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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Althea Medical Journal Mutiara Medika: Jurnal Kedokteran dan Kesehatan The Indonesian Journal of Occupational Safety and Health Berkala Kedokteran Jurnal Respirasi (JR) Medica Hospitalia Jurnal Ners JOURNAL LA MEDIHEALTICO Jurnal Riset Indragiri
Ali Assagaf
Department Of Pulmonology And Respiratory Medicine, Faculty Of Medicine, Lambung Mangkurat Univesity, Ulin General Hospital, Banjarmasin
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Differentiation of Malignant Pleural Effusions from Lung Squamous Cell Carcinoma and Adenocarcinoma through FTIR Spectroscopy: A Prognostic Approach Madargerong, Vincentius Adrian; Suhartono, Eko; Oktaviyanti, Ika Kustiyah; Haryati, Haryati; Isa, Mohamad; Assagaf, Ali; Kusumawardhani, Erna; Nurrasyidah, Ira; Syafa’ah, Irmi
Jurnal Respirasi Vol. 11 No. 2 (2025): May 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.2.2025.114-122

Abstract

Introduction: Malignant pleural effusion (MPE) is common in cancer patients and is often caused by neoplastic involvement of the pleural surface. This study aimed to determine the utility of Fourier transform infrared spectroscopy (FTIR) spectral analysis and anatomical pathological differentiation in MPE, squamous cell carcinoma (SCC), and lung adenocarcinoma as prognostic predictors. Methods: This study used a cross-sectional design at Ulin General Hospital, Banjarmasin, involving advanced lung cancer patients with MPE. A non-probability sampling technique was used to recruit 30 patients. Fourier transform infrared spectroscopy was analyzed to evaluate anatomical pathology differentiation. Results: Differences were observed in the FTIR spectral ratios A1080/A1243 and A1080/A1170 between SCC and adenocarcinoma, with p-values of 0.026 and 0.022, respectively. Significant differences were also found in the A2959/A1545 ratio between well-differentiated and poorly differentiated adenocarcinomas, with a p-value of 0.023. The receiver-operating characteristic curve (ROC) indicated good predictive value for poorly differentiated adenocarcinoma at a cut-off value of 0.944, with a sensitivity of 50% and specificity of 100%. However, no significant correlation was found between FTIR absorbance and anatomical pathology differentiation in MPE due to SCC and lung adenocarcinoma. Conclusion: The FTIR spectral ratios A1080/A1243 and A1080/A1170 differentiate SCC from adenocarcinoma. Fourier transform infrared spectroscopy may be an adjunct to cytology, offering a more rapid and cost-effective method for differentiating MPE.
The Effect of Platinum-Based Chemotherapy in Advanced Non-Small Cell Carcinoma Lung Cancer (NSCLC) on Cardiovascular Events in Ulin Hospital Banjarmasin Widya Ramadhaniati; Erna Kusumawardhani; Haryati Haryati; Dwi Laksono Adi Putro; Moh. Isa; Ali Assagaf
Jurnal Ners Vol. 9 No. 2 (2025): APRIL 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i2.39470

Abstract

Chemotherapy for lung cancer can provide many benefits, but it also has side effects that cause side effects of treatment, one of which is in the field of cardiology. This study was conducted to assess the cardiovascular side effects of platinum-based chemotherapy in advanced stage non-small cell lung cancer. This research method uses a retrospective cohort design. Samples diagnosed with advanced stage KPKBSK who underwent first-line platinum-based chemotherapy underwent electrocardiography and echocardiography assessments at the beginning and after the fourth cycle or when cardiovascular disorders occurred to assess the incidence of atrial fibrillation, PAC, ST-T segment changes, prolonged QT, decreased EF and E/A ratio at Ulin Banjarmasin Regional General Hospital in April 2022-April 2023. The results of this study indicate that chemotherapy for lung cancer with hypertension has an effect on decreasing ejection fraction (p-value <0.05, OR: 0.409). In the group of lung cancer with coronary heart disease receiving chemotherapy, the incidence of atrial fibrillation increased (p-value <0.05, OR: 20). Furthermore, cardiovascular events such as atrial fibrillation increased (p-value <0.05, OR: 6.800) and PAC (p-value <0.05, OR: 6.800) in the squamous cell carcinoma and adenocarcinoma lung cancer groups (p-value <0.05, OR: 0.409). There was no decrease in the E/A ratio and prolonged QT with chemotherapy. The conclusion of this study is that there is no effect of platinum-based chemotherapy on cardiovascular events in advanced lung cancer, but administration to groups with comorbid hypertension and coronary heart disease has an effect on increasing cardiovascular events in lung cancer patients at Ulin Banjarmasin Hospital.
Co-Authors Aminuddin Kasim Arganita, Fidya Rahmadhany As Syifa Ulchairan Desi Rahmawaty Desi Rahmawaty Dewi Indah Noviana Pratiwi, Dewi Indah Noviana Dwi Laksono Adi Putro Eko Suhartono Eko Suhartono Elok Hikmatun Nikmah Erna Kusumawardhani Ferryansyah, Ferryansyah Fidya Rahmadhany Arganita Harnoto, Yulia Octaviany Haryati Haryati Haryati Haryati Ika Kustiyah Oktaviyanti Ira Nurrasyidah Isa Ansori Isa, Mohamad Juhairina, Juhairina Kusumawardhani, Erna Madargerong, Vincentius Adrian Meitria Syahadatina Noor Moh. Isa Mohamad Isa Mohammad Isa Muhamad Taufiqurrahman, Muhamad Pradana Maulana Putra Surachman Syafa’ah, Irmi Widya Ramadhaniati