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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Kimia Riset Molecular and Cellular Biomedical Sciences (MCBS) Indonesian Journal of Chemistry Jurnal Layanan Masyarakat (Journal of Public Service) Proceeding Biology Education Conference Berkala Penelitian Hayati Journal of Advanced Technology and Multidiscipline (JATM) Andan Jejama: Indonesian Journal Of Community Engagement

Hery Suwito

Department Of Chemistry, Faculty Of Sciences, Airlangga University, Surabaya

Author-ID : 2970175

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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PRODUKSI ELISITOR UNTUK MENSTIMULASI METABOLIT SEKUNDER PADA KULTUR JARINGAN TUMBUHAN Junairiah, Junairiah; Nimatuzahroh, Nimatuzahroh; Suwito, Hery
Proceeding Biology Education Conference: Biology, Science, Enviromental, and Learning Vol 11, No 1 (2014): Prosiding Seminar Nasional XI Biologi
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar

One method in improving secondary metabolites in plant tissue culture is through elicitation, by adding elicitor to plant cells which is intended to induce and enhance secondary metabolites production. In this research, Trichoderma sp and Penicillium sp grown on amylum and Carboxy Methyl Cellulose (CMC) medium were used as elicitor. The results of this research showed that the best growth of the two fungi was produced on amylum medium, with incubation time six days and one day, wet weight 105,8 g/L and 87,4 g/L respectively.Â Keywords: elicitor, secondary metabolites

Mechanism of cytotoxic activity of chalcone derivatives against K562 leukemia cell lines Arina Novilla; . Mustofa; Indwiani Astuti; . Jumina; Hery Suwito
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 49, No 4 (2017)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Two chalcone derivatives i.e. (E)-1-(4-aminophenyl)-3-(2,3dimethoxyphenyl)-prop-2-en-1-one (Compound-1), and (E)-1-(4-aminophenyl)-3-phenylprop-2-en-1-one) (Compound-2),has been proven to have potential cytotoxic activity. The aim of this study was toevaluate the effect of these compounds on PI3K/Akt signalling pathway in K562 celllines. After incubation with the tested compounds, AKT, caspase-3, STAT3 and cyclinD1 concentrations were measured using ELISA. Furthermore, cell cycle was analysedusing flowcytometry. Imatinib and isotretinoin were used as positive control, whereascell culture without treatment was used as negative control. The AKT concentration aftertreatment with Compound-1 and -2 was significantly lower than that control, imatiniband isotretinoin (p<0.05). The apoptotic indices after treatment with Compound-1 and-2 were significantly higher than control, however they were lower than imatinib andisotretinoin (p<0.05). The caspase-3 concentration after treatment with Compound-1 at5 and 10 μg/mL and Compound-2 at 10 μg/mL was significantly higher than that controland imatinib, however it was lower than isotretinoin (p<0.05). The STAT3 concentrationafter treatment with Compound-1 and -2 was significantly lower than that control andisotretinoin at 50 μg/mL (p<0.05) and similar with imatinib (p>0.05). The cyclin D1concentration after treatment with Compound-1 and -2 was significantly lower than thatcontrol, imatinib and isotretinoin (p<0.05). In addition, Compound-1 and -2 arrested G0/G1 and G2/M phase in K562 cell lines, with comparable results to imatinib and isotretinoin.In conclusion, the mechanism of cytotoxic activity of Compound-1 and -2 are through thePI3K/Akt signalling pathway inhibition, apoptosis induction by upregulation of apoptoticmarkers, and inhibition of cell cycle progression by regulating cell cycle-related factors.

STUDI PELEPASAN TERKONTROL TERHADAP NANOENKAPSULASI DIMETOKSI AMINO CALKON SEBAGAI DESAIN KANDIDAT SENYAWA ANTI KANKER YANG EFEKTIF Mochamamad Zakki Fahmi; Hery Suwito; Shofi Yasmin Nurain; Yogi Putra Hidayatullah
Jurnal Kimia Riset Vol. 1 No. 2 (2016): Desember
Publisher : Universitas Airlangga

ABSTRAKEnkapsulasi merupakan sebuah proses dimana partikel kecil dikemas dalam sebuah partikel yang lebih besar sehingga membentuk kapsul. Metode tersebut akan digunakan untuk memodifikasi calkon, senyawa anti kanker yang memiliki kelarutan dalam air sangat rendah, dengan menggunakan Bovine Serum Albumin sebagai enkapsulan. Modifikasi senyawa calkon ini dilakukan dengan mencampurkan larutan BSA dalam air dan larutan calkon dalam kloroform kemudian diultrasonikasi. Senyawa hasil sonikasi tersebut disebut produk nanoenkapsulan BSA-calkon. Produk selanjutnya diuji ketahanannya terhadap perubahan pH, penambahan garam dan suhu. Produk kemudian dikarakterisasi menggunakan spektrofotometer UV-Vis, FTIR dan DLS. Proses nanoenkapsulasi dapat dikatakan berhasil dilakukan, ditunjukkan dengan produk nanoenkapsulan BSA-calkon yang dapat larut dalam air. Hasil karakterisasi menggunakan DLS menunjukkan bahwa produk nanoenkapsulan BSA-amino calkon memiliki rata-rata diameter partikel sebesar 457,5 nm dan 201,0 nm untuk produk nanoenkapsulan BSA-dimetoksi amino calkon. Hasil FTIR dari nanoenkapsulan BSA-amino calkon memunculkan serapan gugus amida pada 1639,55 cm-1. Sedangkan pada nanoenkapsulan BSA-dimetoksi amino calkon, gugus amida muncul pada serapan 1635,69 cm-1.Kata kunci : Nanoenkapsulasi, calkon, Bovine Serum Albumin, anti kanker.ABSTRACTEncapsulation is a process where a small particles packaged in a larger particles and it forms into a capsule. This method will be used to modify chalcone, an anticancer compound that have very low solubility in water. So it can’t be applied into human bodies. This chalcone will be encapsulated by Bovine Serum Albumin. Modification of chalcone is carried out by mixing a BSA solution in water and chalcone solution in chloroform by an ultrasonication process. The product will be tested for the resistance of pH, salt addition and temperature. The products also characterized using UV-Vis, FTIR and DLS instruments. Nanoencapsulation process was successfully do, it’s indicated by the nanoencapsulan product that has a high solubility in water. The results of DLS indicate that products have an average particle size is 457,5 nm for BSA-amine chalcone and 201,0 nm for BSA-dimethoxy amine chalcone. FTIR results shows that nanoencapsulation BSA-chalcone has amide groups, it showed by the absorption peak which raises at 1639,55 cm-1 for amine chalcone, and 1635,69 cm-1 for dimethoxy amine chalcone.Keywords : Nanoencapsulation, chalcone, bovine serum albumin, anti-cancer.

HIDROLISIS BEBERAPA JENIS XILAN DENGAN ENZIM XILANOLITIK TERMOFILIK REKOMBINAN Ni Nyoman Tri Puspaningsih; Hery Suwito; Sri Sumarsih; Ali Rohman; One Asmarani
JURNAL PENELITIAN BIOLOGI BERKALA PENELITIAN HAYATI Vol 12 No 2 (2007): June 2007
Publisher : The East Java Biological Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23869/353

The aims of this research were to know the ability of recombinant xylanolytic enzyme from recombinant E. coli DH5a (pTP510) to hydrolyze several commercial xylan and analysis the reduction sugar product. Recombinant xylanolytic enzyme (exo-xylanase, b-xylosidase and a-L-arabinofuranosidase) could hydrolyzed several commercial xylan (oat-spelt xylan, birchwood, wheat, rye, and arabinan) with xylanolytic activities are: oat-spelt xylan (1.73 U/mL), birchwood (0.92 U/mL), wheat (6.52 U/mL), rye (4.94 U/mL), and arabinan (3.40 U/mL). Xylanolytic enzyme assay use specific substrate p-nitrophenyl-b-D-xylopyranoside (pNP-X) shown xylosidase activity 15.869 U/mL. Hydrolysis product was analyzed by HPLC. The results showed that xylose, arabinose, and xylo-oligosaccharide were produced from birchwood, wheat, rye, and arabinan hydrolysis, although xylose and arabinose were produced from hydrolysis of oat-spelt xylan.

Cytotoxic Activity of Methoxy-4’amino Chalcone Derivatives Against Leukemia Cell Lines Arina Novilla; Mustofa Mustofa; Indwiani Astuti; Jumina Jumina; Hery Suwito
Molecular and Cellular Biomedical Sciences Vol 3, No 1 (2019)
Publisher : Cell and BioPharmaceutical Institute

Background: Chemotherapy is a common treatment for leukemia as well as in other cancer treatment. The lack of tumor selectivity and development of multi-drug resistance by chemotherapy caused the development of new strategy in cancer treatment become a pressing need. This study was performed to evaluate the anticancer activity and selectivity of seven derivatives of chalcones against K562 and HL-60 leukemia cell lines. Materials and Methods: The cytotoxicity of chalcone’s seven derivatives (compound 1-7) was tested by using MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxyme-thoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) method. The percentage of cell mortality data was calculated then the IC50 was analyzed using probit analysis (SPSS 17). The selectivity index (SI) then calculated from IC50 ratio of normal lymphocyte cells and cancerous cells line (HL-60 and K562).Results: The IC50 of almost all seven tested compounds were lower in HL-60 cell lines than K562 cell lines, except for Compound 7. The number and position of methoxy groups in chalcone derivatives influenced the anticancer and cancer selectivity of chalcone derivatives.Conclusion: The results revealed that the number and position of methoxy groups in chalcone derivatives influenced the anticancer and cancer selectivity of chalcone derivatives.Keywords: anticancer, chalcone derivatives, methoxy-4’-amino chalcone, leukemia, cytotoxic, selectivity

ANTHRAQUINONE FROM THALLUS OF LICHEN Ramalina javanica Nyl Suyanto Suyanto; Wahyudi Priyono Suwarso; Soleh Kosela; Hery Suwito; Pratiwi Pudjiastuti; Sri Winiati; Nurdin Saidi
Indonesian Journal of Chemistry Vol 6, No 1 (2006)
Publisher : Universitas Gadjah Mada

The isolation of 1,3,8- trihydroxy-2(1'-pentanol)-6-methoxy anthraquinone from acetone extract of lichen thallus of Ramalina javanica Nyl. was carried out. Its structure was determined based on spectroscopic evidences.

In Silico Analysis of Chalcone Derivatives as Potential Antibacterial Agents against DHPS Enzyme Ilma Amalina; Ni Nyoman Tri Puspaningsing; Hery Suwito
Journal of Advanced Technology and Multidiscipline Vol. 2 No. 1 (2023): Journal of Advanced Technology and Multidiscipline
Publisher : Faculty of Advanced Technology and Multidiscipline Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jatm.v2i1.43817

Chalcone and its derivatives have been reported to perform as antibacterial agents. With the increasing threat of antibacterial resistance in pharmaceutical sector today, the discovery of new antibacterial agents is essential to accomplish good health and well-being in supporting Sustainable Development Goals (SDGs) point 4. In silico analysis is a method used to evaluate some candidates of active compounds before the synthesis process is conducted. This study aims to investigate three chalcone derivatives as potential antibacterial agents using in silico method of molecular docking. The three chalcone derivatives, 3-(4-methoxyphenyl)1-phenylprop-2-en-1-one (1), 1-(4-aminophenyl)-3-(4- methoxyphenyl) prop-2-en-1-one (2) and 1-(4-bromophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one (3), were designed as pABA competitive inhibitor on DHPS and analyzed against Eschericia coli. This inhibitory mechanism was folate synthesis inhibition as precursor to DNA and RNA synthesis. Molecular docking of three chalcone derivatives with DHPS was generated using Autodock4. The results of this study showed that free energy binding (kcal/mol) of compounds (1), (2) and (3) were -6.27, -5.35 and -5.77, respectively. Besides, the Ki constant for three compounds in order were 25.50 µM, 120.32 µM and 58.84 µM, respectively. In fact, the molecular docking positions illustrated that three chalcone derivatives occupied the active site cleft. Specifically, compound (1) indicated the best outcome among the two other candidates. Meanwhile, sulfadiazine molecular docking as positive control showed lower free binding energy (-0.86 kcal/mol) and Ki constant (233.19 mM) compared to three other candidates. Therefore, three chalcone derivatives analyzed in this study demonstrated a role as potential antibacterial agents.

THE INTEGRATION OF COMPUTATIONAL CHEMISTRY TO SUPPORT INTERACTIVE LEARNING MEDIA FOR SENIOR HIGHSCHOOL: AN INNOVATIVE STRATEGY TO IMPLEMENT ‘KURIKULUM MERDEKA’ Haq, Kautsar Ul; Kristanti, Alfinda Novi; Suwito, Hery; Aminah, Nanik Siti; Rusdipoetra, R. Aryabraga; Alfian, Fariz Rizky; Asyura, Syarifah
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 8 No. 4 (2024): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jlm.v8i4.2024.526-536

Simulation or chemical modeling with computers is a major topic in computational chemistry. This subject is not covered in high school material, however, this method can be applied to support a more interactive learning process. Computational chemistry can be used as a virtual teaching aid and can also be used to help explain or predict chemical reactivity. The aim of this Community Service is to improve teachers' understanding of computational chemistry, both in theory and practice, according to the curriculum. The training activities were conducted using two methods: Lectures and practical sessions. Avogadro 1.2.0 and MOPAC2016 software were used for this training. The outcome of this program were evaluated using quantitative and qualitative analysis. The sustainability of the program was analyzed from the assignments regarding the plan to integrate the material provided into the learning process at schools. Based on the evaluation results, participants felt that the training they had received met their teaching needs. After participating in this training, the participants had various ideas for integrating computational chemistry into learning activities.

Peningkatan Wawasan Kimia Organik dalam Menunjang Pembelajaran Kimia di SMA Kristanti, Alfinda Novi; Aminah, Nanik Siti; Suwito, Hery
ANDAN JEJAMA: Indonesian Journal of Community Engagement (IJCE) Vol. 1 No. 1 (2022): Indonesian Journal of Community Engagement (IJCE) ANDAN JEJAMA
Publisher : FMIPA Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/ijceaj.v1i1.2

The role of practical work in Organic Chemistry is to provide experience to gain skills and to reinforce concepts that have been obtained from theory and also to increase understanding and to increase interest or motivation. However, practical work has not been an activity that can always be done in high school, especially for chemistry due to facility lack. For this reason, a workshop is needed to increase the understanding of high school chemistry teachers in basic Organic Chemistry, as well as to increase the insight of chemistry teachers in creating practical topics that are in accordance with the facilities available at school. The workshop was held for high school chemistry teachers in Mojokerto. The workshop consisted of an explanation of the basic of Organic Chemistry and the use of Chem Office software, accompanied by practical work in laboratory. The workshop held was successfully added the insights of the teachers and it was hoped that the knowledge obtained would be applied in learning process in their respective high schools.

Co-Authors . Jumina Alfian, Fariz Rizky Alfinda Novi Kristanti Ali Rohman Arina Novilla Arina Novilla Haq, Kautsar Ul Ilma Amalina Indwiani Astuti Indwiani Astuti Jumina Jumina Junairiah Junairiah Mochammad Zakki Fahmi Mustofa Mustofa Mustofa Mustofa Nanik Siti Aminah Ni Nyoman Tri Puspaningsih Ni Nyoman Tri Puspaningsing Nimatuzahroh, Nimatuzahroh Nurdin Saidi One Asmarani Pratiwi Pudjiastuti Rusdipoetra, R. Aryabraga Shofi Yasmin Nurain Soleh Kosela Sri Sumarsih Sri Winiati Suyanto Suyanto Syarifah Asyura, Syarifah Wahyudi Priyono Suwarso Yogi Putra Hidayatullah

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