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Budi Setiabudiawan
Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Padjadjaran/Rumah Sakit Dr. Hasan Sadikin Bandung
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Perbedaan Kadar Platelet Activating Factor Plasma antara Penderita Demam Berdarah Dengue dan Demam Dengue Setiabudi, Djatnika; Setiabudiawan, Budi; Parwati, Ida; Garna, Herry
Majalah Kedokteran Bandung Vol 45, No 4 (2013)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Manifestasi klinis infeksi virus dengue dapat berupa demam dengue atau keadaan yang lebih berat yaitu demam berdarah dengue. Patogenesis yang menerangkan hal tersebut belum jelas. Teori yang sering dikemukakan yaitu pada penyakit dengue berat terjadi peningkatan kadar mediator proinflamasi. Tujuan penelitian ini untuk melihat perbedaan kadar platelet activating factor plasma penderita demam berdarah dengue dengan demam dengue. Penelitian observasional dengan rancangan potong lintang dilakukan pada Januari–Februari 2013. Subjek penelitian adalah penderita dengue usia 1–14 tahun yang dirawat di Rumah Sakit Dr. Hasan Sadikin Bandung, RSUD Kota Bandung (Ujungberung), dan RSUD Kota Cimahi (Cibabat). Diagnosis dengue dikonfirmasi dengan pemeriksaan antigen nonstruktural-1 dan atau pemeriksaan serologis imunoglobulin M dan G. Sampel darah fase demam, kritis dan pemulihan diambil untuk pemeriksaan kadar platelet activating factor plasma menggunakan metode enzymelinked immunosorbent assay. Selama kurun waktu penelitian didapat 26 penderita dengue, terdiri atas 14 kasus demam dengue dan 12 demam berdarah dengue. Kadar platelet activating factor plasma pada fase kritis penderita demam berdarah dengue [541,45 (239,30–2.449,00)] pg/mL lebih tinggi secara bermakna dibandingkan dengan penderita demam dengue [289,55 (149,50–961,50)] pg/mL; p=0,007. Simpulan, kadar platelet activating factor plasma pada fase kritis penderita demam berdarah dengue lebih tinggi daripada penderita demam dengue. [MKB. 2013;45(4):251–6]Kata kunci: Demam berdarah dengue, demam dengue, platelet activating factor The Difference of Platelet Activating Factor Plasma Level between Dengue Hemorrhagic Fever and Dengue Fever patientsDengue virus infection can manifest as dengue fever and, more severely, as dengue hemorrhagic fever. Their pathogenesis until now is not fully understood. One of the most favorable theories stated the presence of increasing titer of pro-inflammatory mediator in severe dengue. The aim of this study was to determine the difference of plasma platelet activating factor titer between dengue hemorrhagic fever and dengue fever patients. This observational study with cross sectional design was conducted during January–February 2013. Subjects were dengue patients, 1 to 14 years old, hospitalized at Dr. Hasan Sadikin General Hospital, Bandung District Hospital (Ujungberung), and Cimahi District Hospital (Cibabat). Dengue cases were confirmed based on nonstructural-1 antigen and/or immunoglobulin M and G rapid test. Blood samples from febrile, critical and recovery phase were drawn for the examination of platelet activating factor titer using the enzyme-linked immunosorbent assay method. There were 26 dengue cases (14 as dengue fever and 12 as dengue hemorrhagic fever). Plasma platelet activating factor titer at the critical phase was significantly higher in dengue hemorrhagic fever patients [541.45 (239.30–2,449.00)] pg/mL compared to dengue fever patients [289.55 (149.50–961.50)] pg/mL; p=0.007. In conclusion, plasma platelet activating factor titer at the critical phase is higher in dengue hemorrhagic fever patients than in dengue fever patients. [MKB. 2013;45(4):251–6]Key words: Dengue hemorrhagic fever, dengue fever, platelet activating factor DOI: http://dx.doi.org/10.15395/mkb.v45n4.172
Prevalensi Sarkopenia pada Lansia di Komunitas (Community Dwelling) berdasarkan Dua Nilai Cut-off Parameter Diagnosis Vitriana, Vitriana; Defi, Irma Ruslina; Irawan, Gaga Nugraha; Setiabudiawan, Budi
Majalah Kedokteran Bandung Vol 48, No 3 (2016)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v48n3.417

Abstract

Sarkopenia, sindrom penurunan massa dan fungsi otot terkait usia dapat mengurangi kualitas hidup dan peningkatan mortalitas pada lanjut usia (lansia). Banyak metode penapisan dan definisi operasional menyebabkan angka prevalensi sarkopenia bervariasi di dunia. Penelitian ini bertujuan mengetahui prevalensi sarkopenia pada lansia yang tinggal di komunitas berdasarkan massa otot yang diukur dengan bioimpedance analysis, kekuatan genggam tangan menggunakan hand dynamometer, serta performa fisik melalui uji jalan 6 menit dengan mempergunakan dua nilai cut-off, nilai rekomendasi Asian Working Group for Sarcopenia (AWGS) dan nilai populasi lansia Taiwan karena belum didapatkan nilai cut-off populasi lansia Indonesia. Penelitian deskriptif potong lintang pada 229 partisipan (71 orang laki-laki dan 158 orang perempuan) dengan menggunakan teknik consecutive sampling dilakukan pada bulan Agustus sampai Desember 2014 pada populasi lansia di Kota Bandung dan Jatinangor. Hasil penelitian menunjukkan angka prevalensi sarkopenia berdasarkan nilai cut-off rekomendasi AWGS adalah 9,1% (7,4% untuk laki-laki dan 1,7% untuk perempuan), sedangkan prevalensi sarkopenia berdasarkan nilai cut-off populasi Taiwan sebesar 40,6% (20,1% untuk laki-laki dan 20,5% untuk perempuan). Perbedaan prevalensi yang cukup besar mendorong diperlukan penetapan nilai cut-off parameter diagnosis sarkopenia spesifik pada populasi lansia Indonesia yang tinggal di komunitas untuk dapat menentukan prevalensi sarkopenia lebih akurat. [MKB. 2016;48(3):164–70]Kata kunci: Cut-off, lansia, komunitas, prevalensi, sarkopenia Sarcopenia Prevalence In Community-Dwelling Elderly based on Two Cut-off Points Diagnosis ParametersSarcopenia, aging muscle mass loss, and function syndromes can lead to decreased quality of life and increased elderly mortality. The availability of various screening methods and operational definitions in different studies has produced different findings of sarcopenia prevalence. The purpose of this study was to discover the prevalence of sarcopenia in Indonesian community-dwelling elderly based on muscle mass measured by bioimpedance analysis, handgrip strength using hand dynamometer, and physical performance based on six minutes walking test  with two different cut-off point parameters of sarcopenia, i.e. the cut-off point recommended by Asian Working Group for Sarcopenia (AWGS) and the cut-off point based on the reference used in  Taiwan elderly population reference due to the lack of references for Indonesian elderly population. A cross-sectional study was conducted to 229 participants (71 men and 158 women) from the community-dwelling elderly population between August and December 2014 in Bandung and Jatinangor. The results of the study showed that the sarcopenia prevalence in this study based on AWGS was 9.1% (7.4% in men and 1.7% in women) while the prevalence based on the Taiwan reference revealed a prevalence of 40.6% (20.1% in men and 20.5% in women). This highly different prevalences shows the importance of defining a specific cut-off point for elderly population in community-dwelling Indonesia to get a more accurate sarcopenia prevalence. [MKB. 2016;48(3):164–70Key words: Community dwelling, cut-off, elderly, prevalence, sarcopenia
The Association Between Initial Solid Food and Atopy in Children with or without Family History of Atopic Disease Perdana, Nanan Surya; Setiabudiawan, Budi; Kartasasmita, Cissy B.
Majalah Kedokteran Bandung Vol 42, No 1
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Atopic diseases are the most common chronic diseases in childhood. Their incidence has a tendency to increase recently. The tendency of atopy could be triggered by many factors originated in the early life, including early introduction of solid food. To investigate the association between initial solid food and atopy, an analytic comparative study with historical cohort design was conducted from May to June 2006 in Pediatric Department of Hasan Sadikin Hospital Bandung. It was the second phase study of 'allergic prevalence and risk factors identification in the first two years of life'. Out of 800 children in Garuda, Padasuka, and Babakansari Primary Health Care Center who were included in the first phase of the study, 749 children were eligible to continue the second phase of the study, 284 children were randomized into two groups of children with and without family history of atopic disease consisting of 142 children each. They then underwent skin prick test. History of initiation time of solid food were obtained from their parents. To analyze the data chi-square and odds ratio with 95% confidence interval were used. Among 284 children who fullfilled the inclusion criteria, 50% had family history of atopic disease. Atopy was found in 28.2% children, 32.4% with family history of atopic disease and 23.9% without family history of atopic disease. There was no significant correlation between family history of atopic disease and atopy (p=0.113). There was a high risk for atopy related to initial solid food (OR = 4.50, 95%CI = 1.96-10.74, p < 0.001). The difference of atopy was strongly significant between children who had initial solid food at the age of <6 months and at the age of >6 months whether or not the children had family history of atopic disease (p=0.016 and p=0.002). Conclusions: A significant increase in the risk of childhood atopy occured if initial solid food is given at the age of <6 months, whether or not the children have family history of atopic disease.Hubungan antara Waktu Pemberian Makanan Pendamping ASI dan Kejadian Atopi pada Anak dengan atau Tanpa Riwayat Penyakit Atopik dalam KeluargaPenyakit atopik merupakan penyakit kronik yang paling sering ditemukan pada anak. Angka kejadian penyakit atopik cenderung meningkat dari tahun ke tahun. Kecenderungan atopi atau timbulnya penyakit atopik dapat dicetuskan oleh faktor faktor yang berpengaruh di awal kehidupan, salah satunya adalah pemberian makanan pendamping ASI (MP ASI). Untuk mengetahui hubungan antara waktu pemberian MP ASI dan kejadian atopi dilakukan penelitian analitik komparatif dengan rancangan historical cohort. Penelitian dilakukan pada bulan Mei-Juni 2006 di Bagian Ilmu Kesehatan Anak Rumah Sakit Hasan Sadikin Bandung. Penelitian ini merupakan fase kedua dari penelitian “Prevalens alergi dan identifikasi faktor risiko pada dua tahun pertama kehidupan”. Penelitian dilakukan di Puskesmas Garuda, Padasuka, dan Babakansari. Dari 800 anak yang mengikuti fase I, sebanyak 749 anak dapat diteliti pada penelitian fase II. Dengan teknik sampling secara acak terpilih 142 anak, masing-masing dari  kelompok dengan dan tanpa riwayat penyakit atopik dalam keluarga. Selanjutnya dilakukan pemeriksaan uji tusuk kulit dan ditanyakan mengenai riwayat pemberian MP ASI. Analisis statistik yang digunakan adalah uji kai-kuadrat dan Odds ratio dengan IK95%. Dua ratus delapan puluh empat anak memenuhi kriteria inklusi penelitian. Dari jumlah tersebut diperoleh 50% anak dengan riwayat penyakit atopik dalam keluarga. Atopi didapatkan pada 28,2% anak, 32,4% di antaranya dengan riwayat penyakit atopik dan 23,9% tanpa riwayat penyakit atopik dalam keluarga. Tidak terdapat hubungan yang bermakna antara anak dengan riwayat penyakit atopik dalam keluarga dan kejadian atopi (p=0,113). Dua ratus delapan (73,2%) anak mendapat MP ASI pada usia <6 bulan, 76 (26,8%) anak mendapat ASI pada usia >6 bulan. Kejadian atopi berbeda bermakna antara anak yang mendapat MP ASI pada usia <6 bulan dan >6 bulan (OR=4,50; IK95%=1,96-10,47; p<0,001), baik pada kelompok anak dengan riwayat penyakit atopik (OR=3,38; IK95%=1,12-10,86; p=0,016) maupun tanpa riwayat penyakit atopik (OR=6,08; IK95%=1,63-26,72, p=0,002) dalam keluarga. Kesimpulan: Pemberian MP ASI pada usia <6 bulan meningkatkan risiko terjadinya atopi, baik pada kelompok anak dengan atau tanpa riwayat penyakit atopik dalam keluarga.DOI: http://dx.doi.org/10.15395/mkb.v42n1.6 
HUBUNGAN ANTARA ATOPI DENGAN RIWAYAT PENYAKIT ALERGI DALAM KELUARGA DAN MANIFESTASI PENYAKIT ALERGI PADA BALITA Weninggalih, Endah; Kartasasmita, Cissy B.; Setiabudiawan, Budi
Majalah Kedokteran Bandung Vol 41, No 1
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Prevalensii penyakit alergi cenderung meningkat dalam dekade terakhir. Hal ini disebabkan karena faktor genetik dan lingkungan. Faktor genetik dibuktikan dengan riwayat penyakit alergi dalam keluarga. Penyakit alergi merupakan gejala alergi pada individu yang atopi. Penelitian ini bertujuan untuk mengetahui apakah atopi dan riwayat penyakit alergi dalam keluarga merupakan faktor risiko timbulnya manifestasi penyakit alergi. Penelitian dilakukan di Puskesmas Garuda, Babakan Sari dan Padasuka Bandung selama bulan Februari-Maret 2007 dengan rancangan cross sectional. Subjek yang telah mempunyai data hasil uji tusuk kulit (UTK) dan ada tidaknya riwayat penyakit alergi dalam keluarga dilakukan pengisian kuesioner standar The International Study of Asthma and Allergies in Childhood (ISAAC) dan pemeriksaan fisis. Subjek dinyatakan atopi bila hasil UTK positif. Hubungan antara variabel dianalisis dengan metode Ki kuadrat dan rumus Mantel Haenszel untuk mengkontrol confounding variabel. Jumlah subjek sebanyak 260 anak (92%), terdiri dari 130 anak dengan riwayat penyakit alergi dalam keluarga dan 130 anak tanpa riwayat penyakit alergi dalam keluarga. Berdasarkan UTK didapat 70 anak atopi dan 190 anak nonatopi. Manifestasi penyakit alergi terdapat pada 86 anak (33,08%). Manifestasi terbanyak adalah rinitis alergika 41 anak (15,77%),kemudian dermatitis atopik 18 anak (6,92%), dan asma 5 anak (1,92%). Kejadian manifestasi penyakit alergi terdapat pada 57,1% anak atopi dan 24,2% anak nonatopi. Kejadian manifestasi penyakit alergi terdapat pada 41,5% anak dengan riwayat penyakit alergi dalam keluarga dan 24,6% anak tanpa riwayat penyakit alergi dalam keluarga. Atopi mempunyai hubungan yang lebih kuat dengan manifestasi penyakit alergi pada balita, namun riwayat penyakit alergi dalam keluarga juga mempunyai hubungan sehingga merupakan hal yang penting untuk ditanyakan kepada orang tua.Kata kunci: Manifestasi penyakit alergi, atopi, riwayat penyakit alergi dalam keluargaASSOSIATION BETWEEN ATOPY WITH ALLERGIC HISTORY IN THE FAMILY AND ALLERGIC DISEASE IN UNDER FIVE YEAR OLD CHILDRENThere was an increase in prevalence of allergic diseases in the last decade. This was because of genetic and environmental factors. Genetic factor were proven by allergic history in the family. Allergic reaction in individu with atopy determined as allergic disease.The aim of this study was to know whether atopy and family allergic disease were risk factors for the occurrence of allergic disease manifestation. This study was conducted at Garuda, Padasuka and Babakan Sari Primary Health Center in Bandung, Indonesia, during February-March 2007, with cross sectional designed. Subjects with skin prick test (SPT) result and history or no history allergic disease data were questioned by The International Study of Asthma and Allergies in Childhood (ISAAC) and physical examination. Data were analyzed >using chi square and Mantel Haenszel test for confounding variables. A total of 260 (92%) children joined the third phase; consisted of 130 children with family history of allergic and 130 children without family history of allergic. Based of SPT consisted of 70 children with positive results and 190 children with negative results. The incidence of allergic disease was confirmed in 86 (33.08%) children: 41 (15.77%) children with allergic rhinitis, 18 (6.92%) children withatopic dermatitis, and 5 (1.92%) with asthma. Allergic diseases manifestation were confirmed in 57.1% atopy children and 24.2% nonatopy children. Allergic diseases manifestation were confirmed in 41.5% children with and 24.6% children without family history of allergic. Atopy has stronger association with allergic disease manifestation in under five children, but family history of allergic also has association so it's important to ask parents.Key words: Allergic diseases manifestation, atopy, family history of allergic
IL-12 PE, CD 69 PERCP, CD3 FITC, AND CD4 APC OPTIMIZATION WITH ACTIVATION OF ISOLATED AGENT HEAT-KILLED SONICATED MYCOBACTERIUM TUBERCULOSIS BEIJING STRAIN RINI SUNDARI; IDA PARWATI; JOHANES C. MOSE; BUDI SETIABUDIAWAN
Proceedings of The Annual International Conference, Syiah Kuala University - Life Sciences & Engineering Chapter Vol 4, No 2 (2014): Life Sciences
Publisher : Syiah Kuala University

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Abstract

Infection caused by Mycobaterium tuberculosis exists in form of intracellular infection, which leads to lymphocyte activation. CD69 is the first lymphocyte activation marker expressed in Th1 lymphocyte, which follows by IL-12 release. Flow cytometry analysis can identify the subpopulations of lymphocytes and  intracellular cytokines such as IL-12, yet precise preparation needs to be done. This research aims to conduct optimization with four color lyse/wash flow cytometry assay system FastImmune™ FACSCalibur examination, with monoclonal antibody IL-12, CD69, CD3, and CD4 in succession uses fluorochrome PE, PerCP, FITC, and APC.To activate the lymphocytes from heparinized whole blood, we used activation agent which derives from isolated heat-killed sonicated Mycobacterium tuberculosis Beijing strain. Optimal concentration from the according activation agents is 40 mL. To determine the compensation, BDTM CompBead and blank-cell unstainning are used, but the maximum result showed by blank-cell unstainning.Each monoclonal antibody dosage of IL-12PE, CD69 PerCP, and CD3 FITC is 40 mL, while CD4 APC 5 mL. Total event lymphocyte is determined minimally by 10,000 events. With 18,510 total events and Th gated events quantity are 4,692, the result obtained is IL12-PE has 7.4% gated (347 events); CD69+ perCP/CD3+ FITC 18.2% (850 events); and CD69+ perCP/CD4+ APC 3.9%.
Laporan Kasus: Penyakit Kawasaki Atipikal Budi Setiabudiawan; Reni Ghrahani; Gartika Sapartini; Mohamad Yanuar Anggara; Herry Garna
Majalah Kedokteran Bandung Vol 43, No 3
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Penyakit Kawasaki merupakan penyebab utama kelainan jantung dapatan yang sering ditemukan pada anak. Di Indonesia, penyakit ini masih sangat jarang didiagnosis karena dianggap masih jarang dan belum diketahui secara luas. Dua laporan kasus berikut merupakan laporan kasus anak perempuan dan laki-laki, masing-masing berusia 17 bulan dan 3 tahun. Keduanya datang dengan demam yang persisten lebih dari 5 hari dan hanya memenuhi 3 kriteria klasik penyakit Kawasaki, yakni mata merah dan disertai dengan perubahan mukosa bibir serta ekstremitas. Penderita kemudian didiagnosis sebagai penyakit Kawasaki atipikal. Pada pemeriksaan laboratorium didapatkan peningkatan C-reactive protein dan laju endap darah disertai gambaran ekokardiografi yang normal. Kedua anak diberikan imunoglobulin intravena (IGIV) dengan dosis 2 gram/kgBB dosis tunggal dan aspirin dosis 80 mg/kgBB/hari. Penderita mengalami perbaikan setelah 1 hari mendapat terapi kombinasi tersebut. Disimpulkan bahwa pengobatan dengan kombinasi IGIV dan aspirin memberikan respons yang baik pada penyakit Kawasaki atipikal. [MKB. 2011;43(3):146–52].Kata kunci: Aspirin, imunoglobulin intravena, penyakit Kawasaki atipikal Case Reports: Atypical Kawasaki DiseaseKawasaki disease is the most common cause of acquired heart disease in children. In Indonesia the disease is rare to diagnosed, because of difficulty in diagnosis and not widely known. These were 2 case reports about a girl and a boy age 17 months and 3 years, who came with persistent fever more than 5 days and only fulfilled 3 criteria of Kawasaki disease, which are red eyes, changes in lips, mucose of oral and extremities. They were diagnosed as atypical Kawasaki disease. Laboratory examinations showed an increased of C-reactive protein and erythrocyte sedimentation rate with normal echocardiography. The patients were improved after treated with 2 grams per bodyweight of intravenous immunoglobulin (IVIG) and 80 mg per bodyweight of aspirin. The patients were better after one day combination therapy. In conclusion that atypical Kawasaki disease has good response to combination of IVIG and aspirin. [MKB. 2011;43(3):146–52].Key words: Aspirin, atypical Kawasaki disease, intravenous immunoglobulin DOI: http://dx.doi.org/10.15395/mkb.v43n3.61
Relationship between Maternal Vitamin D Level and Small for Gestational Age Infant in West Java, Indonesia Setyorini Irianti; Raden Tina Dewi Judistiani; Sylvia Rachmayati; Jusuf Sulaeman Effendi; Budi Setiabudiawan
Majalah Kedokteran Bandung Vol 52, No 3 (2020)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Small for gestational age (SGA) infants is one of the unfavorable outcomes of pregnancy that needs to be prevented. There are not many studies available on the association of maternal vitamin D levels during pregnancy and SGA infants. This study aimed to discover the association between maternal vitamin D level and SGA infants in West Java. A cohort study was performed from February 2018 to January 2019 by recruiting 304 pregnant women in Bandung, Cimahi, Waled, and Sukabumi, West Java Province, Indonesia. Of that number, 203 women were followed until the delivery date. Data were collected from the results of serial ultrasonography examinations and maternal vitamin D level measurements. Bivariate analysis and logistic regression were then performed to determine the relationship between variables. This study showed that 30 of 203 (14.78%) infants were born as SGA infants. The mothers of these SGA infants had a lower maternal vitamin D level at the beginning of the second trimester and smaller anthropometric measurements at the beginning of the third trimester. However, no significant difference was found between normal infants and SGA infants when the overall values for all trimesters were compared. It can be inferred that the maternal vitamin D level has a negative relationship with SGA infants in West Java, Indonesia. Further studies are required to prove the relationship between maternal vitamin Dl level and SGA infants.Hubungan Kadar Vitamin D Ibu dan Bayi Kecil Masa Kehamilan di Jawa BaratBayi kecil masa kehamilan (KMK) adalah luaran kehamilan yang perlu dicegah. Informasi tentang hubungan kadar vitamin D ibu dengan kejadian bayi KMK di Indonesia masih terbatas. Kadar vitamin D dan karakteristik ibu diduga berpengaruh dalam kejadian bayi KMK. Tujuan penelitian ini adalah mengetahui hubungan kadar vitamin D ibu dengan kejadian KMK pada bayi. Studi kohort dilakukan dari Februari 2018 hingga Januari 2019 dengan merekrut 304 ibu hamil di Bandung, Cimahi, Waled, dan Sukabumi, Provinsi Jawa Barat, Indonesia.  Dari jumlah 203 orang diantaranya berhasil diikuti sejak trimester satu hingga persalinan dan terpilih menjadi  subjek penelitian kasus kontrol. Pemeriksaan ultrasonografi, kadar vitamin D dan hemoglobin ibu dilakukan serial tiap trimester. Dilakukan analisis bivariat dan regresi logistik untuk menentukan hubungan antar variabel yang diteliti. Dari penelitian ini didapatkan sebanyak 30 dari 203 (14,78%) persalinan  dengan luaran bayi KMK.  Bayi KMK cenderung  mempunyai riwayat kadar vitamin  D yang lebih rendah pada awal trimester kedua dan hasil antropometri yang lebih rendah pada awal trimester tiga, namun secara statistik tidak berbeda signifikan. Simpulan penelitian ini bahwa kadar vitamin D ibu hamil memiliki korelasi negatif dengan bayi KMK. Penelitian lebih lanjut diperlukan untuk membuktikan hubungan antara kadar vitamin D ibu dan bayi KMK. 
Noma management in a child with systemic lupus erythematosus Irna Sufiawati; Asri Arum Sari; Budi Setiabudiawan; Rahmat Gunadi
Dental Journal (Majalah Kedokteran Gigi) Vol. 43 No. 1 (2010): March 2010
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (476.055 KB) | DOI: 10.20473/j.djmkg.v43.i1.p6-10

Abstract

Background: Noma, also known as cancrum oris, is an orofacial gangrene, which during its fulminating stage causes progressive and mutilating destruction of the infected tissues. The disease occurs mainly in children with malnutrition, poor oral hygiene and debilitating concurrent illness. Purpose: The aim of this paper was to report a unique case of noma associated with systemic lupus erythematosus in an 8-year-old boy. Case: An 8-year-old boy referred to Oral Medicine Department complaining about an ulcer at the left corner of his mouth for 1 month, painful and difficulty in opening the mouth. The patient was diagnosed systemic lupus erythematosus since 14 months before and had been given immunosuppressive therapy. The patient was also diagnosed severe malnutrition. Haematologic investigations revealed anemia. Case management: Panoramic radiography was performed to check for dental or periodontal foci of infection, but no abnormalities were present. The microbiology examination revelaed Fusobacterium necrophorum, Staphylococcus aureus, and Klabsiella. The patient has been treated with oral irrigation using hydrogen peroxide, saline and 0.2% chlorhexidine, thus helped to slough the necrotic tissue. Oral antibiotics and analgesics were prescribed. The patient was admitted to hospital under the care of a pediatrician, allergy and immunology specialist, and a nutritionist. The result of the comprehensive disease management showed that the lesion healed completely, but leaving a scar on his corner of the mouth. Its physical effects are permanent and may require reconstructive surgery to be repaired by oral surgeon. Conclusion: Noma is not a primary disease, there are various predisposing factors usually precede its occurrence. The management of noma requires a multidisciplinary approach.Latar Belakang: Noma, dikenal sebagai cancrum oris, adalah gangren pada daerah orofasial, yang menyebabkan kerusakan progresif dari jaringan yang terinfeksi. Penyakit ini terjadi terutama pada anak dengan gizi buruk, kesehatan mulut yang buruk dan penyakit yang melemahkan. Tujuan: Makalah ini bertujuan untuk melaporkan sebuah kasus noma yang unikpada seorang anak laki-laki berusia 8 tahun yang menderita lupus eritematosus sistemik. Kasus: Seorang anak laki-laki 8 tahun dirujuk ke Bagian Ilmu Penyakit Mulut, mengeluh adanya luka di sudut mulut sebelah kiri yang telah diderita selama 1 bulan, terasa sangat sakit dan sulit membuka mulut. Pasien didiagnosis lupus eritematosus sistemik sejak 14 bulan sebelumnya dan telah diberikan terapi imunosupresif. Pasien juga didiagnosis menderita malnutrisi yang berat. Pemeriksaan hematologi menunjukkan pasien menderita anemia. Tatalaksana kasus: Radiografipanoramik dilakukan untuk memeriksa fokus infeksi dental atau periodontal, tetapi tidak ditemukan adanya kelainan. Pada pemeriksaan mikrobiologi ditemukan adanya Fusobacterium necrophorum, Staphylococcus aureus, dan Klabsiella. Perawatan pada pasien meliputi irigasi pada daerah gangren dengan hidrogen peroksida, larutan salin dan klorheksidin 0,2% untuk membersihkan jaringan nekrotik. Pasien juga diberikan antibiotik dan analgesik. Pasien dirawat di rumah sakit di bawah perawatan dokter spesialis anak, dokter spesialis alergi imunologi, dan ahli gizi. Hasil penatalaksanaan penyakit secara komprehensif memperlihatkan adanya penyembuhan, tetapi meninggalkan jaringan parut pada sudut mulutnya. Kelainan fisik tersebut bersifat permanen dan memerlukan pembedahan rekonstruktifoleh dokter gigi spesialis bedah mulut. Kesimpulan: Noma bukanlah penyakit primer, terdapat berbagai faktor predisposisi yang biasanya mendahului terjadinya penyakit tersebut. Pengelolaan noma memerlukan pendekatan multidisiplin.
The efficacy of sarang semut extract (Myrmecodia pendens Merr & Perry) in inhibiting Porphyromonas gingivalis biofilm formation Zulfan M. Alibasyah; Ambrosius Purba; Budi Setiabudiawan; Hendra Dian Adhita; Dikdik Kurnia; Mieke H. Satari
Dental Journal (Majalah Kedokteran Gigi) Vol. 50 No. 2 (2017): June 2017
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (989.148 KB) | DOI: 10.20473/j.djmkg.v50.i2.p55-60

Abstract

Background: Porphyromonas gingivalis (P. gingivalis) is a pathogenic bacteria present in the oral cavity involved in the pathogenesis of chronic periodontitis and biofilm. This mass of microorganisms represents one of the virulent factors of P. gingivalis which plays an important role as an attachment initiator in host cells. Sarang semut is a natural material possessing the ability to inhibit the growth of P. gingivalis. Purpose: This study aims to analyze the effect of sarang semut extract on the formation of P. gingivalis biofilm. Methods: The study used methanol sarang semut extract and P. gingivalis ATCC 33277 and phosphomycin as a positive control. Treatment was initiated by means of culturing. Biofilm test and P. gingivalis biofilm formation observation were subsequently performed by means of a light microscope at a magnification of 400x. Results: The formation of P. gingivalis biofilms tended to increase at 3, 6, and 9 hours. Results of the violet crystal test showed that concentrations of 100% and 75% of the sarang semut extract successfully inhibited the formation of P. gingivalis biofilm according to the incubation time. Meanwhile, the sarang semut extracts at concentrations of 50%, 25%, 12.5%, and 6.125% resulted in weak inhibition of the formation of P. gingivalis biofilm. The biofilm mass profile observed by a microscope tended to decrease as an indicator of the effects of the sarang semut extract. Conclusion: Sarang semut extract can inhibit the formation of P. gingivalis biofilm, especially at concentrations of 100% and 75%. Nevertheless, phosphomycin has stronger antibiofilm of P. gingivalis effects than those of the sarang semut extract at all of the concentrations listed above.
Correlation of Maternal Serum Hepcidin, Soluble Transferrin Receptor (sTfR) and Cholecalciferol with Third Trimester Anemia: Findings from A Nested Case-control Study on A Pregnancy Cohort Raden Tina Dewi Judistiani; Sefty Mariany Samosir; Setyorini Irianti; Benny Hasan Purwara; Budi Setiabudiawan; Johannes Cornelius Mose; Budi Handono
The Indonesian Biomedical Journal Vol 12, No 4 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i4.1252

Abstract

BACKGROUND: Cholecalciferol, hepcidin, and soluble transferrin receptor (sTfR) interaction play an essential role in iron hemostasis. Anemia in pregnancy contributes to morbidity and mortality both for the mother and baby. In this study, we assessed the correlation between hepcidin, sTfR and cholecalciferol in third trimester maternal anemia. We aimed to find the cut-off for hepcidin and sTfR.METHODS: A case-control study involving 56 pregnant women in each anemia and healthy group was nested on a previous larger cohort study in Indonesia. Serum hepcidin, sTfR and cholecalciferol level were measured by enzyme-linked immunosorbent assay (ELISA) method.RESULTS: Serum hepcidin and sTfR level were significantly higher in case group, while serum cholecalciferol level has no difference between the two groups. New cut-off points were found for hepcidin (<15.93 ng/mL) and sTfR level (>2234.45 ng/mL). Low level of hepcidin (OR=5.32) and high level of sTfR (OR=8.28) increase the risk of anemia. High level of sTfR (adjusted OR=4.725; CI 95%=1.730-12.904; p=0.02) was the most important factor contributes to anemia, followed by the low level of hepcidin (adjusted OR=3.677; CI 95%=1.363-9917; p=0.01).CONCLUSION: The high level of sTfR is the most important factor related to anemia in the third trimester, followed by the low level of hepcidin. Low cholecalciferol level tends to favor the incident of anemia. The new cut-off point of third trimester sTfR and third trimester hepcidin were established in this study and may be useful for risk assessment and treatment monitoring for anemia in pregnancy.KEYWORDS: anemia, cholecalciferol, hepcidin, pregnancy, soluble transferrin receptor
Co-Authors Abdurachman Sukadi Abdurachman Sukadi Ahmad Zaeni Syafii Alex Chairulfatah Ambrosius Purba Anang Endaryanto Andhika T. Hutapea Andri Firdaus Ani Melani Maskoen Arini Setiawati Asep Aziz Asopari Asri Arum Sari Atu Purnama Dewi Ayu Alia Aziz, Muhammad Alamsyah Bakhtiar Bakhtiar Basrowi, Ray Wagiu Benny Hasan Purwara Budi Handono Cissy B. Kartasasmita Cissy B. Kartasasmita Citra Amelinda Dedi Rachmadi Diana Rosifah Diet Sadiah Rustama Dikdik Kurnia Dilantika, Charisma Dina Muktiarti, Dina Dita Lasendra Djatnika Setiabudi Dwi Prasetyo Edhyana Sahiratmadja Edhyana Sahiratmadja Elza Noviani Endang Sutedja Erny Rachmawati Triwardhani Fedri Ruluwedrata Rinawan Gaga Irawan Nugraha Gartika Sapartini Harold Eka Atmaja Harry Raspati Hendra Dian Adhita Henni Djuhaeni Herry Garna Hesti Puspasari Ida Parwati Ika Agus Rini Irma Ruslina Defi Irman Permana Irna Sufiawati Isabella Riandani Johanes C. Mose Johanes C. Mose Johannes Cornelius Mose Johannes Hudyono Juandy Jo Jusuf Sulaeman Effendi Kartjito, Melissa Stephanie Keri Lestari Ketut Dewi Kumara Wati Kuswandewi Mutyara Laniyati Hamijoyo, Laniyati Lelani Reniarti M. Thaufiq S. Boesoirie, M. Thaufiq S. Mahesa Suryanagara Melati Sudiro Melva Louisa Mieke H. Satari Minerva Riani Kadir Mohamad Yanuar Anggara Myrna Soepriadi Nur Melani Sari Perdana, Nanan Surya Putria Rayani Putria Rayani Apandi Raden Tina Dewi Judistiani Rahmat Gunadi Reni Ghrahani Reni Ghrahani Reni Ghrahani Reni Ghrahani Reni Ghrahani DM Riana Novy RINI SUNDARI RINI SUNDARI, RINI Rovina Ruslami, Rovina Saputri, R. Ayu Hardianti Sasfia Candrianita Sefty Mariany Samosir Setyorini Irianti Sheba, Shiane Hanako Sinta Boesoerie Sitorus, Nova Sjarif Hidayat Effendi Sofie R. Krisnadi Sumadiono Sumadiono Sunjaya, Deni K. Surapsari, Juwalita Susy P. Wihadi Sylvia Rachmayati Teti Madiadipoera Tetty Yuniati Tetty Yuniati Thaufiq S. Boesoirie Tisnasari Hafsah Triana Nurul Meirina Triatmaja, Dendy Vitriana Vitriana Vycke Yunivita Kusumah Dewi Weninggalih, Endah Yulia Yulia Zakiudin Munasir Zulfan M. Alibasyah