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Institut Kesehatan Medistra Lubuk Pakam
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Physics test of water in refill drinking water in Tanjung Morawa Sub-district, Deli Serdang District Ajeng Prahesti; Yosi Darmirani; Suprianto
Medistra Medical Journal (MMJ) Vol 2 No 2 (2025): Medistra Medical Journal (MMJ)
Publisher : Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/mmj.v2i2.2375

Abstract

Introduction: Humans use water to fulfill various daily needs. Each individual's water needs vary from one location to another and at each level of demand. The higher the standard of living in a place, the greater the need for water. Objective:  This study aims to examine the quality of water in several depots in Tanjung Morawa District. Method: The method used in this study is a gravimetric method in which the parameters measured determine the quality of water, namely TDS (Total Dissolved Solid) and TSS (Total Suspended Solid). Then measure the pH using a universal pH indicator, litmus paper and a pH meter. As well as the measurement of taste and turbidity. Result: The results of this study indicated that 8 out of 9 samples of TDS levels had levels higher than the maximum 2010 PERMENKES quality standard, namely 500 mg/L. TSS (Total Suspend Solid) is still lower when compared to the maximum standard content of refill drinking water stipulated by SNI (Indonesian National Standard) for clean water, which is 50 mg/L. The pH level is within normal limits, there is a sweet taste in drinking water and at turbidity levels clear drinking water has particles and is clear without particles.
Analisis Vitamin C Daging dan Kulit Buah Semangka Merah dan Kuning (Citrullus vulgaaris Schard) dengan Spektrofotometri UV Lidiya Sasmaita Sihotang; Suprianto; Samran; Debi Meilani
Jurnal Indah Sains dan Klinis Vol 5 No 2 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i2.06

Abstract

Latar Belakang: Iklim tropis negara Indonesia karena terletak di daerah khatulistiwa yang memberi peluang berbagai tanaman tumbuh dengan subur, termasuk buah-buahan. Umumnya, vitamin C merupakan salah satu kandungan yang terdapat pada buah-buahan, yang berperan sebagai antioksidan. Sekian banyaknya buah-buahan, slah satunya buah semangka (Citrullus vulgaris Schard). Buah semangka juga dimanfaatkan untuk menurunkan tekanan darah bagi penderita hipertensi, karena kandungan air dan kaliumnya yang tinggi sehingga mampu menstabilisasikan tekanan darah. Tujuan: Tujuannya untuk mendeteksi keberadaan dan kuantitas vitamin C pada daging dan kulit buah semangka merah dan kuning. Metode: Metode yang digunakan meliputi uji kualitas dan kuantitas masing-masing dengan pereaksi warna dan spektrofotometri UV. Hasil: Penelitian memberi informasi pada daging dan kulit buah semangka terdapat vitamin C dengan tanda ada perubahan warna maupun pengendapan kuning-merah bata dan coklat. Vitamin C dari daging dan kulit buah semangka merah dan kuning masing-masing adalah 50,688; 42.482; 34.764; dan 42,152 gr/L. Kesimpulan: Daging maupun kulit buah semangka merah dan kuning ditemukan vitamin C.
Skrining Fitokimia, Profil Kromatografi Lapis Tipis dan Karakterisasi FTIR Ekstrak Etanol Daun Rambutan (Nephelium lappaceum L.) Adinda Seftia; Suprianto; Effendy De Lux Putra; Samran; Siti Nurbaya
Jurnal Indah Sains dan Klinis Vol 6 No 3 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i3.02

Abstract

Background: Rambutan (Nephelium lappaceum L.) leaves have potential as a source of bioactive secondary metabolites, yet baseline data on their preliminary chemical profile and functional-group features are still limited. Objective: This study aimed to (i) screen the phytochemical constituents of rambutan leaf ethanol extract, (ii) verify major metabolite classes using thin-layer chromatography (TLC), and (iii) characterize dominant functional groups by Fourier Transform Infrared (FTIR) spectroscopy. Method: Dried rambutan leaves collected from Langkat Regency and Binjai City were extracted by maceration with 96% ethanol (1:10; 3×24 h), followed by remaceration (1×24 h). The filtrate was concentrated at 58 °C. Qualitative tests were conducted for alkaloids, flavonoids, tannins, saponins, and steroids. TLC analysis employed silica gel 60 F254 plates with class-specific mobile phases, while FTIR spectra were recorded in the range of 4000–600 cm⁻¹. Results: The extract yield was 25.7%. Phytochemical screening confirmed the presence of alkaloids, flavonoids, tannins, saponins, and steroids, with TLC Rf values of 0.70 and 0.46 (alkaloids), 0.80 (flavonoids), 0.70 (tannins), and 0.50 (steroids). FTIR bands at 3365 cm⁻¹ (O–H), 3010 cm⁻¹ (aromatic C–H), 1629 cm⁻¹ (C=C), and 1048 cm⁻¹ (C–O) indicated oxygenated secondary metabolites, particularly phenolic-related compounds. Conclusion: The integrated phytochemical screening, TLC, and FTIR approach provides a concise chemical baseline for rambutan leaf ethanol extract, supporting its potential use in further standardization and marker-based studies.
Aktivitas Antibakteri Kombinasi Ekstrak Etanol Daun Kumis Kucing (Orthosiphon aristatus) dan Daun Mangga Madu (Mangifera indica L.) terhadap Propionibacterium acnes Agus Kristina; Suprianto; Debi Meilani; Andy Febriadi; Shofian Syarifuddin
Jurnal Indah Sains dan Klinis Vol 6 No 3 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i3.03

Abstract

Background: Acne is strongly linked to the overgrowth of Propionibacterium acnes. Because long-term use of conventional antibacterials may contribute to resistance and irritation, plant-derived extracts are being explored as alternative or complementary options. Kumis Kucing (Orthosiphon aristatus) and Mangga Madu (Mangifera indica L.) leaves are known to contain secondary metabolites that may help suppress bacterial growth. Objective: This study aimed to evaluate the antibacterial effect of combined ethanol extracts of O. aristatus and M. indica leaves against C. acnes and to determine which formulation ratio produced the best inhibition. Method: Each plant material was extracted separately using ethanol, then blended into five different combination formulas (F1–F5). Antibacterial activity was assessed in vitro using the disc diffusion technique with a standardized inoculum (0.5 McFarland). The diameter of the clear zone around each disc was measured and used to categorize antibacterial strength. Results: Qualitative phytochemical screening confirmed that both extracts contained key metabolite groups, including alkaloids, tannins/phenolics, flavonoids, and saponins. The negative control showed no clear zone, while clindamycin (positive control) produced a strong inhibition zone of 19.2 mm. All combined formulas inhibited C. acnes, with inhibition zones between 8.6 mm and 11.5 mm. Formula 3 generated the widest zone (11.5 mm; strong category), whereas Formula 2 showed the smallest inhibition (8.6 mm; weak category). Conclusion: The ethanol extracts of O. aristatus and M. indica leaves, when combined, were able to inhibit C. acnes. The level of inhibition varied with the mixing ratio, and Formula 3 demonstrated the most promising antibacterial activity among the tested formulations
Penetapan Kadar Total Fenol dan Total Flavonoid pada Lotion Berbahan Ekstrak Daun Sisrsak (Annona muricata) dan Kulit Buah Naga Merah (Hylocereus polyrhizus) Menggunakan Spektrofotometri UV–VIS Suci Rahmadani Siregar; Suprianto; Chandra Pranata; Intan Coni Caroline Marbun
Jurnal Indah Sains dan Klinis Vol 6 No 3 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i3.04

Abstract

Background: Phenolic and flavonoid compounds from soursop (Annona muricata) leaves and red dragon fruit (Hylocereus polyrhizus) peel have potential applications in lotion formulations; therefore, their quantification is important for quality evaluation. Objective: To determine total phenolic content (TPC) and total flavonoid content (TFC) in lotion formulations containing combined plant extracts and to assess the analytical method performance. Method; Four formulations were prepared: F0 (without extract), F1 (0.5% + 0.5%), F2 (1.0% + 1.0%), and F3 (1.5% + 1.5%). TPC was measured using the Folin–Ciocalteu method (mg GAE/g) and TFC using the AlCl₃ colorimetric method (mg QE/g). Method validation included repeatability (%RSD, n = 6) and spike-recovery accuracy at 80–120%. Results: The method showed good precision (%RSD 1.08% for TPC and 1.21% for TFC) and acceptable accuracy with recoveries of 98–102%. F0 showed non-detectable values, while increasing extract concentration resulted in higher TPC (3.82 ± 0.14 to 9.71 ± 0.33 mg GAE/g) and TFC (0.86 ± 0.05 to 2.35 ± 0.10 mg QE/g). Differences among formulations were statistically significant (p < 0.05). Conclusion: The UV–Vis method is suitable for determining TPC and TFC in lotion matrices, and higher levels of combined extracts significantly increase both parameters, supporting their use for quality standardization of herbal lotions.
Formulasi Sediaan Lotion Antioksidan Ekstrak Daun Sirsak (Annona muricata L.) dan Ekstrak Kulit Buah Naga Merah (Hylocereus polyrhizus) sebagai Pelembab Sumardi; Suprianto; Innayah Azzahra; Lisa Syafrida
Jurnal Indah Sains dan Klinis Vol 6 No 3 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i3.05

Abstract

Background: A lotion made from ethanol extracts of Sirsak (Annona muricata) leaves and Naga Merah fruit (Hylocereus polyrhizus) peels is a potential antioxidant moisturizer, but its quality, safety, and hydration effect need confirmation. Objective: To formulate five oil-in-water lotions with different extract ratios (total extract 3% w/w) and evaluate physical quality, preliminary safety, and moisturizing performance. Method: The formulations were tested for organoleptic properties, homogeneity, pH, and spreadability. A simple irritation test and a three-day forearm hydration assessment using a skin analyzer were conducted in 25 panelists, followed by one-way analysis of variance. Results: All formulations had pH 6.67–6.96, with minor inhomogeneity observed in one formulation. Acceptable spreadability was achieved by three formulations under specific loads. No irritation occurred. All formulations increased hydration, with significant differences between them (p < 0.001); the two best-performing formulations produced the highest and most stable moisture over three days. Conclusion: The combined-extract oil-in-water lotion at 3% w/w is feasible and preliminarily safe, and the two top formulations are recommended for further development
Co-Authors Adinda Seftia Agus Kristina Ajeng Prahesti Andy Febriadi Chandra Pranata Debi Meilani Effendy De Lux Putra, Effendy De Lux Innayah Azzahra Intan Coni Caroline Marbun Lidiya Sasmaita Sihotang Lisa Syafrida Samran, Samran Shofian Syarifuddin Siti Nurbaya Suci Rahmadani Siregar Sumardi Yosi Darmirani