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All Journal Jurnal Farmasi Higea

Zet Rizal

Sekolah Tinggi Ilmu Farmasi (STIFARM) Padang

Author-ID : 3768599

Medicine & Pharmacology

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Pengaruh Ekstrak Etanol Daun Sukun (Artocarpus Altilis (Parkinson Ex F.A. Zorn) Fosberg) terhadap Kadar LDL (Low Density Lipoprotein) pada Mencit Putih Jantan Hiperkolesterol Helmi Arifin; Zet Rizal; Meri Susilawati
Jurnal Farmasi Higea Vol 7, No 1 (2015)
Publisher : STIFARM Padang

The research has been about effect of ethanol extract of breadfruit leaves (Artocarpus altillis (Parkinson ex F.A. Zorn) Forsberg) to cholesterol levels in white male mice. Mice used 45 individuals were divided into 5 groups of animal that group I as a negative control group was given only the standard diet food. Group II is the positive control induced hight-fat foods and suspension PTU. Group III, IV and V are given foods containing high fat and suspension PTU with extract variations along with dose of 100, 300, and 900 mg/kg body weight once a day for 7,14 and 21. Then LDL levels measured on day 7, 14, and 21. The results of resarch showed that there are variations influence the dose and duration of administration of the decreased levels of blood LDL white male mice. The highest levels decrease at a dose of 900 mg/kg for 21 day.

Kajian Efek Stimulan Dari Beberapa Minuman Energi Kemasan Sachet Yang Beredar Di Pasaran Zet Rizal; Candra Syuryani; Helmi Arifin
Jurnal Farmasi Higea Vol 5, No 2 (2013)
Publisher : STIFARM Padang

A research of some sachet energy drinks on the market on the activity of the central nervous system stimulant for white mice (Mus musculus, L.) has been done. The samples labelled Minuman Energi Sachet MES 1, MES 2, MES 3, MES 4 and MES 5 and administered perorally. Parameters used for stimulant activity were endurance tested using Rotary road, while motoric activity and curiosity tested using Automatic Hole Board. Each sample has administration volume of 0.52 ml/20 g BW. Comparator ued is caffeine 0.13 mg/ 20 g BW. From the research that has been done, it is known that MES 1, MES 2, MES 3, MES 4 and MES 5 has a central nervous system stimulant activity by increasing endurance, motoric activity and curiosity in mice significantly.

Pengaruh Ekstrak Wortel (Daucus Carota Linn.) Terhadap Aterosklerosis Pada Burung Puyuh Jantan (Cortunic-Cortunix Japonica) Suhatri Suhatri; Hel Amir; Zet Rizal
Jurnal Farmasi Higea Vol 6, No 2 (2014)
Publisher : STIFARM Padang

Has done research the effect of extracts of carrot (Daucus carota Linn.) Against atherosclerosis in male quail (Cortunix-cortunix japonica). Atherosclerosis induced by administering Prophylthiouracyl (PTU) and high-fat foods (MLT). Carrot extract dose given on quail is 50 mg / kg BW, 100 mg / kg BW and 200 mg / Kg BW on quail males given orally for 60 Days. The results showed that the administration of carrot extract at a dose of 100 mg / kg BW and 200 mg / kg BW can prevent the formation of atherosclerosis in male quail, marked on the wall thickness of the aorta, the aortic lumen and extensive damage to endothelial cells was not different from the negative control (P < 0.05). Carrot extract dose of 50 mg / kg BW for 60 days can not be pried prevent its established atherosclerosis, characterized in aortic wall thickness, area of the aortic lumen and endothelial cell damage is not different from the positive control (P> 0.05).

Penggunaan Antibiotik Pada Bangsal Mata RSUP Dr. M. Djamil Padang Tahun 2005 sampai dengan Tahun 2007 Zet Rizal; Rostin Rostin; Helmi Arifin
Jurnal Farmasi Higea Vol 1, No 2 (2009)
Publisher : STIFARM Padang

Research about usage of antibiotic at Barn Eye of RSUP DR. M. Djamil Padang to year 2005 up to 2007. Result of obtained research pursuant to data of retrospective at cataract patient, pterigium, tumor and conjunctivitis show eye patient which is higher infection of year 2005 equal to 19.49 % year 2006 equal to 18.57 % year 2007 equal to 25.67 %. So that usage of high antibiotic also in the year 2005 equal to 47.37 %. year 2006 equal to 79.79 %. year 2007 equal to 45.26 %. Usage of antibiotic pursuant to precisely indication at disease of cataract, pterigium, tumor and conjunctivitis at precise eye patient 100 % in the year 2005 up to 2007. Precisely dose usage of antibiotic at cataract patient of pterigium, tumor and konjungtivitis at precise eye 100 % in the year 2005 up to 2007. Usage of correct antibiotic of patient, precise of drug, precise is way of wearing, at type medicines amoxicillin, chloramphenicol, and precise siprofloxacin 100 % in the year 2005 up to 2007. From result of interview obtained at patient which less than five day taken care of to get continuation recipe to go home.

Isolasi Dan Karakterisasi Flavonoid Antioksidan Dari Herba Meniran (Phyllanthus niruri L.) Harrizul Rivai; Diyah Permata Sari; Zet Rizal
Jurnal Farmasi Higea Vol 4, No 2 (2012)
Publisher : STIFARM Padang

The isolation of flavonoid substance from Meniran has been performed. Of 100 grams of Meniran’s dried powder, 4.286 grams (4.286%) of thick extract, 1.76 grams of n-hexane fraction, 1.91 grams of CHCl3 fraction, 1.8 grams ofethyl acetate fraction, 2.12 grams of butanol fraction and 24.86 grams of residual fraction has been derived. After preparative chromatography,which is to isolate flavonoid, had been performed, it acquired four blotches which were marked as A,B,C and D. And afterwards it was evaporated which resulted 26.9 mg of flavonoid A, 30.4 mg of flavonoid B, 34.6 mg of flavonoid C and 35.4 mg of flavonoid D. Characterization was focused on flavonoid C as it has the highest antioxidant activities which was recognized from its high inhibition persentage which was attained following a DPPH test. flavonoid C is amorf, yellow coloured, and dissipated at 161.8o – 163.2o C. Based on UV spectrum with slide reactor and infrared spectrum, it was assumed that flavonoid C is an aglicone isoflavone which has an –OH on the 5th position and an o-diOH in ring A (6.7 or 7.8).

Uji Efek Teratogen Ekstrak Etanol Daun Patikan Kebo (Euphorbia Hirta L.) Terhadap Fetus Mencit Putih Suhatri Suhatri; Agusdi Firdaus; Zet Rizal
Jurnal Farmasi Higea Vol 6, No 1 (2014)
Publisher : STIFARM Padang

Has done research about the teratogenic effects ethanol of extract test patikan Kebo leaves (Euphorbia hirta L.) concerning to fetal white mice. Animal experiments were grouped into 4 groups consisting of group I as negative control given only 0.5% suspension of Na CMC, group II, group III and group IV was given the ethanol extract of patikan kebo leaves with variations dose of 25 mg / kg BW, 50 mg / kg BW, and 100 mg / kg BW once a day from day 6 to day 15 of pregnancy. 18th day of pregnancy mice dilaparaktomi. Dose of 25 mg / kg BW, dose of 50 mg / kg BW did not cause teratogenic effects. Teratogenic effect was found at dose of 100 mg/kg BW there was the discovery of defects cleft palate. The results showed the ethanol extract of patikan kebo leaves not affected weight gain parent mice were significantly (p> 0.05) when compared to the negative control. Amount of fetuses were significantly reduced (p <0.05) when compared to the negative control. Fetal weight showed no significant effect (p> 0.05) if compared with negative controls.

Pengaruh Pemberian Gambir dari Uncaria gambir (Hunter) Roxb terhadap pH dan Tukak Lambung pada Tikus Putih Jantan Suhatri Suhatri; Zet Rizal; Debhi Mutiara Iryanda
Jurnal Farmasi Higea Vol 7, No 1 (2015)
Publisher : STIFARM Padang

The effect of gambir Uncaria gambir (Hunter) Roxb on pH and gastric ulcers in male rats induced by 1 mL/200 gram body weight by oral admistration. The parameter taken to asses antiulcer activity were change of gastric acid pH and ulcer index to normal condition. The result indicate that the gambir Uncaria gambir (Hunter) Roxb at doses of 20 mg, 40 mg and 80 mg/Kg BB body weight significantly decreases the ulcer index with curative ratio were 51.93 %, 55.98 % and 63.90 % (Gambir of two days) and 68.43 %, 77.69 % and 82.61 % (Gambir of four days) with respect to control group. The gambir at 20 mg, 40 mg and 80 mg/Kg BB body weight also significanthy decrease the gastric acid pH to its normal value (P<0.05).

Efek Ekstrak Etanol Daun Cacao Theobroma Cacao L. terhadap Aktifitas Sistem Saraf Pusat Zet Rizal; Harto H.; Helmi Arifin
Jurnal Farmasi Higea Vol 1, No 1 (2009)
Publisher : STIFARM Padang

The research about stimulant activity of the central nervous system from the ethanol extract of cacao leaves ( Theobroma cacao L.) to mice ( Mus musculus ) has been done. The observation of stimulant activity from the other doses gives to experiment of animal with oral. It does with rota – road tools, the motoric of activity test, automatichole board tools and the times of inductive sleep and the long time sleep by mice with 50 mg/Kg BB i.p doses. The finalty reseach knows that ethanol extract of cacao leaves with 250 and 500 mg/Kg BB doses characteristic stimulant. It looks that mount the power of venture, activity motoric, feel knows, the time of inductive sleep and the short time with experiment of animal if it compare with control group.

Pengaruh Cara Pengeringan Oven Dan Microwave Terhadap Perolehan Kadar Senyawa Fenolat Dan Daya Antioksidan Dari Herba Meniran (Phyllanthus niruri L.) Zet Rizal; Fitri Ledia; Harrizul Rivai
Jurnal Farmasi Higea Vol 2, No 1 (2010)
Publisher : STIFARM Padang

Effect of drying method in gaining of extractive, phenolic content and antioxidant activity from Phyllanthus niruri (Linn.) leaves have been investigated by UV-Visible spectrofotometric. The drying method tested were air-drying, microwave drying and oven drying at 400C. The determination of phenolics compounds was carried out accourding to Folin Ciocalteau method and antioxidant activity was evaluated by DPPH as oxidant and gallic acid as reference. The determination of extractive compounds showed that the air-drying, microwave drying and oven drying at 40 0C countained 17.54 %; 11.84 %; 14.22 % with the water content 8.2%; 6.6%; 6.7%. The phenolic compounds 2,63900 %; 2,24585 %; 2,28095 %. Then IC50 of the sample were 0.49 mg/mL, 0.51 mg/mL, 0.53 mg/mL respectively.

Efek Jus Terung Pirus (Cyphomandra betacea Sendtn.) Terhadap Jumlah Sel Darah Merah (Eritrosit) Dan Nilai Hematokrit Pada Mencit Putih Jantan Yufri Aldi; Yanelita Vipri; Zet Rizal
Jurnal Farmasi Higea Vol 5, No 1 (2013)
Publisher : STIFARM Padang

Evaluation about the effect of pirus juice (Cyphomandra betacea Sendtn.) on hematology parameters (red blood cells, reticulocytes, hemoglobin and hematocrit) for male white mice has been done. The juice was administrated orally one times a day during 20 days. The 1th day until the 20th day the animal induction with Chloramphenicol 130 mg / kg orally, followed by the provision of pirus juice with various doses of 0.26 mL and 0.52 mL. The effect was observed on day 5, 10, 15, 20, 25 and 30. The result showed that administration of pirus juice can increase the number of red blood cells, reticulocytes, hemoglobin and hematocrit male white mice at each dose is highly significant (p <0.05). Dose of 0.52 mL of the nicest effects compared with other doses (p <0.05).

Co-Authors Agusdi Firdaus Aried Eriadi Barmitoni Barmitoni Candra Syuryani Debhi Mutiara Iryanda Desis Rena Deswati Deswati Diyah Permata Sari Elfia Nasri Erdinal Erdinal Fitri Ledia Harrizul Rivai Harto H. Hel Amir Helmi Arifin Leli Sriyani Meri Susilawati Novika Maulina Rosa Julia Wijaya Rostin Rostin Rusmayanti Rusmayanti Suhatri Suhatri Surya Dharma Widya Nengsih Yanelita Vipri Yaser Arafat Yimmi Syavardie Yufri Aldi

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