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All Journal Lumbung Farmasi : Jurnal Ilmu Kefarmasian SIMBIOSA Journal Pharmasci (Journal of Pharmacy and Science) Borneo Journal of Pharmacy Strada Jurnal Ilmiah Kesehatan (SJIK)
Silfiana Nisa Permatasari
Akademi Farmasi Surabaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Sintesis dan Karakterisasi Kitosan dari Limbah Kulit Udang Kaki Putih (Litopenaeus vannamei) Hilya Nur Imtihani; Silfiana Nisa Permatasari
SIMBIOSA Vol 9, No 2 (2020): JURNAL SIMBIOSA
Publisher : Universitas Riau Kepulauan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33373/sim-bio.v9i2.2699

Abstract

Udang kaki putih (Litopenaeus vannamei) merupakan salah satu krustasea yang banyak dikomsumsi dan dibudidayakan di Indonesia sehingga menghasilkan banyak limbah kulit udang. Limbah tersebut dapat menyebabkan terjadinya permasalahan lingkungan seperti pencemaran karena baunya yang tidak sedap. Dilain hal kulit udang mengandung zat yang dapat disajikan sebagai bahan baku kitosan yang bermanfaat untuk berbagai keperluan terutama bidang kesehatan berperan sebagai antihiperlipidemia dan antibakteri. Tujuan penelitian adalah melakukan sintesis kitosan yang merupakan turunan dari kitin yang diambil dari kulit udang kaki putih (L. vannamei) dan dilakukan karakterisasi. Metode sintesis dilakukan dengan menggunakan metode Knorr yaitu proses pre-treatment, demineralisasi dan deproteinasi untuk menghasilkan kitin selanjutnya dilakukan deasetilasi untuk menghasilkan kitosan. Karakterisasi kitosan dilakukan dengan menguji Derajat Deasetilasi (DD) menggunakan spektroskopi FTIR, uji rendemen, uji ninhidrin, dan uji organoleptik. Hasil penelitian menunjukkan uji kemurnian DD mendapatkan nilai sebesar 76,24%, hasil uji rendemen sebanyak 16,21%, uji ninhidrin positif berwarna ungu, dan uji organoleptik menghasilkan serbuk berwarna putih kekuningan. Hasil ini menunjukkan bahwa kitosan yang dihasilkan memiliki kemurnian yang sangat baik dan sesuai dengan persyaratan.
Profil Penggunaan Obat Antihipertensi di Puskesmas Surabaya. Iin Ernawati; Selly Septi Fandinata; Silfiana Nisa Permatasari
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 3, No 2 (2022): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v3i2.7679

Abstract

ABSTRAKHipertensi adalah penyakit kronis dengan tekanan darah sistolik dan diastolic meningkat ≥140/90 mmHg. Prevalensi pasien hipertensi meningkat di Puskesmas, sehingga perlu adanya observasi penggunaan obat antihipertensi sebagai data awal untuk melakukan monitoring penggunaan dan pengadaan obat. Penelitian ini dilakukan untuk mengetahui profil penggunaan obat antihipertensi yang meliputi nama obat, golongan dan aturan pakai obat antihipertensi. Penelitian ini merupakan penelitian observasional cross-sectional, yang dilakukan di 5 Puskesmas di Surabaya antara lain Puskesmas Benowo, Jeruk, Tambak Rejo, Gayungan, dan Ketabang. Pengumpulan data retrospektif dilakukan selama 2 bulan pada bulan Mei-Juni 2020. Berdasarkan hasil penelitian diketahui bahwa mayoritas pasien mendapatkan obat antihipertensi golongan CCB (Calcium Channel Blocker ) sebesar 82,37% dengan obat amlodipine 5 mg (49,19%) dan amlodipine 10 mg (32,95%), sedangkan untuk penggunaan obat antihipertensi kombinasi, mayoritas golongan CCB dan Diuretik Thiazid dengan nama obat Amlodipine 5 mg dan Hidroklorotiazid 25 mg (6,63%). Obat Amlodipine sebagai obat antihipertensi golongan CCB yang paling banyak digunakan dengan aturan pakai sekali sehari. Amlodipine salah satu obat antihipertensi yang toleran terhadap pasien geriatri dengan efek samping vasodilatasi yang lebih rendah dibanding obat lain dari golongan CCB dan memiliki waktu paruh yang panjang sehingga dapat diaplikasikan pada pasien kronis rawat jalan hipertensi dengan pemberian sekali sehari. Kata kunci : Obat antihipertensi; Puskesmas; Hipertensi; Profil. ABSTRACTHypertension is a chronic disease that is an increase in systolic and diastolic blood pressure 140/90 mmHg. The prevalence of hypertension patients is increasing at the Puskesmas, so it is necessary to observe the usage profile of antihypertensive drugs. This research is needed as initial data to monitor the use and procurement of drugs. This study aims to determine the profile of the use of antihypertensive drugs which includes the name of the drug and the rules of antihypertensive drugs. This observation is a cross-sectional study, which was conducted in 5 Public Health Center (Puskesmas) in Surabaya, including Benowo, Jeruk, Tambak Rejo, Gayungan, and Ketabang Public Health Center. Retrospective data collection was carried out for two months in May-June 2020. Based on the results of the study, it was found that the majority of patients received antihypertensive drugs from the Calcium Channel Blocker (CCB) class of 82.37% with amlodipine 5 mg (49.19%) and amlodipine 10 mg (32.95%), while for the use of combination antihypertensive drugs, the majority CCB and Thiazide Diuretics with the drug names Amlodipine 5 mg and Hydrochlorothiazide 25 mg (6.63%). Amlodipine as an antihypertensive drug of the CCB class is the most widely used in this research. Amlodipine is an antihypertensive drug that is tolerant to geriatric patients with lower vasodilation side effects than other drugs from the CCB group and has a long half-life so it can be applied to chronic hypertension outpatients and is given once a day. Keywords : Antihypertensive drug; Community Health Center; Hypertension; Profile.
Comparison and Evaluation of Fermentation Results of Probiotic Products by Acenobacter xylinum: Komparasi dan Evaluasi Hasil Fermentasi Produk Probiotik dengan Kultur Acenobacter xylinum Kinanti Lestari; Floreta Fiska Yuliarni; Lailatus Sa’diyah; Silvi Ayu Wulansari; Selvyronica Eka Agustine; Fatma Ariska Trisnawati; Silfiana Nisa Permatasari
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 8 No. 1 (2023): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v8i1.334

Abstract

products with Acetobacter xylinum starter included Nata and Kombucha. The large number of studies on probiotic product innovation should be followed by a survey on public acceptance of the products. This research aim to compare of the yield of probiotic products after fermentation process which was evaluated from a physical perspective, pH and public acceptance. This research is an experimental study to compared the fermented results of two types of probiotic products, nata and kombucha which are differentiated based on their raw ingredients. The nata products sample which had the largest thickness and weight of cellulose biofilm was NDC, while the kombucha products sample which had the largest thickness and weight of cellulose biofilm was KGF. pH of all samples, both nata and kombucha, decreased during the fermentation process. The samples of nata products that were most accepted by the panelists were NDC and NDM in terms of color, smell and taste. The samples of kombucha products that were most accepted by the panelists were KAF and KMF in terms of color, smell and taste.
Formulation and Evaluation of Solid Dispersion Chitosan Tablet from Whiteleg Shrimp (Litopenaeus vannamei) Using PVP K-30 As a Carriers Hilya Nur Imtihani; Fitria Abbas Thalib; Silfiana Nisa Permatasari
Borneo Journal of Pharmacy Vol. 4 No. 1 (2021): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v4i1.1557

Abstract

Whiteleg shrimp (Litopenaeus vannamei) on the market are processed or sold only to take part in the meat. The head, shell, and tail are thrown away without any prior processing. Underutilized waste causes environmental problems. An alternative to overcome this environmental disturbance phenomenon is to utilize shrimp shells containing chitin and subsequently transformed into chitosan that can be applied in various fields. Chitosan has poor solubility in water but high permeability; thus, improve bioavailability is accomplished by making solid dispersions. This study aims to formulate and evaluate the solid dispersion tablet using chitosan extract from L. vannamei as an active agent with PVP K-30 as a carrier. The formulation divided into three groups, that was F1 (chitosan : PVP K-30 = 1 : 1 solid dispersion), F2 (chitosan : PVP K-30 = 1 : 3 solid dispersion), and F3 (pure chitosan). The result of chitosan solid dispersion was molded into tablets by the direct compression method. The tablets were evaluated by weight and size uniformity, hardness, friability, and disintegration time. All the formulas by weight and size uniformity as well as disintegration time fulfill the requirements. The hardness of the tablets from F3 with 4,275 kg was the best from F1 and F2. By statistic analytical from weight uniformity, hardness and disintegration time give significant difference with sig. <0.05.
The Effect of The Number of Drugs Received On The Level of Adherence to Drug Consumption (Morisky, Green, Levine Adherence Scale Questionnaire) of Hypertensive Patients Iin Ernawati; Selly Septi Fandinata; Silfiana Nisa Permatasari
STRADA : Jurnal Ilmiah Kesehatan Vol. 9 No. 2 (2020): November
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjik.v9i2.394

Abstract

Hypertension is a chronic disease that requires long-term treatment, where it is very prone to non-adherence in taking antihypertensive drugs. This study aims to determine the effect of the number of drugs received by patients on the level of adherence to the consumption of antihypertensive drugs. This research is a cross-sectional observational study that was conducted in 4 community health centers in Surabaya City. The measurement of adherence in this study used the Indonesian version of the MGLS questionnaire. The number of subjects in this study was 143 which fit the inclusion criteria. The majority of the adherence levels of the study subjects were moderate (MGLS questionnaire). Based on statistical analysis, it is known that there is a significant effect (P = 0.035) of the number of drugs received by patients on the level of drug consumption adherence e as measured using the Indonesian version of the MGLS questionnaire.
Co-Authors Fatma Ariska Trisnawati Fitria Abbas Thalib Hilya Nur Imtihani Iin Ernawati Kinanti Lestari Lailatus Sa’diyah Selvyronica Eka Agustine Septi Fandinata, Selly Wulansari, Silvi ayu Yuliarni, Floreta Fiska