Article Per Year (5 Year)
p-Index From 2021 - 2026
0.888
P-Index
This Author published in this journals
All Journal Jurnal Keperawatan Soedirman (The Soedirman Journal of Nursing) Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional Universa Medicina Acta Pharmaciae Indonesia : Acta Pharm Indo JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Farmasi Indonesia
Esti Dyah Utami
Department of Pharmacy, University of Jenderal Soedirman
Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

Published : 12 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 12 Documents
Search

 1   2 
Gastroprotective Effect of Galangal, Turmeric and Their Combination on Rats’ Gastric Ulcers Ekowati, Heny; Anwar, Amalia Meisya; Audina, Fuzilestari Nur; Utami, Esti Dyah
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 3 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.49741

Abstract

Galangal (AG) and turmeric (CL) have potential gastroprotective activity. Both have been shown to prevent oxidation by scavenging free radicals and blocking oxidative enzymes. This study evaluated the gastroprotective effects of galangal, turmeric, and their combination extract against gastric mucosal lesions induced by ethanol-hydrochloric acid (HCl). The experimental design comprised 5 groups: group I was administered with Tween 80 (1%), and group II was administered ranitidine (50 mg/kgBW) orally. The other three groups were administered AG and CL, and their combination was administered (1:1) (100 mg/200 kg BW) orally for six days. On the 7th day, the rats were induced by ethanol-HCl (1: 1 v/v) 8 mL/KgBW. Six hours later, the rat was sacrificed and dissected for their gastric. Gross ulcer area, lesion length, histology, pH, and ulcer index were observed. There were improvements in pH, lesion score, ulcer index, and curative ratio. The histopathological profile showed ulcer repairment and lowering of neutrophil inflammatory cell infiltration. Statistical analysis showed the potential equivalence of the single and combination treatments in their gastroprotective effects. Galangal, turmeric, and its combination have gastroprotective activities by repair of ulcer and gastric pH, increasing the curative ratio, and decreasing the ulcer index in the rat model.
Potential Antibiotic-Drug Interactions: Analysis of Pediatric Patient Prescriptions at Omnia Farma Pharmacy Purwokerto Utami, Esti Dyah; Maharani, Farah Ayu; Ekowati, Heny; Suryoputri, Masita Wulandari
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 16, No 1
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.101427

Abstract

Background: The use of drugs in pediatric patients requires special attention because pediatrics have physiological and anatomical differences with adults. Children are more susceptible to infectious diseases and often get antibiotic therapy and other symptomatic drugs to support recovery, thus increasing the potential for drug interactions.Objectives: The study aimed to analyze the incidence of potential antibiotic drug interactions prescribed to pediatric patients at Omnia Farma Pharmacy Purwokerto. Methods: This observational study was conducted retrospectively by collecting prescription data of pediatric patients aged 0-18 years at Omnia Farma Pharmacy Purwokerto from January to December 2023 using a simple random sampling method. Data were analyzed descriptively using the standard of the Lexicomp Interaction Checker database and other scientific literature. Results: There were 286 patient prescriptions that met the inclusion criteria. The majority of patients were male, aged 1-5 years, with the most prescribed antibiotic being amoxicillin (73.13%). The study only found potential drug interactions in 12 antibiotic prescriptions (4.20%), of which 50% were interactions between azithromycin and salbutamol. Most of the potential antibiotic-drug interactions found were of minor severity (91.67%), with pharmacodynamic interaction mechanisms (83.33%).Conclusion: The antibiotic prescriptions given to pediatric patients at Omnia Farma Pharmacy were quite good in terms of the minimal number of potential drug interactions found. Special attention to the therapy of pediatric patients through the collaboration of doctors and pharmacists is important to help patients get optimal therapy.
Co-Authors . Harwoko Andaru Dahesihdewi ANDRIANA, DOROTHEA DWI ANISYAH ACHMAD Anwar, Amalia Meisya Audina, Fuzilestari Nur Endang Lukitaningsih Hanif Nasiatul Baroroh Heny Ekowati Ika Puspitasari Laksmi Maharani Lestari, Putri Dwi Lesty, Rupa Maharani, Farah Ayu MUSTIKANINGTIAS, IKA Nia Kurnia Sholihat, Nia Kurnia Nurmahmudah, Nurmahmudah Nurmahmudah, Nurmahmudah Rizka Humardewayanti Asdie Suryoputri, Masita Wulandari Suryoputri, Masita Wulandari Tuti Sri Suhesti Zulkepli, Nur Ayunie