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All Journal Jurnal Keperawatan Soedirman (The Soedirman Journal of Nursing) Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional Universa Medicina Acta Pharmaciae Indonesia : Acta Pharm Indo Jurnal Farmasi Indonesia
Esti Dyah Utami
Department of Pharmacy, University of Jenderal Soedirman
Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Gastroprotective Effect of Galangal, Turmeric and Their Combination on Rats’ Gastric Ulcers Ekowati, Heny; Anwar, Amalia Meisya; Audina, Fuzilestari Nur; Utami, Esti Dyah
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 3 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.49741

Abstract

Galangal (AG) and turmeric (CL) have potential gastroprotective activity. Both have been shown to prevent oxidation by scavenging free radicals and blocking oxidative enzymes. This study evaluated the gastroprotective effects of galangal, turmeric, and their combination extract against gastric mucosal lesions induced by ethanol-hydrochloric acid (HCl). The experimental design comprised 5 groups: group I was administered with Tween 80 (1%), and group II was administered ranitidine (50 mg/kgBW) orally. The other three groups were administered AG and CL, and their combination was administered (1:1) (100 mg/200 kg BW) orally for six days. On the 7th day, the rats were induced by ethanol-HCl (1: 1 v/v) 8 mL/KgBW. Six hours later, the rat was sacrificed and dissected for their gastric. Gross ulcer area, lesion length, histology, pH, and ulcer index were observed. There were improvements in pH, lesion score, ulcer index, and curative ratio. The histopathological profile showed ulcer repairment and lowering of neutrophil inflammatory cell infiltration. Statistical analysis showed the potential equivalence of the single and combination treatments in their gastroprotective effects. Galangal, turmeric, and its combination have gastroprotective activities by repair of ulcer and gastric pH, increasing the curative ratio, and decreasing the ulcer index in the rat model.
Co-Authors . Harwoko Andaru Dahesihdewi ANDRIANA, DOROTHEA DWI ANISYAH ACHMAD Anwar, Amalia Meisya Audina, Fuzilestari Nur Endang Lukitaningsih Hanif Nasiatul Baroroh Heny Ekowati Ika Puspitasari Laksmi Maharani Lestari, Putri Dwi Lesty, Rupa MUSTIKANINGTIAS, IKA Nia Kurnia Sholihat, Nia Kurnia Nurmahmudah, Nurmahmudah Nurmahmudah, Nurmahmudah Rizka Humardewayanti Asdie Suryoputri, Masita Wulandari Tuti Sri Suhesti Zulkepli, Nur Ayunie