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POTENSI PENERAPAN KONSEP HOSPITAL WITHOUT WALLS DALAM RANGKA MENURUNKAN ANGKA COLD CASE Emiliana Sastri Sumule; Gustaaf Ratag; Jimmy Posangi
Jurnal Kesehatan Medika Saintika Vol 12, No 2 (2021): Desember 2021
Publisher : Stikes Syedza Saintika Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30633/jkms.v12i2.1122

Konsep hospital without walls merupakan salah satu strategi dalam menurunkan angka cold case. Peranan hospital without walls sangat dibutuhkan untuk meningkatkan aksessibilitas dalam meratakan pelayanan primer khususnya di bagian obstetri dan ginekologi. Penelitian ini bertujuan untuk mengetahui potensi penerapan konsep hospital without walls pada pelayanan kesehatan obstetri dan ginekologi dan kendala-kendala yang dihadapinya. Desain penelitian kualitatif, dilaksanakan di RSUP Ratatotok Buyat dari November 2020 sampai April 2021. Penelitian ini menggunakan metode wawancara mendalam kepada 11 informan. Instrumen berupa daftar pertanyaan, alat perekam, dan alat tulis menulis serta pemantauan data observasi. Hasil penelitian informan menjelaskan dalam konsep hospital without walls dapat diselenggarakan dengan tetap memperhatikan standar-standar pelayanan. Selanjutnya kendala yang dihadapi rumah sakit dan puskesmas yaitu kurangnya pengetahuan masyarakat tentang penerapan konsep hospital without walls ini yang sudah berjalan. Kesimpulan penelitian ini yaitu rumah sakit Ratatotok Buyat berpotensi untuk menerapkan konsep hospital without walls. Kendala-kendala yang dihadapi dilihat dari adanya potensi penerapan konsep hospital without walls pada pelayanan kesehatan obstetri dan ginekologi di RSUP Ratatotok Buyat yakni kurangnya pengetahuan masyarakat tentang konsep ini yang sebenarnya sudah berjalan tapi masih pada tahap menimal, selain itu sarana dan prasarana termasuk akses. Saran dari penulis, perlunya penyiapan sumber daya manusia yang menjadi tim kerja, baik secara kualitas maupun kuantitas serta perlu sosialisasikan kepada masyarakat tentang konsep ini lewat promkes..Kata Kunci: Hospital without walls; cold case.

Effect of Health Promotion with Audiovisual on Knowledge of the Use of Personal Protective Equipment for Covid-19 in Health Workers Christine T. Siwi; Suryadi N. N. Tatura; Jimmy Posangi
e-CliniC Vol. 10 No. 1 (2022): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v10i1.36881

Abstract: Health workers are very risky to be infected by Covid-19 virus. The use of personal protective equipment (PPE) for Covid-19 can minimize the transmission of Covid-19. This study was aimed to determine the effect of audio-visual health promotion on knowledge of the use of Covid-19 PPE among health workers. This was a pre-experimental study waith one-grup pre test post test design. Data were analyzed univariately as well as bivariately with paired t-test. Respondents were 40 health workers at the Ratahan Health Center, Southeast Minahasa Regency. The activity was started by signing the approval for filling out questionnaires, doing the pretest, then audiovisual health promotion intervention was carried out and continued with filling out the questionnaire posttest. The results showed that before the health promotion about Covid-19 PPE, most respondents had lack of knowledge as many as 35 health workers (87.5%) and after the health promotion was carried out the knowledge of health workers was categorized as good, namely 36 health workers (90%). The paired t-test showed tat the average value of health worker knowledge before the health promotion about Covid-19 PPE was 22.48Â±1.5, and after the health promotion the knowledge of health workers was increased to 34.0Â±0.0 with a p-value of 0.0. In conclusion, the audiovisual health promotion about Covid-19 PPE increases the knowledge of health workers.Keywords: personal protective equipment (PPE); health workers; health promotionÂ Abstrak: Tenaga kesehatan (nakes) sangat berisiko terhadap terinfeksi oleh virus Covid-19. Penggunaan alat pelindung diri (APD) Covid-19 dapat meminimalisir penularan Covid-19. Penelitian ini bertujuan untuk mengetahui pengaruh promosi kesehatan dengan audiovisual terhadap pengetahuan penggunaan APD Covid-19 pada nakes. Jenis penelitian ialah pre-eksperimental dengan one-grup pre test post test design. Analisis data menggunakan analisis univariat dan analisis bivariat dengan uji paired t-test. Responden penelitian ini sebanyak 40 nakes di Puskesmas Ratahan, Kabupaten Minahasa Tenggara. Kegiatan dimulai dengan menandatangani persetujuan pengisian kuesioner pretest kemudian dilakukan intervensi promosi kesehatan menggunakan audiovisual, dan dilanjutkan dengan pengisian kuesioner posttest. Hasil penelitian mendapatkan bahwa sebelum diberikan promosi kesehatan tentang APD Covid-19 pengetahuan nakes terbanyak berada pada kategori kurang yaitu 35 orang (87,5%) dan setelah diberikan promosi kesehatan pengetahuan nakes berada pada kategori baik yaitu 36 orang (90%). Hasil analisis bivariat dengan uji paired t-test menunjukkan nilai rerata pengetahuan nakes sebelum diberikan promosi kesehatan sebanyak 22,48Â±1,5 dan setelah diberikan promosi kesehatan pengetahuan nakes meningkat sebanyak 34,0Â±0,0 dengan nilai p=0,0. Simpulan penelitian ini ialah promosi kesehatan dengan audiovisual tentang APD Covid-19 berpengaruh dalam meningkatkan pengetahuan tenaga kesehatan.Kata kunci: alat pelindung diri (APD); tenaga kesehatan; promosi kesehatan

Determinants of Work Motivation for Manado Adventist Hospital Health Workers during the Covid-19 Pandemic Christa J. Egeten; Jimmy Posangi; Joshua Runtuwene
Medical Scope Journal Vol. 3 No. 2 (2022): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v3i2.40353

Abstract: Work motivation is a set of attitudes and values that influence an individual to achieve more detailed things according to his/her goal. This study aimed to obtain the determinants of work motivation of health workers at Manado Adventist Hospital during the Covid-19 pandemic. This was a quantitative study. Population consisted of all health workers totaling 238 meanwhile samples were 70 people. Data were analyzed using the chi square test and logistic regression test. The results showed that physical working condition was 64.3% good and 35.7% poor; interpersonal relationship was 44.3% good and 55.7% poor; company policy was 30% good and 70% poor; salary was 62.9% good and 37.1% poor; and work motivation was 44.3% good and 55.7% poor. The chi square test showed that there were significant relationships between physical working condition and work motivation (p=0.013); interpersonal relationship and work motivation (p=0.000); company policy and work motivation (p=0.019); salary and work motivation (p=0.028). The logistic regression test confirmed that interpersonal relationship had the closest relationship with work motivation. In conclusion, work motivation determinants in this study are physical working condition, interpersonal relationship, company policy, and salary. Interpersonal relationship has the closest relationship to work motivation.Keywords: physical working conditions; interpersonal relation; policies; salary; work motivationÂ Abstrak: Motivasi kerja yaitu serangkaian sikap dan juga nilai yang memengaruhi individu untuk menggapai hal yang lebih detail sesuai dengan tujuannya. Penelitian ini bertujuan untuk mengetahui determinan motivasi kerja tenaga kesehatan Rumah Sakit Advent Manado di masa pandemi Covid-19. Jenis penelitian ialah kuantitatif. Populasi ialah seluruh tenaga kesehatan berjumlah 238 orang dengan sampel berjumlah 70 orang. Analisis statistik menggunakan uji chi square dan regresi logistik. Hasil penelitian mendapatkan variabel kondisi kerja fisik baik sebesar 64,3% dan kurang baik 35,7%. Hubungan interpersonal didapatkan kategori baik 44,3% dan kurang baik 55,7%. Kebijakan perusahaan didapatkan kategori baik 30% dan kurang baik 70%. Gaji didapatkan kategori baik 62,9% dan kurang baik 37,1%. Motivasi kerja didapatkan kategori baik 44,3% dan kurang baik 55,7%. Hasil uji chi square menegaskan adanya hubungan bermakna antara: kondisi kerja fisik dengan motivasi kerja (p=0,013); hubungan interpersonal dengan motivasi kerja (p=0,000; kebijakan perusahaan dengan motivasi kerja (p=0,019); dan gaji dengan motivasi kerja (p=0,028). Hasil uji regresi logisitik menunjukkan bahwa hubungan interpersonal yang paling berhubungan erat dengan motivasi kerja. Simpulan penelitian ini ialah determinan motivasi kerja yang didapatkan ialah kondisi kerja fisik, hubungan interpersonal, kebijakan perusahaan, dan gaji. Hubungan interpersonal yang paling berhubungan kuat dengan motivasi kerja.Kata kunci: kondisi kerja fisik; hubungan interpersonal; kebijakan; gaji; motivasi kerja

Evaluasi Penggunaan Antikoagulan Profilaksis terhadap Pasien COVID-19 Elna D. S. Rante; Edward Nangoy; Jimmy Posangi
eBiomedik Vol. 10 No. 1 (2022): eBiomedik
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ebm.v10i1.38121

Abstract: The occurrence of hyperinflammation in COVID-19 patients results in increased activation of the coagulation cascade and excessive thrombin production. Coagulopathy in patients with COVID-19 is associated high risk of VTE with an increased risk of death. Prophylactic anticoagulation has been recommended for the prevention of thromboembolic events in COVID-19 patients. This study aims to determine the evaluation prophylactic anticoagulants related to the type, dose, administration, and outcome for COVID-19 patients who are hospitalized with moderate, severe, to critical degrees. The research method used is a literature review. The results showed that types of anticoagulant prophylaxis used in hospitalized COVID-19 patients are parenteral anticoagulants namely LMWH, UFH, and fondaparinux. The most widely used anticoagulant is LMWH, especially enoxaparin with a standard dose of 30-40 mg OD or BID adjusted for CrCl and BMI administered subcutaneously. Standard-dose prophylactic anticoagulants can reduce mortality without increasing risk of bleeding.Keywords: Prophylactic anticoagulation; COVID-19; hospitalizedÂ Abstrak: Kejadian hiperinflamasi pada pasien COVID-19 mengakibatkan peningkatan aktivasi kaskade koagulasi dan produksi trombin yang berlebihan. Koagulopati pada pasien dengan COVID-19 terkait dengan risiko tinggi VTE dikaitkan dengan peningkatan risiko kematian. Penggunaan antikoagulan profilaksis telah direkomendasikan untuk pencegahan kejadian tromboemboli pada pasien COVID-19. Penelitian ini bertujuan untuk mengetahui evaluasi penggunaan antikoagulan profilaksis terkait jenis, dosis, teknik pemberian, dan luaran terhadap pasien COVID-19 yang dirawat di rumah sakit dengan derajat sedang, berat, hingga kritis. Metode penelitian yang digunakan yaitu literature review. Hasil penelitian menunjukkan antikoagulan profilaksis yang digunakan pada pasien COVID-19 yang dirawat di rumah sakit, yaitu antikoagulan parenteral berupa LMWH, UFH, dan fondaparinux. Jenis dan dosis antikoagulan yang paling banyak digunakan adalah LMWH, terutama enoxaparin dengan dosis standar 30-40 mg SC OD atau BID yang disesuaikan CrCl dan BMI. Antikoagulan profilaksis dosis standar dapat menurunkan tingkat mortalitas tanpa meningkatkan risiko perdarahan.Kata kunci: Antikoagulan Profilaksis; COVID-19; dirawat di rumah sakit

Efektivitas Penggunaan Empagliflozin terhadap Nilai HbA1c pada Pasien Diabetes Melitus Tipe 2 Tesalonika Rawung; Jimmy Posangi; Edward Nangoy
Medical Scope Journal Vol. 5 No. 2 (2023): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v5i2.45424

Abstract: Type 2 diabetes mellitus (T2DM) is the most common type of diabetes today. Lifestyle changes are one of the causes of DM problems. Patients with T2DM are usually treated with oral hypoglycemic drugs. The sodium glucose cotransporter 2 (SGLT-2) group is a type of oral hypoglycemic drug groups that plays a role in reducing HbA1c level. Empagliflozin is a drug included in the SGLT-2 group. Previous clinical trials showed that empagliflozin could lead to a reduction in HbA1c level. This study aimed to determine the effectiveness of using empagliflozin on HbA1C values in T2DM patients. This was a literature review study with data searching using three databases namely, Pubmed, Google Scholar, and Science Direct. The results obtained 10 literatures to be reviewed. All literatures showed that there was a significant effect of empagliflozin on HbA1c value of T2DM patients. In conclusion, type 2 diabetes mellitus patients using empagliflozin show significant decreases in HbA1c values. Keywords: type 2 diabetes mellitus; empagliflozin; HbA1c; sodium glucose cotransporter 2 Abstrak: Diabetes melitus tipe 2 (DMT2) merupakan jenis diabetes yang paling umum ditemukan saat ini. Perubahan gaya hidup menjadi salah satu penyebab timbulnya masalah DM. Penyandang DMT2 biasanya diterapi dengan obat hipoglikemik oral (OHO). Golongan obat sodium glucose cotransporter 2 (SGLT-2) merupakan salah satu jenis golongan obat OHO yang berperan dalam menurunkan kadar HbA1c, salah satunya ialah empagliflozin. Penelitian sebelumnya menunjukkan peran empaglifozin dalam uji klinis dapat menyebabkan penurunan kadar HbA1c. Penelitian ini bertujuan untuk mengetahui efektivitas penggunaan empagliflozin terhadap nilai HbA1C pada pasien DMT2. Jenis penelitian ini ialah suatu literature review dengan pencarian data menggunakan tida sumber basis data yaitu, Pubmed, Google Scholar dan Science Direct. Hasil penelitian mendapatkan sebanyak 10 literatur yang dilakukan review. Kesepuluh artikel memperlihatkan adanya pengaruh bermakna dari penggunaan empagliflozin terhadap nilai HbA1c dari pasien DMT2. Simpulan penelitian ini ialah penggunaan empagliflozin pada pasien diabetes melitus tipe 2 menunjukkan terjadinya penurunan nilai HbA1c yang bermakna. Kata kunci: diabetes melitus tipe 2; empagliflozin; HbA1c; sodium glucose cotransporter 2

Faktor-faktor yang Berhubungan dengan Kepuasan Pasien di Instalasi Rawat Jalan RSUP Prof. Dr. R. D. Kandou, Manado Pontoh J. Ch. Putera; Jimmy Posangi; Aaltje E. Manampiring
Medical Scope Journal Vol. 5 No. 2 (2023): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v5i2.46227

Abstract: Measuring the level of patient satisfaction in hospitals must be carried out periodically, accurately, and continuously. Patient satisfaction can be achieved if the patient receives services according to what is needed and expected. The level of patient satisfaction describes the quality of services provided by the hospital. This study aimed to analyze factors related to outpatient satisfaction at Prof. Dr. R. D. Kandou Hospital, Manado. This was a quantitative study with a cross sectional approach. This study was conducted at Prof. Dr. R. D. Kandou Hospital with a total sample of 390 patients taken by simple random sampling. Data were obtained from questionnaires and were analyzed univariately, bivariately using the chi-square test, and multivariately using the logistic regression test. Statistical calculation using the SPSS program. The results of the chi-square test showed the p-values of relationships between patient satisfaction and the variable aspects, as follows: tangibles p=0.000; responsiveness p=0.000; reliability p=0.000; assurance p=0.000; and empathy p=0.000. The results of multivariate analysis using the logistic regression test obtained that the highest Exp (B) value of 586.267 on the tangibles aspect. In conclusion, tangibles, responsiveness, reliability, assurance and empathy have significant relationships with patient satisfaction to the services at Prof. Dr. R. D. Kandou Manado. The most related factor with patient satisfaction is tangibles. Keywords: patient satisfaction; service quality; tangibles; responsiveness; reliability; assurance; empathy Abstrak: Pengukuran tingkat kepuasan pasien di rumah sakit wajib dilakukan seara berkala, akurat dan berkesinambungan. Kepuasan pasien dapat tercapai apabila pasien menerima pelayanan sesuai dengan yang dibutuhkan dan diharapkan. Tingkat kepuasan pasien menggambarkan kualitas pelayanan yang diberikan oleh rumah sakit. Penelitian ini bertujuan untuk menganalisis faktor yang berhubungan dengan kepuasan pasien rawat jalan di RSUP Prof. R. D. Kandou Manado. Jenis penelitian ialah kuantitatif dengan desain potong lintang. Penelitian ini dilaksanakan di RSUP Prof. R. D. Kandou Manado dengan jumlah sampel 390 pasien yang diambil secara simple random sampling. Data diperoleh melalui kuesioner, kemudian dianalisis secara univariat, bivariat dengan menggunakan uji chi square, dan multivariat menggnakan uji regresi logistik. Penghitungan statistik menggunakan program SPSS. Hasil uji chi-square terhadap hubungan dengan kepuasan pasien mendapatkan untuk aspek tangibles p=0,000; responsiveness p=0,000; reliability p=0,000; assurance p=0,000; dan empathy p=0,000. Hasil analisis multivariat menggunakan uji regresi logistik mendapatkan nilai Exp (B) tertinggi yaitu 586,267 pada aspek tangibles. Simpulan penelitian ini ialah tangibles, responsiveness, reliability, assurance, dan empathy berhubungan bermakna dengan kepuasan pasien terhadap pelayanan di RSUP Prof. R. D. Kandou Manado. Faktor yang paling berhubungan dengan kepuasan pasien yaitu tangibles. Kata kunci: kepuasan pasien; kualitas layanan; tangibles; responsiveness; reliability; assurance; empathy

Pengaruh Evolocumab terhadap Pasien Dislipidemia dengan Intoleransi Statin Kristiani A. Laluyan; Edward Nangoy; Jimmy Posangi
e-CliniC Vol. 12 No. 1 (2024): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v12i1.45494

Abstract: Statins, lipid-lowering drugs, are used to reduce low density lipoprotein cholesterol (LDL-C). Although statins are well tolerated by most people, their side effects e. g. myopathy and statin intolerance have impacts on dose reduction and therapy discontinuation. Evolocumab is considered in patients with statin intolerance. This study aimed to determine the effect of evolocumab on LDL-C levels in patients with dyslipidemia and statin intolerance. This was a literature review study using literature search on three databases, namely PubMed, ClinicalKey, and ScienceDirect with the keywords Dyslipidemia AND Evolocumab AND Statin Intolerance. The results obtained seven related literatures. In general, evolocumab therapy was safe and effective in reducing LDL-C levels for patients who needed drugs to lower LDL-C. Based on the literatures, inhibition of PCSK9 activity on evolocumab had an effect on reducing LDL-C levels by 50-70%. This therapy could reduce the risk of cardiovascular diseases such as the ratio of Apo B/Apo A1, triglycerides, and total cholesterol. In conclusion, evolocumab therapy is generally safe and effective in significantly reducing LDL-C. Adverse effects caused by the therapy tend to be mild. Keywords: dyslipidemia; low density lipoprotein cholesterol; statins; statin intolerance; evolocumab Abstrak: Statin merupakan obat penurun lipid untuk menurunkan kolesterol low density lipoprotein (K-LDL) dan umumnya dapat ditoleransi dengan baik namun miopati dan efek samping lainnya serta intoleransi statin dapat mengarah ke penurunan dosis atau penghentian terapi. Pemberian evolocumab dapat dipertimbangkan pada keadaan intoleransi statin. Penelitian ini bertujuan untuk mengetahui pengaruh evolocumab terhadap kadar K-LDL pasien dengan dislipidemia dan intoleransi statin melalui suatu literature review. Pencarian literatur pada tiga database, yaitu PubMed, ClinicalKey, dan ScienceDirect dengan kata kunci Dyslipidemia AND Evolocumab AND Statin Intolerance. Hasil penelitian mendapatkan tujuh literatur untuk dikaji. Berdasarkan kajian literatur didapatkan terapi evolocumab umumnya aman dan efektif dalam menurunkan kadar K-LDL bagi pasien yang membutuhkan obat untuk penurunan kolesterol. yang telah didapat. Penghambatan aktivitas PCSK9 pada evolocumab berpengaruh dalam menurunkan kadar K-LDL sekitar 50-70%. Terapi tersebut dapat mengurangi risiko penyakit kardiovaskular seperti rasio Apo B/Apo A1, trigliserida, dan kolesterol total. Simpulan penelitian ini ialah terapi evolocumab umumnya aman dan efektif dalam menurunkan kadar K-LDL secara bermakna. Kejadian yang tidak diinginkan yang ditimbulkan oleh terapi cenderung ringan. Kata kunci: dislipidemia; kolesterol low density lipoprotein; statin; intoleransi statin; evolocumab

Analisis Konsep Hospital Without Walls pada Pelayanan Kelainan Refraksi di UPTD Rumah Sakit Mata Provinsi Sulawesi Utara Gabriella O. Mokolensang; Aaltje E. Manampiring; Jimmy Posangi
Medical Scope Journal Vol. 6 No. 1 (2024): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v6i1.49221

A hospital without walls or known as a hospital without walls is very useful for patients who come to the hospital for treatment with referrals from the public health center as the entry point for referral diagnosis, this is to minimize the risk of infection transmission and other disease problems. The purpose of this study is to analyze the concept of a hospital without walls and the obstacles and challenges in providing refractive errors. The research was conducted at the UPTD Eye Hospital in North Sulawesi Province, from January to December 2022 using in-depth interviews with five research informants, namely the director, head of medical services, ophthalmologist, family doctor and patient. Instruments in the form of in-depth interview guidelines and a list of questions that have been provided. The stages of data processing are narrating, inferring, reducing, recording, sampling, unitizing. Data analysis is content analysis. The validity of the research results using triangulation of data sources and methods. The results of this study were obtained from the summary of the answers of the research informants that the concept of a hospital without walls all understand and know this concept to mitigate the accumulation of services in hospitals, but this concept has not been implemented because there are several factors such as standard operating procedures, human resources and infrastructure which is not yet possible for some FKTPs to be able to complete services at the community health center or family doctor, the obstacle presented by the informant is that there are still many patients who want to carry out direct services to the hospital without going to the health center or family doctor, another obstacle is the lack of tools for examining refractive errors and competence general practitioners to be able to make referrals in the diagnosis of disease. Hospital income will also increase if implementing this concept, if there is collaboration with related stakeholders such as BPJS Health, the Health Service, and other private parties, so that this will also have a good impact on the quality of service when hospital accreditation is carried out. The sophistication of information technology needs to be implemented as much as possible from the hospital so that it is easier so that patients do not pile up during services by registering online. The conclusion of this study is that the concept of a hospital without walls has not been implemented in the Eye Hospital of North Sulawesi Province because it has not followed standard operating procedures, quality competent resources and adequate infrastructure. FKTP Puskesmas in providing refractive error services have not provided complete supporting tools and the skills of FKTP doctors are still lacking, this will have an impact on assessing hospital accreditation in the quality of health services. Keywords: hospitals without walls, eye refractive error, family doctors

Pengaruh Pandemi Covid-19 Terhadap Aktivitas Fisik dan Penerapan Prinsip Gizi Seimbang Pada Mahasiswa Pascasarjana M. Fadhel Nurmidin; Fatimawali Fatimawali; Jimmy Posangi
Indonesian Journal of Public Health and Community Medicine Vol. 1 No. 4 (2020): Oktober 2020
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35801/ijphcm.1.4.2020.31169

Latar Belakang: Aktivitas fisik dan penerapan prinsip gizi seimbang pada saat pandemi Covid-19 kemungkinan akan mengalami perubahan dikarenakan pandemi Covid-19 yang mengharuskan semua orang untuk bekerja dan belajar dari rumah. Salah satunya yang terdampak dengan kondisi ini yaitu mahasiswa termasuk mahasiswa program Pascasarjana. Tujuan penelitian ini ialah untuk mengetahui pengaruh pandemi Covid-19 terhadap aktivitas fisik dan penerapan prinsip gizi seimbang pada mahasiswa Pascasarjana Ilmu Kesehatan Masyarakat Universitas Sam Ratulangi. Metode Penelitian: Penelitian ini merupakan penelitian kuantitatif dengan rancangan cross-sectional. Penelitian ini dilaksanakan pada Juni-Juli 2020 terhadap 51 mahasiswa program Pascasarjana Universitas Sam Ratulangi. Variabel dalam penelitian ini yaitu aktivitas fisik dan penerapan prinsip gizi seimbang. Instrumen yang digunakan yaitu kuesioner. Analisis data dilakukan secara univariat dan bivariat. Hasil Penelitian: Hasil penelitian menunjukkan bahwa responden terdistribusi paling banyak berumur 20-30 tahun (68,6%), berjenis kelamin perempuan (60,8%), telah bekerja (76,5%) dan tidak mempunyai fasilitas olahraga (58,8%). Selanjutnya, terlihat bahwa nilai rataan aktivitas fisik sebelum pandemi sebesar 3017,49 dan mengalami penurunan saat pandemi sebesar 2289,90. Nilai rataan penerapan prinsip gizi seimbang sebelum pandemi sebesar 70,02 menjadi 74,12 selama pandemi. Analisis data menunjukkan bahwa ada pengaruh pandemi Covid-19 terhadap aktivitas fisik (p-value= 0,03) dan penerapan prinsip gizi seimbang (p-value=0,000). Kesimpulan: Kesimpulan dari penelitian ini yaitu terdapat pengaruh pandemi Covid-19 terhadap aktivitas fisik dan penerapan prinsip gizi seimbang. Berdasarkan hasil penelitian ini maka responden harus menjaga imunitas tubuh melalui melakukan aktivitas fisik setiap hari minimal 30 menit dan mengkonsumsi makan bergizi seimbang

In Silico Study of Quercetin and Its Derivatives as Potential Antituberculosis Angelina Stevany Regina Masengi; Greachylia Chelzy; Jimmy Posangi; Trina Ekawati Tallei; Fatimawali; Christi Diana Mambo; Dian Augina Rintibulawan Rambulangi
JURNAL BIOS LOGOS Vol. 15 No. 1 (2025): JURNAL BIOS LOGOS
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jbl.v15i1.60150

Tuberculosis (TB) remains the second leading cause of death in the world, with the resistance of Mycobacterium tuberculosis to first-line drugs, such as isoniazid (INH), contributing to the emergence of multi-drug resistant TB (MDR-TB). This study aims to evaluate the potential of quercetin and its derivatives as InhA enzyme inhibitors through an in silico approach to offer innovative therapeutic alternatives to improve the effectiveness of TB treatment. The analysis includes physicochemical properties, ADMET profiles, molecular interactions, and affinity of compounds to the InhA enzyme as an antituberculosis target. The study workflow included ligand and receptor preparation, prediction of biological activity, physicochemical and ADMET analysis, docking validation, molecular docking, and visualization of molecular interactions. Molecular docking was performed using Gnina software, showing that rutin has the lowest binding energy (ΔG) of -12.22 kcal/mol, indicating strong interaction affinity. In addition, ADMET and toxicity analysis showed good pharmacokinetic potential for the test compounds Docking validation confirmed the reliability of the employed methodology, further supporting the potential of quercetin and its derivatives as antituberculosis candidates. However, although quercetin and its derivatives showed promising biological activity, the ADMET profile results were variable, requiring further optimization to develop effective and safe TB therapies.

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