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All Journal Media Kesehatan Masyarakat Indonesia Jurnal Penelitian Sains Jurnal Penelitian Kesehatan Suara Forikes As-syifaa Jurnal Farmasi Jurnal Ilmiah Manuntung Martabe : Jurnal Pengabdian Kepada Masyarakat Journal Syifa Sciences and Clinical Research (JSSCR) Jurnal Bidang Ilmu Kesehatan J-ADIMAS (Jurnal Pengabdian kepada Masyarakat) Jurnal Midpro JPKMI (Jurnal Pengabdian Kepada Masyarakat Indonesia) Lumbung Farmasi : Jurnal Ilmu Kefarmasian International Journal Of Science, Technology & Management (IJSTM) Journal Pharmasci (Journal of Pharmacy and Science) International Journal of Islamic and Complementary Medicine Indonesian Journal of Community Dedication in Health (IJCDH) Borneo Journal of Pharmacy Jurnal Teknologi dan Sains Modern (Medical Scientific Journal) MESINA Jurnal Kefarmasian Indonesia Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Strada Jurnal Ilmiah Kesehatan (SJIK)
Septi Fandinata, Selly
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PERBEDAAN KEPATUHAN MINUM OBAT PADA PASIEN YANG BARU TERDIAGNOSA DAN SUDAH LAMA TERDIAGNOSA PENYAKIT DIABETES MELITUS TIPE 2 Fandinata, Selly Septi; Darmawan, Rizky
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (198.29 KB) | DOI: 10.51352/jim.v6i1.310

Abstract

Diabetes mellitus is a chronic disease caused by insufficient insulin effectively. Compliance medication in patients diabetes mellitus is important to achieve treatment goals and effective to prevent complications in diabetes mellitus. The duration of suffering from DM is one of the factors that influences medication adherence. The purpose of this study is to compare the differences in adherence to taking medication between patients who have just been diagnosed with diabetes mellitus type II. Questionnaire instrument 4 indicators of compliance (right dose, right frequency, right interval, right time). Analysis statistical of the Mann-Whitney test. Total of 10 new patients and 20 old patients were diagnosed. The results study is patient to be compliant with right dose adherence 8 new patients (80%), 19 old patients (95%). Right frequency adherence 9 new patients (80%), 19 old patients (95%). Timely compliance 7 new patients (70%), 16 old patients (80%). Right interval adherence 4 new patients (40%), 13 old patients (65%). The results of data analysis showed p-value = 0.076> 0.05 there was no significant difference in adherence to taking medication between old patients and new patients with diabetes mellitus type II.
Perubahan Kadar Protein dalam Urin terhadap Penggunaan Obat Antihipertensi (Valsartan) pada Pasien Nefropati Fandinata, Selly Septi
Journal of Pharmacy and Science Vol. 4 No. 1 (2019): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v4i1.121

Abstract

ABSTRAKDiabetes mellitus (DM) adalah suatu sindroma gangguan metabolisme yang dicirikan dengan hiperglikemia abnormal sebagai akibat dari suatu defisiensi sekresi insulin, berkurangnya efektivitas aktivitas biologis insulin atau adanya resistensi insulin. Komplikasi kronik mikrovaskular, salah satunya yaitu Penyakit Ginjal Diabetik. Penyakit Ginjal Diabetik didefinisikan secara klinik yaitu penyakit DM dengan proteinuria yang menetap dalam urin. Meta analisis melaporkan bahwa proteinuria merupakan marker terjadinya kerusakan ginjal. Beberapa penelitian membuktikan bahwa terapi ARB dapat menurunkan derajat proteinuria pada pasien ginjal-diabetik. Terapi ARB yang paling banyak digunakan di RSUD Dr. Sutomo adalah valsartan. Tujuan dari penelitian ini adalah untuk mengetahui perubahan kadar protein dalam urin terhadap penggunaan antihipertensi (valsartan) pada pasien penyakit Nefropati. Penelitian dilakukan di Instalasi Rawat Jalan Penyakit Dalam RSUD Dr. Sutomo. Kriteria Inklusi yaitu penderita penyakit ginjal diabetik di Instalasi rawat jalan dengan proteinuria dan tekanan darah terkontrol (≤130/80mmHg), yang menggunakan terapi antihipertensi tunggal valsartan. Kriteria Eksklusi yaitu hiperkalemia, ISK, menggunakan obat-obatan yang mempengaruhi proteinuria (NSAID, vit B6, B12) dan kontraindikasi terhadap valsartan. Dari penelitian ini disimpulkan bahwa pada pemberian valsartan tidak terjadi perubahan distribusi derajat proteinuria, dari 27 penderita 29,6% mengalami penurunan, 59,26% tetap dan 11,11% mengalami peningkatan derajat proteinuria. Kesimpulan pada penelitian ini bahwa valsartan tidak mengalami perubahan dalam menurunkan deraajat proteinuria.Kata kunci: nefropati, proteinuria, ARB, valsartan. ABSTRACTDiabetes Mellitus (DM) is a syndrome of metabolic disorder characterized by abnormal hyperglicemia. One of the chronic complication DM is renal microangiopathy called Diabetic Nephropathy (DN). In addition, clinical DN is defined as DM with proteinuria. Meta analysis reported proteinuria as a marker of kidney damage as predictor of progressive kidney disease is robust. Moreover several trials concluded ARBs treatment could reduce the level of proteinuria in DN patients. ARBs treatment used in RSUD Dr. Soetomo Central Hospital Surabaya is valsartan. The purpose of this study was to determine the effect of valsartan treatments on the proteinuria level in DN patients. This study was done at the outpatients clinic departement RSUD Dr. Soetomo Central Hospital Surabaya. The inclusion criteria were DN patients with normal blood pressure (≤130/80mmHg). Twenty seven patients were enrolled in this study. The result showed valsartan antiproteinuria, there was no change in proteinuria level distribution. From twenty seven patients 29,6% decreased, 59,26% did not change and 11,11% increased proteinuria level. As a conclusion, valsartan treatment no change in proteinuria level distribution.Keywords: diabetic nephropathy, proteinuria, ARBs, valsartan.
Perbandingan Angiotensin II Receptor Blocker Candesartan vs Termisartan vs Valsartan pada Monitoring Tekanan Darah Pasien Chronic Kidney Disease Selly Septi Fandinata; Rizky Darmawan
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 13, No 1 (2022): Januari 2022
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf.v13i1.1520

Abstract

 Hypertension is a health problem that needs to be taken seriously because it is the most powerful killer disease in the world. Blood pressure is a determining factor to achieve and target BP. The recommended antihypertensive guidelines are ACEI, ARB, diuretic, CCB or B-blocker. ARBs have a cardiorenal protective effect. This study aims to compare the effectiveness of blood pressure drugs valsartan, termisartan and candesartan in hypertensive patients with chronic kidney disease. This study was a prospective observational cohort study by measuring blood pressure before and after at the 1st and 6th months and then processed using statistical analysis of the independent t-test and Wilcoxon. The results of this study obtained data as many as 72 patients who met the inclusion criteria consisting of 24 patients (candesartan), 27 patients (termisartan) and 21 patients (valsartan). The candesartan therapy group, the average difference in systolic decline was 18.46±16.14 mmHg and diastolic 2.04±15.16 mmHg with systolic pressure p-value = 0.000, diastolic p value = 0.217. Termisartan therapy had an average difference in systolic pressure reduction of 18.19±12.12 mmHg and diastolic pressure of 9.44±8.01 mmHg with systolic p-value = 0.000 and diastolic p-value = 0.000. The valsartan therapy group averaged a difference in systolic decrease of 0.14±1.2 mmHg, diastolic 2.71±2.84 mmHg with systolic pressure p-value = 0.766 and diastolic p-value = 0.102. So that of the three antihypertensive drugs, the most effective ARB in lowering systolic and diastolic blood pressure is telmisartanKeywords: blood pressure; termisartan; chronic kidney disease ABSTRAK Hipertensi merupakan masalah kesehatan yang perlu ditangani secara serius karena merupakan penyakit pembunuh paling dahsyat di dunia. Tekanan darah merupakan faktor penentuan agar tercapai dan target TD. Pedoman antihipertensi direkomendasikan yaitu ACEI, ARB, diuretik, CCB atau B-blocker. ARB memiliki efek protektif kardiorenal. Penelitian ini bertujuan untuk mengetahui perbandingan efektifitas tekanan darah obat valsartan, termisartan dan candesartan pada pasien hipertensi dengan chronic kidney disease. Penelitian ini merupakan penelitian kohort pengambilan data secara observasional prospektif dengan mengukur tekanan darah sebelum sesudah pada bulan ke 1 dan ke 6 kemudian diolah menggunakan analisa statistika uji t-independent dan Wilcoxon. Hasil penelitian ini didapatkan data sebanyak 72 pasien yang memenuhi kriteria inklusi terdiri 24 pasien (candesartan), 27 pasien (termisartan) dan 21 pasien (valsartan). Kelompok terapi candesartan, rata-rata selisih penurunan sistolik 18,46±16,14 mmHg dan diastolik 2,04±15,16 mmHg dengan tekanan sistolik nilai p = 0,000, diastolik nilai p = 0,217. Terapi termisartan rata-rata selisih penurunan tekanan sistolik 18,19±12,12 mmHg dan diastolik 9,44±8,01 mmHg dengan sistolik nilai p = 0,000 dan diastolik nilai p = 0,000. Kelompok terapi valsartan rata-rata selisih penurunan sistolik 0,14±1,2 mmHg, diastolik 2,71±2,84 mmHg dengan tekanan sistolik nilai p = 0,766 dan diastolik nilai p = 0,102. Sehingga dari ketiga obat anhipertensi golongan ARB yang paling efektif dalam menurunkan tekanan darah sistolik dan diastolik adalah telmisartan.Kata kunci: tekanan darah; termisartan; gagal ginjal kronik
ANALISIS EFEKTIFITAS CEFAZOLINE, CEFTRIAXONE, CEFOTAXIME SEBAGAI ANTIBIOTIK PROFILAKSIS PADA PASIEN SECTIO CAESAREA Ninik Mas Ulfa; Selly Septi Fandinata; Yuni Hendrawati
As-Syifaa Jurnal Farmasi Vol 11, No 2 (2019): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v11i2.567

Abstract

Prophylactic antibiotics is very necessary in labor with the aim of avoiding infection during SC surgery. This study was descriptive observational with retrospective data collection. The subjects observed in this study were medical records documents of SC patients in RJI hospitals in the area of South Surabaya for the period February - April 2017, with 39 documents were divided into 3 groups. Group A which received Cefazolin, Group B received Ceftriaxone, and Group C which received Ceftaxime. This study was comparison of the effectiveness of these 3 prophylactic antibiotics was measured by temperature parameters, leukocytes and observation of the condition of the surgical wound. Based on statistical analysis using the Kruskal Wallis test, it was found that the effectiveness of antibiotic prophylaxis Cefazolin was more effective in reducing the temperature and leukocytes of SC patients compared to Ceftriaxon and Cefotaxim, with an average rating of Cefazolin in temperature parameters of 27.58 and an average ranking in leukocyte parameters ie 25.81. Meanwhile in observing surgical wounds from three groups of antibiotic prophylaxis there was no redness, no swollen wounds, no discharge and no pus from surgical wounds
The Level Of Knowledge on the Use Of NSAIDs As Analgesic For Dysmenorrhea Case In Faculty of Health Universitas Muhammadiyah Lamongan Primanitha Ria Utami; Devi Ristian Octavia; Selly Septi Fandinata
Jurnal MIDPRO Vol 12, No 2 (2020): JURNAL MIDPRO
Publisher : Universitas Islam Lamongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30736/md.v12i2.245

Abstract

Non-steroidal anti-inflammatory (anti-inflammatory) drugs, or better known as NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) or NSAIDs are a group that has analgesic (pain reliever), anti-pyretic (fever) properties. to determine the level of knowledge on the use of NSAIDs as anti-pain in cases of dysmenorrhea in the University of Muhammadiyah Lamongan. The research design used in this research is descriptive, in taking the sample using the total sampling technique. Collecting data by distributing questionnaires with data analysis presented in tabular form. The results of this study indicate that of the 266 respondents, almost all respondents know about knowledge of dysmenorrhea well (83.8%). In the results of this study, there were still respondents who did not know the proper use of NSAIDs as analgesic. So in this case the role of pharmaceutical personnel is needed in providing information or education to people who consume NSAIDs, in order to achieve a quality of life for the community and avoid unwanted therapeutic responses. Keywords : NSAID ; dysmenorrhea ; analgesic 
GERAKAN EDUKASI LINDUNGI DIRI, KELUARGA DAN MASYARAKAT DENGAN VAKSINASI COVID – 19 Selly Septi Fandinata; Mercysca Suryandari
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 5, No 1 (2022): Martabe : Jurnal Pengabdian Kepada Masyarakat
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v5i1.94-100

Abstract

Pandemi COVID-19 yakni masalah terbesar meningkatkan tingkat kesehatan warga Indonesia serta berakibat terhadap sistem kesehatan Indonesia berdampak pengurangan kinerja pada program kesehatan. Tujuan Vaksinasi COVID-19 untuk menurunkan penularan COVID- 19, merendahkan angka kesakitan serta kematian akibat COVID- 19, herd immunity serta protectif warga dari COVID-19 supaya senantiasa produktif secara sosial serta ekonomi. Kegiatan ini bertujuan untuk sosialisasi gerakan vaksinasi covid-19 dengan target siswa siswi SMK Farmasi Surabaya. Tata cara aktivitas dedikasi warga ini merupakan ceramah, Tanya jawab dan pemberian kuisioner pre post secara daring menggunakan aplikasi zoom meeting diikuti oleh 24 peserta. Hasil pada kegiatan ini adalah tingkat pengetahuan peserta pada pengisian kuisioner pre mayoritas memiliki tingkat pengetahuan cukup 14 peserta (58,33%) meningkat pada hasil kuisioner post memiliki tingkat pengetahuan yang baik 24 peserta (100%). Dengan meningkatnya tingkatan pengetahuan partisipan sehabis di bagikan penyuluhan ini diharapkan kesiapan peserta tentang vaksin covid 19 ini pada golongan baik.
Formulasi Sediaan Masker Gel Peel-Off dari Ekstrak Buah Tomat (Solanum Lycopersicum L.) Beserta Uji Aktivitas Antioksidan Wa Ode Sitti Zubaydah; Selly Septi Fandinata
Journal Syifa Sciences and Clinical Research Vol 2, No 2 (2020): Volume 2 Edisi 2 2020
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v2i2.6980

Abstract

Tomatoes are well-known as the source of antioxidants due to the content of lycopene, i.e., a potential free radical inhibitor. Gel peel-off masks are among the chemical products containing antioxidants. The first step of the study was extracting tomato fruits by macerating the fruits using alcohol solvents 96%. The obtained thick extract was used as the material of the gel mask; the percentage of the extract comprised 3% (F1), 5% (F2), and 7% (F3), and it used PVA basis 11% and viscolam 3%. According to the result, the gel peel-off masks meet the requirements of physical and storage stability evaluation. The result of the antioxidant test reveals that the IC50 value of the three masks is F1 189.22 µg/mL, F2 89.34 µg/mL, and F3 36.77 µg/mL. Further, the result of T-Test reveals that P-value = 0.019 (α = 0.05), indicating a difference in the result of the antioxidant test of the three formulae in day one (t0) and day 28 (t28).
Evaluasi Penggunaan Antibiotika Profilaksis Operasi Digestif Laparatomi Selly Septi Fandinata; Eziah Ika Lubada; Ilil Maidatuz Zulfa
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13496

Abstract

Laparotomy is a major operation and causes a lot of injuries, so the risk of infection of the laparotomy surgery wound is quite high. Surgical Site Infection (ILO) or Surgical Site Infection (ITP). Prevention of postoperative infection in patients with clean-contaminated surgery, and some clean operations with the use of prophylactic antibiotics. The purpose of this study was to evaluate the use of prophylactic antibiotics in patients with laparotomy surgery in a hospital in Surabaya. The research method is descriptive operational with retrospective data. The results of this study obtained as many as 160 patients aged 46-55 years at 20.6%, the sex of the respondents were dominated by male sex 66.3%, and the diagnosis of generalized peritonitis was 46.9%. The use of prophylactic antibiotics is class I cephalosporin antibiotics (cefazolin) with a dose of 1000-2000 mg, which is by the 2011 Ministry of Health guidelines.
Hubungan Antara Peran Pengawas Menelan Obat (PMO) dengan Keberhasilan Pengobatan Tuberkulosis Paru Kategori I Selly Septi Fandinata; Rizky Darmawan
Journal Syifa Sciences and Clinical Research Vol 1, No 2 (2019): Volume 1 Edisi 2 2019
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (545.754 KB) | DOI: 10.37311/jsscr.v1i2.2664

Abstract

TB is an infectious disease caused by Gercobacterium tuberculosis that attacks the lungs and can cause disturbances in the respiratory tract. The DOTS Program can help the achievement of successful treatment targets. The role and motivation of PMO and family are essential for the successful treatment of lung TB patients. This type of study is an analytical observational research with prospective data collection in March – May 2019, which is recorded as medical data of patients diagnosed with lung TB category I in September – November 2018 at Rubaru Puskesmas Sumenep Regency. The purpose of this research is to know the role of PMO relationship with the successful treatment of lung TB category I. With the number of samples of this research 40 patients. The results of this study using Pearson correlation statistics indicate that the value significance 0.013 < 0.05, this means a significant link between the PMO role with the success of patient treatment. The value of the correlation coefficient R obtained from 0388, the relationship between PMO role and the success of patient treatment in direct, this means that the greater the role of PMO then the higher the success of treatment, the smaller the PMO role then the lower the Successful treatment. In addition, the table also gained that the relationship between the PMO role and the successful treatment of the patient is weak due to the correlation coefficient of R < 0.4.
Pengaruh Kepatuhan Minum Obat Oral Anti Diabetik Terhadap Kadar Gula Darah Pada Pasien Diabetes Mellitus Tipe II Selly Septi Fandinata; Rizky Darmawan
JURNAL BIDANG ILMU KESEHATAN Vol 10, No 1 (2020): Jurnal Bidang Ilmu Kesehatan
Publisher : Universitas Respati Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52643/jbik.v10i1.825

Abstract

Diabetes Melitus (DM) adalah penyakit metabolik yang ditandai dengan kadar glukosa darah tinggi (hiperglikemia) diakibatkan karena sekresi insulin, gangguan aktivitas insulin atau keduanya. Kepatuhan minum obat sangat penting untuk mencapai keberhasilan terapi pengobatan dan mencegah komplikasi. Keberhasilan terapi sangat dipengaruhi oleh kepatuhan pasien dalam minum obat. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh kepatuhan terhadap obat oral anti-diabetes terhadap kadar gula darah pada pasien dengan diabetes mellitus tipe 2. Penelitian ini adalah kualitatif dengan metode analisis asosiatif dan metode pengambilan sampel menggunakan teknik convenience sampling. Hasil penelitian menggunakan analisis statistik uji korelasi Pearson (Product Momment) menunjukkan bahwa nilai-p = 0,048 <0,05 sehingga terdapat hubungan yang signifikan antara kepatuhan minum obat dengan perubahan kadar gula darah pasien dengan diabetes mellitus tipe 2. Hubungan yang signifikan diklasifikasikan dalam kategori lemah dengan nilai koefisien korelasi Pearson adalah 0,363 <0,4, koefisien korelasi positif sehingga hubungan antara kepatuhan minum obat dengan perubahan kadar gula darah tidak searah, artinya, semakin besar skor kepatuhan minum obat maka semakin besar pula selisih kadar gula darah pre dan post terapi.
Co-Authors Alfiana, Silvina Sita Amriani, Annisa Andik Isdianto Anita Purnamayanti Annisa Amriani Aristyawan, Andhika Dwi Aryanda Putra, Deddy Deddy Aryanda Putra Devi Ristian Octavia Djamilah Arifiyana Eziah Ika Lubada Eziah Ika Lubada Eziah Ika Lubada Fitriya Fitriya Fitrya Fitrya Iin Ernawati Ike Dhiah Rochmawati Indra Puspitasari Indra Puspitasari, Indra Lubada, Eziah Ika Luthfiah, Annisa Mas Ulfa, Ninik Mercysca Suryandari Ninik Mas Ulfa Ninik Mas Ulfa Ninik Mas Ulfa Ninik Mas Ulfa Norma Nisya Novita, Rennie Puspa Permatasari, Silfiana Nisa Primanitha Ria Utami Primanitha Ria Utami Primanitha Ria Utami Puji, Kinanti Ayu Puspa Novita, Rennie Putra, Deddy Aryanda Rennie Puspa Novita Rizky Darmawan Rizky Darmawan Rizky Darmawan Rizky Darmawan Rizky Darmawan Rizky Darmawan Rizky Darmawan, Rizky Silfiana Nisa Permatasari Suryandari, Mercysca Suryandari, Mercyska Ulfa, Ninik Mas Utari, Yunita Winda Vitri Agustiarini Wa Ode Sitti Zubaydah Yuni Hendrawati Zakiyah , Farah Afifatuz Zulfa, Ilil Maidatuz