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All Journal Pelita Perkebunan Jurnal Kimia Riset Indonesian Journal of Chemistry Journal of halal product and research (JHPR) Bubungan Tinggi: Jurnal Pengabdian Masyarakat Berkala Penelitian Hayati
Pratiwi Pudjiastuti
Chemistry Department, Faculty Of Science And Technology, Airlangga University, Surabaya, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Economics, Econometrics & Finance Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Veterinary Other

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PEMBUATAN DAN KARAKTERISASI MEMBRAN FOTOKATALITIK HOLLOW FIBER SELULOSA ASETAT-TiO2 UNTUK DEGRADASI REMAZOL RED 198 Mevitri Rahmiati; Siti Wafiroh; Pratiwi Pudjiastuti
Jurnal Kimia Riset Vol. 3 No. 1 (2018): Juni
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (788.548 KB) | DOI: 10.20473/jkr.v3i1.8238

Abstract

Pengolahan limbah cairdapat menggunakan membran fotokatalitik yang dikompositkan dengan TiO2, salah satunya untuk degradasi limbah zat warna remazol red 198. Tujuan penelitian ini untuk pembuatan dan karakterisasi membran fotokatalitik hollow fiberselulosa asetat-TiO2untuk degradasi remazol red 198. Membran hollow fiberdibuat dengan metode inversi fasa menggunakan larutan dopedengan perbandingan komposisi selulosa asetat, aseton, dan formamida (22%, 51%, dan 27%). Kemudian TiO2ditambahkan dengan variasi konsentrasi 0,10%; 0,15%; 0,20%; 0,25%; 0,30% (b/b). Karakterisasi membran hollow fibermeliputi uji ketebalan, uji mekanik, uji kinerja dan efisiensi membran fotokatalitik hollow fiberuntuk degradasi remazol red 198. Dari hasil penelitian diperoleh membran hollow fiberselulosa asetat-TiO2yang optimum pada penambahan TiO2sebesar 0,25%. Membran hollow fiberselulosa asetat-TiO2yang optimum mempunyai sifat mekanik yaitu keteblannya 0,1433 mm nilai tegangan 502,74 kN/m2nilai regangan 0,133 dan modulus young4781,13 kN/m2. Kinerja membran fotokatalitik hollow fiber mempunyai nilai fluks 17,41 L/m2jam dan rejeksi 91,8%. Efisiensi degradasi membran selulosa asetat-TiO2dan TiO2terhadapremazol red 198murni sebesar 92,43% dan 95,56%. Sedangkan efisiensi degradasi membran selulosa asetat-TiO2dan TiO2terhadap limbah cair sebesar 81,77% dan 88,34%.
STRUKTUR MOLEKUL SENYAWA ASAM 3,4 SECO BRIONONAT DALAM KULIT BATANG TANAMAN KECAPI KERA Sandoricum emarginatum Hiern Pratiwi Pudjiastuti
JURNAL PENELITIAN BIOLOGI BERKALA PENELITIAN HAYATI Vol 1 No 1 (1995): June 1995
Publisher : The East Java Biological Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (351.443 KB) | DOI: 10.23869/168

Abstract

Kecapi kera (Sandoricum emarginatum Hiern) is a plant grow in Sumatera, Indonesia bong the familia Meliaceae. There are two species of Sandoricum in Indonesia, Sandoricum koetjape and Sandoricum emarginatum. The S.koetjape plant has been investigated and contains some chemical compounds and there are two of which have a cytotoxic activity to the cell culture P 388 but Sandoricum emarginatum not yet investigated. The aim of this research was to determine the molecular structure compound of stem bark of Kecapi kera which soluble in chloroform. The chemical compound in stem bark of Kecapi kera was extracted with petroleum ether, chloroform, and methanol, respectively. Chloroform fraction was separated and isolated with column chromatography, n-hexane-ethyl acetate as mobile phase and silica gel as stationary phase. Molecular structure determination was carried out using spectroscopy method such IR, NMR, and MS. As the result a white crystal, 3,4-seco bryo-nonat could be isolated. The crystal has a needle like form and had melting point between 226-228oC.
BRINE SHRIMP TEST TRITERPENES FROM ROOT BARK OF Sandoricum emarginatum Pratiwi Pudjiastuti; Suyanto; Sudestry Manik; Cicik S. Cahyandari; Alfinda N. Kristanti
JURNAL PENELITIAN BIOLOGI BERKALA PENELITIAN HAYATI Vol 3 No 2 (1997): December 1997
Publisher : The East Java Biological Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23869/515

Abstract

The root of Sondoricum emargiatum, Meliaceae was collected in North Tapanuli, North Sumatera. Local people use this timber plant for construction and the fruit bark for cooking (Naito, 1986). In the previous investigation, 1,3,4 cuparatrien-15-ol, 4.15-cubebene and secobryononic acid were isolated from stem bark of Sondoricum emargiatum (Pratiwi). Further fractionation of n-hexane extract of root bark of Sondoricum emargiatum in the isolation of two triterpenes resulted byononic (1) and 3,4-seco-olean-4 (23), 12-dien-3,29-dionic acids (3) and their structures were elucidated by IR, MS, and NMR-spectroscopy. Compound (1) and (3) were forund more active than methyl bryononic derivate (2) with Brine Shrimp as bioindicator.
ANTHRAQUINONE FROM THALLUS OF LICHEN Ramalina javanica Nyl Suyanto Suyanto; Wahyudi Priyono Suwarso; Soleh Kosela; Hery Suwito; Pratiwi Pudjiastuti; Sri Winiati; Nurdin Saidi
Indonesian Journal of Chemistry Vol 6, No 1 (2006)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (234.471 KB) | DOI: 10.22146/ijc.21780

Abstract

The isolation of 1,3,8- trihydroxy-2(1'-pentanol)-6-methoxy anthraquinone from acetone extract of lichen thallus of Ramalina javanica Nyl. was carried out. Its structure was determined based on spectroscopic evidences.
A Novel Spectrophotometric Method for Determination of Histamine Based on Its Complex Reaction with Ni(II) and Alizarin Red S Miftakhul Jannatin; Ganden Supriyanto; Pratiwi Pudjiastuti
Indonesian Journal of Chemistry Vol 17, No 1 (2017)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (253.05 KB) | DOI: 10.22146/ijc.23621

Abstract

The development of analytical methods of histamine using Ni (II) and alizarin red S reagents by UV-Vis spectrophotometry has been done. The objective of this research is to determine the ability of Ni(II) and alizarin red S to form color complex compound with histamine and it will be used to detect the presence of histamine qualitatively and quantitatively as well. Absorbance was measured at a maximum wavelength of 604 nm. In this method, it has been carried out optimization of analytical parameters such as the concentration of Ni(II), the concentration of alizarin red S, pH, and respond time. Analytical parameter optimization showed concentration of Ni(II) is 20 ppm, alizarin red S 75 ppm, pH 8, and a respond time of 15 minutes. Method validation indicated that the coefficient of variation, detection limit, and the limit of quantitation are 0.245%; 9.49 ppm; and 31.62 ppm respectively with a sensitivity of 0.0063/ppm and linearity of 0.99. Accuracy to histamine with a concentration of 50, 75, and 125 ppm are 105.87%, 101.06%, 97.21%, respectively.
Analysis of Dissolution of Salicylamide from Carrageenan Based Hard-Shell Capsules: A Study of the Drug-Matrix Interaction Muhammad Al Rizqi Dharma Fauzi; Esti Hendradi; Pratiwi Pudjiastuti; Riyanto Teguh Widodo
Indonesian Journal of Chemistry Vol 21, No 1 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.55047

Abstract

In drug release kinetics, the drug-matrix interaction is one of the important mechanisms to be dictated. Unfortunately, there is still minimum information discussing the effect of interaction between a drug and its matrix to the release profile of the drug. Therefore, there is an urgent need to conduct research related to the study of drug-matrix interaction. This paper reports the preparation of a drug delivery system (DDS) in the form of hard-shell capsules containing salicylamide (SCA) and analyses its drug-matrix interaction via dissolution test at different pH media and various release kinetics models. The matrix of hard-shell capsules was prepared from κ-carrageenan (CRG), crosslinked with maltodextrin (MD), and plasticized by sorbitol (SOR). The chemical properties of SCA were compared with paracetamol (PCT) using computational analysis to help to depict its drug-matrix interaction. The statistical analyses showed that SCA and PCT at pH 1.2, 4.5, and 6.8 had all different release profiles. Based on the goodness of fit evaluation, the diffusion mechanism of SCA at pH 1.2 and 4.5 could be best described by the Peppas-Sahlin model while the zeroth-order model fitted the dissolution profile at pH 6.8. In summary, it was proven that a different drug-matrix interaction produced a different dissolution profile.
Characterization and release profile of sodium diclofenac halal hard shell capsules made from k-carrageenan and xanthan gum with sorbitol plasticizer Tri Susanti; Siti Wafiroh; Esti Hendradi; Pratiwi Pudjiastuti
Journal of halal product and research (JPHR) Vol. 3 No. 1 (2020): Journal of Halal Product and Research (JHPR)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jhpr.vol.3-issue.1.1-8

Abstract

Halal hard shell capsules are importantly needed by Indonesian consumers, who are predominantly Muslim, to substitute mostly used and commercially available products made from non-halal ingredients such as gelatin. The objective of this study is to prepare, characterize, and evaluate halal hard shell capsules made from k-carrageenan-xanthan gum with sorbitol as the plasticizer with diclofenac sodium as the model drug. Hardshell capsules were prepared with combinations of κ-carrageenan-xanthan gum at a weight ratio of 4:2 with the addition of 70% sorbitol, which added at a varied volume of 0.25; 0.50; 0.75; and 1.00 mL. Characterization of halal hard shell capsules includes swelling degree, tensile strength, Fourier Transformed Infrared (FTIR) and Scanning Electron Microscope (SEM), as well as disintegration test. The diclofenac sodium profile release was evaluated through the dissolution test at pH 6.8. The best physical characteristics were obtained by preparing capsule shells with a mixture of carrageenan-xanthan gum at a weight ratio of 4:2 with the addition of 0.25 mL sorbitol. The evaluation of Halal hard shell capsules showed that it had a swelling rate of 3.46% in water media, stress modulus of 28.6 MPa, strain modulus of 4.3 MPa, and modulus young of 362,3%, as well as disintegration time of capsules, was 51.8 minutes at pH 6.8. The dissolution test showed that diclofenac sodium was released at a level of 2.7% for 16 minutes. Based on this data, it can be concluded that the Halal hard shell capsule of κ-carrageenan-xanthan gum with the addition of sorbitol can be used as an alternative for the gelatin capsule with more controlled release.
Peningkatan Kesehatan Masyarakat melalui Edukasi Pemanfaatan Tanaman Obat di Pondok Pesantren An-Nidhomiyah Ngelom Sidoarjo Qurrota A'yuni; Fatiha Khairunnisa; Kautsar Ul Haq; Yanuardi Raharjo; Mulyadi Tanjung; Pratiwi Pudjiastuti; Purkan Purkan; A. Budi Prasetyo; Sofijan Hadi; Hamizah Haula'; Diana Merna; Eksan Ar Rasyid
Bubungan Tinggi: Jurnal Pengabdian Masyarakat Vol 5, No 1 (2023)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/btjpm.v5i1.7115

Abstract

Tanaman obat merupakan jenis tanaman yang memiliki khasiat sebagai obat serta dapat dimanfaatkan sebagai bahan pembuatan obat tradisional yaitu jamu untuk membantu masyarakat dalam pemeliharaan kesehatan, pencegahan penyakit dan perawatan kesehatan terutama di era new normal dan post-pandemi Covid-19. Beberapa khasiat dari obat tradisional yang umumnya dimanfaatkan masyarakat antara lain meringankan gejala flu, batuk, sakit tenggorokan, sakit kepala, nyeri haid, dan lain-lain. Tanaman obat dapat dibudidayakan di lingkungan sekitar tempat tinggal seperti rumah atau pondok pesantren. Kegiatan pengabdian kepada masyarakat (PkM) ini bertujuan untuk memberikan edukasi publik khususnya di lingkungan pondok pesantren mengenai manfaat tanaman obat sebagai upaya untuk meningkatkan pengetahuan, keterampilan, dan kesehatan masyarakat. Rangkaian kegiatan ini diselenggarakan di Pondok Pesantren An-Nidhomiyah pada Bulan Juli 2022. Kegiatan ini diselenggarakan secara luring dengan tetap memenuhi protokol kesehatan. Peserta kegiatan ini yaitu santri putra dan putri pondok pesantren An-Nidhomiyah yang berjumlah 30 peserta. Kegiatan ini dilakukan melalui metode pendampingan dan workshop dengan pemaparan materi, praktik pembuatan obat tradisional, dan penanaman tanaman obat di halaman pondok. Kegiatan ini mendapatkan antusiasme yang besar dari peserta. Hasil survei kepuasan peserta menunjukkan trendline sebesar 87% yang termasuk dalam kategori sangat memuaskan untuk semua aspek, yang berarti sebagian besar peserta sangat puas terhadap kegiatan PkM ini, baik dari segi materi, metode, narasumber, hingga fasilitas yang diberikan. Medicinal plants are plants that have efficacy for medicinal and can be used as ingredients for making traditional medicines, namely herbs, to help the community in health care, disease prevention, and health care, especially in the new normal era and the post-pandemic Covid-19. Some of the benefits of traditional medicine commonly used by the community include relieving symptoms of flu, cough, sore throat, headache, menstrual pain, and others. Medicinal plants can be cultivated around the residence, such as in houses or Islamic boarding schools. This community service activity aims to provide public education, especially in Islamic boarding schools, about the benefits of medicinal plants to improve knowledge, skills, and public health. This activity was held at the An-Nidhomiyah Islamic Boarding School in July 2022. This activity was held offline by implementing health protocols. The participants of this activity were students of the An-Nidhomiyah Islamic boarding school, totaling 30 participants. The activity is carried out through mentoring and workshop methods, including presentations, traditional medicine production practices, and planting medicinal plants in the boarding school yard. This activity received great enthusiasm from the participants. The participant satisfaction survey results show a trendline of 87%, which is included in the very satisfied category for all aspects, which means that most of the participants were very satisfied with this PkM activity in terms of topics, methods, speakers, and facilities provided.
Synthesis and Antidiabetic Evaluation of N’-Benzylidenebenzohydrazide Derivatives by In Silico Studies Yusuf Syaril Alam; Pratiwi Pudjiastuti; Saipul Maulana; Nur Rahmayanti Afifah; Fahimah Martak; Arif Fadlan; Tutik Sri Wahyuni; Syukri Arief
Indonesian Journal of Chemistry Vol 23, No 4 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.82073

Abstract

Two new of N’-benzylidenebenzohydrazide (NBB) derivatives were successfully synthesized and yielded 50–58%. FTIR, ESI-MS, 1H-NMR and 13C-NMR were used to investigate the characteristic of NBB derivates. The structure and relationship of NBB derivatives into α-glucosidase and α-amylase as good targets for diabetes treatment were evaluated using in silico screening. Molecular Mechanics-Poisson Boltzmann/Generalized Born Surface Area (MM-PB/GBSA) was used to calculate the free binding energy (ΔGbind (MM-GBSA)) of NBB to α-glucosidase and α-amylase receptors showed that the results of −0.45 and −20.79 kcal/mol respectively. In the ortho position, NBB derivatives exhibited electron donating groups (EDG like -OCH3, -OH and -Cl with binding free energies of −21.94, −6.71 and 21.94, respectively, and acarbose, a native ligand energy of 32.62 kcal/mol. In addition, the binding free energy of N-2-(-OCH3, -OH and -Cl)-NBB to the α-amylase receptor showed the number of −39.33, −43.96, −42.81, respectively and −46.51 kcal/mol in comparing with a native ligand. As a result, it was found that all the NBB derivatives were able to interact with several amino acids in the α-glucosidase cavity as well as the native ones, including Ala281, Asp282, and Asp616.  NBB and native ligand showed similar interaction between α-amylase with Gly110 amino acid residue.
Uterus Weight of Ovariectomized Rats Given Cocoa Powder and Extract Ariza Budi Tunjung; Misnawi Jati; Pratiwi Pudjiastuti; Afaf Baktir
Pelita Perkebunan (a Coffee and Cocoa Research Journal) Vol 33 No 1 (2017)
Publisher : Indonesian Coffee and Cocoa Research Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22302/iccri.jur.pelitaperkebunan.v33i1.253

Abstract

Estrogen is a hormone that influences the growth of uterus. Ovariectomized rats lose their ovaries as the main source of estrogen so their uterus tends to shrink. The objective of thise study was to evaluate the potency of cocoa as an estrogen substitute, which was done through an experiment that tested the influence of cocoa products on the uterus weight of ovariectomized rats. There were five treatments and in each of the treatments, six wistar rats were given the substance for three days. Four groups of treatment consisted of ovariectomized rats given cocoa extract (875.2 ppm of polyphenols, 1 g/kg of body weight, BW), cocoa powder (369.8 ppm of polyphenols, 1 g/kg BW), olive oil (10 mL/kg BW), or estradiol valerate (1 mg/kg BW). The fifth group consisted of intact (non-ovariectomized) rats given 10 mL/kg BW of water. The finding showed that the ovariectomized rats given olive oil had lower uterus weight than that of intact rats, while the ovariectomized rats given estradiol valerate had higher uterus weight compared to the intact and olive oil groups. The ovariectomized rats given cocoa powder and extract had higher uterus weight compared to those given only olive oil; although they were not significantly different. Correlation between the body weight and uterus weight varied across treatment groups. The rats given olive oil showed significant, positive correlation, while the intact rats showed moderate, positive correlation. The rats given estradiol valerate and cocoa powder showed non-significant correlation. Since the polyphenol content in cocoa powder was at lower concentration than that in the cocoa extract, it was predicted that cocoa polyphenols are more potential in the lower concentration. This study concludes that even though consumption of cocoa powder and extract did not significantly induced uterus growth, cocoa is still considered having estrogenic activity by lowering the correlation between the body weight and uterus weight in ovariectomized rats.
Co-Authors A. Budi Prasetyo AFAF BAKTIR Alfinda N. Kristanti Ariza Budi Tunjung Ariza Budi Tunjung Sari Cicik S. Cahyandari Diana Merna Eksan Ar Rasyid Esti Hendradi Fadlan, Arif Fahimah Martak Fatiha Khairunnisa Ganden Supriyanto Hamizah Haula' Hery Suwito Kautsar Ul Haq Mevitri Rahmiati Miftakhul Jannatin Misnawi Jati Misnawi Misnawi Muhammad Al Rizqi Dharma Fauzi Mulyadi Tanjung Nur Rahmayanti Afifah Nurdin Saidi Purkan Purkan Qurrota A’yuni Riyanto Teguh Widodo Saipul Maulana Siti Wafiroh Sofijan Hadi Soleh Kosela Sri Winiati Sudestry Manik Sugeng, Santoso Suyanto Suyanto Suyanto Tri Susanti Tutik Sri Wahyuni Wahyudi Priyono Suwarso Yanuardi Raharjo, Yanuardi Yusuf Syaril Alam