Article Per Year (5 Year)
p-Index From 2020 - 2025
0.61
P-Index
This Author published in this journals
All Journal Journal of Agromedicine and Medical Sciences Journal of Islamic Medicine
Nurfianti Indriana
Department Of Obstetrics And Gynecology, Faculty Of Medicine And Health Sciences, Universitas Islam Negeri Maulana Malik Ibrahim, Malang, Indonesia
Health Professions Medicine & Pharmacology

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
High Degree of Parasitemia Induces Placental Hypoxia and Low Birth Weight Nurfianti Indriana; Zainabur Rahmah; Alvi Milliana
Journal of Agromedicine and Medical Sciences Vol 8 No 2 (2022)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v8i2.31243

Abstract

Placental malaria causes low fetal weight associated with infiltration of monocytes and parasites in the placenta resulting in placental hypoxia. Hypoxia is characterized by HIF expression. HIF-1α expression responds early to the occurrence of hypoxia (<24 hours) and HIF-2α promotes chronic hypoxia (>24 hours). There were two groups in this study, namely the control group (10 pregnant mice without Plasmodium berghei infection) and the treatment group (10 pregnant mice infected with Plasmodium berghei). Pregnant mice were operated on on the 18th day after mating. The degree of parasitemia was measured by Giemsa staining. Expression of HIF-1α and HIF-2α in placental tissue was measured by immunohistochemistry. Results by paired t test, HIF-1α expression in the placental tissue in the treatment group was higher than the control group (p=0.02), HIF-2α expression in the placental tissue was higher in the treatment group than in the control group (0, 01) the fetal weight in the treatment group was lower than in the control group (p=0.01). By using SEM analysis, the degree of parasitemia caused high expression of HIF-1α in placental tissue (tcount = 4.625, ttable = 1.96). High expression of HIF-2α in placental tissue (tcount = 2.672 ttable = 1.96). The degree of parasitemia causes low fetal weight (tcount = 27.764 ttable = 1.96). The results also showed that HIF-1 caused low birth weight (tcount = 2.376 ttable=1.96) also HIF-2α caused low fetal weight (tcount = 4.267 ≥ 1.96). Conclusions the degree of parasitemia causes high expression of HIF-1α and HIF-2α in placental tissue and low birth fetuses. Expression of HIF-1α and HIF-2 also causes low birth weight. Keywords: malaria in pregnancy, degree of parasitemia, HIF-1α , HIF-2α , birth weight
Pregnancy Complication Due to Malaria in Mice BALB/C : The Role of TNF-α, Anemia, and Low Birth Weight Alvi Milliana; Nurfianti Indriana; Zainabur Rahmah
Journal of Islamic Medicine Vol 7, No 1 (2023): JOURNAL OF ISLAMIC MEDICINE EDISI MARET 2023
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v7i1.20828

Abstract

Background : Malaria infection in pregnant women or called placental malaria is characterized by the accumulation of Plasmodium-infected red blood cells in the intervillous space of the placenta. This causes adverse perinatal outcomes such as stillbirth, low birth weight, premature birth, and small neonates of gestational age while in the mother it causes anemia. Inflammatory responses such as TNF-α expression can promote complications in pregnancy. TNF-α plays an important role in the immune response in acute malaria but inhibits erythropoiesis. Objective : This study aims to determine the relationship between malaria infection and TNF-α expression with the incidence of anemia and birth weight in pregnant mice infected with Plasmodium berghei. Methods: Twenty BALB/C pregnant mice were divided into 2 groups, control group (10 pregnant mice without infection) treatment group (10 pregnant mice infected with Plasmodium berghei). TNF-α expression was observed by immunohistochemical method using anti-TNF-α Chip Grade antibody from abcam, anemia examination using Cyanmethemoglobin and all fetuses were weighed using an analytical balance. Statistical analysis using Structural Equation Modeling. Results: Malaria infection causes high expression of TNF-α in the placenta (tcount=2.97≥ ttable = 1.96), causes anemia (tcount=1,97≥ttable = 1.96) and causes low fetal weight tcount=2,16 ≥ ttable =1, 96. Conclusion: Malaria infection can cause high expression of TNF-α in the placenta causing anemia and low birth weight of the fetus
The Relationship Between Proteinuria Degree of Pre-eclampsia Mother and Incidence of Neonatal Low Birth Weight at General Hospital Karsa Husada Batu Yuwan Ihzudin Sumitro; Alifia Putri Febriyanti; Prida Ayudianti; Putri Wulan Akbar; Nurfianti Indriana
Journal of Agromedicine and Medical Sciences Vol 9 No 3 (2023)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v9i3.42833

Abstract

Preeclampsia is hypertension that occurs after 20 weeks of gestation with proteinuria. As one of the second highest causes of maternal death in Indonesia, preeclampsia must be detected and managed quickly and appropriately before complications that threaten the mother and fetus arise. One of the conditions that can be associated with preeclampsia is the outcome of low birth weight babies (LBW). This study aimed to determine the relationship between the degree of proteinuria in preeclampsia mothers and incidence of LBW at RSU Karsa Husada Batu. This study used a cross-sectional study design. Data was collected from medical record. The independent variable in this study was the degree of proteinuria and the dependent variable was diagnosis of LBW. The population in this study were all preeclampsia mothers and their babies from preeclampsia patients at RSU Karsa Husada Batu in 2021 with total of 38 patient. Sampling was done by total population sampling. Data analysis used in the study is chi square test. The results of this study showed that there is a relationship between the degree of proteinuria in preeclampsia mothers and incidence of LBW or the higher the degree of proteinuria, the higher the risk of babies from preeclampsia patients experiencing LBW ( p=0,005 ; CI = 95%). Keywords: Preeclampsia, Proteinuria, LBW
Co-Authors Alifia Putri Febriyanti Alvi Milliana Prida Ayudianti Putri Wulan Akbar Yuwan Ihzudin Sumitro Zainabur Rahmah