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All Journal Archive of Community Health journal of internal medicine E-Jurnal Medika Udayana JSFK (Jurnal Sains Farmasi & Klinis) ISM (Intisari Sains Medis) : Jurnal Kedokteran Health and Medical Journal

I Gede Ketut Sajinadiyasa

Departemen Pulmonologi Dan Kedokteran Respirasi Fakultas Kedokteran Universitas Udayana

Author-ID : 368745

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Assessment of quality of life among chronic kidney disease patients undergoing hemodialysis in Sanglah General Hospital, Denpasar from April-May 2017 using EQ-5D-5L questionnaire Ni Putu Rani Apsari Dewi; Yenny Kandarini; I Gde Ketut Sajinadiyasa; Triharnoto Triharnoto
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Introduction: Hemodialysis or renal function replacement therapy is routine medical care for chronic kidney disease (CKD) patients. Many problems arise among patients with chronic kidney disease (CKD) undergoing hemodialysis, including physical, psychological, social and family relationships. Those will affect patientâ€™s quality of life (QOL).Method: A cross-sectional study performed from April-May 2017 in Sanglah General Hospital Denpasar using EuroQol 5 (EQ-5D-5L) Questionnaire to assess the Health-Related Quality of Life (HRQOL). All of CKD patients undergoing hemodialysis in Sanglah General Hospital Denpasar that matched the inclusion and exclusion criteria were recruited to this study.Results: There were 46 patients participated in this study. Overall, 37 (86.05%) were male and divided into four age groups. The reported HRQOL as measured by means of EQ-5D-5L Index Value and EQ-VAS (Visual Analog Scale) Score was 0.71 Â± 0.22 and 75.7 Â± 0.635, respectively. The median of EQ-5D-5L Index Value and EQ-VAS Score was 0.71 [0.63-0.84] and 75 [70-80].Conclusion: This study provided associations between sociodemographic characteristics and their HRQOL. Healthcare providers should be aware of low HRQOL among patients with female gender, elderly patients and unemployed patients to improve their quality of life.

Diagnosis dan penatalaksanaan tuberkulosis sistem saraf pusat Prima Yogi; I Putu Andrika; I Gede Ketut Sajinadiyasa; I Made Bagiada
Intisari Sains Medis Vol. 12 No. 3 (2021): (Available online: 1 December 2021)
Publisher : DiscoverSys Inc.

Introduction: Central nervous system (CNS) tuberculous are the most dangerous form of extrapulmonary TB. CNS tuberculous can present as meningoencephalitis, intracranial tuberculomas, and vasculitis. CNS tuberculous accounts for about 1% of all TB cases and is associated with high mortality. Tuberculous meningoencephalitis commonly presents with classic symptoms of fever, headache, meningism (neck stiffness), seizures as well as focal neurologic deficits, and altered consciousness. The diagnosis and treatment of CNS tuberculosis is still a formidable clinical challenge.Case report: Patient presented with fever, headache, meningismus, convulsion, and decreased consciousness. CT scan showed cerebral tuberculoma in the left parietal lobe. Examination gene-Xpert of the cerebrospinal fluid showed Mycobacterium tuberculosis. The patient was given category 1 of anti-tuberculosis drugs.Conclusion: CNS tuberculosis has non-specific symptoms, difficult diagnosis, and high mortality. In this case report, the diagnosis of CNS tuberculosis was established based on the presence of Mycobacterium tuberculosis on the CSF molecular rapid test examination, and a CT scan of the head with contrast found cerebral tuberculoma.

Anosmia dan ageusia sebagai faktor prognosis baik pada pasien COVID-19 rawat inap di RSUP Sanglah Denpasar Senja Decy Ningrum; Ida Bagus Ngurah Rai; I Gede Ketut Sajinadiyasa; Anak Agung Raka Sudewi; Ida Ayu Jasminarti Dwi Kusumawardani; Ni Wayan Candrawati; Ni Luh Putu Eka Arisanti
Intisari Sains Medis Vol. 13 No. 3 (2022): (In Press 1 December 2022)
Publisher : DiscoverSys Inc.

Background: Anosmia and ageusia are early symptoms that are widely reported in COVID 19 patients and are associated with low rates of intensive care and mortality, so the hypothesis arises that anosmia and ageusia can be good prognostic factors in COVID-19 patients. This study aims to examine anosmia and ageusia as prognostic factors in COVID-19 patients. Methods: This study is an observational analytic study with a retrospective cohort design conducted at Sanglah General Hospital Denpasar from January to June 2022. Results: obtained a total of 1048 subjects with 344 subjects experiencing anosmia, 210 subjects experiencing ageusia, and 474 subjects experiencing a combination of anosmia and ageusia. Variable symptoms of anosmia and ageusia were statistically significant predictors for the recovery of COVID-19 patients (p<0.05). The cure rate in the group of patients with symptoms of anosmia was 1.8 times (RR = 1.783, 95% CI = 1.667-1.908) and the group of patients with symptoms of ageusia experienced 1.6 times higher recovery (RR = 1.564, 95% CI = 1.478 -1,655). After adjusting for other variables as confounders, the combination of symptoms of anosmia and ageusia in patients was a significant predictor of recovery for COVID-19 patients by 1.5 times compared to patients who did not experience the combination of symptoms of anosmia and ageusia (ARR = 1.523, 95% CI = 1.245- 1.864, p<0.05). Conclusion: Anosmia, ageusia and the combination of both, indicate protective factors against possible mortality and indicate a good prognosis in COVID-19 patients. Latar belakang: Anosmia dan ageusia merupakan gejala awal yang banyak dilaporkan pada pasien COVID-19 serta dikaitkan dengan tingkat rawat intensif dan mortalitas yang rendah sehingga muncul hipotesis bahwa anosmia dan ageusia dapat menjadi faktor prognosis yang baik pada pasien COVID-19. Penelitian ini bertujuan untuk meneliti anosmia dan ageusia sebagai faktor prognosis pada pasien COVID- 19. Metode: Penelitian ini merupakan studi analitik observasional dengan rancangan kohort retrospektif yang dilakukan di RSUP Sanglah Denpasar pada bulan Januari hingga Juni 2022. Hasil: Didapatkan total 1048 subjek dengan 344 subjek mengalami anosmia, 210 subjek mengalami ageusia, serta 474 subjek mengalami kombinasi anosmia dan ageusia. Variabel gejala anosmia maupun ageusia secara statistik merupakan prediktor signifikan untuk kesembuhan pasien COVID-19 (p<0,05). Tingkat kesembuhan pada kelompok pasien bergejala anosmia mencapai 1,8 kali (RR = 1,783, IK 95% = 1,667-1,908) lebih tinggi dan kelompok pasien bergejala ageusia mengalami kesembuhan 1,6 kali lebih tinggi (RR = 1,564, IK 95% = 1,478-1,655). Setelah disesuaikan dengan variabel lain sebagai perancu, kombinasi gejala anosmia dan ageusia pada pasien menjadi prediktor kesembuhan pasien COVID-19 secara signifikan sebesar 1,5 kali lipat dibandingkan pasien yang tidak mengalami kombinasi gejala anosmia dan ageusia (ARR = 1,523, IK95% = 1,245-1,864, p<0,05). Simpulan: Anosmia, ageusia, dan kombinasi keduanya menunjukkan adanya faktor protektif terhadap kemungkinan mortalitas serta menandakan adanya prognosis yang baik pada pasien COVID-19

Comparison between serum pleural effusion albumin gradient, total protein, lactate dehydrogenase, and erythrocyte count in malignant and non-malignant pleural effusion Victor Nugroho Wijaya; I Gede Ketut Sajinadiyasa; Ni Wayan Candrawati; Ida Ayu Jasminarti Dwi Kusumawardani; Ni Luh Putu Eka Arisanti; I Gusti Ngurah Bagus Artana; Ida Bagus Ngurah Rai
Intisari Sains Medis Vol. 13 No. 3 (2022): (In Press 1 December 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/ism.v13i3.1502

Background: Malignant pleural effusion carries a bad prognosis. Pathologic examination as the gold-standard diagnosis of malignant pleural effusion has sensitivity limitations and may cause delayed diagnosis. Several affordable examinations, such as serum pleural effusion albumin gradient, total protein, lactate dehydrogenase (LDH), and erythrocyte count, might be useful as malignant pleural effusion diagnostic tools. Methods: This is an observational analytic study with a cross-sectional design conducted at Sanglah Central General Hospital in Denpasar from December 2021 to July 2022. Pleural effusion fluid and blood were taken from subjects with malignant and non-malignant pleural effusion. Data were analyzed with SPSS version 25 software for Windows. Results: Total subjects were 47 persons consisting of 26 subjects with malignant pleural effusion and 21 subjects with non-malignant pleural effusion. Results from statistical analysis of malignant and non-malignant pleural effusion were serum pleural effusion albumin gradient median (IQR) 0.91 (0.65) g/dL vs. 1.22 (1.2) g/dL (p=0.129), total protein mean 3.92±0.95 g/dL vs. 3.52±1.67 g/dL (p=0.334), LDH median 535 (840) IU/L vs. 187 (1,016) IU/L (p=0.057), and erythrocyte count median 23,500 (109,250) cells/mm3 vs. 3,000 (11,000) cells/mm3 (p=0.004). The AUC of erythrocyte count from the ROC method was 0.745 (95%CI=0.599-0.890; p=0.004). Using a cut-off point ≥ 4,500 cells/mm3, it had a sensitivity of 80.8%, specificity of 61.9%, and Odds Ratio (OR) of 6.8 (95%CI=1.8-25.4). Conclusion: Erythrocyte count as routine examination showed good validity for diagnosing malignant pleural effusion and expected to reduce diagnosis delay. Meanwhile, albumin gradient, total protein, and LDH delivered no difference.

KEAMANAN DAN EFEKTIVITAS E-CIGARETTE SEBAGAI ALTERNATIF ROKOK KONVENSIONAL TERHADAP PARU BERDASARKAN PERBANDINGAN TES SPIROMETRI: A SYSTEMATIC REVIEW Elkurnia, Raymond Timothy; Rai, Ida Bagus Ngurah; Candrawati, Ni Wayan; Sajinadiyasa, I Gede Ketut
E-Jurnal Medika Udayana Vol 11 No 8 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i8.P11

E-cigarette kerap dijadikan alternatif bagi orang yang ingin berhenti merokok, namun e-cigarette tidak dapat dipastikan kemananan serta efektivitasnya. Systematic review ini dibuat dengan tujuan untuk mengetahui keamanan penggunaan e-cigarette dibandingkan dengan rokok konvensional terhadap fungsi paru, serta efektivitas penggunaanya. Pencarian studi dengan karakteristik randomized controlled trial/RCT dilakukan sesuai dengan kaidah PRISMA dengan menggunakan kata kunci‘ electronic nicotine delivery system’, ‘e-cigarette’, ‘e-cig’, ‘lung function’, ‘spirometry’, ‘FEV1/FVC’. Dari 110 studi, didapatkan 5 studi RCT yang memiliki hasil yang bervariasi.

Efek Samping Obat Gefitinib pada Pasien Kanker Paru dengan Epidermal Growth Factor Receptor (EGFR) Mutasi Positif Parwatininghati, Ni Putu; Rahmawati, Fita; Sajinadiyasa, I Gede Ketut
JSFK (Jurnal Sains Farmasi & Klinis) Vol 10 No 2 (2023): J Sains Farm Klin 10(2), Agustus 2023
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.10.2.238-247.2023

Deteksi mutasi Epidermal Growth Factor Receptor (EGFR) pada pasien kanker paru akan membantu dalam pemilihan targeted therapy yaitu gefitinib. Studi mengenai evaluasi profil keamanan gefitinib di Indonesia sangat terbatas sehingga penelitian ini bertujuan untuk mengetahui efek samping obat hematologi dan non hematologi dari gefitinib pada pasien kanker paru dengan EGFR mutasi positif. Rancangan penelitian adalah observasional cross sectional. Data sekunder diambil melalui rekam medis tahun 2020 sampai 2022 pada 44 pasien. Probabilitas efek samping obat diukur dengan Naranjo Adverse Drug Reaction Probability Scale dan tingkat keparahan efek samping obat dinilai menggunakan Common Terminology Criteria for Adverse Events (CTCAE). Hasil penelitian menunjukkan efek samping hematologi yang paling sering muncul adalah anemia grade 1 pada 18 pasien (40.91%). Pada efek samping non hematologi, rash grade 2 mendominasi pada 20 pasien (45.46%), 14 pasien (31.82%) mengalami peningkatan serum transaminase grade 1, diare grade 1 terjadi pada 5 pasien (11.36%) dan mual muntah grade 2 dialami oleh 3 pasien (6.82%). Total 36 pasien (81.82%) mengalami efek samping dengan 19 kejadian termasuk kategori possible dan 17 kejadian termasuk kategori probable. Efek samping yang muncul bersifat ringan, dapat ditangani dan tidak kumulatif. Tidak didapatkan penyesuaian dosis atau penghentian penggunaan obat yang disebabkan oleh efek samping obat.

Co-Authors Anwar Santoso Candrawati, Ni Wayan Deddy Pratama Elkurnia, Raymond Timothy Fita Rahmawati Herni Damayanti Hindun Wilda Risni I B Ngurah Rai I M Bagiada I Made Agus Satrya Wibawa IB Ngurah Rai Ida Ayu Jasminarti Dwi Kusumawardani Ida Bagus Ngurah Ra Ida Bagus Ngurah Rai IGN Bagus Artana LG Sriyeni Ni Kadek Ari Cipta Pratiwi Ni Luh Putu Eka Arisanti Ni Putu Rani Apsari Dewi Ni Wayan Candrawati Parwatininghati, Ni Putu Prima Yogi Putu Andrika Rai, Ida Bagus Ngurah Raka-Sudewi A. A. Rani Sauriasari Sagun Chandra Yowani Senja Decy Ningrum Triharnoto Triharnoto Victor Nugroho Wijaya Wayan Evie Frida Yustin Wayan Rismayanti Yenny Kandarini

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