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Sandro Vento
Faculty of Medicine, University of Puthisastra, Phnom Penh, Cambodia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Acute severe hepatitis of unknown etiology in children: A mini-review Andri Frediansyah; Malik Sallam; Amanda Yufika; Khan Sharun; Muhammad Iqhrammullah; Deepak Chandran; Sukamto S. Mamada; Dina E. Sallam; Yousef Khader; Yohannes K. Lemu; Fauzi Yusuf; James-Paul Kretchy; Ziad Abdeen; J. Smith Torres-Roman; Yogesh Acharya; Anastasia Bondarenko; Aamer Ikram; Kurnia F. Jamil; Katarzyna Kotfis; Ai Koyanagi; Lee Smith; Dewi Megawati; Marius Rademaker; Talha B. Emran; Ziad A. Memish; Sandro Vento; Firzan Nainu; Harapan Harapan
Narra J Vol. 2 No. 2 (2022): August 2022
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v2i2.83

Abstract

The emergence of acute, severe non hepA–E hepatitis of unknown etiology (ASHUE) has attracted global concern owing to the very young age of the patients and its unknown etiology. Although this condition has been linked to several possible causes, including viral infection, drugs and/or toxin exposure, the exact cause remains unknown; this makes treatment recommendation very difficult. In this review, we summarize recent updates on the clinical manifestations, complemented with laboratory results, case numbers with the global distribution and other epidemiological characteristics, and the possible etiologies. We also provide the proposed actions that could be undertaken to control and prevent further spread of this hepatitis. Since many etiological and pathological aspects of the acute non hepA–E hepatitis remain unclear, further research is needed to minimize the severe impact of this disease.
Acceptance and willingness to purchase a hypothetical COVID-19 vaccine in a region under Shariah law: A cross-sectional study in Aceh, Indonesia Muhammad A. Rayhan; Mudatsir Mudatsir; Nurjannah Nurjannah; Ichsan Ichsan; Mehrdad Amir-Behghadami; Yousef S. Khader; Ai Koyanagi; Ranjit Sah; Sandro G. Viveiros-Rosa; Mohammed A. Mamun; Yohannes K. Lemu; Assarag Bouchra; Laure SG. Linguissi; Aamer Ikram; Dina E. Sallam; Konstantinos Parperis; Uwe Wollina; Marius Rademaker; Sandro Vento; Said Usman
Narra J Vol. 2 No. 2 (2022): August 2022
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v2i2.85

Abstract

Vaccines are urgently needed to control the coronavirus disease 2019 (COVID-19) pandemic. The aim of this study was to determine the acceptance of and willingness to purchase a hypothetical COVID-19 vaccine in the general population of Aceh, a holistic Shariah law implementation province in Indonesia. An online cross-sectional study was conducted using a quota sampling technique between 1 to 24 September 2021. To determine hypothetical vaccine acceptance, respondents were asked if they were willing to accept vaccines with combinations of either 50% or 95% effectiveness and either 5% or 20% risk of adverse effects. Willingness to purchase was assessed by asking whether the participants would pay for such vaccines at certain price points. Logistic regression analysis was used to assess the associated determinants. Out of 377 respondents included in the final analysis, 86.5% were willing to accept a COVID-19 vaccine with 95% effectiveness and 5% adverse effects. The acceptance rate dropped to 45.1% if the risk of adverse effects was 20%. Vaccines with 50% effectiveness and 5% adverse effects were acceptable to 42.2% but the acceptance went down to 17.2% if the risk of adverse effects increased to 20%. Multivariate analysis found that men were twice as likely to accept a vaccine with 95% effectiveness and 5% adverse effects compared to females (aOR: 2.01; 95% CI 1.05–3.86). We found that 156/377 (41.3%) of respondents were willing to purchase a COVID-19 vaccine and of these participants 71.1% were willing to pay between Indonesian Rupiah (IDR) 50,000–150,000 (US$ 3.33–10.00). In conclusion, the acceptance rate of a hypothetical COVID-19 vaccine varied based on effectiveness and the risk of adverse effects.
Monkeypox: Immune response, vaccination and preventive efforts Youdiil Ophinni; Andri Frediansyah; Salin Sirinam; Dewi Megawati; Ana M. Stoian; Seyi S. Enitan; Richard Y. Akele; Ranjit Sah; Krit Pongpirul; Ziad Abdeen; Sevda Aghayeva; Aamer Ikram; Yohannes Kebede; Uwe Wollina; Kannan Subbaram; Ai Koyanagi; Abdulwahed Al Serouri; H. Blaise Nguendo-Yongsi; Jeffrey Edwards; Dina E. Sallam; Yousef Khader; Sandro G. Viveiros-Rosa; Ziad A. Memish; Mehrdad Amir-Behghadami; Sandro Vento; Marius Rademaker; Malik Sallam
Narra J Vol. 2 No. 3 (2022): December 2022
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v2i3.90

Abstract

Infectious threats to humans are continuously emerging. The 2022 worldwide monkeypox outbreak is the latest of these threats with the virus rapidly spreading to 106 countries by the end of September 2022. The burden of the ongoing monkeypox outbreak is manifested by 68,000 cumulative confirmed cases and 26 deaths. Although monkeypox is usually a self-limited disease, patients can suffer from extremely painful skin lesions and complications can occur with reported mortalities. The antigenic similarity between the smallpox virus (variola virus) and monkeypox virus can be utilized to prevent monkeypox using smallpox vaccines; treatment is also based on antivirals initially designed to treat smallpox. However, further studies are needed to fully decipher the immune response to monkeypox virus and the immune evasion mechanisms. In this review we provide an up-to-date discussion of the current state of knowledge regarding monkeypox virus with a special focus on innate immune response, immune evasion mechanisms and vaccination against the virus.
Global research profile on monkeypox-related literature (1962–2022): A bibliometric analysis Fajar Sofyantoro; Hendrix I. Kusuma; Sandro Vento; Marius Rademaker; Andri Frediansyah
Narra J Vol. 2 No. 3 (2022): December 2022
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v2i3.96

Abstract

The recent monkeypox or mpox outbreak has been a global concern. The present study evaluated the global research outputs, research trends, and topics of published research on monkeypox using a bibliometric approach. The Scopus database was searched for terms associated with "monkeypox" or "monkey pox" up until 19 November 2022. Maps and bibliometric indicators of the retrieved documents were shown and analyzed. A total of 1,422 documents were obtained from Scopus. Other than monkeypox, the most commonly used terms included epidemic, disease outbreaks, smallpox vaccine, and orthopoxvirus. In total, 90.3% of the documents were published between 2002 and 2022. The United States, the United Kingdom, and India were the top three countries in terms of productivity. Most of the institutions were from the United States. The International Journal of Surgery, the Journal of Medical Virology, and the Travel Medicine and Infectious Disease are some of the top journals currently publishing research on monkeypox. Tecovirimat, coronavirus disease 2019 (COVID-19), homosexuality, and pandemic are emerging topics related to monkeypox.
Co-Authors Aamer Ikram Aamer Ikram Abdulwahed Al Serouri Ai Koyanagi Ai Koyanagi Amanda Yufika Ana M. Stoian Anastasia Bondarenko Andri Frediansyah Andri Frediansyah Andri Frediansyah Assarag Bouchra Deepak Chandran Dewi Megawati Dewi Megawati Dina E. Sallam Dina E. Sallam Dina E. Sallam Fajar Sofyantoro Fauzi Yusuf Firzan Nainu H. Blaise Nguendo-Yongsi Harapan Harapan Hendrix I. Kusuma Ichsan Ichsan Iqhrammullah, Muhammad J. Smith Torres-Roman James-Paul Kretchy Jeffrey Edwards Kannan Subbaram Katarzyna Kotfis Khan Sharun Konstantinos Parperis Krit Pongpirul Kurnia F. Jamil Laure SG. Linguissi Lee Smith Malik Sallam Malik Sallam Marius Rademaker Marius Rademaker Marius Rademaker Marius Rademaker Mehrdad Amir-Behghadami Mohammed A. Mamun Mudatsir Mudatsir Muhammad A. Rayhan Nurjannah Nurjannah Ranjit Sah Ranjit Sah Richard Y. Akele Said Usman Salin Sirinam Sandro G. Viveiros-Rosa Sandro G. Viveiros-Rosa Sevda Aghayeva Seyi S. Enitan Sukamto S. Mamada Talha B. Emran Uwe Wollina Uwe Wollina Yogesh Acharya Yohannes K. Lemu Yohannes K. Lemu Yohannes Kebede Youdiil Ophinni Yousef Khader Yousef Khader Yousef S. Khader Ziad A. Memish Ziad A. Memish Ziad Abdeen Ziad Abdeen