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Topical gel preparation from Staphylococcus epidermidis isolate extract accelerated healing on incision wound model in rats Mochtar, Chaerul Fadly; Bakhtiar, Muh Irham; Hamzah, Hasyrul; Pratama, Aldo; Rasyidah, Jamiatur; Indriyani, Juniar Rakhmatia; Alfiannur, Muhammad Rizky; Amalia, Nadhifah Suci; Putri, Nur Octaviany; Damis, Nur Lutfiah
Indonesian Journal of Pharmacology and Therapy Vol 5 No 1 (2024)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.11510

Abstract

A wound is a disorder of skin integrity caused by physical trauma or disease. Wound healing is a natural restorative response to tissue injury. It is a complex dynamic physiological process involving several overlapping phases. Although wound management has been applied, however, some time it is associated withmajor drawbak including invasiveness, antibiotic resistance, and high costs. Natural medicines are being developed for wound management to resolve the drawback. Commensal Staphylococcus epidermidis was proven to play a role in natural wound healing process. This study aimed to investigate the wound healingactivity of a topical gel preparation containing S. epidermidis isolate extract on an incision wound model in rats. The methanol extract of S. epidermidis isolate was prepared by maceration and used as an active ingredient of the topical gel using NaCMC as a gelling agent. A physical stability test was carried out by assessingorganoleptic properties, pH value, homogeneity, dispersion, and viscosity of the gel preparation. The gel preparation was then topically applied once-daily for 11 d on incision wound model of male white rats (Rattus norvegicus). The wound healing was observed daily and calculated using Morton’s formula. Nosignificant change in the physical stability parameters of the gel preparation was observed during observation on day 1, 7, and 14 (p>0.05). A significant increase in wound healing after the application of the gel preparation compared to negative control was observed (p<0.05). In contrast, no significant difference inwound healing between the gel preparation and the positive control group was observed (p>0.05). In conclusion, the topical gel preparation from S. epidermidis isolate extract accelerates healing on incision wound models in rats.
In Vivo Antihyperuricemia Activity of Kelubut Leaf Ethyl Acetate Extract (Passiflora foetida, L.) From Samarinda City Mochtar, Chaerul Fadly; Faradillah, Ayu; Bakhtiar, Muh Irham; Devi, Reni Selviana; Husna, Qur’anni Akhwatun; Hafidzah, Elva; Varizza, Fathiah Putri; Aisyiyah, Novia Misnawati
Journal of Fundamental and Applied Pharmaceutical Science Vol. 5 No. 1 (2024): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v5i1.19171

Abstract

The development of the times creates shifts in lifestyle and eating patterns that trigger hyperuricemia. Hyperuricemia is generally treated with synthetic drugs, but on the other hand, it causes side effects. So the use of natural ingredients such as kelubut leaves can be an alternative treatment. The purpose of this study was to determine the ethyl acetate extract of kelubut leaves has activity as an anti-hyperuricemia. The research uses experimental research methods with a design in the form of a pretest and posttest design. Mice were used and divided into 5 groups, namely the positive control group, the negative control and the group given the extract with three different doses including doses of 250 mg/Kg BW, 125 mg/Kg BW, and 62.5 mg/Kg BW. Mice will be conditioned by hyperuricemia and given different treatments in each group. Data on uric acid levels were analyzed by Kruskal-Wallis and Mann-Whitney. The results of the study showed that administration of the extract at a concentration of 250 mg/Kg BW reduced uric acid levels as much as the positive control group at 120 minutes, but was not statistically different (p>0.05) from the positive control. This study concludes that the ethyl acetate extract of kelubut leaves has anti-hyperuricemic activity at a dose of 250 mg/Kg BW showing the best-reducing activity in reducing uric acid levels in mice.