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All Journal Journal of Agromedicine and Medical Sciences Journal of Islamic Pharmacy Journal of Islamic Medicine Jurnal Ilmiah Kesehatan Media Husada The Avicenna Medical Journal INTERNATIONAL JOURNAL OF SOCIETY REVIEWS (INJOSER)
Zainabur Rahmah
Department Of Parasitology, Faculty Of Medicine And Health Sciences, Universitas Islam Negeri Maulana Malik Ibrahim, Malang, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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MALARIA PADA KEHAMILAN DAN KONSEKUENSINYA PADA IBU DAN JANIN Rahmah, Zainabur
Journal of Islamic Medicine Vol 1, No 1 (2017): Journal of Islamic Medicine
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (173.073 KB) | DOI: 10.18860/jim.v1i1.4120

Abstract

Malaria is an infectious disease remains a major health problem in the world. Malaria attacks without differentiating individual age and sex of pregnant women are no exception. Pregnant women have a risk of malaria by Plasmodium parasites is more severe in comparison with non-pregnant women. When a pregnancy will occur immunosuppression both humoral and cellular purpose of this paper is to discuss the mechanism of occurrence of malaria in pregnancy and its consequences on the mother and fetus. Parasite adhesion receptors Chondroitin Sulfate A (CSA) and Hyaluronic Acid (HA) in the placenta can trigger an inflammatory process involving the secretion of cytokines. Inflammatory component that appears after the accumulation of parasites in the placenta is associated with immune pathology in the Pregnancy-Associated Malaria (PAM), such as thickening of the membrane cytotrophoblasts that disrupt blood flow, inhibiting the transfer of IgG across the placenta and the exchange of nutrients from mother to fetus, causing lesions in the placenta. Malaria infection during pregnancy is a process of mediation by protein cytoadherence in Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP-1) encoded by genes that bind to receptors on Var2CSA this causes placental sequestration of infected erythrocytes on endothelial cells resulting in anemia in pregnant while on fetus causes low birth weight, premature birth and stillbirth.
Respon Jamaah Haji terhadap Kualitas Pelayanan Kesehatan di Daerah Kecamatan Pademawu Kabupaten Pamekasan Rahmah, Zainabur; Fitrianingsih, Avin Ainur; Rachma, Lailia Nur; Astari, Lina Fitria; Riskiyana, Riskiyana
Journal of Islamic Pharmacy Vol 5, No 1 (2020): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v5i1.9487

Abstract

The number of pilgrims of various ages and levels of education experience many health problems such as hypertension, respiratory infections and heart problems. From these problems encourage researchers to determine the response of prospective pilgrims to health services in Pademawu Pamekasan. The object of this study is the pilgrims in Pademawu Pamekasan Regency. The purpose of this study was to determine the response of the pilgrims in Pademawu District, Pamekasan Regency. This research uses a quantitative approach that is data collection using a questionnaire instrument. The sampling technique uses a total sampling population of 70 pilgrims. The study was conducted in the District of Pademawu Pamekasan to the Hajj pilgrims in 2018. The results of the study of the pilgrims' response to the quality of service include cognitive, affective, conative, age and education levels. Overall, the response of the haj pilgrims to the quality of service on the cognitive aspect was 29.5%. In the affective aspect of 4.69%. In the conative aspect 2.05%. At the age factor of 4.51% and at the aspect of Education level as much as 2.19%. The quality of health services affects the response of the pilgrims to the cognitive, affective and conative aspects but is not influenced by the age and level of education of the pilgrims.Keywords: hajj response, service, health
Potential Test Of Ethanol Extract From Onion (Allium Cepa L) Leaves As A Repellent To Aedes Aegypti Adnani, Basyar; Rahmah, Zainabur; Fitrianingsih, Avin Ainur; Setiawan, Abdul Malik
Journal of Islamic Medicine Vol 4, No 2 (2020): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2020
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v4i2.10171

Abstract

Background : The most dangerous vector of mosquito-borne disease, namely Dengue Haemorrhagic Fever (DHF), is Aedes aegypti. One of the most commonly used prevention methods is using repellent.Objective: This study aims to know red onion (Allium cepa L) leaves ability as a repellent against mosquitoes bites, primarily Aedes aegypti. Onion leaves are known to have flavonoids and essential oil content that believed to have health benefits such as anti-inflammatory, insecticide, antifungal, and repellency effects.Method: This study design was a post test only control group of true experiment, with ± 300 mosquitoes in five treatment groups. The study design was a true experimental post-test only control group using ± 300 mosquitoes divided into five treatment groups. Positive control, negative control, and three groups with each extract containing 5%, 10%, and 20% content. The data taken is the number of mosquitoes alighted on attractants available, for five consecutive days. The analytical test used is the KruskalWalls and Spearman test with α coefficient 0.05.Results: the number of mosquitoes perching on each of the extract treatment plates decreased with increasing extract concentration. In the treatment control group, the negative control had the highest number of mosquitoes perching, while the positive control had the least number of perching mosquitoes. All concentrations of ethanol extract, either 10%, 15%, or 10%, all have the effect of repellent against Aedes aegypti.Conclusion : 20% of ethanol extract has the most repellency effect on Aedes aegypti mosquitoes.
Perbandingan Uji Aktivitas Antibakteri Umbi Bawang Merah (Allium Cepa L) Dan Umbi Bawang Putih (Allium Sativum) Terhadap Pertumbuhan Bakteri Shigella Dysenteriae Purnomo S, Fahrurrozi Hari; Fitrianingsih, Avin Ainur; Rahmah, Zainabur; Milliana, Alvi
Journal of Islamic Medicine Vol 4, No 2 (2020): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2020
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v4i2.10169

Abstract

Background :Diarrhea is one of the causes of morbidity and mortality in infants and children around the world. One of the causes of diarrhea is Shigella sp bacteria or shigellosis. Nowadays, many antibiotics resistant to the Shigella sp bacteria are one example of chloramphenicol, so it is necessary to have other alternatives such as natural ingredients. Objective: Determine the activity of the red onion (Allium cepa L) and garlic (Allium sativum), which is known to possess antibacterial phytochemical compounds against the Shigella dysenteriae bacteria. Method: This research is a laboratory experimental study to determine antibacterial activity using the Kirby-Bauer or diffusion method of discs and to determine the presence of Minimum Inhibitory Concentration (MIC) and Minimum Bacterial Concentration (MBC). The study uses five treatments i.e., onion extracts and garlic extracts with a concentration of 30%, 40%, 50%, 60%, 70%, control positive (Ciprofloxacin), and negative control (aquadest). Results: Red onion diffusion has the best antibacterial activity at concentrations 70% while garlic has the best antibacterial activity at a concentration of 70%. In this study, there were no MIC and MBC. The MIC data analyzed with the crucial test of Kruskal-Wallis (p 0.05) i.e., in onion extract p = 0.003 and in garlic P = 0.003, which means significant. The MBC Data is analyzed by crucial test (P 0.05) in the onion extract p = 0.003 and on garlic p = 0.04. Conclusion : the disc diffusion and the MBC can be concluded that garlic extract can inhibit the growth of S. dysenteriae compared to red onion extracts. onion extracts).
The Effect of Azadirachta indica leaves extract on Transforming Growth Factor-β and Tumor Necrosis Factor-α in a Plasmodium berghei infected Mice model Zainabur Rahmah
Journal of Agromedicine and Medical Sciences Vol 7 No 1 (2021)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v7i1.21867

Abstract

Malaria is a health problem for the world's population and is predominantly located in tropical and subtropical areas. The three countries with the most malaria cases are India (58%), followed by Indonesia (20%), then Myanmar (16%). This study aims to determine the effect of neem leaf extract on increasing TGF-β expression and decreasing TNF-α expression in mice infected with Plasmodium berghei. In this study there were four groups, namely Treatment 1 (in Plasmodium berghei infection without therapy). Treatment 2 (in Plasmodium berghei infection and treated with Azadirachta indica leaf extract at a dose of 0.25 mg / g BW). Treatment 3 = (in Plasmodium berghei infection and therapy with Azadirachta indica leaves at a dose of 0.5 mg / g BW). Treatment 4 = (in Plasmodium berghei infection and treated with Azadirachta indica leaves at a dose of 1 mg / g BW). TGF-β examination by elisa method and TNF-α by immunohistochemistry. Data analysis using SEM (Structural Equation Modeling) The results of treatment 1 and 2 showed a decrease in plasma TGF-β expression (t = 1.13; tcount = 1.93; ≥ttabel = 1.96) and spleen (tcount = 1.53; tcount = 1.45; ≥ttabel = 1.96) but there was an increase in spleen TNF-α expression (tcount = 1.77; tcount = 1.00; ≥ttabel = 1.96). Groups 3 and 4 showed an increase in plasma TGF-β expression (tcount = 5.13; tcount = 2.42; ≥ttable = 1.96) and spleen (tcount = 2.00; tcount = 1.97; ≥ttabel = 1.96) but there was a decrease in spleen TNF-α expression (tcount = 2.03; tcount = 2.11; ≥ttabel = 1.96). Conclusion: Azadirachta indica leaf therapy can increase TGF-β expression and decrease TNF-α expression in the spleen. Keywords: Azadirachta indica ethanol extract, transforming growth factor- β, tumor necrosis factor-α
High Degree of Parasitemia Induces Placental Hypoxia and Low Birth Weight Nurfianti Indriana; Zainabur Rahmah; Alvi Milliana
Journal of Agromedicine and Medical Sciences Vol 8 No 2 (2022)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v8i2.31243

Abstract

Placental malaria causes low fetal weight associated with infiltration of monocytes and parasites in the placenta resulting in placental hypoxia. Hypoxia is characterized by HIF expression. HIF-1α expression responds early to the occurrence of hypoxia (<24 hours) and HIF-2α promotes chronic hypoxia (>24 hours). There were two groups in this study, namely the control group (10 pregnant mice without Plasmodium berghei infection) and the treatment group (10 pregnant mice infected with Plasmodium berghei). Pregnant mice were operated on on the 18th day after mating. The degree of parasitemia was measured by Giemsa staining. Expression of HIF-1α and HIF-2α in placental tissue was measured by immunohistochemistry. Results by paired t test, HIF-1α expression in the placental tissue in the treatment group was higher than the control group (p=0.02), HIF-2α expression in the placental tissue was higher in the treatment group than in the control group (0, 01) the fetal weight in the treatment group was lower than in the control group (p=0.01). By using SEM analysis, the degree of parasitemia caused high expression of HIF-1α in placental tissue (tcount = 4.625, ttable = 1.96). High expression of HIF-2α in placental tissue (tcount = 2.672 ttable = 1.96). The degree of parasitemia causes low fetal weight (tcount = 27.764 ttable = 1.96). The results also showed that HIF-1 caused low birth weight (tcount = 2.376 ttable=1.96) also HIF-2α caused low fetal weight (tcount = 4.267 ≥ 1.96). Conclusions the degree of parasitemia causes high expression of HIF-1α and HIF-2α in placental tissue and low birth fetuses. Expression of HIF-1α and HIF-2 also causes low birth weight. Keywords: malaria in pregnancy, degree of parasitemia, HIF-1α , HIF-2α , birth weight
Kajian Pustaka Tentan Apoptosis Pada Kehamilan Normal dan Abnormal Zainabur Rahmah
Jurnal Ilmiah Kesehatan Media Husada Vol 1 No 1: Agustus
Publisher : LPPMK STIKES Widyagama Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1168.079 KB) | DOI: 10.33475/jikmh.v1i1.85

Abstract

Apoptosis terjadi selama kehamilan normal dan abnormal. Apoptosis telah ditunjukkan terjadi di dalam smooth muscle cell (VSMC) membran desidua dan membran amnion. Tujuan dari makalah ini adalah untuk menentukan mekanisme apoptosis smooth muscle cell (VSMC), desidua dan membran ketuban pada kehamilan yang normal dan abnormal. Apoptosis pada kehamilan normal VSMC mensekpresikan TRAIL (DR4 dan DR5) yang menyebabkan apoptosis pada VSMC terkait dengan renovasi arteri spiralis uterus pada trimester pertama kehamilan. Apoptosis pada desidua diinduksi oleh hormon steroid seperti estrogen, progesteron dan hCG sehingga meningkatkan regulasi FasL dalam desidua basalis yang memainkan peran dalam proses implantasi. Apoptosis pada membran ketuban ada dua jalur yaitu jalur kematian reseptor dan jalur mitokondria
Pregnancy Complication Due to Malaria in Mice BALB/C : The Role of TNF-α, Anemia, and Low Birth Weight Alvi Milliana; Nurfianti Indriana; Zainabur Rahmah
Journal of Islamic Medicine Vol 7, No 1 (2023): JOURNAL OF ISLAMIC MEDICINE EDISI MARET 2023
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v7i1.20828

Abstract

Background : Malaria infection in pregnant women or called placental malaria is characterized by the accumulation of Plasmodium-infected red blood cells in the intervillous space of the placenta. This causes adverse perinatal outcomes such as stillbirth, low birth weight, premature birth, and small neonates of gestational age while in the mother it causes anemia. Inflammatory responses such as TNF-α expression can promote complications in pregnancy. TNF-α plays an important role in the immune response in acute malaria but inhibits erythropoiesis. Objective : This study aims to determine the relationship between malaria infection and TNF-α expression with the incidence of anemia and birth weight in pregnant mice infected with Plasmodium berghei. Methods: Twenty BALB/C pregnant mice were divided into 2 groups, control group (10 pregnant mice without infection) treatment group (10 pregnant mice infected with Plasmodium berghei). TNF-α expression was observed by immunohistochemical method using anti-TNF-α Chip Grade antibody from abcam, anemia examination using Cyanmethemoglobin and all fetuses were weighed using an analytical balance. Statistical analysis using Structural Equation Modeling. Results: Malaria infection causes high expression of TNF-α in the placenta (tcount=2.97≥ ttable = 1.96), causes anemia (tcount=1,97≥ttable = 1.96) and causes low fetal weight tcount=2,16 ≥ ttable =1, 96. Conclusion: Malaria infection can cause high expression of TNF-α in the placenta causing anemia and low birth weight of the fetus
COMPARISON OF EFFICACY OF TRADITIONAL AND MODERN MEDICINE IN DIABETES MELLITUS MANAGEMENT Doby Indrawan; Iwal Reza Ahdi; Zainabur Rahmah
INTERNATIONAL JOURNAL OF SOCIETY REVIEWS Vol. 2 No. 7 (2024): JULY
Publisher : Adisam Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diabetes mellitus is a chronic disease with an increasing prevalence globally. Diabetes management involves a multifaceted approach that includes lifestyle changes, blood sugar monitoring, and the use of medications. While modern medicine has become fundamental in the management of diabetes, traditional medicine is also still widely used. This study aims to evaluate and compare the efficacy of traditional and modern medicine in the management of diabetes. The research method used in this study is literature review. The results showed that modern medicine, which is based on strong scientific evidence and clinical validation, consistently showed higher efficacy in controlling blood sugar and reducing the risk of diabetes complications compared to traditional medicine. Drugs such as Metformin, DPP-4 inhibitors, and GLP-1 analogs have strong evidence of efficacy. On the other hand, studies on traditional medicine show mixed results with some offering potential benefits in controlling blood sugar. However, evidence regarding traditional medicine often lacks consistency and is poorly understood in the context of a clear mechanism of action.
Social Support Build Resilience in Multidrug-Resistant Tuberculosis Patients: A Cross-Sectional Study in MDR-TB Patient Support Group Akbar, Putri Wulan; Rachma, Lailia Nur; Rahmah, Zainabur; Firdaus, Muhammad Iqbal; Nanggali, Bryka Vian
The Avicenna Medical Journal Vol 5, No 2 (2024): The Avicenna Medical Journal
Publisher : Faculty of Medicine, UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/avicenna.v5i2.42615

Abstract

Background: Multidrug-resistant tuberculosis (MDR-TB) patient faces multi-dimensional challenges due to the physical factor, long-term treatment, negative stigma, and psychosocial challenge. Addressing these issues patient requires a resilience. The formation of resilience is influenced by both internal and external factors, including social support. This study purposed to assess the social support impact on resilience in MDR-TB patients. Methods: This study was an observational analytic study with cross sectional design. A total of 33 respondents with MDR-TB confirmed, a member of MDR-TB support group, and under treatment were involved. The social support level was measured using the ISEL-12 (Interpersonal Support Evaluation List) questionnaire, while the level of resilience was assessed using the CD-RISC-25 (Connor-Davidson Resilience Scale). Spearman correlation test in SPSS Ver 24.0 was used to examine the relationship between social support and resilience among patients with MDR-TB. Results: Majority of respondents (17 respondents, 51.6%) have good social support and 23 respondents (69.7%) exhibited a good level of resilience. The Spearman correlation test revealed a significant positive correlation between social support and resilience, with a p-value of 0.030 and a moderate strength correlation coefficient (r) of 0.378. Conclusion: This finding showed that good social support toward MDR-TB patients gives positive impact to patients’ resilience. Thus strengthens the system of social support in support group is important to decrease the psychosocial challenges and help to succeed the treatment.
Co-Authors Abdul Malik Setiawan Adnani, Basyar Alvi Milliana Astari, Lina Fitria Avin Ainur Fitrianingsih Doby Indrawan Firdaus, Moh. Iqbal Indriana, Nurfianti Iwal Reza Ahdi Lailia Nur Rachma Muhammad Iqbal Firdaus, Muhammad Iqbal Nanggali, Bryka Vian Nurfianti Indriana Purnomo S, Fahrurrozi Hari Putri Wulan Akbar Riskiyana, Riskiyana