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All Journal Journal Syifa Sciences and Clinical Research (JSSCR)
Widysusanti Abdulkadir
Jurusan Farmasi, Fakultas Olahraga dan Kesehatan, Universitas Negeri Gorontalo, Jl. Jenderal Sudirman No. 06 Kota Gorontalo 96128, Indonesia
Chemistry Medicine & Pharmacology

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Gambaran Efek Samping Obat Antituberkulosis Pada Pasien Tuberkulosis Widysusanti Abdulkadir; Endah Nurrohwinta Djuwarno; Nur Rasdianah; Faramita Hiola
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.14292

Abstract

Pulmonary tuberculosis is a communicable disease caused by Mycobacterium tuberculosis bacteria that mostly attack lungs, yet they also possibly attack other organs. The use of tuberculosis drug oftentimes leads to side effects on the patients. This research intends to determine the side effects of anti-tuberculosis drugs of tuberculosis patients. It employed a cross-sectional approach, in which the data were collected from questionnaires. As many as 50 patients were selected as the sample using purposive sampling, i.e., a sampling technique based on inclusion and exclusion criteria. The results indicate that the majority of the patients suffering from tuberculosis are men (27 people, 54%), aged 16-27 years (30%), graduating from elementary school (60%), with another job (farmer, 76%).  In addition, the frequently-occurring side effects include red urine (22%), nausea (18%), being limp (14%), vomit (12%), joint pain and itch (8%), and loss of appetite (2%).
Tingkat Pengetahuan Pasien Penderita Tuberculosis Dalam Program Pengobatan Tuberculosis di Puskesmas Madania Madania; Mahdalena Sy Pakaya; Teti Sutriati Tuloli; Widysusanti Abdulkadir
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.14220

Abstract

Tuberculosis is an infectious disease caused by bacteria known as mycobacterium tuberculosis. In Indonesia, tuberculosis is the third common public health problem the prevalence of the disease in this country is among the highest in the world after China and India. Sufficient knowledge of diseases and medicines correlates with the result of therapy in general. Knowledge about drugs is important for patients since it helps them to consume drugs properly (which result in maximum therapy) and to avoid complications. The purpose of this descriptive study is to determine the level of knowledge of patients suffering from tuberculosis in the tuberculosis treatment program at Bulango Utara Puskesmas (Community Health Center) by a questionnaire. It applied a cross-sectional approach with primary data obtained from the result of a sample questionnaire totaling 24 patients taken by saturated sampling. The result of this present study reveal that the level knowledge of patients with tuberculosis in the area is still relatively low at 75%, while only 25% is classified as moderate.
Efek Antihiperurisemia Ekstrak Etanol Daun Pandan (Pandanus Amaryllifolius ) Pada Mencit (Mus Musculus) Widysusanti Abdulkadir; Dizky Ramadani Putri Papeo; Juliyanty Akuba; Andi Makkulawu
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.7719

Abstract

Hyperuricemia is a condition in which the kidneys fail to excrete uric acid, resulting in high levels of uric acid. (Kaneko et al., 2014). Uric acid will be excreted into the kidneys along with urine. The decrease of uric acid secretion into the kidney tubules due to interference of uric acid elimination to the kidneys which causes uric acid levels in the blood to increase (Ningtiyas Ramadhian, 2016). An adult male is suffering from hyperuricemia when his serum uric acid level is more than 7.0 mg/dl, while hyperuricemia in adult women occurs when the serum uric acid level is above 6.0 mg/dl. Hyperuricemia therapy management in the community is very diverse, ranging from traditional medicines and synthetic drugs. One of the traditional plants used as traditional medicine is pandan leaves. This study aimed to determine the anti-hyperuricemia effect of ethanol extract of Pandanus amaryllifolius leaves on mice (Mus musculus L.). The study involved 25 male mice which were divided into 5 groups; each group consisted of five male mice. Group I was a negative control with Na-CMC 1% w/v, while Group II was a positive control with Allopurinol 0.117 g w/v. Further, Groups III, IV, and V were given Ethanol Extract of 0.5 gr w/v, 1 g w/v, 1.5 g w/v of Pandan Leaves, respectively. The results showed that there was no significant decrease in uric acid levels in group I. Meanwhile, Groups II, III, IV, and V showed a significant reduction in uric acid levels with identical effectiveness. The results of the study were then tested using the One-Way ANOVA statistical test; the p-value was 0.01 (α 0.01). The best dose was 1.5 g of extract since there was a significant difference from the pandan leaves extract with 1.5 g (p 0.01). In conclusion, pandan leaves extract can reduce uric acid levels in the blood. This was evidenced by a decrease of 4.1 mg/dl in uric acid levels in mice during the experiment.
Co-Authors Andi Makkulawu Endah Nurrohwinta Djuwarno Madania, Madania Mahdalena Sy Pakaya Nur Rasdianah Papeo, Dizky Ramadani Putri Selvi Marcellia Teti Sutriyati Tuloli