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Nasution, Huwainan Nisa
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Relationship between Frequency of Sugar Sweetened-Beverages (SSB) Consumption and Prediabetes: Aim For Screening Prediabetes Among Medical Students Nasution, Huwainan Nisa; Febriyanti, Eka; Suryani, Des
Buletin Farmatera Vol 7, No 1 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i1.9439

Abstract

Sugar sweetened-beverages (SSB) is not only found in soft drinks, fruit juice drinks, or energy drinks, but also various drinks that are currently "trending" such as boba drinks with various flavors, coffee or milk coffee, even tea or milk tea with various flavors. The lifestyle of consuming drinks that are high in sugar will lead to a tendency to several diseases such as prediabetes, diabetes mellitus (DM), metabolic syndrome and cardiovascular disease. Prevention and screening of prediabetes and DM at a young age in Indonesia must be increased, especially in high-risk groups because most of the initial conditions of the disease are asymptomatic. The aim of this study is to analyze the association between frequency of sugar sweetened-beverages (SSB) consumption and prediabetes in medical students. This study was an observational analytic study with cross sectional design conducted at Medical Faculty Universitas Muhammadiyah Sumatera Utara. The subjects of this study was 70 subjects. Examination of frequency of SSB consumption was carried out with a validated questionnaire and food frequency questionnaire (FFQ) of nutrient intake for the past 24 hours. There is no significant relationship between gender, family history of DM, smoking history, physical activity and hypertension with prediabetes. However, there is a significant relationship between obesity and prediabetes with p value 0,010. Meanwhile, the relationship between frequency of SSB consumption and prediabetes showed with p 0.05. There is no significant relationship between frequency of SSB consumption and prediabetes, but there is significant relationship between obesity and prediabetes.
Perioperative Management of Systemic Lupus Erythematosus Patient with Perianal Abscess Complication due to Trauma Nasution, Huwainan Nisa; Rahmawati, Lita Diah
Buletin Farmatera Vol 6, No 3 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i3.7059

Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease that can damage organs and cells due to autoantibodies and immune complexes bound to tissue. Infection is a major source of co-morbid in patients with SLE. The infection has been the second major cause of death in SLE, after disease activity itself. Perianal abscess is part of anorectal abscess which can occur in patients that have a risk factor of trauma on the anorectal region. Management of the patient consists of non-operative and operative procedures. In SLE patients that undergo the operative procedure, it is necessary to do perioperative preparation to prevent post-operative complications such as "flare-up" condition due to SLE. Evaluation of medicines and adjustment of glucocorticoid dosage based on the risk of surgery is important in perioperative preparation.
Effect of Avocado Flesh (Persea Americana) Extract on HbA1c and Fasting Blood Glucose Levels in Type 2 Diabetes Mellitus Patients Rahman, Shahrul; Septina, Lina; Nasution, Huwainan Nisa
Jurnal Kesehatan Masyarakat Vol 20, No 1 (2024)
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v20i1.47573

Abstract

 Diabetes mellitus is a complicated necessitates ongoing medical attention and is a serious health problem that has grown to worrisome proportions. The study aimed to assess the avocado pulp extract’s glycemic control in individuals with type 2 diabetes mellitus (T2DM) in a clinical setting in 2023. From the Klinik IMAN database, patients 18 years with T2DM who had previously been treated with oral hypoglycemic medications were included. The index date—the first day that avocado pulp extract was consumed—was used to collect baseline data. A laboratory measurements analysis was used to evaluate the change in glycated hemoglobin (HbA1c) and fasting blood glucose levels after a month of consuming avocado pulp extract and placebo. At one month, the percentage of patients who achieved their goal HbA1c and fasting blood glucose levels was determined. Overall, 30 patients were included and had baseline HbA1c and fasting blood glucose levels values available. Added avocado flesh extract not associated with improved HbA1c (0.04 [95% CI: -0.22-0.30], p0.05) and fasting blood glucose levels values (0.85 [95% CI: - 24.7-26.4], p0.05) versus baseline at a month. Added avocado flesh extract not associated with improved glycemic control during a month of follow-up in patients with T2DM.
Identifikasi Prediabetes dan Edukasi Konsumsi Kopi Sehat sebagai Upaya Promotif Kesehatan Metabolik pada Pegawai Universitas Muhammadiyah Sumatera Utara (UMSU) Febriyanti, Eka; Nasution, Huwainan Nisa; Lufiana, Fadella
Jurnal SOLMA Vol. 14 No. 2 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/solma.v14i2.18849

Abstract

Background: Prediabetes merupakan kondisi awal gangguan metabolik yang ditandai dengan peningkatan kadar glukosa darah di atas normal namun belum memenuhi kriteria diabetes melitus. Deteksi dini terhadap prediabetes menjadi langkah penting dalam mencegah progresivitas penyakit menuju diabetes tipe 2. Di sisi lain, konsumsi kopi yang merupakan kebiasaan umum di kalangan masyarakat, termasuk pegawai perguruan tinggi, memiliki pengaruh terhadap metabolisme glukosa dan sensitivitas insulin, baik secara positif maupun negatif tergantung pada pola konsumsinya. Metode: Kegiatan pengabdian masyarakat ini bertujuan untuk mengidentifikasi status prediabetes pada pegawai Universitas Muhammadiyah Sumatera Utara (UMSU) melalui pemeriksaan glukosa darah puasa, serta memberikan edukasi tentang konsumsi kopi yang sehat dan berbasis bukti ilmiah. Metode yang digunakan meliputi penyuluhan interaktif dan pemeriksaan gula darah secara langsung menggunakan teknik spektofotometri kepada 48 orang pegawai UMSU. Hasil: Hasil kegiatan menunjukkan bahwa sebagian peserta memiliki kadar glukosa darah yang berada dalam rentang prediabetes, serta sebagian besar belum mengetahui hubungan antara konsumsi kopi dan kesehatan metabolik. Edukasi yang diberikan meningkatkan pemahaman peserta tentang pentingnya konsumsi kopi secara moderat dan disesuaikan dengan kondisi kesehatan masing-masing. Kesimpulan: Kegiatan ini dapat meningkatkan kesadaran serta mendorong perubahan gaya hidup sehat pada kalangan pegawai perguruan tinggi.
Upaya Promotif Kesehatan Metabolik melalui Identifikasi Prediabetes dan Edukasi Kopi Sehat pada Pegawai BKKBN di Sumatera Utara: Metabolic Health Promotion Efforts through Identification of Prediabetes and Healthy Coffee Education for BKKBN Employees in North Sumatra Nasution, Huwainan Nisa; Febriyanti, Eka; Lufiana, Fardella
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 10 No. 9 (2025): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v10i9.10058

Abstract

Prediabetes is a condition characterized by glucose or HbA1C levels that do not meet the criteria for diabetes but have abnormal carbohydrate metabolism that results in abnormal glucose levels between normoglycemia and diabetes. Early screening in young adults is an effort to prevent progression to diabetes mellitus. On the other hand, coffee consumption habits in young adults, including office workers, affect glucose metabolism and insulin sensitivity. This activity aims to identify prediabetes status in employees of Badan Kependudukan dan Keluarga Berencana Nasional (BKKBN) in North Sumatra through fasting blood glucose level examinations, as well as providing education about prediabetes and healthy coffee. The methods used include interactive counseling and fasting blood glucose level examinations using spectrophotometry techniques. The results of the activity showed that 26.7% of participants suffered from prediabetes, and most of them did not know the relationship between coffee consumption and prediabetes. Conclusion: This activity increased participants' knowledge and awareness of healthy coffee and efforts to prevent prediabetes.
EFFECT OF SOURSOP LEAF EXTRACT (ANNONA MURICATA L.) ON FASTING BLOOD GLUCOSE LEVELS IN ALLOXAN-INDUCED RATS Halim, Shiyang Yang; Huwainan Nisa Nasution
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 12 No. 3 (2025): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v12i3.687

Abstract

Soursop plant is one of the herbal plants used by the community to overcome various diseases. Soursop plant utilization is widely used for the leaves only. One of the benefits of soursop leaves is to reduce blood glucose levels. This is because soursop leaves contain flavonoids, tannins, and alkaloid compounds. Flavonoid compounds have hypoglycemic effects and act like insulin. Tannin compounds can activate enzymes to facilitate glucose entry into cells and alkaloid compounds can regenerate pancreatic beta cells. This study aims to evaluate the hypoglycemic effect of soursop leaf extract on rats that have been induced by alloxan. This study is a pretest-posttest experimental study with control group design. The study was conducted on white male Wistar rats given soursop leaf extract at a dose of 400mg/KgBW and 800mg/KgBW for 5 days. The analysis test used was One-Way ANOVA. From the research conducted shows that there is a significant relationship between the administration of soursop leaf extract on fasting blood glucose levels in the intervention group with the administration of soursop leaf extract at a dose of 400mg/KgBW and 800mg/KgBW with a value of p = 0.000 in rats induced alloxan with the mean difference in fasting blood glucose levels in the K + group with P1 and P2 is 61.143mg/dL and 82.000mg/dL.
Efektivitas Ekstrak Daun Sambiloto (Andrographis Paniculata) Terhadap Kadar Glukosa Darah Puasa Pada Pasien Diabetes Melitus Tipe 2 Di Klinik Mediska Medan Dita Fazhari Murtanto; Huwainan Nisa Nasution
Journal of Innovative and Creativity Vol. 5 No. 3 (2025)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v5i3.6244

Abstract

Latar Belakang : Diabetes melitus merupakan salah satu penyakit metabolisme yang ditandai dengan peningkatan kadar glukosa dalam darah di atas nilai normalnya yang disebabkan terganggunya kerja dan sekresi insulin. Sambiloto (Andrographis paniculata) memiliki senyawa utama yaitu Andrographolide dan senyawa bioaktif lainnya seperti, flavonoid, alkaloid, dan tanin polifenol yang berperan secara signifikan mampu meningkatkan aktivitas antioksidan serta dapat menginduksi terjadinya regenerasi sel beta pankreas yang rusak. Tujuan : Menganalisis efektivitas ekstrak daun sambiloto (Andrographis paniculata) terhadap kadar glukosa darah puasa pasien diabetes melitus tipe 2. Metode : Penelitian ini adalah penelitian eksperimental pre test dan post test group design with control group. Sampel merupakan penderita diabetes melitus tipe 2 yang berjumlah 28 orang yang berobat di Klinik Mediska Medan. Kelompok perlakuan diberikan ekstrak daun sambiloto dengan dosis 550 mg 2 kali 2 kapsul selama 28 hari, sementara pada kelompok kontrol diberikan plasebo selama 28 hari. Hasil : Hasil rata-rata kadar glukosa darah puasa pada kelompok perlakuan pada hari ke-1 adalah 160,36 mg/dl dan pada hari ke-28 adalah 141,07 mg/dl, pada kelompok kontrol pada hari ke-1 adalah 160 mg/dl dan pada hari ke-28 adalah 158,71 mg/dl. Efektivitas ekstrak daun sambiloto (Andrographis paniculata) terhadap kadar glukosa darah puasa menunjukkan hasil signifikan dengan nilai p- value 0.001 (p<0.05). Kesimpulan : Pemberian ekstrak daun sambiloto (Andrographis paniculata) efektif terhadap penurunan kadar glukosa darah puasa pada pasien diabetes melitus tipe 2.
Uji Efektivitas Ekstrak Daun Binahong (Anredera cordifolia (Ten.) Steenis) dan Madu Sidr Sebagai Nefroprotektor pada Tikus (Rattus novergicus) Jantan Galur Wistar Maharani, Dhea; Nasution, Huwainan Nisa
ANATOMICA MEDICAL JOURNAL | AMJ Vol 9, No 1 (2026)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/amj.v9i1.28064

Abstract

Penggunaan obat herbal yang luas oleh masyarakat dapat membantu mengurangi kemungkinan terjadinya efek samping yang merugikan, seperti gangguan fungsi ginjal. Senyawa antioksidan yang terdapat dalam tanaman herbal dapat melindungi ginjal dari zat nefrotoksik. Tujuan penelitian ini adalah untuk mengetahui efektivitas "ekstrak daun binahong (Anredera cordifolia (Ten.) Steenis)" dan madu sidr sebagai nefroprotektor pada tikus jantan galur wistar. Metode: Menggunakan eksperimental pada 35 tikus jantan galur wistar, yang dibagi menjadi 5 kelompok dalam penelitian ini. Kelompok KN hanya diberikan pakan dan air suling. Kelompok KP diberikan dosis induksi gentamisin 80 mg/KgBB. Kelompok P1 diberikan dosis ekstrak daun binahong 150 mg/KgBB dan dosis induksi gentamisin 80 mg/KgBB. Kelompok P2 dosis madu sidr 1 g/KgBB dan dosis induksi gentamisin 80 mg/KgBB. Kelompok P3 kombinasi dosis ekstrak daun binahong 150 mg/KgBB, dosis madu sidr 1 g/KgBB dan dosis induksi gentamisin 80 mg/KgBB. Perlakuan tersebut diberikan secara bersamaan selama 8 hari. Hasil: Uji One Way ANOVA pada kadar ureum terjadi peningkatan kadar ureum pada kelompok KP secara signifikan (P0.05) dan menurunnya kadar ureum pada kelompok P3 secara signifikan (0.05). Pada hasil uji Kruskal Wallis kadar kreatinin didapatkan (P0.05) di semua kelompok perlakuan yang mempunyai arti kadar kreatinin tidak mengalami penurunan secara signifikan. Kesimpulan: Tikus (Rattus novergicus) jantan galur wistar dapat mengalami penurunan kadar ureum ketika diberikan kombinasi ekstrak daun binahong 150 mg/kgBB dan madu sidr 1 g/KgBB selama 8 hari secara bersamaan, yang diinduksi dengan gentamisin 80 mg/KgBB.Kata kunci: ekstrak daun binahong, madu sidr, gentamisin, kreatinin, ureum
The Effect of Katuk Leaf Extract (Sauropus androgynus (L.) Merr.) Administration on the Libido of Male White Rats (Sprague Dawley) Watsiqoh Anisti Harahap; Huwainan Nisa Nasution
MESINA (Medical Scientific Journal) Vol 6, No 2 (2026): Medical Scientific Journal (MESINA)
Publisher : Universitas Muhammadiyah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/msj.v6i2.10365

Abstract

ABSTRACT Low libido is one of the most common forms of sexual dysfunction among adult men and has a relatively high prevalence, including in Indonesia. The increasing public interest in herbal medicine has encouraged the use of katuk leaves (Sauropus androgynus (L.) Merr), which contain bioactive compounds such as saponins, alkaloids, and flavonoids that are presumed to possess aphrodisiac properties. This study aimed to evaluate the effect of katuk leaf extract on libido enhancement in male white rats. This study employed a true experimental design using a post-test with control group approach. The animals were divided into three groups, namely a negative control group receiving distilled water and standard feed, and two treatment groups receiving katuk leaf extract at doses of 100 mg/kgBW and 200 mg/kgBW, respectively. The extract was obtained through maceration using 96% ethanol. The observed parameters were the frequencies of introduction and climbing as indicators of libido-related behaviour. The analysis showed no statistically significant differences among the groups for the introduction parameter (p = 0.310) and the climbing parameter (p = 0.368). These findings indicate that administration of katuk leaf extract for 7 days did not significantly enhance libido. This outcome may have been influenced by several factors, including the absence of estrous phase screening in female rats, excessive cage lighting, and a possible reduction in bioactive compound content due to a suboptimal drying process. Previous studies reporting significant effects generally used longer treatment durations and stricter control of physiological conditions. Keywords: Aphrodisiac, Libido, Sauropus androgynus (L.) Merr. 
Co-Authors Des Suryani Dita Fazhari Murtanto Fardella Lufiana Febriyanti, Eka Fitri Nur Malini Hadiq Firdausi Halim, Shiyang Yang Khairunisa, Sukma Lufiana, Fadella Maharani, Dhea Rahmawati, Lita Diah Ratih Yulistika Utami SADILA KELIAT Septina, Lina Shahrul Rahman, Shahrul Ugroseno Yudho Bintoro Watsiqoh Anisti Harahap Zahrah, Nadianty Az