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All Journal Jurnal Ilmu Kefarmasian Indonesia Lansau: Jurnal Ilmu Kefarmasian
Sundani Nurono Soewandhi
Sekolah Farmasi ITB Bandung
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Pembuatan dan Karakterisasi Ko-kristal Flukonazol-Resorsinol Fikri Alatas Alatas; Hestiary Ratih; Titta Hartyana Sutarna; Yoga Windu Wardhana; Dini Tereslina; Sundani Nurono Soewandhi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 2 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v18i2.779

Abstract

Fluconazole (FLU), an oral antifungal widely used in the treatment of vaginitis andcandidiasis, is known to have low bioavailability due to its low solubility. The purpose of this studywas to prepare and characterize co-crystal fl uconazole-resoscinol (FLU-RES). The preparation ofco-crystal was performed by grinding together the equimolar mixture of FLU-RES which is drippedwith a few ethanol. Powder X-ray diff raction, diff erential scanning calorimetry (DSC), and polarizedmicroscopy methods were performed to characterize the formation of FLU-RES co-crystal. Relevantphysicochemical properties include solubility tests in water and dissolution tests in pH 1.2; 4.5 and6.8 buff er solution. The powder X-ray diff ractogram of FLU-RES milled result showed the presenceof new peaks and loss of the main peaks of FLU and RES. The characterization of grinding result byDSC and polarized microscopy methods also showed the co-crystal formation between FLU and RES.The solubility of FLU-RES co-crystal in water is solubility two folds more than pure FLU, while itsdissolution rate is 1.67-1.72 times faster than pure FLU.
Pengaruh Disintegran dan Cara Pencampuran Terhadap Sifat Fisika Kimia Telmisartan Hestiary Ratih; Fikri Alatas; Jessie Sofia Pamudji; Sundani Nurono Soewandhi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.1013

Abstract

Telmisartan (TMS) has a compact structure and is interlocked between crystal units. As a result, the substance has a high electrostatic force, which causes TMS to sintering when compressed into tablets. One method of overcoming sintering on TMS tablets is to add a disintegrant to the compressed tablet. The disintegrants used are derived from starch groups: Starch 1500® (S1500) and sodium starch glycolate (SSG), as well as microcrystalline cellulose (MCC) and croscarmellose sodium (CCS) groups. The purpose of this study was to examine the effects of several disintegrants on the dissolution and physicochemical properties of TMS with various treatments. TMS was varied with each disintegrant at a ratio of 1:9 % b/b. The treatment of TMS binary mixtures with various disintegrants includes physical mixtures, milled mixtures, compressed mixtures, and crushed compressed mixtures. Characterization and evaluation include PXRD and SEM testing as well as dissolution test. The characterization of PXRD and SEM in various treatments showed the effect of physicochemical properties on the TMS binary mixture with various disintegrants. The combination of TMS:CCS with a ratio of (1:9) resulted in the highest dissolution rate in all treatments.The treatment of the milled mixture produced the highest dissolution with DP60 minutes, which was around 55.86±2.47%. The addition of disintegrants to TMS with various treatments may reduce sintering but is not sufficient to meet the requirements for TMS dissolution, which dissolves within 30 minutes in phosphate buffer medium pH 7.5 with Q>75%.
Preparasi dan Karakterisasi Interaksi Antarmolekular Glimepirid dan Metformin HCl dengan Metode Solvent Drop Grinding Sitti Raodah Nurul Jannah; Sundani Nurono Soewandhi; Rachmat Mauludin; Handoyo Sahumena, Muhamad
Lansau: Jurnal Ilmu Kefarmasian Vol. 2 No. 1 (2024): Lansau: Edisi April 2024
Publisher : Fakultas Farmasi Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33772/lansau.v2i1.21

Abstract

Interaksi antar molekular dari campuran glimepirid (GMP) dan metformin HCl (MET) dapat menyebabkan perubahan pada sifat fisikokimia komponen penyusunnya. Telah dilakukan penelitian tentang karakterisasi interaksi antar molekular menggunakan metode solvent drop grinding (SDG). Metode SDG digunakan sebagai identifikasi awal pembentukan interaksi antar kedua komponen dengan rasio perbandingan molar GMP: MET yaitu 1:1. Karakterisasi interaksi antar molekular GMP-MET meliputi pengamatan habit Kristal menggunakan mikroskop polarisasi, sifat termal menggunakan instrument TG/DTA, spektroskopi infra merah (FTIR), difraksi sinar-X serbuk (PXRD), scanning electron microcope (SEM), uji kelarutan dan uji disolusi. Hasil pengamatan habit Kristal menunjukkan. Diagram fase campuran GMP-MET menunjukkan terbentuknya dua puncak endotermik yang mengindikasikan adanya interaksi antarmolekular dengan titik lebur senyawa peritektikum yaitu 197,02 dan 216,64 °C. Analisis mikrofoto SEM menunjukkan perubahan habit dan morfologi kristal berupa tabular yang memanjang. Difraktogram sinar-X menunjukkan terjadi penurunan intensitas derajat kristalin dari kedua komponen, sedangkan spektra IR menunjukkan tidak adanya puncak khas baru atau pergeseran bilangan gelombang baik campuran fisik maupun hasil SDG. Profil disolusi GMP dalam medium dapar fosfat pH 7,4 meningkat dibandingkan dengan bentuk murni glimepirid. Hasil disolusi GMP tertinggi yaitu pada campuran GMP-MET hasil perlakuan metode SDG sebesar 57,33%.
Co-Authors Dini Tereslina Fikri Alatas Handoyo Sahumena, Muhamad Hartyana Sutarna, Titta Hestiary Ratih Jessie Sofia Pamudji Rachmat Mauludin Sitti Raodah Nurul Jannah Yoga Windu Wardhana