5 grams, in the test group 400 mg / kg obtained 387 grams. The conclusion of this study is that the activity of Tin leaf extract (Ficus carica Linn) can be used as an anti-obesity.
In Silico Molecular Docking and Toxicity Studies of Bioactive Fucoidan Compound from Brown Seaweed as Potential of Antihypertensive Agus Kurniawan; Siswandono Siswandono; Esti Mumpuni; Syamsudin Abdillah
Pharmacon: Jurnal Farmasi Indonesia Vol 19, No 1 (2022)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v19i1.15933

Abstract

Angiotensin Converting Enzyme (ACE) is an enzyme that can convert angiotensin 1 to angiotensin 2 peptide, which is a strong vasoconstrictor that causes hypertension. Fucoidan (4,5-dihydroxy-2,6-dimethyltetrahydro-2H-pyran-3-yl hydrogen sulfate) is one of the polysaccharide chemical compounds found in seaweed and is reported to have the ability to inhibit ACE activuty in vitro. The aim of this study is to predict of the binding interaction between fucoidan and amino acids in ACE and to use the native captopril ligand (MCO702) as the standard ligand. Analysis of the molecular docking of fucoidan and captopril compounds against ACE (1UZF) using Molegro 6.0 and Chemoffice Professional 17.1 Software and for toxicity analysis using pkCMS online tools. The results of the docking prediction showed that fucoidan had MolDock and Rerank Score values of -82.311 kcal/mol and -70.872 kcal/mol, respectively, which were not much different from captopril, namely -84.816 kcal/mol and -74.758 kcal/mol. Fucoidan and captopril are also easily absorbed and have good permeability and are classified as low toxicity, but are dangerous if ingested in the 2000 LD50≤ 5000 mg/kg range. Fucoidan has the potential as a candidate for antihypertensive drugs because it is predicted that in silico has the same ability as captopril.
Co-Authors Agus Kurniawan Errol Rakhmad Noordam Esti Mumpuni Liliek Nurhidayati Mohamad Rafi Siswandono, Siswandono Swasono R. Tamat Yashinta Fitriani