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All Journal JCPS (Journal of Current Pharmaceutical Sciences) Jurnal Insan Farmasi Indonesia Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Innovation Research and Knowledge Medical Sains : Jurnal Ilmiah Kefarmasian
Raudatul Patimah
Fakultas Farmasi, Universitas Muhammadiyah Banjarmasin
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Physics Social Sciences

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PENGARUH HPMC 606 TERHADAP KADAR PENETRASI COENZYME Q10 DALAM SISTEM NANOSTRUCTURED LIPID CARRIER (NLC) PADA PATCH TIPE MEMBRAN Raudatul Patimah; Esti Hendradi; Isnaeni Isnaeni
JCPS (Journal of Current Pharmaceutical Sciences) Vol 4 No 1 (2020): September 2020
Publisher : LPPM - Universitas Muhammadiyah Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Coenzyme Q10 berfungsi sebagai antioksidan yang dapat melindungi tubuh dari kerusakan yang dikarenakan radikal bebas. Coenzyme Q10 tidak stabil dan mudah terdegradasi ketika terpapar cahaya sehingga perlu dipilih suatu sistem penghantaran yang dapat memperbaiki stabilitas serta dapat meningkatkan penetrasinya. Nanostructured Lipid Carier (NLC) merupakan salah satu metode untuk meningkatkan penetrasi obat melalui stratum corneum. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh HPMC 606 terhadap kadar Coenzyme Q10 yang terpenetrasi pada kulit tikus. Pada penelitian ini dibuat sediaan patch tipe membran menggunakan sistem NLC. Coenzyme Q10 sebagai drug reservoir, sedangkan HPMC 606 sebagai rate controlling membran dengan kadar 20%, 15%, dan 10%. Uji penetrasi Coenzyme Q10 dari sediaan patch secara in vivo dengan menggunakan kulit tikus Wistar. Semakin kecil kadar HPMC 606 yang digunakan (20%, 15%, 10%) ternyata menghasilkan nilai fluks yang cenderung semakin besar (F1 = 15,714±0,257 %/jam ; F2 = 14,778±0,224 %/jam ; dan F3 = 13,765±0,182 %/jam) dan lag time yang semakin cepat (F1 = 0,523±0,029 jam ; F2 = 0,657±0,021 jam ; dan F3 = 0,679±0,016 jam). Dari hasil tersebut dapat disimpulkan bahwa semakin kecil HPMC 606 yang digunakan sebagai rate controlling membrane, maka semakin besar Coenzyme Q10 yang berpenetrasi, sehingga F1 terpilih sebagai formula yang paling baik.
OPTIMASI FORMULASI TABLET EFFERVESCENT EKSTRAK KULIT PUTIH BUAH SEMANGKA (Citrulluslanatus) MENGGUNAKAN ASAM TARTRAT ASAM SITRAT : OPTIMIZATION FORMULATION OF EFFERVESCENT TABLETS EXTRACT WHITE SKIN OF WATERMELE (Citrulluslanatus) USING CITRIC ACID TARTRATIC ACID Aris Purwanto; Raudatul Patimah; Nor Latifah; Sofia Nabila Safitri
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 1 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i1.464

Abstract

Kulit putih buah semangka memiliki kandungan senyawa sitrulin yang berkhasiat sebagai antioksidan, untuk menghantarkan senyawa berkhasiat tersebut diperlukan formulasi sediaan tablet effervescent sebagai antioksidan dengan kombinasi asam tartrat dan asam sitrat guna mempercepat kelarutan obat. Penelitian ini bertujuan untuk melakukan optimasi formulasi asam sitrat dan asam tartrat sebagai zat pengasam pada tablet effervescent dengan menggunakan metode simplex lattice design. Pembuatan tablet menggunakan metode kempa langsung dengan evaluasi tablet meliputi uji organoleptik, keseragaman bobot tablet, keseragaman ukuran, kekerasan, kerapuhan dan waktu larut tablet. Analisis data dengan menggunakan metode simplex lattice design software design expert versi 10.0. Hasil evaluasi fisik 5 formula tablet effervescent pada uji keseragaman bobot dan keseragaman ukuran semua formula sudah memenuhi persayaratan, sedangkan yang memenuhi syarat  pada evaluasi kerapuhan tablet dari 5 formula, hanya pada F2 dan  F4 yang memenuhi persyaratan. Adapun hasil evaluasi fisik kekerasan dan waktu larut tablet effervescent pada 5 formula tersebut sudah memenuhi persyaratan. Kombinasi asam tartrat dan asam sitrat berpengaruh terhadap evaluasi kekerasan, kerapuhan dan waktu larut tablet effervescent ekstrak kulit putih buah semangka dengan adanya nilai positif pada masing-masing respon.  Konsentrasi optimal berdasarkan analisis simplex lattice design didapatkan pada F4 dengan konsentrasi asam tartrat 70 mg dan asam sitrat 1,5 mg.
THE ISOLATION OF α-CELLULOSE & THE PREPARATION OF MICROCRYSTALLINE CELLULOSE FROM SOURSOP LEAVES (Annona muricata L.) Yulianita Pratiwi Indah Lestari; Mi'rajunnisa; Raudatul Patimah
Jurnal Insan Farmasi Indonesia Vol 6 No 1 (2023): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v6i1.1298

Abstract

Powder characteristics are very important to consider in the tablet manufacturing process because they can affect the characteristics of the resulting tablets. This study aims to determine the characteristics of microcrystalline cellulose powder isolated from soursop leaves. This research method includes preparation of soursop leaves raw material, isolation of α-cellulose using 17.5% NaOH solution with 3.5% nitric acid (containing 20 mg sodium nitrite), manufacture of microcrystalline cellulose using 1 M HCl solution, and characterization of microcrystalline cellulose including quality checks. powder (organoleptic, identification, solubility), and pH testing. The results showed that the yield of microcrystalline cellulose (MCCDSr) was 96.59% against α-cellulose. The results of the characterization of microcrystalline cellulose powder including organoleptic, identification, solubility, melting point, and pH showed similar characteristics with Avicel® PH 101 as a comparison. Based on the research that has been done, the characteristics of microcrystalline cellulose powder from soursop leaves are similar to Avicel® PH 101.
UJI AKTIVITAS ANTIOKSIDAN PADA EKSTRAK ETANOL 70% TANAMAN TERATAI PUTIH (Nymphaea nouchali L) Yulianita Pratiwi Indah Lestari; Raudatul Patimah; Mustika Muthaharah; Rizka Mulya Miranti; Tuty Mulyani; Aris Purwanto
Journal of Innovation Research and Knowledge Vol. 3 No. 4: September 2023
Publisher : Bajang Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53625/jirk.v3i4.6551

Abstract

Many aquatic plants grow in these rivers, one of which is the lotus. Lotus (Nymphaea) is a plant that often lives in the swamplands of South Kalimantan, especially Banjarmasin. The lotus is a wild plant in its natural habitat, which is not foreign to Indonesian people. Some Indonesian people only know about the beauty of this plant. It turns out that apart from its beauty, the lotus also has benefits for curing various diseases. The lotus plant can also be used as medicine because it contains several different chemical ingredients in each part. This research aims to determine the antioxidant activity of extracts from various parts of the White Lotus plant (Nymphaea nouchali L) using the DPPH method. The plant parts tested include: flower parts, flower stalks, leaves and petioles. Based on the research results, the highest antioxidant activity test was found in flower extract, namely with an IC50 value of 66.906 μg/mL, and the lowest was found in leaf extract, namely with an IC50 value of 99.449 μg/mL. Quercetin as a comparison standard has an IC50 value of 6.337 μg/mL with a "very strong" antioxidant activity category, while flower extract, flower stalk extract, leaf extract and leaf stalk extract have a "strong" antioxidant activity category.
OPTIMASI FORMULASI TABLET EFFERVESCENT EKSTRAK KULIT PUTIH BUAH SEMANGKA (Citrulluslanatus) MENGGUNAKAN ASAM TARTRAT ASAM SITRAT : OPTIMIZATION FORMULATION OF EFFERVESCENT TABLETS EXTRACT WHITE SKIN OF WATERMELE (Citrulluslanatus) USING CITRIC ACID TARTRATIC ACID Aris Purwanto; Raudatul Patimah; Nor Latifah; Sofia Nabila Safitri
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 1 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i1.464

Abstract

Kulit putih buah semangka memiliki kandungan senyawa sitrulin yang berkhasiat sebagai antioksidan, untuk menghantarkan senyawa berkhasiat tersebut diperlukan formulasi sediaan tablet effervescent sebagai antioksidan dengan kombinasi asam tartrat dan asam sitrat guna mempercepat kelarutan obat. Penelitian ini bertujuan untuk melakukan optimasi formulasi asam sitrat dan asam tartrat sebagai zat pengasam pada tablet effervescent dengan menggunakan metode simplex lattice design. Pembuatan tablet menggunakan metode kempa langsung dengan evaluasi tablet meliputi uji organoleptik, keseragaman bobot tablet, keseragaman ukuran, kekerasan, kerapuhan dan waktu larut tablet. Analisis data dengan menggunakan metode simplex lattice design software design expert versi 10.0. Hasil evaluasi fisik 5 formula tablet effervescent pada uji keseragaman bobot dan keseragaman ukuran semua formula sudah memenuhi persayaratan, sedangkan yang memenuhi syarat  pada evaluasi kerapuhan tablet dari 5 formula, hanya pada F2 dan  F4 yang memenuhi persyaratan. Adapun hasil evaluasi fisik kekerasan dan waktu larut tablet effervescent pada 5 formula tersebut sudah memenuhi persyaratan. Kombinasi asam tartrat dan asam sitrat berpengaruh terhadap evaluasi kekerasan, kerapuhan dan waktu larut tablet effervescent ekstrak kulit putih buah semangka dengan adanya nilai positif pada masing-masing respon.  Konsentrasi optimal berdasarkan analisis simplex lattice design didapatkan pada F4 dengan konsentrasi asam tartrat 70 mg dan asam sitrat 1,5 mg.
Pengaruh Cycling Test Terhadap Mutu Fisik Sabun mandi Cair ekstrak Meniran Hijau (Phyllanthus Ninuri L) Nor Latifah; Raudatul Patimah; Kurnia
JCPS (Journal of Current Pharmaceutical Sciences) Vol. 9 No. 1: March 2025
Publisher : LRI - Universitas Muhammadiyah Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35747/jcps.v9i1.1263

Abstract

The skin can be cleansed and treated using soap. The most common bacteria found on the skin is Staphylococcus aureus, which can cause various skin problems. A natural ingredient known for its antibacterial properties is green Phyllanthus niruri leaves. To facilitate its application, it is necessary to develop it into a stable liquid soap formulation in terms of physical quality. The aim of this study was to determine the physical stability of a liquid soap formulation containing ethanol extract of green Phyllanthus niruri leaves, both before and after undergoing a cycling test on the best formulation.This research began with the processing of simplicia and extraction, followed by the formulation of liquid soap using green Phyllanthus niruri leaf extract with variations in KOH concentrations (14%, 16%, and 18%). The liquid soap formulations were then evaluated until the best formula was selected and subjected to a cycling test. Among the three formulas tested, the best formulation based on physical characteristics was F2, which used 16% KOH concentration. This formula was subsequently subjected to a cycling test for six cycles. The cycling test included organoleptic examination, homogeneity, pH, viscosity, foam height, and foam stability. The conclusion of this research on cycling tests shows that the physical quality of the preparation in the best formula, namely F2 (16%), showed significant changes in physical quality which was stable for 6 cycles.
Co-Authors Aris Purwanto Esti Hendradi Isnaeni Isnaeni Kurnia Mi'rajunnisa Mustika Muthaharah Nor Latifah Rizka Mulya Miranti Sofia Nabila Safitri Tuty Tuty Mulyani Yulianita Pratiwi Indah Lestari