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All Journal JURNAL BIOMEDIK Komunikasi Fisika Indonesia Buletin Farmatera Best Journal (Biology Education, Sains and Technology) JURNAL ILMIAH SIMANTEK Jurnal Implementa Husada Jurnal Pandu Husada
Aidil Akbar
Departemen Obstetri Dan Ginekologi, Fakultas Kedokteran, Universitas Muhammadiyah Sumatera Utara
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Veterinary

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Journal : Buletin Farmatera

 1 
Metformin Improves Fertility in Women with Polycystic Ovary Syndrome (PCOS): A Systematic Review Aidil Akbar
Buletin Farmatera Vol 8, No 2 (2023)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v8i2.16295

Abstract

Abstract: Polycystic ovary syndrome (PCOS) Causes 6-15% of female infertility, of which 80% is characterized by the occurrence of hyperinsulinemia resulting in impaired endometrial function. Metformin therapy in improving insulin sensitivity has been widely reported, but investigations are needed to determine the characteristics of metformin therapy research in PCOS cases with a literature review study approach. In the collection of systematic studies, Publish and Perish, Mendeley and Microsoft Excel applications, using the keyword metformin improves fertility in women with PCOS. From 500 articles collected, 16 articles were included in the inclusion criteria, and it was found that many studies had been conducted in several countries (Iran, India, USA, Italy, Egypt, Pakistan and Saudi Arabia involving 2295 subjects, with a dose range of 500 mg to 2000 mg, with a duration of administration of 14 days to 9 months. In this study, it was concluded that metformin intervention studies both singly and in combination clinically have been conducted in several countries where most studies show that metformin can improve clinical and laboratory improvements in PCOS patients, which can improve the fertility rate of women with PCOS.
Micronutrient Supplementation Therapy in Subfertile Men: A Systematic Study Akbar, Aidil
Buletin Farmatera Vol 6, No 3 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i3.8920

Abstract

In Indonesia, the infertility rate reaches 16% of couples of childbearing age, and 50% of cases are caused by male reproductive disorders. In the current study, micronutrient substitution therapy can increase sperm count and motility in subfertile men but has not shown consistent results. This study is a systematic study that aims to determine the effectiveness of micronutrient supplementation therapy for subfertile cases and what micronutrients are used for subfertile therapy. A literature search was carried out using the Google Scholar application with the keywords supplementation therapy in subfertile, from the results of a literature search using the prism method, 18 articles were found that included in the inclusion criteria, and it was found that almost all articles stated that micronutrition supplementation therapy in subfertile patients showed improved results. the number and motility of sperm cells and the micronutrients that are widely used are zinc, carnitine, Co-Q10, Vitamin E, Vitamin C, Selenium, Vitamin B12. It can be concluded that micronutrient supplementation can improve the number of live sperm cells and sperm motility.
Resistance Training Has an Effect on Lowering Insulin Resistance Based on HOMA IR Examination in Poly Cystic Ovarian Syndrome (PCOS) Patients: Meta-Analysis Nasution, Muhammad Solih; Akbar, Aidil
Buletin Farmatera Vol 10, No 3 (2025)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v10i3.24468

Abstract

Abstract: Poly Cystic Ovarian Syndrome (PCOS) is a complex endocrine disorder that affects women of reproductive age. Insulin resistance, obesity, and hormonal imbalances are the main characteristics of this condition. Physical exercise, including weight training or resistance training , is suspected to be effective in lowering insulin resistance, but direct comparisons based on the results of the HOMA IR examination have not been carried out systematically. This meta-analysis aimed to evaluate the effectiveness of weight training in lowering insulin resistance based on the results of the HOMA IR examination in PCOS patients. Four clinical studies that met the inclusion criteria and included 87 women diagnosed with PCOS and 93 women without PCOS were analyzed for their insulin resistance conditions. Insulin resistance check parameters using the HOMA IR test. Statistical analysis using a fixed effect model with a paired t test. Overall, resistance training interventions  showed a negative effect on the difference in HOMA-IR between pre-test and post-test. The mean HOMA-IR score after the intervention was lower compared to the pre-intervention score. This suggests that resistance training can lower insulin resistance in PCOS patients. Resistance training can reduce insulin resistance in PCOS patients as measured by HOMA-IR examination. However, variations in results between studies suggest that the effects of resistance training on insulin resistance are not entirely uniform, depending on factors such as exercise intensity, duration, and characteristics of study participants.
Co-Authors Alltop Amri Ya Habib Amalina, Fildzah Nur Amelia Eka Damayanty CHALIL, MUHAMMAD JALALUDDIN ASSUYUTHI Cut Mourisa Faried Lubis, Taufik Akbar Hamama, Putri Harahap, Sri Dwi Putri Hasbina Wildani Nasution, Muhammad Solih Parhusip, Tiara Aulia Putri Agni Panyya Rahmi Rahmi Simanjuntak, Asnika Putri Sipahutar, Brigita Ramayanti Tengku Emrinaldi Ulfah Nur Ramadhani WIDYA NINGSIH, PARAMITHA Zaldi Zaldi