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All Journal Jurnal Kartika Kimia Kartika : Jurnal Ilmiah Farmasi Jurnal Sains dan Kesehatan
Hernandi Sujono
Department Of Chemistry, Faculty Of Sciences And Informatics, Universitas Jenderal Achmad Yani, Jl. Terusan Jenderal Sudirman, Cimahi, 40531
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences

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Antifungal Activity of Red Galangal Oil (Alpinia purpurata K. SCHUM) Against Malassezia furfur Hernandi Sujono; Senadi Budiman; Yusi Fudiesta; Ahmad Sahroni; Jasmansyah Jasmansyah; Lela Lailatul Khumaisah
Jurnal Kartika Kimia Vol 2 No 2 (2019): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, Jenderal Achmad Yani University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (494.865 KB) | DOI: 10.26874/jkk.v2i2.40

Abstract

Plant red galangal (Alpinia purpurata K. Schum) is one of the many spices used as bio-pharmacy products which contain essential oil that is active as an antifungal and antibacterial agent. Isolation of volatile oil from red galangal rhizome (Alpinia purpurata K. Schum) uses the method of water and steam distillation so as to get the rendemen 0.1062%, the density 0.9524 g/mL and the index of refraction by 1.4862. Results from GC-MS (Gas Chromatography-Mass Spectrometry) retrieved 30 compounds contained in red galangal rhizome oil with 10 major compounds i.e. 1,8-cineole (40.92%), acetyl chavicol (10.33%), cis β-farnesene (6.91%), 1-caryophillene (6.32%), 1-β-bisabolene (3.37%), β-elemene (3.23%), α-pinene (3.20%), β-sesquiphellandrene (2.32%), β-pinene (2.21%), and germacrene-D (1.90%). The inhibition test was done by agar diffusion method and different variations of concentration (1, 2, 3 and 4%) compared with ketoconazole 2% as positive controls and dimethyl sulfoxide (DMSO) as negative controls with an incubation period of 2x24 hours. The test results show that the essential oil of red galangal rhizome (Alpinia purpurata K. Schum) can inhibit the growth of the fungus Malassezia furfur with the inhibitory power on concentrations1, 2, 3 and 4% were 7.15 mm, 13.87 mm, 16.05 mm and 20.05 mm, respectively. As for comparison, ketoconazole 2% was used as positive (+) control that produces inhibitory zone 27.20 mm and dimethyl sulfoxide (DMSO) as negative control (-) which does not produce inhibitory zones. Keywords: Essential oil, red galangal rhizome (Alpinia purpurata K. Schum), Malassezia furfur
PENGEMBANGAN DAN VALIDASI METODE KROMATOGRAFI CAIR KINERJA TINGGI (KCKT) UNTUK ESTIMASI KADAR SIMULTAN ANTIEMETIK PIRIDOKSIN HIDROKLORIDA DAN PIRATIAZIN TEOKLAT DALAM BENTUK SEDIAAN TABLET Fikri Alatas; Hernandi Sujono; Woro Artati Sucipto
Kartika : Jurnal Ilmiah Farmasi Vol 6 No 2 (2018)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v6i2.187

Abstract

Abstrak Metode kromatografi cair kinerja tinggi (KCKT) dengan detektor ultra lembayung telah dikembangkan dan divalidasi untuk estimasi kadar secara simultan campuran piridoksin hidroklorida (PH) dan piratiazin teoklat (PT)dalam sediaan tablet antiemetik. Proses pemisahan terjadi dalam kolom Inertsil® ODS-3 pada panjang gelombang 280 nm dengan laju alir 1,0 mL/menit. Fase gerak yang optimal untuk pemisahan adalah campuran methanol-asam asetat 1% (20:80) dengan waktu retensi PH dan PT berturut-turut adalah 1,2 dan 9,8 menit. Perolehan kembali PH dan PT berturut-turut adalah 100,13 dan 99,78 %. Batas deteksi untuk PH dan PT berturut-turut adalah 0,21 dan 0,22 µg/mL, sedangkan batas kuantisasinya berturut-turut adalah 0,70 dan  0,72 µg/mL. Metode ini dapat diterapkan sebagai metode untuk estimasi kadar campuran piridoksin hidroklorida dan piratiazin teoklat dalam bentuk sediaan tablet secara simultan. Kata kunci: Piridoksin hidroklorida, piratiazin teoklat, KCKT, tablet Development and validation of high performance liquid chromatography (HPLC) method for simultaneous estimation of antiemetic pyridoxyne hydrochloride and pyrathiazine theoclate in tablet dosage form Abstract The high performance liquid chromatography (HPLC) method with an ultra violet detector has been developed and validated for simultaneous estimation of pyridoxine hydrochloride (PH) and pyrathiazine theoclate (PT) in antiemetic tablet preparations. The separation process occurs in the Inertsil® ODS-3 column at a wavelength of 280 nm with a flow rate of 1.0 mL /min. The optimal mobile phase for separation is a mixture of methanol-acetic acid 1% (20:80) with the retention times of PH and PT 1.2 and 9.8 minutes respectively. The recoveries of PH and PT were 100.13 and 99.78%, respectively. The detection limits for PH and PT were 0.21 and 0.22 µg / mL respectively, while the quantisation limits were 0.70 and 0.72 µg / mL, respectively. This method can be applied as a method for simultaneous estimating the levels of pyridoxine hydrochloride and pyrathiazine theoclate in tablet dosage form. Keywords: Pyridoxine hydrochloride, pyrathiazine theoclate, HPLC, tablet
Moluskisida Kombinasi Mikroenkapsulasi Daun Kacang Babi, Daun Serai Wangi, dan Kitosan sebagai Pembasmi Keong Mas pada Tanaman Padi Valentina Adimurti Kusumaningtyas; Devitri Amisa; Hernandi Sujono; Senadi Budiman; Sukrido Sukrido; Trisna Yuliana; Melina Melina; Yana Maolana Syah; Lia Dewi Juliawaty; Tia Setiawati; Endang Rosdiana
Jurnal Sains dan Kesehatan Vol. 2 No. 4 (2020): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v2i4.146

Abstract

Abstract In this research, acombination biopesticide, a combination biopesticide from Tephrosia vogelii leaves and Cymbopogon nardus leaves has been made as an exterminator of golden snail in rice plants. The golden snail is one of the plant pest organism in rice plants which are capable of damaging plant in a short time. This study aim to determine the efficacy of a combination biopesticide of a mixture of T. vogelii leaves extract, C nardus leaves and kitosan as golden snail pest exterminators in rice plants. Three types of variance were used, namely formula I (1:1:1), II (1:2:1) and III (2:1:1) from the mixture of T. vogelii leaves extract, C nardus leaves powder and chitosan. From the test results obtained the fastest inial death time were formulation I (24.49 hours), LC50 of 10,60 g/kg which mildly toxic, 100 % daily mortaly in formulation III (day 5) and the fastest efficacy in formulation III were 38.89 % (day 2). Keywords : Golden snail, combinations biopesticide, Tephrosia vogelii, cymbopogon nardus and chitosan Abstrak Pada penelitian ini telah dilakukan pembuatan biopestisida kombinasi dari daun kacang babi, daun serai wangi dan kitosan sebagai pembasmi keong mas pada tanaman padi. Keong mas merupakan salah satu organisme pengganggu tumbuhan pada tanaman padi yang mampu merusak tanaman dalam waktu cepat. Penelitian ini bertujuan untuk mengetahui efikasi biopestisida kombinasi dari campuran ekstrak daun kacang babi, daun serai wangi dan kitosan sebagai pembasmi hama keong mas pada tanaman padi. Digunakan tiga jenis variansi yaitu formula I (1:1:1), II (1:2:1) dan III (2:1:1) dari campuran ekstrak daun kacang babi , serbuk daun serai wangi dan kitosan. Dari hasil pengujian diperoleh waktu awal kematian tercepat yaitu formula I (24,49 jam), LC50 sebesar 10,60 g/kg yang bersifat tosik ringan, mortalitas harian 100 % pada formula III (hari ke-5) dan rfikasi tercepat pada formula III yaitu 38,89 %(hari ke-2). Kata kunci : Keong mas, biopestisida kombinasi, kacang babi, serai wangi dan kitosan
Co-Authors Ahmad Sahroni Devitri Amisa Endang Rosdiana Fikri Alatas Jasmansyah Jasmansyah Lela Lailatul Khumaisah Lia Dewi Juliawaty Melina Melina Senadi Budiman Senadi Budiman Sukrido Sukrido Tia Setiawati Valentina Adimurti Kusumaningtyas Woro Artati Sucipto Yana Maolana Syah Yana Maolana Syah Yuliana, Trisna Yusi Fudiesta