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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Medical Journal of Indonesia Jurnal Farmasi Klinik Indonesia Jurnal Untuk Masyarakat Sehat (JUKMAS) Indonesian Journal of Pharmaceutical and Clinical Research Journal of Social Research Indonesian Journal of Biomedicine and Clinical Sciences Indonesian Journal of Pharmacology and Therapy
Abraham Simatupang
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Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Alpha-lipoic acid and stem cell approach for chronic diseases Simatupang, Abraham
Medical Journal of Indonesia Vol 20, No 2 (2011): May
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (76.827 KB) | DOI: 10.13181/mji.v20i2.549

Abstract

[No Abstract Available]
Utilization of Statins, an HMG-CoA reductase inhibitors, in Ambon District Hospital, Maluku: a retrospective study Simatupang, Abraham; Huningkor, Yusuf; Gasperz, Westi C; Nindatu, Maria; Noya, Farah; Sanaky, Marliyati; Hutagalung, Inggrid; Yolanda, Denny; Kailola, Natalie
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 2 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (306.282 KB) | DOI: 10.19106/JMedSci005002201810

Abstract

Non-infectious diseases, including hypercholesterolemia, are now ranked top 10 inIndonesia. Statins are inhibitors of HMG-CoA reductase, an enzyme for biosynthesis ofcholesterol in the liver. Statins have been proven to reduce the risk of death due to CHDand mortality from various reasons. The objective of the study is to know the utilizationof statins in peripheral area of Indonesia. This retrospective study on utilization of statinsprescribed for hypercholesterolemia was taken from medical record year of 2014-2015of a District Hospital – Dr. Haulussy, Ambon, and Maluku. We collected demographicdata, pre- and treated concentrations of total cholesterol (TC), low-density lipoproteincholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG),types and dosages of statins or other lipid-lowering medications given. Student t-testusing was performed to check statistical differences for all cholesterol and TG differencesprior to therapy versus during treatment. Eighty three respondents consisted of 26 men(31.3%) and 57 women (68.7%) with mean age 60 ± 11 years old. The pre-treatment/post-treatment values (mg/dL) of TC: 245.22 ± 51.40/224.97 ± 98.79 (p=0.004);LDL-C: 166.07 ± 45.36/146.00 ± 41.07; HDL-C: 54.52 ± 37.95/43.00 ± 0.00; andTG: 177.36 ± 103.25/121.00 ± 52.87, respectively. Seventy-nine patients (95.2%)were treated with statins. The dosage given were 10 mg (n=19, 22.9%), 20 mg (n=63, 75.9%), and 40 mg (n=1, 1.2%). Twenty-eight patients (33.7%) had no posttreatmentdata of cholesterol, and 31 out of 55 patients (56%) were responders. Allcholesterol levels were decreased, but responder rate was only 56%. Therefore, dosageadjustment and prerequisite cholesterol level during and post-treatment measurementshould be made regularly.
Hubungan Indeks Massa Tubuh, Aktivitas Fisik dan Asupan Makan Dengan Hipertensi Pada Lanjut Usia Desta, Desta Ayu; Indrawati, Lili; Tapal, Zarfiel; Simatupang, Abraham
Jurnal Untuk Masyarakat Sehat (JUKMAS) Vol 8, No 2 (2024): Jurnal Untuk Masyarakat Sehat (JUKMAS)
Publisher : LPPM Universitas Respati Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52643/jukmas.v8i2.4807

Abstract

Perubahan fisik pada lansia dapat memicu penyakit tidak menular (PTM) dan degeneratif khususnya hipertensi. Penelitian kuantitatif dengan rancangan studi kasus kontrol ini bertujuan menjelaskan hubungan antara variabel Indeks Massa Tubuh, Aktivitas Fisik Dan Asupan Makan dengan hipertensi pada lansia. Sampel penelitian yakni lanjut usia di kelurahan Jatiwaringin, Kota Bekasi. Penelitian dilakukan pada bulan April – Mei 2024 pada berjumlah 126 responden terdiri dari 63 kasus dan 63 kontrol. Kriteria inklusi kelompok kasus adalah lansia yang berdomisili di satu RT 04 Kelurahan Jatiwaringin dan didiagnosis oleh tenaga medis (dokter) menderita hipertensi, sedangkan untuk kelompok Kontrol adalah lansia berdomisili di RT 004 Kelurahan Jatiwaringin lokasi yang sama, tidak memiliki riwayat hipertensi dan saat diteliti memiliki tekanan darah normal (sistolik
Perception and use of herbal medicine by Indonesian Medical Doctors Simatupang, Abraham; Widyawati, Tri; Susilaningsih, Neni; Tobing, Romauli; Kurniaty, Linggom; Silaban, Hertina; Djojosaputro, Mulyadi; Mahabuana, Bintang
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 1 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i1.15768

Abstract

Indonesia has a long experience in traditional medicine such as jamu. The government has been encouraging all sectors, especially pharmaceutical industries together with research institutions and academia to increase herbal medicine research so that herbal medicine is increasingly used in health services, including by medical doctors. Various efforts have been made but empirically it seems that this goal has not been achieved. For this reason, it is necessary to conduct a survey to determine the understanding and use of herbal medicine among doctors. I was a cross-sectional study using an electronic questionnaire distributed to doctors who are members of the Indonesian Medical Association (IMA) per province. Three-hundred sixty-two respondents from 29 out of 38 (76%) provinces of Indonesia responded, and 263 out 362 respondents (72%) are general practitioners. In prescribing herbal medicines only 18.5% prescribed, 35% did not and 46.6% sometimes prescribed, respectively. Of the eleven phytopharmaceuticals/standardised herbal medicines only one medicine No. 5 was widely recognized by respondents (46.6%). This study showed that doctors' understanding of herbal medicine still needs to be improved through various means including webinars/seminars, journals that show good clinical trials so that they are more confident when prescribing herbal medicine to their patients. There is a need for more comprehensive information regarding the indications, efficacy and side effects of herbal medicine, through books or formularies that can be accessed by doctors. In addition, respondents agreed that herbal medicine should be taught in medical schools both in the pre-clinical and clinical phases.
Effect of Poor Glycemic Control with Length of Pulmonary Tuberculosis Treatment in Type 2 Diabetes Mellitus Patients Widihastuti, Anastasya; Sirait, Robert Hotman; Simatupang, Abraham; Idhayu, Adeputri Tanesha
Indonesian Journal of Clinical Pharmacy Vol 12, No 1 (2023)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2023.12.1.1

Abstract

Type 2 Diabetes Mellitus (T2DM) is one of the leading risk factors in developing Pulmonary Tuberculosis (PTB) and associated with a higher risk in recurrence, treatment failure, and MDR-TB. Duration of PTB treatment usually takes six months with first line regimen, however in uncontrolled blood glucose confirmed by HbA1c, Fasting Blood Glucose (FBG), and Postprandial Glucose (PPG) the treatment takes longer than usual because of the difficulty to achieve an optimal management in both diseases. The aim of this study was to assess the correlation between glycemic control and duration of anti-tuberculosis treatment at Persahabatan General Hospital, Jakarta in 2019-2021. It was a non-experimental study with analytical observational design and retrospective approach by using medical records. Data were analyzed descriptively and by the chi square method. Odds ratio and relative risk measure the association between duration of treatment in PTB patients and their gylcemic controls. The results showed that 57 PTB patients with T2DM (69.5%) received nine months course of anti-tuberculosis therapy. Most patients tend to have poor glycemic control shown by HbA1c level >7% (79.3%), FBG >130 mg/dL (72%), and PPG >180 mg/dL (80.5%). Correlation between glycemic control and duration of PTB treatment are significant shown by p-value result 0,001. The OR result was found to be 8.74 (95% CI 2.45-31.11) which indicate that patients with poor glycemic control have a greater risk to experience longer duration of PTB treatment. In conclusion, duration of PTB treatment are mostly done in more than six months due to poor glycemic control.
HISTOPATHOLOGICAL PICTURE OF THE PANCREAS OF MICE (MUS MUSCULUS) DIABETES INDUCED BY STREPTOZOTOCIN-SUKROSA BY GIVING PEPAYA SEED EXTRACT (CARICA PAPAYA L.) Sitompul, Fransiska; Christy, Chatrine Angelica Dwi; Sani, Yulvian; Simatupang, Abraham
Journal of Social Research Vol. 3 No. 3 (2024): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v3i3.1962

Abstract

This study aimed to investigate the potential of papaya seed extract as an antihyperglycemic agent and to determine the histopathological features of the pancreas of female mice induced by streptozotocin-sucrose. The study used female DDY mice and divided them into five groups, including a negative control group, a positive control group, and three test groups given different doses of papaya seed methanol extract. The parameters measured were the decrease in fasting blood glucose levels, the number, diameter, and area of the islets of Langerhans in each group. The data was analyzed using the one-way ANOVA method with a confidence level of 95% followed by a comparison test using the Least Significant Difference method. The results showed that the methanol extract of papaya seeds has the potential to reduce blood glucose levels and improve the histological structure of the pancreas of diabetic mice induced by streptozotocin-sucrose at an optimum dose of 100 mg/kgBW. There was a significant difference in reducing blood glucose levels between the negative control group and the test group given 100 mg/kgBW papaya seed methanol extract after seven days of treatment. After fourteen days, there was a significant difference between the negative control group and test groups I, II, and III. Although no significant differences were found in the number, diameter, and area of the islets of Langerhans through morphometric photo testing, microscopic photo testing showed that test group I had the best histopathological picture with no vacuolization and necrosis found.
Comparison of antihypertensive drug utilization in community health centre and type B teaching hospital Sitorus , Tromphin; Simatupang, Abraham
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 6 No. 1 (2023): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v6i1.11982

Abstract

Antihypertensive medicine is one of the many complex factors contributing to the sustained rise in hypertension prevalence, which remains a global health concern. The Social Security Agency on Health, or Badan Penyelenggara Jaminan Social (BPJS) Kesehatan, in Indonesia is an integrated healthcare system that provides universal healthcare to its citizens. This retrospective cross-sectional study examined the use of antihypertensive medications covered by BPJS between January and December 2021 at the Rawabuntu Primary Health Centre and the Universitas Kristen Indonesia (UKI) type B public hospital. The necessary data was extracted from the medical files of 192 hypertensive patients. The patients' characteristics were analysed descriptively. The rationality of antihypertensive medication use was evaluated in accordance with Association of Indonesian Hypertension Physicians-approved guidelines. The majority of patients in both categories were female (52.1 percent at the Rawabuntu Primary Health Centre and 60 percent at the teaching facility). In both healthcare facilities, the correct indication, patient, and dosage were administered 100 percent of the time, according to this study. While only 66.7% and 85.4% of patients at the Rawabuntu Primary Health Centre and UKI hospital received the correct drug category, respectively. The rational use of antihypertensive medications was substantially lower at the Primary Health Centre than it was at the UKI Hospital (p = 0.001).
Evaluation of administration and use of antihypertensive drugs in severe preeclampsia patients at X General Hospital in Jakarta Simatupang, Abraham; Ida Bagus Sutha Dwipajaya
Indonesian Journal of Pharmacology and Therapy Vol 2 No 2 (2021)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.1347

Abstract

The high number of maternal mortality rate (MMR) is still a problem in Indonesia. Three ethyologies of maternal death are infection (12%), hypertension in pregnancy (25%) and bleeding (30%). Pre-eclampsia as a form of hypertension during pregnancy requires antihypertensive drug therapy. Rationality assessment for any kinds of pharmacotherapy is based on the right indication, the right medicine, the right patient, and the right dose. The main indication for antihypertensive medication in pregnancy is applied to the mother’s in preventing cerebrovascular disease. The aim of this study was to evaluate the characteristics, patterns and accuracy of the administration and use of antihypertensive drugs in patients with severe preeclampsia at X General Hospital in Jakarta in 2018. It was a non-experimental study with a descriptive and retrospective design using medical records. Administration and use of antihypertensive drugs in patients with severe preeclampsia at the X General Hospital in Jakarta showed 91.9% right indication, 86.72% right drug, 96.9% right patient and only 5.26% right dose with 4.0% accuracy of rational administration and use of drugs. In conclusion, the right dose in the management of patients with severe preeclampsia in X General Hospital in Jakarta is still low. Further training and close monitoring and evaluation on the rational use of antihypertension in severe preeclampsia is needed.
Knowledge of hypertension and its therapy in lay people Simatupang, Abraham; Sitompul, Fransiska; Kurniaty, Linggom; Djojosaputro, Mulyadi; Lumbantobing, Romauli; Silaban, Hertina
Indonesian Journal of Pharmacology and Therapy Vol 3 No 3 (2022)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.4468

Abstract

Hypertension is one of the non-communicable diseases that is becoming a global health problem. Hypertension can be identified by systolic blood pressure of 140 mmHg and diastolic 90 mmHg . Uncontrolled hypertension can lead to complications such as stroke, ischemic heart disease, heart attack, heart failure, kidney failure, blindness, etc. According to Basic Health Research 2018 ( Ris et Kesehatan Dasar 2018/Ris kesdas 2018) the prevalence of hypertension for >18 years old wa s 8.4%, and through measurements taken in health care facilities by 34.1%. Prevalence in the city was 34.4%, in the village was 33.7%, while according to gender 31.3% f or male and 36.9% for female. The study aimed to find out the knowledge and awareness of laypeople on hypertension and its therapy. This was a cross-sectional online study with 11 questions. Respondents were recruited from social media groups. The results showed 5 00 respondents (62.8 % female and 37.2 % male) involved in this study . The most common age range was 21-40 years (36.2 %), followed by 41-55 years (38.2%) , and the least was 56-65 years old (18.4%). Seventy-two percent of respondents did not have hypertension, and 9% said they did not know. Fifty-three percent of respondents knew about the value of high blood pressure, and 89% of the respondents said hypertension should be treated regularly. The most hypertension complications answered by respondents were stroke (40%), heart attack (26%) , and heart failure (16%). Amlodipine was the most mentioned by the respondents, and the second was ACE-inhibitor. However, omeprazole and omega-3 were also mentioned as anti-hypertension. Genetic s and a high salt diet were risk factors that many respondents chose. In conclusi on, the r espondents have a good understanding of hypertension. Information related to behaviour is needed to discontinue the increasing prevalence.
Co-Authors Adeputri Tanesha Idhayu Christy, Chatrine Angelica Dwi Desta, Desta Ayu Farah Christina Noya Gasperz, Westi C Huningkor, Yusuf Hutagalung, Inggrid Ida Bagus Sutha Dwipajaya Kailola, Natalie Kurniaty, Linggom Lili Indrawati Lumbantobing, Romauli Mahabuana, Bintang Mulyadi Djojosaputro, Mulyadi Neni Susilaningsih Nindatu, Maria Sanaky, Marliyati Silaban, Hertina Sirait, Robert Hotman Sitompul, Fransiska Sitorus , Tromphin Tapal, Zarfiel Tobing, Romauli Tri Widyawati, Tri Widihastuti, Anastasya Yolanda, Denny Yulvian Sani