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All Journal Current Biochemistry Jurnal Pusat Inovasi Masyarakat Jurnal Manajemen, Akuntansi, Ekonomi Sahid Business Journal: Jurnal Penelitian Manajemen Bisnis Syariah: Program Studi Manajemen Bisnis Syariah Buitenzorg: Journal of Tropical Science
Syaefudin
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Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Social Sciences

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The Inhibitory Activity and Kinetics of α-Glucosidase by Toona sinensis Stem Bark Extracts Melati Devina Gustini Wirastuti; Syamsul Falah; Syaefudin
Current Biochemistry Vol. 9 No. 1 (2022)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.9.1.2

Abstract

Research on the potential of the Surian tree (Toona sinensis) for medicine has been carried out, especially for the leaves. However, the bark section has not been done much. This study aimed to determine the inhibitory activity of -glucosidase and IC50 extract as well as the fraction of surian bark as antidiabetic in vitro. The reflux method with water at 90oC and maceration using 70% ethanol at room temperature was carried out to obtain aqueous and ethanol extracts. Furthermore, the ethanol extract was fractionated successively using n-hexane, diethyl ether, and ethyl acetate. Phytochemical screening test showed that the aqueous extract contained flavonoids, saponins, and tannins. Meanwhile, the 70% ethanol extract and its fraction showed terpenoid content, in addition to flavonoid compounds, saponins, and tannins. The best -glucosidase inhibition was shown by 70% ethanol extract, which was 70.45 ppm followed by ethyl acetate fraction, n-hexane fraction, diethyl ether fraction, and water extract of surian bark with values of 81.96 g/mL, 98.76 g/mL, respectively. , 140.25 g/mL, and 242.85 g/mL. Kinetics of -glucosidase inhibition showed that 70% ethanol extract of surian bark inhibited through a non-competitive inhibition mechanism, characterized by a decrease in Vmax from 8.29x10-3 mM/min to 1.65x10-3 mM/min and a decrease in Km from 0.17 mM to 0.03 mM.
ANALISIS PERSEPSI KEPUASAN PENGGUNA LULUSAN FAKULTAS EKONOMI DAN BISNIS ISLAM INSTITUT AGAMA ISLAM SAHID BOGOR PERIODE 2015-2021 Syaefudin; Thantawi, Tubagus Rifqy; Fadilah, Hafid
Sahid Business Journal : Jurnal Penelitian Manajemen Bisnis Syariah: Program Studi Manajemen Bisnis Syariah Vol 3 No 2 (2024): Mei 2024
Publisher : Jurnal Penelitian Manajemen Bisnis Syariah: Program Studi Manajemen Bisnis Syariah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56406/sahidbusinessjournal.v3i2.166

Abstract

This research is motivated by the influence of graduates of the Faculty of Economics and Islamic Business, Sahid Islamic Institute of Islam on the company. The purpose of this study was to analyze the influence of graduates of the Faculty of Economics and Islamic Business, Sahid Islamic Institute, Bogor. This research is qualitative and the method of data collection is by distributing questionnaires and by filling out questionnaires to colleagues from the graduates of the Faculty of Economics and Islamic Business, the Sahid Islamic Institute of Bogor, in their respective companies. The sample in this study were 40 people as respondents. There are several respondents who were included in the study, namely Gender, Place of Work, Position of Users of Graduates of the Faculty of Economics and Islamic Business, Sahid Islamic Institute Bogor, Year of Starting Work and Employment Status. To explain some of the respondents in question. This research shows that the analysis consisting of knowledge of the Faculty of Economics and Islamic Business Sahid Islamic Institute Bogor, simultaneously affects users of graduates of the Faculty of Economics and Islamic Business, Sahid Islamic Institute Bogor.
Analisis Tingkat Pengangguran Terhadap Transaksi Judi Online di Indonesia: Perspektif Sosial Ekonomi Misla, Misla Nurhasanah; Syaefudin; Rolis; Rinol Sumantri; Muhammad Faris Afif; M. Iqbal
Jurnal Manajemen, Akuntansi, Ekonomi Vol. 4 No. 1 (2025): Jurnal Manajemen, Akuntansi, Ekonomi
Publisher : CV. Era Digital Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59066/jmae.v4i1.1230

Abstract

Penelitian ini bertujuan untuk menganalisis kontribusi judi online terhadap tingkat pengangguran dan dampaknya dari perspektif ekonomi Islam. Metode yang digunakan adalah kuantitatif dengan pendekatan survei dan analisis data sekunder. Hasil penelitian menunjukkan bahwa judi online memperburuk kondisi finansial masyarakat, meningkatkan kecanduan, dan pada akhirnya berkontribusi pada peningkatan pengangguran. Intervensi kebijakan diperlukan untuk menangani pengangguran dan dampak negatif judi online dalam konteks ekonomi Islam. Adanya penurunan jumlah pengangguran di Indonesia, meskipun menunjukkan tren positif, belum diiringi dengan perbaikan signifikan dalam kualitas hidup masyarakat. Banyak individu, terutama dari kalangan lulusan pendidikan menengah ke bawah, beralih ke aktivitas berisiko seperti judi online sebagai pelarian dari kesulitan ekonomi. Beberapa faktor utama penyebab pengangguran di Indonesia mencakup kurangnya lapangan kerja, keterampilan yang tidak memadai, kurangnya informasi pekerjaan, ketidakmerataan peluang kerja, dan rendahnya efisiensi pelatihan kerja oleh pemerintah.
Peredaman Radikal Bebas DPPH dan Aktivitas Inhibisi α-Glukosidase oleh Ekstrak Air Jahe Merah Safithri, Mega; Syaefudin; Putri, Azka Adzkya Emalia
Current Biochemistry Vol. 10 No. 2 (2023)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.10.2.5

Abstract

Red ginger (Zingiber officinale Roxb. var. Rubrum) contains phenolic compounds that have potential to reduce blood glucose levels (antihyperglycemic) in patients with diabetes mellitus. This study aimed to determine the inhibitory activity toward α-glucosidase, antioxidant activity in reducing DPPH free radicals, and total phenolic content of aqueous extract of red ginger. The red ginger was extracted using water solvent at 100 oC for 15 minutes. Analysis of antioxidant activity, inhibitory activity of α-glucosidase, and total phenolic content using the spectrofotometry. Antioxidant activity showed that the extracts from the first, second and third replicates were not significantly different (p<0.05). α-glucosidase inhibition activity showed that the 1st replicate extract had the highest value of 97.729% and was significantly different (p<0.05) from the 2nd and 3rd replicate extracts and acarbose. The total phenolic content showed that the 2nd replicate extract had the highest value, namely 27,624 mg GAE/g extract and was significantly different (p<0.05) from the 1st and 3rd replicate extracts. The 1st, 2nd, and 3rd replicates of red ginger aqueous extract has the same antioxidant activity and equivalent glucosidase inhibitory activity as acarbose.
In Vitro Analysis of Gradual Water Extract of Red Betel Leaf (Piper crocatum) as Free Radical Scavenging and Inhibitor of α-Glucosidase Safithri, Mega; Fibri Yuniasih, Tiara; Syaefudin
Current Biochemistry Vol. 10 No. 1 (2023)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.10.1.5

Abstract

Red betel (Piper crocatum) has antihyperglycemic activity for diabetic treatment. The purpose of this study was to investigate the activity of DPPH free radical scavenging, the α-glucosidase inhibitory activity, and total phenolics of the aqueous extract of P. crocatum (1st extract, 1st extract residue, and 2nd extract residue). The infundation method was used with spectrophotometric test techniques. The red betel leaves extract in all extracts and extract residues had a small of α-glucosidase inhibition activity ranging from 0.76% - 1.43%. Meanwhile, the antioxidant activity of DPPH and total phenolic levels showed significantly different results (p<0.05) in the 1st extract, 1st extract residue, and 2nd extract residue. The highest antioxidant capacity and total phenolic content were found in the first extract, it were 59.64 ± 0.18 mg AAE/g extract and 55.50 ± 0.14 mg GAE/g, respectively. Gradual extraction reduced DPPH free radical scavenging activity, α-glucosidase inhibition activity and phenolic total content.
Ketegangan permukaan dan aktivitas penghambatan tirosinase in vitro pada minyak tamanu (Calophyllum inophyllum L.) Kusnaedi, Anggi; Andrianto, Dimas; Syaefudin
Buitenzorg: Journal of Tropical Science Vol 1 No 2 (2024): Buitenzorg: Journal of Tropical Science
Publisher : Innovation Centre for Tropical Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70158/buitenzorg.v1i2.11

Abstract

Tamanu or nyamplung oil, derived from Calophyllum inophyllum L., is commonly used in traditional medicine and occasionally used as a moisturizer in skincare cosmetics. In silico predictions suggested that tamanu oil contained compounds capable of inhibiting tyrosinase activity. This study aimed to measure the surface tension of tamanu oil and evaluate its tyrosinase inhibitory activity in vitro. The surface tension of tamanu oil was measured using the du-Nouy ring method with a tensiometer, while tyrosinase inhibitory activity was assessed by spectrophotometry using a microplate reader. The study revealed that the surface tension of tamanu oil was measured at 41.83±0.76 mN/m, and the tyrosinase inhibitory activity of tamanu oil was determined to be 83.75±0.41%. Notably, the inhibitory activity of tamanu oil was comparable to that of the positive control, kojic acid, which exhibited a tyrosinase inhibition of 84.59±2.04%. We concluded that tamanu oil has potential as a natural surfactant raw material and may serve as an effective tyrosinase inhibitor.   Keywords: Calophyllum inophyllum L., nyamplung, surface tension, tamanu oil, tyrosinase inhibitor
Pelatihan Pembuatan Pupuk Kompos, Biopestisida, dan Bioherbisida sebagai Upaya Revitalisasi Pertanian Berkelanjutan di Desa Ngadireso, Malang Maulana Arham; Muhammad Ikhwan Ramadhan; Nurul Rahma Khaerunisa; Markus Amartya Sam Hutahaean; Hemas Aulia Fazzahra; Kinaya Aliqa Wijaya; Resta Maryamzahra; Gathan Ferbiansyah Kusworo; Syaefudin
Jurnal Pusat Inovasi Masyarakat Vol. 7 No. 2 (2025): Oktober 2025
Publisher : Direktorat Pengembangan Masyarakat Agromaritim, Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jpim.7.2.200-210

Abstract

Ngadireso Village has significant agricultural potential, particularly in cultivating horticultural commodities such as cabbage, chili, and oranges, which serve as the main sources of livelihood for the local community. However, agricultural practices in Ngadireso Village are still largely dominated by the use of chemical-based fertilizers, pesticides, and herbicides that pose risks to human health and the environment, while also increasing production costs. The community service activity conducted in Ngadireso Village aimed to enhance public understanding of the production of compost fertilizer, natural biopesticides, and bioherbicides that are more environmentally friendly, easy to make, and cost-effective. The methods used included socialization, demonstration of the production process, and hands-on practice with the Sri Rahayu 1 farmer group in Ngadireso Village. The materials used were locally sourced and easily obtainable within the village area. The results of the activity showed that the community was highly enthusiastic in participating in the training and gained a better understanding of the importance of sustainable agriculture. In addition to reducing dependency on synthetic chemicals, this activity also encouraged the utilization of local waste and promoted farmers’ self-reliance. It is expected that through this initiative, the people of Ngadireso Village will continue to develop a healthier, more economical, and environmentally conscious agricultural system.
Co-Authors DIMAS ANDRIANTO Fadilah, Hafid Fibri Yuniasih, Tiara Gathan Ferbiansyah Kusworo Hemas Aulia Fazzahra Kinaya Aliqa Wijaya Kusnaedi, Anggi M. Iqbal Markus Amartya Sam Hutahaean Maulana Arham Mega Safithri Melati Devina Gustini Wirastuti Misla, Misla Nurhasanah Muhammad Faris Afif Muhammad Ikhwan Ramadhan Nurul Rahma Khaerunisa Putri, Azka Adzkya Emalia Resta Maryamzahra Rinol Sumantri Rolis Syamsul Falah Thantawi, Tubagus Rifqy