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All Journal Jurnal Keterapian Fisik Jurnal Biologi Tropis Jurnal Riset Kesehatan Nasional ad-Dawaa : Journal of Pharmaceutical Sciences BIO-EDU: Jurnal Pendidikan Biologi Udayana Journal of Social Sciences and Humanities (UJoSSH) Jurnal Pijar MIPA JRKN Sciences of Pharmacy Jurnal Pengabdian Kepada Masyarakat Itekes Bali
Putu Indrayoni
Institut Teknologi Dan Kesehatan Bali
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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Liver Histology of Male Rat (Rattus norvegicus) Feed L-Carnitine Supplement Padmiswari, Anak Agung Istri Mas; Indrayoni, Putu; Wulansari, Nadya Treesna
Jurnal Pijar Mipa Vol. 19 No. 4 (2024): July 2024
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v19i4.6900

Abstract

Obesity is a condition where the body is overweight due to fat accumulation, each exceeding 20-25% of body weight for men and women. L-carnitine is a nutrient that plays a role in transporting fat to the mitochondria to be burned and converted into energy for the body. Sufficient L-carnitine allows the body to burn fat at optimal levels. This research aims to determine the side effects of fed L-carnitine supplements against liver histology. This study used a completely randomized design (CRD) with four groups comprising six albino rats. The treatments were fed orally by distilled water 1 ml/day (Control), P1 fed by L-carnitine supplement dose 100 mg/kg body weight orally 1ml/day, P2 fed by L-carnitine supplement dose 150 mg/kg body weight orally 1ml/day, P3 fed by L-carnitine supplement dose 200 mg/kg body weight orally 1ml/day. Treatments were given to albino rats every day for 90 days. Variables observed measured were lipid degeneration, central vein dilation, and pyknotic nuclei. Data were analyzed with the statistical program (SPSS 22.0 for Windows) with One Way ANOVA. The results showed that feeding L-carnitine supplements in high doses for long periods can damage the liver cells of male rats. The microscopic liver damage statistical analysis showed significant differences (P<0.05) between the control and treatment groups.
The Effect of Acupuncture Therapy on the Concentration Level of Health Students Ayu Anom Rastiti, Ida; Ayu Suptika Strisanti, Ida; Rosa Tri Anggaraeni, Komang; Indrayoni, Putu
Jurnal Keterapian Fisik Jurnal Keterapian Fisik Volume 9 Issue 2 Year 2024
Publisher : Poltekkes Kemenkes Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37341/jkf.v9i2.446

Abstract

Background: Health students face various challenges during their studies. The demands of mastering clinical skills and the ability to build therapeutic relationships with patients require high concentration from health students. So it is important for health students to have good concentration during the learning process so that students' mastery of clinical skills can be achieved optimally. Acupuncture is a therapeutic modality that has been proven to have a function to improve individual cognitive abilities. This study aims to identify the effectiveness of acupuncture therapy in improving the concentration of health students. Methods: The research sample in this study is 60 undergraduate nursing students of the Institute of Technology and Health Bali who are divided into an intervention group (n = 30) and a control group (n = 30). The instrument that will be used in this study is the Grid Concentration test to assess the level of student concentration. Results: There was a significant increase (p < 0.05) in the concentration score in the treatment group, where before acupuncture the concentration score was (median = 14) and after acupuncture, the concentration score became (median = 20.50). Conclusion: According to the results above, it proves that acupuncture therapy is effective in improving student concentration and can directly optimize working memory capacity.
Characterization of Gomphrena globosa L. Flower Extract and Anti-Acne of Formulated Cream Against Cutibacterium acnes Wuryanto, Stefani Alya Swasa; Damayanti, Ida Ayu Manik; Indrayoni, Putu
Sciences of Pharmacy Volume 5 Issue 3 (2026)
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0502675

Abstract

Cutibacterium acnes is a cause of acne. Conventional treatments often lead to side effects and bacterial resistance, necessitating natural alternatives. Globe Amaranth (Gomphrena globosa L.) shows potential as an anti-acne agent. This study employed an in vitro experimental laboratory design to evaluate the anti-acne activity of G. globosa L. flower extract formulated cream against C. acnes using the well diffusion method. Antibacterial activity was tested using KN (base cream), KP (1% clindamycin cream), F1 (10%), F2 (15%), and F3 (20%), and the data were analyzed using SPSS statistical analysis. Results indicated that the ethanolic extract of GA flowers has an IC50 of 85.483 ppm, TPC of 60.456 ± 0.589 mg GAE/g, and TFC of 34.390 ± 0.989 mg QE/g. It exhibited antibacterial activity against C. acnes, with inhibition zone diameters of 6.693 ± 0.2 mm for the 15% formula and 7.382 ± 0.22 mm for the 20% formula. The antibacterial activity is believed to be driven by the presence of secondary metabolites, particularly phenols and flavonoids identified in the extract.
Co-Authors AA Istri Mas Padmiswari Anjasmara, Dewa Gede Anom Asthadi Mahendra Bhandesa, Asthadi Mahendra Ayu Anom Rastiti, Ida Ayu Suptika Strisanti, Ida I Gusti Bagus Teguh Ananta I Gusti Ngurah Made Kusuma Negara Ida Ayu Manik Damayanti Ida Ayu Putu Ary Widnyani Kartiningsih, Ni Luh Putu Made Rismawan Nadya Treesna Wulansari Nadya Treesna Wulansari Pande P Elza Fitriani Putu Rima Sintyadewi Rosa Tri Anggaraeni, Komang Sri Dewi Megayanti Wulansari, Nedya Treesna Wuryanto, Stefani Alya Swasa