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All Journal Majalah Patologi Indonesia The New Ropanasuri Journal of Surgery The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Marini Stephanie
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Akurasi Diagnosis Pemeriksaan Biopsi Aspirasi Jarum Halus Tumor Tulang di Departemen Patologi Anatomik FKUI/RSCM Tahun 2015- 2019 Putri, Vabiayu; Stephanie, Marini
Majalah Patologi Indonesia Vol. 31 No. 1, Januari 2022
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v31i1.491

Abstract

BackgroundFine needle aspiration biopsy (FNAB) is a safe and rapid technique and has an important role in making the preoperative diagnosisof bone tumors because it can help clinicians determine treatment for patients. This retrospective study aims to assess the accuracyof the FNAB cytological examination compared with the histopathological examination in preoperative diagnosis of bone tumors.MethodsThe data comes from the archives of the Department of Anatomic Pathology, FKUI/RSCM 2015-2019 in the form of a cytologicalexamination of FNAB lesions on bone. Then the histopathological examination data were searched for each cytology preparation.There were 133 pairs of cytology, and histopathology preparations. The preparations were reviewed by the investigator andsupervisor, assessed for the suitability of the cytologic diagnosis, and compared with the histopathological diagnosis.ResultsThere were 84 (63.2%) cases of malignant tumors, 44 (33.1%) cases of benign tumors, and 5 (3.7%) cases of non-tumors. Thediagnostic test results showed an accuracy rate of 86.5% with a sensitivity of 85.9%, a specificity of 100%, a positive predictivevalue (PPV) of 100%, and a negative predictive value (NPV) of 21.7%.ConclusionFNAB cytology examination of bone tumors that have adequate sample quality, supported by complete clinical information andinformative radiological images can produce an accurate preoperative diagnosis
Profil ekspresi von Hippel-Lindau (pVHL) pada adenokarsinoma duktal pankreas dan jaringan pankreas non-neoplastik serta hubungannya dengan faktor klinikopatologi Prisscila, Jessica; Stephanie, Marini; Rahadiani, Nur; Manatar, Amelia Fossetta; Krisnuhoni, Ening
Majalah Patologi Indonesia Vol. 35 No. 1 (2026): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v35i1.658

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Introduction Pancreatic malignancy, primarily Pancreatic Ductal Adenocarcinoma (PDAC), presents a significant challenge due to its aggressive nature and late-stage diagnosis. This study explores the role of von Hippel-Lindau gene product (pVHL) in PDAC and non-neoplastic pancreatic tissues, investigating their relationship with PDAC clinicopathological characteristics. Method This research was carried out at the Faculty of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital.   The cases analyzed spanned from January 2012 to September 2023. Immunohistochemistry of pVHL was used, and the Histoscore/H-score calculations were utilized to classify pVHL expression as either high or low. Results A total of 54 cases of PDAC and non-neoplastic pancreatic tissue exhibited varying levels of pVHL expression. Cases of PDAC with positive surgical margin, absence of lymphovascular and perineural invasion, pT2, pN0, M0 stage, and survival exceeding 7 months were the profiles in which low pVHL expression was detected. Significant result was found on the correlation between pVHL with pN status. Conclusion The levels of pVHL expression varied between PDAC and non-neoplastic pancreatic tissue. There were no differences in the clinicopathological profile of PDAC tumors, except for pN stage. Further research, with a larger sample size, is needed to determine pVHL's diagnostic value and its expression in different clinicopathological profiles.
Effect of Everolimus on the Liver Function of Children Receiving Liver Transplant with Chronic Rejection: An Evidence–Based Case Report Puruboyo, Adi ND; Rahayatri, Tri H; Stephanie, Marini
The New Ropanasuri Journal of Surgery Vol. 8, No. 2
Publisher : UI Scholars Hub

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Abstract

Introduction. Chronic rejection, a complication after pediatric living donor liver transplantation (LDLT), is challenging to treat as management generally requires retransplantation. However, retransplantation is avoided because of rejection risks, longer operating time, higher mortality, and lower survival rates. Immunosuppressant therapy has potential as an option for nonsurgical treatment. Everolimus, a mammalian target of rapamycin inhibitors (mTOR inhibitors), is a well-known immunosuppressant in treating chronic rejection of LDLT. However, studies in the pediatric field remain minimum. Method. The discussion was based on evidence found from studies found through a systematic literature search. These three studies showed permanent liver function improvement after LDLT on immunosuppressant therapy without Everolimus. Liver function and fibrosis stability improved without mortalities. Differences in Everolimus’ efficacy in improving liver function due to the lack of facility to control Everolimus level in the blood resulted in overwhelming infection due to over-immunosuppression of this drug since Everolimus has a narrow therapeutic range. Conclusion. The administration of Everolimus pediatric after living donor liver transplantation reduces ALT and AST levels and improves fibrosis stability.
Co-Authors Alif Gilang Perkasa Anak Agung Istri Sri Wiadnyani Bayu Perkasa Rosari Chairil Hamdani Dhuhani, Ika Diah Rini Handjari Diah Rini Handjari Ening Krisnuhoni Handjari, Diah R. Hanifah Oswari Linggodigdo, Michelle Lisnawati - Manatar, Amelia Fossetta Michelle Linggodigdo Nur Rahadiani Nurjati C. Siregar Perkasa, Alif Gilang Prisscila, Jessica Puruboyo, Adi ND Putri, Vabiayu Rahadiani, Nur Rahayatri, Tri H Rahmiati - Ria Kodariah Rosari, Bayu Perkasa Sarwanti Sufangga, Fili Toar J.M. Lalisang Vabiayu Putri Wijaya, Yan Cahya Yan Cahya Wijaya Yefta Moenadjat